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Conserved domains on  [gi|1706883516|ref|NP_001358552|]
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treacle protein isoform h [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12218018)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
387-904 6.18e-74

Treacher Collins syndrome protein Treacle;


:

Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 256.92  E-value: 6.18e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  387 APAPPGKTGPAVAKAQAGKREEDSQSSSEES------DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 460
Cdd:pfam03546    1 TPATPGKAGPAATQAKAGKPEEDSESSSEEEsdseeeTPAAKTPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  461 PAAAQVQVGKQEEDSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Cdd:pfam03546   81 PAAAQAQAGKPEEDSESSSEESDSDGETPAAAtlttSPAQVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAPLV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  537 QVGKweedSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSE 612
Cdd:pfam03546  161 QVGK----KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGaapaPPQKAGPVATQVKAERSKEDSESSE 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  613 ESSDSADSEEAPAAMTAAqaKPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP 689
Cdd:pfam03546  237 ESSDSEEEAPAAATPAQA--KPALKTPQTKASPRKGTpiTPTSAKVPPVRVGTPAPWKAGTVTSPACaSSPAVARGAQRP 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  690 aEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
Cdd:pfam03546  315 -EEDSSSSEESESEEETAPAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEES 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Cdd:pfam03546  394 DSEEAAATPAQVKASGKTPQAKANPAPTKASSAKGAASAPGKVVAAAAQAKQGSPAKVKPPARTPQNSAISVRGQASVPA 473

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1706883516  850 VGKAVATAAQAQTGPEEDSG---SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Cdd:pfam03546  474 VGKAVATAAQAQKGPVGGPQeedSESSEEESDSEEEAPAQAKPSGKTPQVRAASAPAK 531
Treacle super family cl25490
Treacher Collins syndrome protein Treacle;
212-511 2.56e-09

Treacher Collins syndrome protein Treacle;


The actual alignment was detected with superfamily member pfam03546:

Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 61.63  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  212 VEGKPSVKPAQVKASS--------VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
Cdd:pfam03546  252 AQAKPALKTPQTKASPrkgtpitpTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETA 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPaakalLQAK 363
Cdd:pfam03546  332 PAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESDSEEAAATP-----AQVK 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  364 ASGKTSQVGAASAPAKESPRKGAAPApPGKTGPAVAKAQAGkreedsqssseesdseeeAPAQAKPSGKAPQVRAASApa 443
Cdd:pfam03546  407 ASGKTPQAKANPAPTKASSAKGAASA-PGKVVAAAAQAKQG------------------SPAKVKPPARTPQNSAISV-- 465

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706883516  444 kespRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMnAAQVKPLGKSPQVKPAST 511
Cdd:pfam03546  466 ----RGQASVPAVGKAVATAAQAQKGPVGGPQEEDSESSEEESDSEEEA-PAQAKPSGKTPQVRAASA 528
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 6-37 2.86e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


:

Pssm-ID: 128913  Cd Length: 34  Bit Score: 36.64  E-value: 2.86e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1706883516     6 KRRELLPLIYHHLLRAGYVRAAREVKEQSGQK 37
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGLS 33
 
Name Accession Description Interval E-value
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
387-904 6.18e-74

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 256.92  E-value: 6.18e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  387 APAPPGKTGPAVAKAQAGKREEDSQSSSEES------DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 460
Cdd:pfam03546    1 TPATPGKAGPAATQAKAGKPEEDSESSSEEEsdseeeTPAAKTPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  461 PAAAQVQVGKQEEDSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Cdd:pfam03546   81 PAAAQAQAGKPEEDSESSSEESDSDGETPAAAtlttSPAQVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAPLV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  537 QVGKweedSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSE 612
Cdd:pfam03546  161 QVGK----KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGaapaPPQKAGPVATQVKAERSKEDSESSE 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  613 ESSDSADSEEAPAAMTAAqaKPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP 689
Cdd:pfam03546  237 ESSDSEEEAPAAATPAQA--KPALKTPQTKASPRKGTpiTPTSAKVPPVRVGTPAPWKAGTVTSPACaSSPAVARGAQRP 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  690 aEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
Cdd:pfam03546  315 -EEDSSSSEESESEEETAPAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEES 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Cdd:pfam03546  394 DSEEAAATPAQVKASGKTPQAKANPAPTKASSAKGAASAPGKVVAAAAQAKQGSPAKVKPPARTPQNSAISVRGQASVPA 473

