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Conserved domains on  [gi|1707919429|ref|NP_001358630|]
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cytochrome P450 20A1 isoform 4 [Homo sapiens]

Protein Classification

cytochrome P450 family protein( domain architecture ID 1750044)

cytochrome P450 family protein may catalyze the oxidation of organic species by molecular oxygen, by the oxidative addition of atomic oxygen into an unactivated C-H or C-C bond

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cytochrome_P450 super family cl41757
cytochrome P450 (CYP) superfamily; Cytochrome P450 (P450, CYP) is a large superfamily of ...
 1-290 0e+00

cytochrome P450 (CYP) superfamily; Cytochrome P450 (P450, CYP) is a large superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs with > 40% sequence identity are members of the same family. There are approximately 2250 CYP families: mammals, insects, plants, fungi, bacteria, and archaea have around 18, 208, 277, 805, 591, and 14 families, respectively. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. Their monooxygenase activity relies on the reductive scission of molecular oxygen bound to the P450 heme iron, and the delivery of two electrons to the heme iron during the catalytic cycle. CYPs use a variety of redox partners, such as the eukaryotic diflavin enzyme NADPH-cytochrome P450 oxidoreductase and the bacterial/mitochondrial NAD(P)H-ferredoxin reductase and ferredoxin partners. Some CYPs are naturally linked to their redox partners and others have evolved to bypass requirements for redox partners, and instead react directly with hydrogen peroxide or NAD(P)H to facilitate oxidative or reductive catalysis.


The actual alignment was detected with superfamily member cd20627:

Pssm-ID: 477761 [Multi-domain]  Cd Length: 394  Bit Score: 554.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429   1 MLKSLLRYQSG-GGSVSENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVM 79
Cdd:cd20627    39 MLKSLLGYQSGsGGDASESHVRKKLYENGVTKALQSNFPLLLKLSEELLDKWLSYPESQHVPLCQHMLGFAMKSVTQMVM 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  80 GSTFEDDQEVIRFQKNHGTI------------------------------------------------------------ 99
Cdd:cd20627   119 GSTFEDDQEVIRFRKNHDAIwseigkgfldgsleksttrkkqyedalmemesvlkkvikerkgknfsqhvfidsllqgnl 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 100 -----LEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTP 174
Cdd:cd20627   199 seqqvLEDSMIFSLAGCVITANLCTWAIYFLTTSEEVQKKLYKEVDQVLGKGPITLEKIEQLRYCQQVLCETVRTAKLTP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 175 VSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTTV 254
Cdd:cd20627   279 VSARLQELEGKVDQHIIPKETLVLYALGVVLQDNTTWPLPYRFDPDRFDDESVMKSFSLLGFSGSQECPELRFAYMVATV 358

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1707919429 255 LLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWIT 290
Cdd:cd20627   359 LLSVLVRKLRLLPVDGQVMETKYELVTSPREEAWIT 394
 
Name Accession Description Interval E-value
CYP20A1 cd20627
cytochrome P450 family 20, subfamily A, polypeptide 1; Cytochrome P450, family 20, subfamily A, ...
 1-290 0e+00

cytochrome P450 family 20, subfamily A, polypeptide 1; Cytochrome P450, family 20, subfamily A, polypeptide 1 (cytochrome P450 20A1 or CYP20A1) is expressed in human hippocampus and substantia nigra. In zebrafish, maternal transcript of CYP20A1 occurs in eggs, suggesting involvement in brain and early development. CYP20A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410720 [Multi-domain]  Cd Length: 394  Bit Score: 554.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429   1 MLKSLLRYQSG-GGSVSENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVM 79
Cdd:cd20627    39 MLKSLLGYQSGsGGDASESHVRKKLYENGVTKALQSNFPLLLKLSEELLDKWLSYPESQHVPLCQHMLGFAMKSVTQMVM 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  80 GSTFEDDQEVIRFQKNHGTI------------------------------------------------------------ 99
Cdd:cd20627   119 GSTFEDDQEVIRFRKNHDAIwseigkgfldgsleksttrkkqyedalmemesvlkkvikerkgknfsqhvfidsllqgnl 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 100 -----LEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTP 174
Cdd:cd20627   199 seqqvLEDSMIFSLAGCVITANLCTWAIYFLTTSEEVQKKLYKEVDQVLGKGPITLEKIEQLRYCQQVLCETVRTAKLTP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 175 VSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTTV 254
Cdd:cd20627   279 VSARLQELEGKVDQHIIPKETLVLYALGVVLQDNTTWPLPYRFDPDRFDDESVMKSFSLLGFSGSQECPELRFAYMVATV 358

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1707919429 255 LLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWIT 290
Cdd:cd20627   359 LLSVLVRKLRLLPVDGQVMETKYELVTSPREEAWIT 394
p450 pfam00067
Cytochrome P450; Cytochrome P450s are haem-thiolate proteins involved in the oxidative ...
 119-279 5.64e-23

Cytochrome P450; Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.


Pssm-ID: 395020 [Multi-domain]  Cd Length: 461  Bit Score: 98.12  E-value: 5.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRtakLTPVSAQL------QDIegKIDRFII 191
Cdd:pfam00067 282 SWALYELAKHPEVQEKLREEIDEVIGDKrSPTYDDLQNMPYLDAVIKETLR---LHPVVPLLlprevtKDT--VIPGYLI 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 192 PRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVM--KTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSV 268
Cdd:pfam00067 357 PKGTLVIVNLYALHRDPEVFPNPEEFDPERFLDENGKfrKSFAFLPFGaGPRNCLGERLARMEMKLFLATLLQNFEVELP 436

                         170
                  ....*....|.
gi 1707919429 269 EGQVIETKYEL 279
Cdd:pfam00067 437 PGTDPPDIDET 447
PLN02394 PLN02394
trans-cinnamate 4-monooxygenase
 120-271 1.25e-14

trans-cinnamate 4-monooxygenase


Pssm-ID: 215221 [Multi-domain]  Cd Length: 503  Bit Score: 73.61  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDI-EGKIDRFIIPRETLV 197
Cdd:PLN02394  315 WGIAELVNHPEIQKKLRDELDTVLGPGnQVTEPDTHKLPYLQAVVKETLRLHMAIPLLVPHMNLeDAKLGGYDIPAESKI 394

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 198 LYALGVVLQDPNTWPSPHKFDPDRF-----DDELVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQ 271
Cdd:PLN02394  395 LVNAWWLANNPELWKNPEEFRPERFleeeaKVEANGNDFRFLPFgVGRRSCPGIILALPILGIVLGRLVQNFELLPPPGQ 474
CypX COG2124
Cytochrome P450 [Secondary metabolites biosynthesis, transport and catabolism, Defense ...
 114-294 1.41e-10

