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Conserved domains on  [gi|1701944695|ref|NP_001358349|]
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interleukin-18 receptor 1 isoform 5 precursor [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 129-208 1.04e-07

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05757:

Pssm-ID: 472250  Cd Length: 92  Bit Score: 49.24  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695 129 IVEVKKFFQITC-ENSYYQTLVNSTSL--YKNCKKLLLENN----KNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKT 201
Cdd:cd05757     6 KLPITKGGKITCpDLDDYKNENVLPPIqwYKDCKPLQGDKRfipkGSKLLIQNVTEEDAGNYTCKFTYTHNGKQYNVTRT 85


                  ....*..
gi 1701944695 202 FNITIVE 208
Cdd:cd05757    86 ISLTVTE 92
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 19-104 4.43e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05756:

Pssm-ID: 472250  Cd Length: 96  Bit Score: 38.94  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695  19 AESCTSRPHITVVEGEPFYLKhcsCSL-AHEIETTTKS---WYKSsGSQEHVELNPRSssRIALHDCVLEFWPVELNDTG 94
Cdd:cd05756     1 DEWGEDIKILVVLEGEPDVIK---CPLfPNFLAQSAGLnltWYKN-DSETPISFEPDS--RIHQEKDKLWFVPALLEDSG 74

                          90
                  ....*....|
gi 1701944695  95 SYFFQMKNYT 104
Cdd:cd05756    75 NYYCVVRNST 84
PHA02785 super family cl31505
IL-beta-binding protein; Provisional
 171-312 1.06e-03

IL-beta-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02785:

Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 40.77  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695 171 IKKNaefeDQGYYSCVHFLHHNGKLFNITKtfnITIVEDRSNIVPvllgPKL---NHVAVELGKNVRLNCSALLNEEDV- 246
Cdd:PHA02785  184 VRKN----DAGYYTCVLKYIYGDKTYNVTR---IVKLEVRDRIIP----PTMqlpEGVVTSIGSNLTIACRVSLRPPTTd 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1701944695 247 --IYW----MFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVlYNC---TVASTGGTDTKSFI 312
Cdd:PHA02785  253 adVFWisngMYYEEDDEDGDGRISVANKIYTTDKRRVITSRLNINPVKEEDATT-FTCmafTIPSISKTVTISIT 326
 
Name Accession Description Interval E-value
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 129-208 1.04e-07

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 49.24  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695 129 IVEVKKFFQITC-ENSYYQTLVNSTSL--YKNCKKLLLENN----KNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKT 201
Cdd:cd05757     6 KLPITKGGKITCpDLDDYKNENVLPPIqwYKDCKPLQGDKRfipkGSKLLIQNVTEEDAGNYTCKFTYTHNGKQYNVTRT 85


                  ....*..
gi 1701944695 202 FNITIVE 208
Cdd:cd05757    86 ISLTVTE 92
Ig1_IL1R_like cd05756
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 19-104 4.43e-04

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409414  Cd Length: 96  Bit Score: 38.94  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695  19 AESCTSRPHITVVEGEPFYLKhcsCSL-AHEIETTTKS---WYKSsGSQEHVELNPRSssRIALHDCVLEFWPVELNDTG 94
Cdd:cd05756     1 DEWGEDIKILVVLEGEPDVIK---CPLfPNFLAQSAGLnltWYKN-DSETPISFEPDS--RIHQEKDKLWFVPALLEDSG 74

                          90
                  ....*....|
gi 1701944695  95 SYFFQMKNYT 104
Cdd:cd05756    75 NYYCVVRNST 84
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-100 5.49e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.36  E-value: 5.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695  28 ITVVEGEPFYLkHCSCSLAHEIETTTKSWYK-SSGSQEHVELNPRSSSR--------------IALHDCVLEFWPVELND 92
Cdd:pfam07686   6 VTVALGGSVTL-PCTYSSSMSEASTSVYWYRqPPGKGPTFLIAYYSNGSeegvkkgrfsgrgdPSNGDGSLTIQNLTLSD 84


                  ....*...
gi 1701944695  93 TGSYFFQM 100
Cdd:pfam07686  85 SGTYTCAV 92
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 171-312 1.06e-03