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1706883516  850 VGKAVATAAQAQTGPEEDSG---SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Cdd:pfam03546  474 VGKAVATAAQAQKGPVGGPQeedSESSEEESDSEEEAPAQAKPSGKTPQVRAASAPAK 531
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
212-511 2.56e-09

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 61.63  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  212 VEGKPSVKPAQVKASS--------VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
Cdd:pfam03546  252 AQAKPALKTPQTKASPrkgtpitpTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETA 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPaakalLQAK 363
Cdd:pfam03546  332 PAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESDSEEAAATP-----AQVK 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  364 ASGKTSQVGAASAPAKESPRKGAAPApPGKTGPAVAKAQAGkreedsqssseesdseeeAPAQAKPSGKAPQVRAASApa 443
Cdd:pfam03546  407 ASGKTPQAKANPAPTKASSAKGAASA-PGKVVAAAAQAKQG------------------SPAKVKPPARTPQNSAISV-- 465

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706883516  444 kespRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMnAAQVKPLGKSPQVKPAST 511
Cdd:pfam03546  466 ----RGQASVPAVGKAVATAAQAQKGPVGGPQEEDSESSEEESDSEEEA-PAQAKPSGKTPQVRAASA 528
PHA03247 PHA03247
large tegument protein UL36; Provisional
 157-535 5.87e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 5.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  157 PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPP 2706

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  237 KAAPAPgkvgdvTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Cdd:PHA03247  2707 TPEPAP------HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKEsprkgaAPAPPGKTGP 396
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------PPPPSLPLGG 2854

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQ---AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQvgkqeE 473
Cdd:PHA03247  2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ-----P 2929

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1706883516  474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKpastmgMGPLGKGAGPVPPGKVGPATPS 535
Cdd:PHA03247  2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW------LGALVPGRVAVPRFRVPQPAPS 2985
PHA03247 PHA03247
large tegument protein UL36; Provisional
 234-676 1.01e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEkilqvRAASAPAKGTPGK 313
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-----PSPAANEPDPHPP 2643

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  314 GATPAPPGKAGAvASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Cdd:PHA03247  2644 PTVPPPERPRDD-PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPakesPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Cdd:PHA03247  2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP----PAAPAAGPPRRLTRPAVASLSESRESL 2798

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPqvkPASTMGMGPLGKGAGPVPP-----GKVGPATPSAQVGKWEEDSESS 548
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPslplgGSVAPGGDVRRRPPSRSPAAKP 2875

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  549 SEESSDSSDGEVPTAVAPAQEK-SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247  2876 AAPARPPVRRLARPAVSRSTESfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1706883516  628 TAAQAKPAL--------KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Cdd:PHA03247  2956 SGAVPQPWLgalvpgrvAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA 3012
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 6-37 2.86e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 36.64  E-value: 2.86e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1706883516     6 KRRELLPLIYHHLLRAGYVRAAREVKEQSGQK 37
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGLS 33
 
Name Accession Description Interval E-value
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
387-904 6.18e-74