Cytochrome P450 [Secondary metabolites biosynthesis, transport and catabolism, Defense mechanisms]; Cytochrome P450 is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441727 [Multi-domain]  Cd Length: 400  Bit Score: 61.45  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEinqvfgngpvtPEKIEQ-----LRYCQHVLCeTVRTAKltpvsaqlQDIEgkIDR 188
Cdd:COG2124   242 TANALAWALYALLRHPEQLARLRAE-----------PELLPAaveetLRLYPPVPL-LPRTAT--------EDVE--LGG 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 189 FIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRfddelvmKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLS 267
Cdd:COG2124   300 VTIPAGDRVLLSLAAANRDPRVFPDPDRFDPDR-------PPNAHLPFGgGPHRCLGAALARLEARIALATLLRRFPDLR 372

                         170       180
                  ....*....|....*....|....*...
gi 1707919429 268 -VEGQVIETKYELVTSSREEAWITVSKR 294
Cdd:COG2124   373 lAPPEELRWRPSLTLRGPKSLPVRLRPR 400
 
Name Accession Description Interval E-value
CYP20A1 cd20627
cytochrome P450 family 20, subfamily A, polypeptide 1; Cytochrome P450, family 20, subfamily A, ...
 1-290 0e+00

cytochrome P450 family 20, subfamily A, polypeptide 1; Cytochrome P450, family 20, subfamily A, polypeptide 1 (cytochrome P450 20A1 or CYP20A1) is expressed in human hippocampus and substantia nigra. In zebrafish, maternal transcript of CYP20A1 occurs in eggs, suggesting involvement in brain and early development. CYP20A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410720 [Multi-domain]  Cd Length: 394  Bit Score: 554.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429   1 MLKSLLRYQSG-GGSVSENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVM 79
Cdd:cd20627    39 MLKSLLGYQSGsGGDASESHVRKKLYENGVTKALQSNFPLLLKLSEELLDKWLSYPESQHVPLCQHMLGFAMKSVTQMVM 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  80 GSTFEDDQEVIRFQKNHGTI------------------------------------------------------------ 99
Cdd:cd20627   119 GSTFEDDQEVIRFRKNHDAIwseigkgfldgsleksttrkkqyedalmemesvlkkvikerkgknfsqhvfidsllqgnl 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 100 -----LEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTP 174
Cdd:cd20627   199 seqqvLEDSMIFSLAGCVITANLCTWAIYFLTTSEEVQKKLYKEVDQVLGKGPITLEKIEQLRYCQQVLCETVRTAKLTP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 175 VSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTTV 254
Cdd:cd20627   279 VSARLQELEGKVDQHIIPKETLVLYALGVVLQDNTTWPLPYRFDPDRFDDESVMKSFSLLGFSGSQECPELRFAYMVATV 358

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1707919429 255 LLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWIT 290
Cdd:cd20627   359 LLSVLVRKLRLLPVDGQVMETKYELVTSPREEAWIT 394
cytochrome_P450 cd00302
cytochrome P450 (CYP) superfamily; Cytochrome P450 (P450, CYP) is a large superfamily of ...
 99-281 2.11e-34

cytochrome P450 (CYP) superfamily; Cytochrome P450 (P450, CYP) is a large superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs with > 40% sequence identity are members of the same family. There are approximately 2250 CYP families: mammals, insects, plants, fungi, bacteria, and archaea have around 18, 208, 277, 805, 591, and 14 families, respectively. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. Their monooxygenase activity relies on the reductive scission of molecular oxygen bound to the P450 heme iron, and the delivery of two electrons to the heme iron during the catalytic cycle. CYPs use a variety of redox partners, such as the eukaryotic diflavin enzyme NADPH-cytochrome P450 oxidoreductase and the bacterial/mitochondrial NAD(P)H-ferredoxin reductase and ferredoxin partners. Some CYPs are naturally linked to their redox partners and others have evolved to bypass requirements for redox partners, and instead react directly with hydrogen peroxide or NAD(P)H to facilitate oxidative or reductive catalysis.


Pssm-ID: 410651 [Multi-domain]  Cd Length: 391  Bit Score: 128.79  E-value: 2.11e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  99 ILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGpvTPEKIEQLRYCQHVLCETVRtakLTPVSAQ 178
Cdd:cd00302   203 IVAELLTLLLAGHETTASLLAWALYLLARHPEVQERLRAEIDAVLGDG--TPEDLSKLPYLEAVVEETLR---LYPPVPL 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 179 L-----QDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFS-GTQECPELRFAYMVT 252
Cdd:cd00302   278 LprvatEDVE--LGGYTIPAGTLVLLSLYAAHRDPEVFPDPDEFDPERFLPEREEPRYAHLPFGaGPHRCLGARLARLEL 355

                         170       180
                  ....*....|....*....|....*....
gi 1707919429 253 TVLLSVLVKRLHLLSVEGQVIETKYELVT 281
Cdd:cd00302   356 KLALATLLRRFDFELVPDEELEWRPSLGT 384
CYP4 cd20628
cytochrome P450 family 4; Cytochrome P450 family 4 (CYP4) proteins catalyze the ...
 119-289 5.21e-25

cytochrome P450 family 4; Cytochrome P450 family 4 (CYP4) proteins catalyze the omega-hydroxylation of the terminal carbon of fatty acids, including essential signaling molecules such as eicosanoids, prostaglandins and leukotrienes, and they are important for chemical defense. There are seven vertebrate family 4 subfamilies: CYP4A, CYP4B, CYP4F, CYP4T, CYP4V, CYP4X, and CYP4Z; three (CYP4X, CYP4A, CYP4Z) are specific to mammals. CYP4 enzymes metabolize fatty acids off various length, level of saturation, and branching. Specific subfamilies show preferences for the length of fatty acids; CYP4B, CYP4A and CYP4V, and CYP4F preferentially metabolize short (C7-C10), medium (C10-C16), and long to very long (C18-C26) fatty acid chains, respectively. CYP4 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410721 [Multi-domain]  Cd Length: 426  Bit Score: 103.37  E-value: 5.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICF----LTTSEEVQKKLYEEINQVFGN--GPVTPEKIEQLRYCQHVLCETVRtakLTP----VSAQL-QDIegKID 187
Cdd:cd20628   246 ASAISFtlylLGLHPEVQEKVYEELDEIFGDddRRPTLEDLNKMKYLERVIKETLR---LYPsvpfIGRRLtEDI--KLD 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 188 RFIIPRETLV---LYALGvvlQDPNTWPSPHKFDPDRFDDELVMK--TFSSLGFS-GTQECPELRFAYMVTTVLLSVLVK 261
Cdd:cd20628   321 GYTIPKGTTVvisIYALH---RNPEYFPDPEKFDPDRFLPENSAKrhPYAYIPFSaGPRNCIGQKFAMLEMKTLLAKILR 397

                         170       180
                  ....*....|....*....|....*....
gi 1707919429 262 RLHLLSVE-GQVIETKYELVTSSREEAWI 289
Cdd:cd20628   398 NFRVLPVPpGEDLKLIAEIVLRSKNGIRV 426
p450 pfam00067
Cytochrome P450; Cytochrome P450s are haem-thiolate proteins involved in the oxidative ...
 119-279 5.64e-23

Cytochrome P450; Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.