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 40.77  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695 171 IKKNaefeDQGYYSCVHFLHHNGKLFNITKtfnITIVEDRSNIVPvllgPKL---NHVAVELGKNVRLNCSALLNEEDV- 246
Cdd:PHA02785  184 VRKN----DAGYYTCVLKYIYGDKTYNVTR---IVKLEVRDRIIP----PTMqlpEGVVTSIGSNLTIACRVSLRPPTTd 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1701944695 247 --IYW----MFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVlYNC---TVASTGGTDTKSFI 312
Cdd:PHA02785  253 adVFWisngMYYEEDDEDGDGRISVANKIYTTDKRRVITSRLNINPVKEEDATT-FTCmafTIPSISKTVTISIT 326
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-111 4.23e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.94  E-value: 4.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695   26 PHITVVEGEPFYLkhcSCSlAHEIETTTKSWYKssGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKN--- 102
Cdd:smart00410   2 PSVTVKEGESVTL---SCE-ASGSPPPEVTWYK--QGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNssg 75

                           90
                   ....*....|
gi 1701944695  103 -YTQKWKLNV 111
Cdd:smart00410  76 sASSGTTLTV 85
 
Name Accession Description Interval E-value
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 129-208 1.04e-07

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 49.24  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695 129 IVEVKKFFQITC-ENSYYQTLVNSTSL--YKNCKKLLLENN----KNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKT 201
Cdd:cd05757     6 KLPITKGGKITCpDLDDYKNENVLPPIqwYKDCKPLQGDKRfipkGSKLLIQNVTEEDAGNYTCKFTYTHNGKQYNVTRT 85


                  ....*..
gi 1701944695 202 FNITIVE 208
Cdd:cd05757    86 ISLTVTE 92
Ig2_IL1R_like cd20994
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 155-208 2.48e-07

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409586  Cd Length: 94  Bit Score: 48.23  E-value: 2.48e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1701944695 155 YKNCKKLLLENN-----KNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVE 208
Cdd:cd20994    36 YKDCKPLLLDDKrfaglESDLLIFNVTVQDQGNYTCHTSYTYMGKQYNISRTISLIVLE 94
Ig1_IL1R_like cd05756
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 19-104 4.43e-04

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409414  Cd Length: 96  Bit Score: 38.94  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695  19 AESCTSRPHITVVEGEPFYLKhcsCSL-AHEIETTTKS---WYKSsGSQEHVELNPRSssRIALHDCVLEFWPVELNDTG 94
Cdd:cd05756     1 DEWGEDIKILVVLEGEPDVIK---CPLfPNFLAQSAGLnltWYKN-DSETPISFEPDS--RIHQEKDKLWFVPALLEDSG 74

                          90
                  ....*....|
gi 1701944695  95 SYFFQMKNYT 104
Cdd:cd05756    75 NYYCVVRNST 84
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-100 5.49e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.36  E-value: 5.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695  28 ITVVEGEPFYLkHCSCSLAHEIETTTKSWYK-SSGSQEHVELNPRSSSR--------------IALHDCVLEFWPVELND 92
Cdd:pfam07686   6 VTVALGGSVTL-PCTYSSSMSEASTSVYWYRqPPGKGPTFLIAYYSNGSeegvkkgrfsgrgdPSNGDGSLTIQNLTLSD 84


                  ....*...
gi 1701944695  93 TGSYFFQM 100
Cdd:pfam07686  85 SGTYTCAV 92
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 56-143 7.41e-04

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 39.32  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695  56 WYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYF--FQMKNytqkwklnviRRNKHSCFterqvtsKIV-EV 132
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPHIIQEGNALWFLPVGVNDSGSYIcrPRIRS----------PQDEACCL-------KIIlEV 110

                          90
                  ....*....|.
gi 1701944695 133 KKFFQITCENS 143
Cdd:pfam18452 111 QPKTNASCSGS 121
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 171-312 1.06e-03

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 40.77  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695 171 IKKNaefeDQGYYSCVHFLHHNGKLFNITKtfnITIVEDRSNIVPvllgPKL---NHVAVELGKNVRLNCSALLNEEDV- 246
Cdd:PHA02785  184 VRKN----DAGYYTCVLKYIYGDKTYNVTR---IVKLEVRDRIIP----PTMqlpEGVVTSIGSNLTIACRVSLRPPTTd 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1701944695 247 --IYW----MFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVlYNC---TVASTGGTDTKSFI 312
Cdd:PHA02785  253 adVFWisngMYYEEDDEDGDGRISVANKIYTTDKRRVITSRLNINPVKEEDATT-FTCmafTIPSISKTVTISIT 326
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-111 4.23e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.94  E-value: 4.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944695   26 PHITVVEGEPFYLkhcSCSlAHEIETTTKSWYKssGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKN--- 102
Cdd:smart00410   2 PSVTVKEGESVTL---SCE-ASGSPPPEVTWYK--QGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNssg 75

                           90
                   ....*....|
gi 1701944695  103 -YTQKWKLNV 111
Cdd:smart00410  76 sASSGTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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