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 256.92  E-value: 6.18e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  387 APAPPGKTGPAVAKAQAGKREEDSQSSSEES------DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 460
Cdd:pfam03546    1 TPATPGKAGPAATQAKAGKPEEDSESSSEEEsdseeeTPAAKTPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  461 PAAAQVQVGKQEEDSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Cdd:pfam03546   81 PAAAQAQAGKPEEDSESSSEESDSDGETPAAAtlttSPAQVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAPLV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  537 QVGKweedSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSE 612
Cdd:pfam03546  161 QVGK----KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGaapaPPQKAGPVATQVKAERSKEDSESSE 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  613 ESSDSADSEEAPAAMTAAqaKPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP 689
Cdd:pfam03546  237 ESSDSEEEAPAAATPAQA--KPALKTPQTKASPRKGTpiTPTSAKVPPVRVGTPAPWKAGTVTSPACaSSPAVARGAQRP 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  690 aEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
Cdd:pfam03546  315 -EEDSSSSEESESEEETAPAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEES 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Cdd:pfam03546  394 DSEEAAATPAQVKASGKTPQAKANPAPTKASSAKGAASAPGKVVAAAAQAKQGSPAKVKPPARTPQNSAISVRGQASVPA 473

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1706883516  850 VGKAVATAAQAQTGPEEDSG---SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Cdd:pfam03546  474 VGKAVATAAQAQKGPVGGPQeedSESSEEESDSEEEAPAQAKPSGKTPQVRAASAPAK 531
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
212-511 2.56e-09

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 61.63  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  212 VEGKPSVKPAQVKASS--------VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
Cdd:pfam03546  252 AQAKPALKTPQTKASPrkgtpitpTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETA 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPaakalLQAK 363
Cdd:pfam03546  332 PAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESDSEEAAATP-----AQVK 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  364 ASGKTSQVGAASAPAKESPRKGAAPApPGKTGPAVAKAQAGkreedsqssseesdseeeAPAQAKPSGKAPQVRAASApa 443
Cdd:pfam03546  407 ASGKTPQAKANPAPTKASSAKGAASA-PGKVVAAAAQAKQG------------------SPAKVKPPARTPQNSAISV-- 465

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706883516  444 kespRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMnAAQVKPLGKSPQVKPAST 511
Cdd:pfam03546  466 ----RGQASVPAVGKAVATAAQAQKGPVGGPQEEDSESSEEESDSEEEA-PAQAKPSGKTPQVRAASA 528
PHA03247 PHA03247
large tegument protein UL36; Provisional
 157-535 5.87e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 5.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  157 PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPP 2706

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  237 KAAPAPgkvgdvTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Cdd:PHA03247  2707 TPEPAP------HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKEsprkgaAPAPPGKTGP 396
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------PPPPSLPLGG 2854

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQ---AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQvgkqeE 473
Cdd:PHA03247  2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ-----P 2929

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1706883516  474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKpastmgMGPLGKGAGPVPPGKVGPATPS 535
Cdd:PHA03247  2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW------LGALVPGRVAVPRFRVPQPAPS 2985
PHA03247 PHA03247
large tegument protein UL36; Provisional
 234-676 1.01e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEkilqvRAASAPAKGTPGK 313
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-----PSPAANEPDPHPP 2643

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  314 GATPAPPGKAGAvASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Cdd:PHA03247  2644 PTVPPPERPRDD-PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPakesPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Cdd:PHA03247  2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP----PAAPAAGPPRRLTRPAVASLSESRESL 2798

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPqvkPASTMGMGPLGKGAGPVPP-----GKVGPATPSAQVGKWEEDSESS 548
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPslplgGSVAPGGDVRRRPPSRSPAAKP 2875

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  549 SEESSDSSDGEVPTAVAPAQEK-SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247  2876 AAPARPPVRRLARPAVSRSTESfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1706883516  628 TAAQAKPAL--------KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Cdd:PHA03247  2956 SGAVPQPWLgalvpgrvAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA 3012
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
883-926 1.58e-04

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 46.22  E-value: 1.58e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1706883516  883 TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQA 926
Cdd:pfam03546   43 TPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTGPAAAQA 86
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
234-499 1.91e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.00  E-value: 1.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  234 PARKAAPAPGkvGDVTPQVKGGALPPAKRAkkpeeesesseEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGK 313
Cdd:PRK07003   360 PAVTGGGAPG--GGVPARVAGAVPAPGARA-----------AAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAP 426