Pssm-ID: 395020 [Multi-domain]  Cd Length: 461  Bit Score: 98.12  E-value: 5.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRtakLTPVSAQL------QDIegKIDRFII 191
Cdd:pfam00067 282 SWALYELAKHPEVQEKLREEIDEVIGDKrSPTYDDLQNMPYLDAVIKETLR---LHPVVPLLlprevtKDT--VIPGYLI 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 192 PRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVM--KTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSV 268
Cdd:pfam00067 357 PKGTLVIVNLYALHRDPEVFPNPEEFDPERFLDENGKfrKSFAFLPFGaGPRNCLGERLARMEMKLFLATLLQNFEVELP 436

                         170
                  ....*....|.
gi 1707919429 269 EGQVIETKYEL 279
Cdd:pfam00067 437 PGTDPPDIDET 447
CYP4V-like cd20660
cytochrome P450 family 4, subfamily V, and similar cytochrome P450s; This group is composed of ...
 114-269 6.30e-22

cytochrome P450 family 4, subfamily V, and similar cytochrome P450s; This group is composed of vertebrate cytochrome P450 family 4, subfamily V (CYP4V) enzymes and similar proteins, including invertebrate subfamily C (CYP4C). Insect CYP4C enzymes may be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. CYP4V2, the most characterized member of the CYP4V subfamily, is a selective omega-hydroxylase of saturated, medium-chain fatty acids, such as laurate, myristate and palmitate, with high catalytic efficiency toward myristate. Polymorphisms in the CYP4V2 gene cause Bietti's crystalline corneoretinal dystrophy (BCD), a recessive degenerative retinopathy that is characterized clinically by a progressive decline in central vision, night blindness, and constriction of the visual field. The CYP4V-like group belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410753 [Multi-domain]  Cd Length: 429  Bit Score: 94.64  E-value: 6.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFG--NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFII 191
Cdd:cd20660   248 TAAAINWALYLIGSHPEVQEKVHEELDRIFGdsDRPATMDDLKEMKYLECVIKEALRLFPSVPMFGRTLSEDIEIGGYTI 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 192 PRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMK--TFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSV 268
Cdd:cd20660   328 PKGTTVLVLTYALHRDPRQFPDPEKFDPDRFLPENSAGrhPYAYIPFSaGPRNCIGQKFALMEEKVVLSSILRNFRIESV 407


                  .
gi 1707919429 269 E 269
Cdd:cd20660   408 Q 408
CYP51-like cd11042
cytochrome P450 family 51 and similar cytochrome P450s; This family is composed of cytochrome ...
 119-282 1.80e-21

cytochrome P450 family 51 and similar cytochrome P450s; This family is composed of cytochrome P450 51 (CYP51 or sterol 14alpha-demethylase) and related cytochrome P450s. CYP51 is the only cytochrome P450 enzyme with a conserved function across animals, fungi, and plants, in the synthesis of essential sterols. In mammals, it is expressed in many different tissues, with highest expression in testis, ovary, adrenal gland, prostate, liver, kidney, and lung. In fungi, CYP51 is a significant drug target for treatment of human protozoan infections. In plants, it functions within a specialized defense-related metabolic pathway. CYP51 is also found in several bacterial species. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410668 [Multi-domain]  Cd Length: 416  Bit Score: 93.43  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICFLTTSEEVQKKLYEEINQVFG--NGPVTPEKIEQLRYCQHVLCETVRtakLTPVSAQL-----QDIEGKIDRFII 191
Cdd:cd11042   233 AWTGLELLRNPEHLEALREEQKEVLGdgDDPLTYDVLKEMPLLHACIKETLR---LHPPIHSLmrkarKPFEVEGGGYVI 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 192 PRETLVLYALGVVLQDPNTWPSPHKFDPDRFDD---ELVMKTFSS-LGF-SGTQECPELRFAYMVTTVLLSVLVKRLHLL 266
Cdd:cd11042   310 PKGHIVLASPAVSHRDPEIFKNPDEFDPERFLKgraEDSKGGKFAyLPFgAGRHRCIGENFAYLQIKTILSTLLRNFDFE 389

                         170
                  ....*....|....*.
gi 1707919429 267 SVEGQVIETKYELVTS 282
Cdd:cd11042   390 LVDSPFPEPDYTTMVV 405
CYP132-like cd20620
cytochrome P450 family 132 and similar cytochrome P450s; This subfamily is composed of ...
 114-274 2.19e-21

cytochrome P450 family 132 and similar cytochrome P450s; This subfamily is composed of Mycobacterium tuberculosis cytochrome P450 132 (CYP132) and similar proteins. The function of CYP132 is as yet unknown. CYP132 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410713 [Multi-domain]  Cd Length: 406  Bit Score: 93.03  E-value: 2.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVR---TAKLTPVSAqLQDIEgkIDRFI 190
Cdd:cd20620   228 TANALSWTWYLLAQHPEVAARLRAEVDRVLGGRPPTAEDLPQLPYTEMVLQESLRlypPAWIIGREA-VEDDE--IGGYR 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 191 IPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMK--TFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLS 267
Cdd:cd20620   305 IPAGSTVLISPYVTHRDPRFWPDPEAFDPERFTPEREAArpRYAYFPFGgGPRICIGNHFAMMEAVLLLATIAQRFRLRL 384


                  ....*..
gi 1707919429 268 VEGQVIE 274
Cdd:cd20620   385 VPGQPVE 391
CYP15A1-like cd20651
cytochrome P450 family 15, subfamily A, polypeptide 1, and similar cytochrome P450s; This ...
 80-275 2.81e-20

cytochrome P450 family 15, subfamily A, polypeptide 1, and similar cytochrome P450s; This subfamily is composed of insect and crustacean cytochrome P450s including Diploptera punctata cytochrome P450 15A1 (CYP15A1 or CYP15A1), Panulirus argus CYP2L1, and CYP303A1, CYP304A1, and CYP305A1 from Drosophila melanogaster. CYP15A1, also called methyl farnesoate epoxidase, catalyzes the conversion of methyl farnesoate to juvenile hormone III acid during juvenile hormone biosynthesis. CYP303A1, CYP304A1, and CYP305A1 may be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. The CYP15A1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410744 [Multi-domain]  Cd Length: 423  Bit Score: 89.97  E-value: 2.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  80 GSTFEDDQEVIrfqknhgtILEDsmiFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG--PVTPEKIeQLR 157
Cdd:cd20651   218 SSSFTDDQLVM--------ICLD---LFIAGSETTSNTLGFAFLYLLLNPEVQRKVQEEIDEVVGRDrlPTLDDRS-KLP 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 158 YCQHVLCETVRTAKLTPVSAQ---LQDIegKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF--DDELVMKTFS 232
Cdd:cd20651   286 YTEAVILEVLRIFTLVPIGIPhraLKDT--TLGGYRIPKDTTILASLYSVHMDPEYWGDPEEFRPERFldEDGKLLKDEW 363

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1707919429 233 SLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIET 275
Cdd:cd20651   364 FLPFGaGKRRCLGESLARNELFLFFTGLLQNFTFSPPNGSLPDL 407
CYP120A1_CYP26-like cd11044
cyanobacterial cytochrome P450 family 120, subfamily A, polypeptide 1 (CYP120A1), vertebrate ...
 114-271 4.22e-20

cyanobacterial cytochrome P450 family 120, subfamily A, polypeptide 1 (CYP120A1), vertebrate cytochrome P450 family 26 enzymes, and similar cytochrome P450s; This family includes cyanobacterial CYP120A1 and vertebrate cytochrome P450s 26A1 (CYP26A1), 26B1 (CYP26B1), and 26C1 (CYP26C1). These are retinoic acid-metabolizing cytochromes that play key roles in retinoic acid (RA) metabolism. Human and zebrafish CYP26a1, as well as Synechocystis CYP120A1 are characterized as RA hydroxylases. RA is a critical signaling molecule that regulates gene transcription and the cell cycle. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410670 [Multi-domain]  Cd Length: 420  Bit Score: 89.26  E-value: 4.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTakLTPVSA----QLQDIEgkIDRF 189
Cdd:cd11044   239 TASALTSLCFELAQHPDVLEKLRQEQDALGLEEPLTLESLKKMPYLDQVIKEVLRL--VPPVGGgfrkVLEDFE--LGGY 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 190 IIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF---DDELVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHL 265
Cdd:cd11044   315 QIPKGWLVYYSIRDTHRDPELYPDPERFDPERFspaRSEDKKKPFSLIPFGgGPRECLGKEFAQLEMKILASELLRNYDW 394


                  ....*.
gi 1707919429 266 LSVEGQ 271
Cdd:cd11044   395 ELLPNQ 400
CYP1 cd11028
cytochrome P450 family 1; The cytochrome P450 family 1 (CYP1 or Cyp1) is composed of three ...
 100-271 1.39e-19

cytochrome P450 family 1; The cytochrome P450 family 1 (CYP1 or Cyp1) is composed of three functional human members: CYP1A1, CYP1A2 and CYP1B1, which are regulated by the aryl hydrocarbon receptor (AhR), ligand-activated transcriptional factor that dimerizes with AhR nuclear translocator (ARNT). CYP1 enzymes are involved in the metabolism of endogenous hormones, xenobiotics, and drugs. Included in the CYP1 family is CYP1D1 (cytochrome P450 family 1, subfamily D, polypeptide 1), which is not expressed in humans as its gene is pseudogenized due to five nonsense mutations in the putative coding region, but is functional in in other organisms including cynomolgus monkey. Zebrafish CYP1D1 expression is not regulated by AhR. The CYP1 family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410654 [Multi-domain]  Cd Length: 430  Bit Score: 88.12  E-value: 1.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 100 LEDSMIFSLASCIITAKLCT------WAICFLTTSEEVQKKLYEEINQVFGNGPV-TPEKIEQLRYCQHVLCETVRTAKL 172
Cdd:cd11028   227 LTDEHIISTVQDLFGAGFDTisttlqWSLLYMIRYPEIQEKVQAELDRVIGRERLpRLSDRPNLPYTEAFILETMRHSSF 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 173 TPVS---AQLQDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF--DDELVMKTFSS--LGFS-GTQECPE 244
Cdd:cd11028   307 VPFTiphATTRDTT--LNGYFIPKGTVVFVNLWSVNHDEKLWPDPSVFRPERFldDNGLLDKTKVDkfLPFGaGRRRCLG 384

                         170       180
                  ....*....|....*....|....*..
gi 1707919429 245 LRFAYMVTTVLLSVLVKRLHLLSVEGQ 271
Cdd:cd11028   385 EELARMELFLFFATLLQQCEFSVKPGE 411
CYP17A1-like cd11027
cytochrome P450 family 17, subfamily A, polypeptide 1, and similar cytochrome P450s; This ...
 93-272 1.40e-19

cytochrome P450 family 17, subfamily A, polypeptide 1, and similar cytochrome P450s; This subfamily contains cytochrome P450 17A1 (CYP17A1 or Cyp17a1), cytochrome P450 21 (CYP21 or Cyp21) and similar proteins. CYP17A1, also called cytochrome P450c17, steroid 17-alpha-hydroxylase (EC 1.14.14.19)/17,20 lyase (EC 1.14.14.32), or 17-alpha-hydroxyprogesterone aldolase, catalyzes the conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione; it catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. This subfamily also contains CYP21, also called steroid 21-hydroxylase (EC 1.14.14.16) or cytochrome P-450c21 or CYP21A2, catalyzes the 21-hydroxylation of steroids and is required for the adrenal synthesis of mineralocorticoids and glucocorticoids. The CYP17A1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410653 [Multi-domain]  Cd Length: 428  Bit Score: 88.04  E-value: 1.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  93 QKNHGTILEDSMIFSLASCII-----TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCET 166
Cdd:cd11027   219 DEDSGLLTDDHLVMTISDIFGagtetTATTLRWAIAYLVNYPEVQAKLHAELDDVIGRDrLPTLSDRKRLPYLEATIAEV 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 167 VRTAKLTPVS---AQLQDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE---LVMKTFSSLGFS-GT 239
Cdd:cd11027   299 LRLSSVVPLAlphKTTCDTT--LRGYTIPKGTTVLVNLWALHHDPKEWDDPDEFRPERFLDEngkLVPKPESFLPFSaGR 376