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  314 GATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Cdd:PRK07003   427 PAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAA 506

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA---------------SAPAKESPRKGAAPAPPRK 458
Cdd:PRK07003   507 VPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAAldvlrnagmrvssdrGARAAAAAKPAAAPAAAPK 586

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1706883516  459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Cdd:PRK07003   587 PAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPP 627
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 385-467 7.67e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.11  E-value: 7.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKT----- 459
Cdd:PRK12270    37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAavede 116

                           90
                   ....*....|...
gi 1706883516  460 -----GPAAAQVQ 467
Cdd:PRK12270   117 vtplrGAAAAVAK 129
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
214-463 1.07e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  214 GKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTpqvkGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKA 293
Cdd:PRK07003   371 GVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAA----GAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGD 446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  294 SEkiLQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGA 373
Cdd:PRK07003   447 AP--VPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA 524

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  374 ASAPAKES-PRKGAAPAPPGKTGPAVAK----AQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA------ASAP 442
Cdd:PRK07003   525 AAPPAPEArPPTPAAAAPAARAGGAAAAldvlRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVqvptprARAA 604

                          250       260
                   ....*....|....*....|.
gi 1706883516  443 AKESPRKGAAPAPPRKTGPAA 463
Cdd:PRK07003   605 TGDAPPNGAARAEQAAESRGA 625
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 177-465 2.61e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 2.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  177 GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Cdd:PRK07764   391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAP 470

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ-------------------VKASEKILQVRAASAPAKG-------- 309
Cdd:PRK07764   471 AAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaddaatlrerwpeilaavPKRSRKTWAILLPEATVLGvrgdtlvl 550

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  310 ---TPGKGATPAPPGKAG-----------------AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS 369
Cdd:PRK07764   551 gfsTGGLARRFASPGNAEvlvtalaeelggdwqveAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPA 630

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  370 QVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK 449
Cdd:PRK07764   631 GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPP 710

                          330
                   ....*....|....*.
gi 1706883516  450 GAAPAPPRKTGPAAAQ 465
Cdd:PRK07764   711 AGQADDPAAQPPQAAQ 726
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 6-37 2.86e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 36.64  E-value: 2.86e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1706883516     6 KRRELLPLIYHHLLRAGYVRAAREVKEQSGQK 37
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGLS 33
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
309-541 3.21e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 3.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  309 GTPGKGATPAPPgKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 388
Cdd:PRK12323   366 GQSGGGAGPATA-AAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  389 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRktgPAAAQVQV 468
Cdd:PRK12323   445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQ---PDAAPAGW 521

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706883516  469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAstmgmgplgkgagPVPPGKVGPATPSAQVGKW 541
Cdd:PRK12323   522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVA-------------PRPPRASASGLPDMFDGDW 581
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 378-465 5.77e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.41  E-value: 5.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  378 AKESPRKGAAPAPPGKTGPAVAKAQAgkreedsqssseesdSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR 457
Cdd:PRK12270    34 ADYGPGSTAAPTAAAAAAAAAASAPA---------------AAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAA 98


                   ....*...
gi 1706883516  458 KTGPAAAQ 465
Cdd:PRK12270    99 PPAAAAAA 106
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
250-466 8.38e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 8.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEkilqvrAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Cdd:PRK12323   365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAP------AAAAAARAVAAAPARRSPAPEALAAARQ 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706883516  330 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKasgktsqvgAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED 409
Cdd:PRK12323   439 ASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPV---------AAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASP 509

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1706883516  410 SQSSSEESDSEEEAPAQAKPSGKAPqvRAASAPAKESPRKGAAPAPPRKTGPAAAQV 466
Cdd:PRK12323   510 APAQPDAAPAGWVAESIPDPATADP--DDAFETLAPAPAAAPAPRAAAATEPVVAPR 564
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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