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1707919429 240 QECPELRFAYMVTTVLLSVLVKRLHLLSVEGQV 272
Cdd:cd11027   377 RVCLGESLAKAELFLFLARLLQKFRFSPPEGEP 409
CYP97 cd11046
cytochrome P450 family/clan 97; CYPs have been classified into families and subfamilies based ...
 84-279 3.62e-19

cytochrome P450 family/clan 97; CYPs have been classified into families and subfamilies based on homology and phylogenetic criteria; family membership is defined as 40% amino acid sequence identity or higher. The plant CYPs have also been classified according to clans; land plants have 11 clans that form two groups: single-family clans (CYP51, CYP74, CYP97, CYP710, CYP711, CYP727, CYP746) and multi-family clans (CYP71, CYP72, CYP85, CYP86). Members of the CYP97 clan include Arabidopsis thaliana cytochrome P450s 97A3 (CYP97A3), CYP97B3, and CYP97C1. CYP97A3 is also called protein LUTEIN DEFICIENT 5 (LUT5) and CYP97C1 is also called carotene epsilon-monooxygenase or protein LUTEIN DEFICIENT 1 (LUT1). These cytochromes function as beta- and epsilon-ring carotenoid hydroxylases and are involved in the biosynthesis of xanthophylls. CYP97 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410672 [Multi-domain]  Cd Length: 441  Bit Score: 87.03  E-value: 3.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  84 EDDQEVIRFQ----KNHGTILE---DSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQ 155
Cdd:cd11046   219 EDDPSLLRFLvdmrDEDVDSKQlrdDLMTMLIAGHETTAAVLTWTLYELSQNPELMAKVQAEVDAVLGDRlPPTYEDLKK 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 156 LRYCQHVLCETVRTAKLTPVSAQLQDIEGKID--RFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDD------ELV 227
Cdd:cd11046   299 LKYTRRVLNESLRLYPQPPVLIRRAVEDDKLPggGVKVPAGTDIFISVYNLHRSPELWEDPEEFDPERFLDpfinppNEV 378

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1707919429 228 MKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRL---------HLLSVEGQVIETKYEL 279
Cdd:cd11046   379 IDDFAFLPFGgGPRKCLGDQFALLEATVALAMLLRRFdfeldvgprHVGMTTGATIHTKNGL 440
CYP3A-like cd11055
cytochrome P450 family 3, subfamily A and similar cytochrome P450s; This family includes ...
 99-284 4.57e-19

cytochrome P450 family 3, subfamily A and similar cytochrome P450s; This family includes vertebrate CYP3A subfamily enzymes and CYP5a1, and similar proteins. CYP5A1, also called thromboxane-A synthase, converts prostaglandin H2 into thromboxane A2, a biologically active metabolite of arachidonic acid. CYP3A enzymes are drug-metabolizing enzymes embedded in the endoplasmic reticulum, where they can catalyze a wide variety of biochemical reactions including hydroxylation, N-demethylation, O-dealkylation, S-oxidation, deamination, or epoxidation of substrates. The CYP3A-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410678 [Multi-domain]  Cd Length: 422  Bit Score: 86.48  E-value: 4.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  99 ILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEKIEQLRYCQHVLCETVRtakL-TPVS 176
Cdd:cd11055   227 IVAQSFIFLLAGYETTSNTLSFASYLLATNPDVQEKLIEEIDEVLPDdGSPTYDTVSKLKYLDMVINETLR---LyPPAF 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 177 AQ----LQDIEgkIDRFIIPRETLVL---YALGvvlQDPNTWPSPHKFDPDRFDDELVMK--TFSSLGF-SGTQECPELR 246
Cdd:cd11055   304 FIsrecKEDCT--INGVFIPKGVDVVipvYAIH---HDPEFWPDPEKFDPERFSPENKAKrhPYAYLPFgAGPRNCIGMR 378

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1707919429 247 FAYMVTTVLLSVLVKRLHLLSVEgqviETKYELVTSSR 284
Cdd:cd11055   379 FALLEVKLALVKILQKFRFVPCK----ETEIPLKLVGG 412
CYP6-like cd11056
cytochrome P450 family 6 and similar cytochrome P450s; This family is composed of cytochrome ...
 130-278 9.93e-19

cytochrome P450 family 6 and similar cytochrome P450s; This family is composed of cytochrome P450s from insects and crustaceans, including the CYP6, CYP9 and CYP310 subfamilies, which are involved in the metabolism of insect hormones and xenobiotic detoxification. The CYP6-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410679 [Multi-domain]  Cd Length: 429  Bit Score: 85.67  E-value: 9.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 130 EVQKKLYEEINQVF--GNGPVTPEKIEQLRYCQHVLCETVRtakLTPVSAQL-----QDIEGKIDRFIIPRETLVL---Y 199
Cdd:cd11056   261 EIQEKLREEIDEVLekHGGELTYEALQEMKYLDQVVNETLR---KYPPLPFLdrvctKDYTLPGTDVVIEKGTPVIipvY 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 200 ALGvvlQDPNTWPSPHKFDPDRFDDELV--MKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIETK 276
Cdd:cd11056   338 ALH---HDPKYYPEPEKFDPERFSPENKkkRHPYTYLPFgDGPRNCIGMRFGLLQVKLGLVHLLSNFRVEPSSKTKIPLK 414


                  ..
gi 1707919429 277 YE 278
Cdd:cd11056   415 LS 416
CYP3A cd20650
cytochrome P450 family 3, subfamily A; The cytochrome P450 3A (CYP3A) subfamily, the most ...
 76-256 1.15e-18

cytochrome P450 family 3, subfamily A; The cytochrome P450 3A (CYP3A) subfamily, the most abundant CYP subfamily in the liver, consists of drug-metabolizing enzymes. In humans, there are at least four isoforms: CYP3A4, 3A5, 3A7, and 3A3. CYP3A enzymes are embedded in the endoplasmic reticulum, where they can catalyze a wide variety of biochemical reactions including hydroxylation, N-demethylation, O-dealkylation, S-oxidation, deamination, or epoxidation of substrates. They oxidize a variety of structurally unrelated compounds including steroids, fatty acids, and xenobiotics. The CYP3A subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410743 [Multi-domain]  Cd Length: 426  Bit Score: 85.54  E-value: 1.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  76 QMVMGSTFEDDQEVIRFQKNHgTILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEKIE 154
Cdd:cd20650   207 QLMIDSQNSKETESHKALSDL-EILAQSIIFIFAGYETTSSTLSFLLYELATHPDVQQKLQEEIDAVLPNkAPPTYDTVM 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 155 QLRYCQHVLCETVRtakLTPVSAQL-----QDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF----DDE 225
Cdd:cd20650   286 QMEYLDMVVNETLR---LFPIAGRLervckKDVE--INGVFIPKGTVVMIPTYALHRDPQYWPEPEEFRPERFskknKDN 360

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1707919429 226 LVMKTFSSLGfSGTQECPELRFAYMVTTVLL 256
Cdd:cd20650   361 IDPYIYLPFG-SGPRNCIGMRFALMNMKLAL 390
CYP313-like cd11057
cytochrome P450 family 313 and similar cytochrome P450s; This subfamily is composed of insect ...
 102-265 1.34e-18

cytochrome P450 family 313 and similar cytochrome P450s; This subfamily is composed of insect cytochrome P450s from families 313 (CYP313) and 318 (CYP318), and similar proteins. These proteins may be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. Their specific function is yet unknown. They belong to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410680 [Multi-domain]  Cd Length: 427  Bit Score: 84.96  E-value: 1.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 102 DSMIFslASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG--PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQ- 178
Cdd:cd11057   233 DTMIF--AGNDTSATTVAYTLLLLAMHPEVQEKVYEEIMEVFPDDgqFITYEDLQQLVYLEMVLKETMRLFPVGPLVGRe 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 179 -LQDIEgkIDR-FIIPRETLVLYALGVVLQDPNTW-PSPHKFDPDRFDDELVMK--TFSSLGFS-GTQECPELRFAYMVT 252
Cdd:cd11057   311 tTADIQ--LSNgVVIPKGTTIVIDIFNMHRRKDIWgPDADQFDPDNFLPERSAQrhPYAFIPFSaGPRNCIGWRYAMISM 388

                         170
                  ....*....|...
gi 1707919429 253 TVLLSVLVKRLHL 265
Cdd:cd11057   389 KIMLAKILRNYRL 401
CYP1_2-like cd20617
cytochrome P450 families 1 and 2, and similar cytochrome P450s; This model includes cytochrome ...
 85-283 1.41e-18

cytochrome P450 families 1 and 2, and similar cytochrome P450s; This model includes cytochrome P450 families 1 (CYP1) and 2 (CYP2), CYP17A1, and CYP21 in vertebrates, as well as insect and crustacean CYPs similar to CYP15A1 and CYP306A1. CYP1 and CYP2 enzymes are involved in the metabolism of endogenous and exogenous compounds such as hormones, xenobiotics, and drugs. CYP17A1 catalyzes the conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products, while CYP21 catalyzes the 21-hydroxylation of steroids such as progesterone and 17-alpha-hydroxyprogesterone (17-alpha-OH-progesterone) to form 11-deoxycorticosterone and 11-deoxycortisol, respectively. Members of this group belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410710 [Multi-domain]  Cd Length: 419  Bit Score: 84.96  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  85 DDQEVIRFQKNHGTILEDSMIFSLASCII-----TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRY 158
Cdd:cd20617   205 DELLLLLKEGDSGLFDDDSIISTCLDLFLagtdtTSTTLEWFLLYLANNPEIQEKIYEEIDNVVGNDrRVTLSDRSKLPY 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 159 CQHVLCETVRTAKLTPVS---AQLQDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF-DDELVMKTFSSL 234
Cdd:cd20617   285 LNAVIKEVLRLRPILPLGlprVTTEDTE--IGGYFIPKGTQIIINIYSLHRDEKYFEDPEEFNPERFlENDGNKLSEQFI 362

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1707919429 235 GFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVI-ETKYELVTSS 283
Cdd:cd20617   363 PFGiGKRNCVGENLARDELFLFFANLLLNFKFKSSDGLPIdEKEVFGLTLK 413
CYP24A1-like cd11054
cytochrome P450 family 24 subfamily A, polypeptide 1 and similar cytochrome P450s; This family ...
 114-281 1.35e-17

cytochrome P450 family 24 subfamily A, polypeptide 1 and similar cytochrome P450s; This family is composed of vertebrate cytochrome P450 24A1 (CYP24A1) and similar proteins including several Drosophila proteins such as CYP315A1 (also called protein shadow) and CYP314A1 (also called ecdysone 20-monooxygenase), and vertebrate CYP11 and CYP27 subfamilies. Both CYP314A1 and CYP315A1, which has ecdysteroid C2-hydroxylase activity, are involved in the metabolism of insect hormones. CYP24A1 and CYP27B1 have roles in calcium homeostasis and metabolism, and the regulation of vitamin D. CYP24A1 catabolizes calcitriol (1,25(OH)2D), the physiologically active vitamin D hormone, by catalyzing its hydroxylation, while CYP27B1 is a calcidiol 1-monooxygenase that coverts 25-hydroxyvitamin D3 to calcitriol. The CYP24A1-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410677 [Multi-domain]  Cd Length: 426  Bit Score: 82.19  E-value: 1.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRtakLTPVSAQL-----QDIEgkID 187
Cdd:cd11054   247 TSNTLAFLLYHLAKNPEVQEKLYEEIRSVLPDGePITAEDLKKMPYLKACIKESLR---LYPVAPGNgrilpKDIV--LS 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 188 RFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF----DDELVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKR 262
Cdd:cd11054   322 GYHIPKGTLVVLSNYVMGRDEEYFPDPEEFIPERWlrddSENKNIHPFASLPFGfGPRMCIGRRFAELEMYLLLAKLLQN 401

                         170
                  ....*....|....*....
gi 1707919429 263 LHLLSVEGQvIETKYELVT 281
Cdd:cd11054   402 FKVEYHHEE-LKVKTRLIL 419
CYP90-like cd11043
plant cytochrome P450s similar to cytochrome P450 family 90, subfamily A, polypeptide 1, ...
 114-262 4.36e-17

plant cytochrome P450s similar to cytochrome P450 family 90, subfamily A, polypeptide 1, cytochrome P450 family 90, subfamily B, polypeptide 1, and cytochrome P450 family 90, subfamily D, polypeptide 2; This family is composed of plant cytochrome P450s including: Arabidopsis thaliana cytochrome P450s 85A1 (CYP85A1 or brassinosteroid-6-oxidase 1), 90A1 (CYP90A1), 88A3 (CYP88A3 or ent-kaurenoic acid oxidase 1), 90B1 (CYP90B1 or Dwarf4 or steroid 22-alpha-hydroxylase), and 90C1 (CYP90C1 or 3-epi-6-deoxocathasterone 23-monooxygenase); Oryza sativa cytochrome P450s 90D2 (CYP90D2 or C6-oxidase), 87A3 (CYP87A3), and 724B1 (CYP724B1 or dwarf protein 11); and Taxus cuspidata cytochrome P450 725A2 (CYP725A2 or taxane 13-alpha-hydroxylase). These enzymes are monooxygenases that catalyze oxidation reactions involved in steroid or hormone biosynthesis. CYP85A1, CYP90D2, and CYP90C1 are involved in brassinosteroids biosynthesis, while CYP88A3 catalyzes three successive oxidations of ent-kaurenoic acid, which is a key step in the synthesis of gibberellins. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410669 [Multi-domain]  Cd Length: 408  Bit Score: 80.69  E-value: 4.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEE----INQVFGNGPVTPEKIEQLRYCQHVLCETVRTAklTPVSA----QLQDIEgk 185
Cdd:cd11043   226 TSTTLTLAVKFLAENPKVLQELLEEheeiAKRKEEGEGLTWEDYKSMKYTWQVINETLRLA--PIVPGvfrkALQDVE-- 301

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1707919429 186 IDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLVKR 262
Cdd:cd11043   302 YKGYTIPKGWKVLWSARATHLDPEYFPDPLKFNPWRWEGKGKGVPYTFLPFgGGPRLCPGAELAKLEILVFLHHLVTR 379
CYP136-like cd11045
putative cytochrome P450 family 136 and similar cytochrome P450s; This group is composed of ...
 80-270 3.16e-16

putative cytochrome P450 family 136 and similar cytochrome P450s; This group is composed of Mycobacterium tuberculosis putative cytochrome P450 136 (CYP136) and similar proteins. It belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410671 [Multi-domain]  Cd Length: 407  Bit Score: 78.13  E-value: 3.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  80 GSTFEDDQEVirfqkNHgtiledsMIFSL--ASCIITAKLCTWAIcFLTTSEEVQKKLYEEInQVFGNGPVTPEKIEQLR 157
Cdd:cd11045   204 GDRFSDDDIV-----NH-------MIFLMmaAHDTTTSTLTSMAY-FLARHPEWQERLREES-LALGKGTLDYEDLGQLE 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 158 YCQHVLCETVRTakLTPVSA----QLQDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDEL----VMK 229
Cdd:cd11045   270 VTDWVFKEALRL--VPPVPTlprrAVKDTE--VLGYRIPAGTLVAVSPGVTHYMPEYWPNPERFDPERFSPERaedkVHR 345

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1707919429 230 tFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVEG 270
Cdd:cd11045   346 -YAWAPFGgGAHKCIGLHFAGMEVKAILHQMLRRFRWWSVPG 386
CYP2AB1-like cd20667
cytochrome P450, family 2, subfamily AB, polypeptide 1 and similar cytochrome P450s; The ...
 50-277 3.57e-15

cytochrome P450, family 2, subfamily AB, polypeptide 1 and similar cytochrome P450s; The function of CYP2AB1 is unknown. CYP2AB1 belongs to family 2 of the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410760 [Multi-domain]  Cd Length: 423  Bit Score: 75.26  E-value: 3.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  50 KWLSYPETQHVPLSQHMLGFAMKSVTQMVMgSTFEDDQEVIRF---------QKNHGTILEDSMI-----FSLASCIITA 115
Cdd:cd20667   164 RYLPGPHQKIFAYHDAVRSFIKKEVIRHEL-RTNEAPQDFIDCylaqitktkDDPVSTFSEENMIqvvidLFLGGTETTA 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 116 KLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGK-IDRFIIPR 193
Cdd:cd20667   243 TTLHWALLYMVHHPEIQEKVQQELDEVLGASqLICYEDRKRLPYTNAVIHEVQRLSNVVSVGAVRQCVTSTtMHGYYVEK 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 194 ETLVLYALGVVLQDPNTWPSPHKFDPDRF---DDELVMKTfSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVE 269
Cdd:cd20667   323 GTIILPNLASVLYDPECWETPHKFNPGHFldkDGNFVMNE-AFLPFSaGHRVCLGEQLARMELFIFFTTLLRTFNFQLPE 401


                  ....*....
gi 1707919429 270 G-QVIETKY 277
Cdd:cd20667   402 GvQELNLEY 410
CYP56-like cd11070
cytochrome P450 family 56-like fungal cytochrome P450s; This group includes Saccharomyces ...
 114-265 4.29e-15

cytochrome P450 family 56-like fungal cytochrome P450s; This group includes Saccharomyces cerevisiae cytochrome P450 56, also called cytochrome P450-DIT2, and similar fungal proteins. CYP56 is involved in spore wall maturation and is thought to catalyze the oxidation of tyrosine residues in the formation of LL-dityrosine-containing precursors of the spore wall. The CYP56-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410693 [Multi-domain]  Cd Length: 438  Bit Score: 75.06  E-value: 4.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGP---VTPEKIEQLRYCQHVLCETVR-------TAKLTPVSAQLQDIE 183
Cdd:cd11070   239 TANTLSFALYLLAKHPEVQDWLREEIDSVLGDEPddwDYEEDFPKLPYLLAVIYETLRlyppvqlLNRKTTEPVVVITGL 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 184 GKidRFIIPRETLVLYALGVVLQDPNTW-PSPHKFDPDRFDDElVMKTFSS----------LGFS-GTQECPELRFAYMV 251
Cdd:cd11070   319 GQ--EIVIPKGTYVGYNAYATHRDPTIWgPDADEFDPERWGST-SGEIGAAtrftpargafIPFSaGPRACLGRKFALVE 395

                         170
                  ....*....|....
gi 1707919429 252 TTVLLSVLVKRLHL 265
Cdd:cd11070   396 FVAALAELFRQYEW 409
CYP110-like cd11053
cytochrome P450 family 110 and similar cytochrome P450s; This group is composed of mostly ...
 114-281 5.70e-15

cytochrome P450 family 110 and similar cytochrome P450s; This group is composed of mostly uncharacterized proteins, including Nostoc sp. probable cytochrome P450 110 (CYP110) and putative cytochrome P450s 139 (CYP139), 138 (CYP138), and 135B1 (CYP135B1) from Mycobacterium bovis. CYP110 genes, unique to cyanobacteria, are widely distributed in heterocyst-forming cyanobacteria including nitrogen-fixing genera Nostoc and Anabaena. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410676 [Multi-domain]  Cd Length: 415  Bit Score: 74.54  E-value: 5.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPvtPEKIEQLRYCQHVLCETVRtakLTPVSAQL-----QDIEgkIDR 188
Cdd:cd11053   239 TATALAWAFYWLHRHPEVLARLLAELDALGGDPD--PEDIAKLPYLDAVIKETLR---LYPVAPLVprrvkEPVE--LGG 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 189 FIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDElvmkTFSS---LGFS-GTQECPELRFAYMVTTVLLSVLVKRLH 264
Cdd:cd11053   312 YTLPAGTTVAPSIYLTHHRPDLYPDPERFRPERFLGR----KPSPyeyLPFGgGVRRCIGAAFALLEMKVVLATLLRRFR 387

                         170
                  ....*....|....*..
gi 1707919429 265 LLSVEGQVIETKYELVT 281
Cdd:cd11053   388 LELTDPRPERPVRRGVT 404
PLN02394 PLN02394
trans-cinnamate 4-monooxygenase
 120-271 1.25e-14

trans-cinnamate 4-monooxygenase


Pssm-ID: 215221 [Multi-domain]  Cd Length: 503  Bit Score: 73.61  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDI-EGKIDRFIIPRETLV 197
Cdd:PLN02394  315 WGIAELVNHPEIQKKLRDELDTVLGPGnQVTEPDTHKLPYLQAVVKETLRLHMAIPLLVPHMNLeDAKLGGYDIPAESKI 394

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 198 LYALGVVLQDPNTWPSPHKFDPDRF-----DDELVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQ 271
Cdd:PLN02394  395 LVNAWWLANNPELWKNPEEFRPERFleeeaKVEANGNDFRFLPFgVGRRSCPGIILALPILGIVLGRLVQNFELLPPPGQ 474
CYP4V cd20680
cytochrome P450 family 4, subfamily V; Cytochrome P450 family 4, subfamily V, polypeptide 2 ...
 114-265 2.25e-14

cytochrome P450 family 4, subfamily V; Cytochrome P450 family 4, subfamily V, polypeptide 2 (CYP4V2) is the most characterized member of the CYP4V subfamily. It is a selective omega-hydroxylase of saturated, medium-chain fatty acids, such as laurate, myristate and palmitate, with high catalytic efficiency toward myristate. Polymorphisms in the CYP4V2 gene cause Bietti's crystalline corneoretinal dystrophy (BCD), a recessive degenerative retinopathy that is characterized clinically by a progressive decline in central vision, night blindness, and constriction of the visual field. The CYP4V subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410773 [Multi-domain]  Cd Length: 440  Bit Score: 72.87  E-value: 2.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG--PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFII 191
Cdd:cd20680   259 TAAAMNWSLYLLGSHPEVQRKVHKELDEVFGKSdrPVTMEDLKKLRYLECVIKESLRLFPSVPLFARSLCEDCEIRGFKV 338

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1707919429 192 PRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMK--TFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHL 265
Cdd:cd20680   339 PKGVNAVIIPYALHRDPRYFPEPEEFRPERFFPENSSGrhPYAYIPFSaGPRNCIGQRFALMEEKVVLSCILRHFWV 415
CYP77_89 cd11075
cytochrome P450 families 77 and 89, and similar cytochrome P450s; This group includes ...
 96-263 3.71e-14

cytochrome P450 families 77 and 89, and similar cytochrome P450s; This group includes cytochrome P450 families 73 (CYP77) and 89 (CYP89), which are sister families that share a common ancestor. CYP89, present only in angiosperms, is younger than CYP77, which is already found in lycopods; thus, CYP89 may have evolved from CYP77 after duplication and divergence. Also included in this group is ent-kaurene oxidase, called CYP701A3 in Arabidopsis thaliana and CYP701B1 in Physcomitrella patens, that catalyzes the oxidation of ent-kaurene to form ent-kaurenoic acid. CYP701A3 is sensitive to inhibitor uniconazole-P while CYP701B1 is not. This CYP77/89 group belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410698 [Multi-domain]  Cd Length: 433  Bit Score: 72.28  E-value: 3.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  96 HGTILEDSMIFSLASCIITAKLCT------WAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVR 168
Cdd:cd11075   223 GERKLTDEELVSLCSEFLNAGTDTtataleWAMAELVKNPEIQEKLYEEIKEVVGdEAVVTEEDLPKMPYLKAVVLETLR 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 169 ---TAKLTPVSAQLQDIegKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF--DDELVMKTFSSLGFS------ 237
Cdd:cd11075   303 rhpPGHFLLPHAVTEDT--VLGGYDIPAGAEVNFNVAAIGRDPKVWEDPEEFKPERFlaGGEAADIDTGSKEIKmmpfga 380

                         170       180
                  ....*....|....*....|....*.
gi 1707919429 238 GTQECPELRFAymvtTVLLSVLVKRL 263
Cdd:cd11075   381 GRRICPGLGLA----TLHLELFVARL 402
CYP5011A1-like cd20621
cytochrome P450 monooxygenase CYP5011A1 and similar cytochrome P450s; This subfamily is ...
 99-222 4.32e-14

cytochrome P450 monooxygenase CYP5011A1 and similar cytochrome P450s; This subfamily is composed of CYPs from unicellular ciliates similar to Tetrahymena thermophila CYP5011A1, whose function is still unknown. It belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410714 [Multi-domain]  Cd Length: 427  Bit Score: 71.90  E-value: 4.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  99 ILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGP-VTPEKIEQLRYCQHVLCETVRtakLTPVSA 177
Cdd:cd20621   230 IIQQFITFFFAGTDTTGHLVGMCLYYLAKYPEIQEKLRQEIKSVVGNDDdITFEDLQKLNYLNAFIKEVLR---LYNPAP 306

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1707919429 178 QL------QDIegKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF 222
Cdd:cd20621   307 FLfprvatQDH--QIGDLKIKKGWIVNVGYIYNHFNPKYFENPDEFNPERW 355
CYP120A1 cd11068
cytochrome P450 family 102, subfamily A, polypeptide 1, also called bifunctional cytochrome ...
 114-225 6.22e-14

cytochrome P450 family 102, subfamily A, polypeptide 1, also called bifunctional cytochrome P450/NADPH--P450 reductase; Cytochrome P450 102A1, also called cytochrome P450(BM-3) or P450BM-3, is a bifunctional cytochrome P450/NADPH--P450 reductase. These proteins fuse an N-terminal cytochrome p450 with a C-terminal cytochrome p450 reductase (CYPOR). It functions as a fatty acid monooxygenase, catalyzing the hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions, with activity towards fatty acids with a chain length of 9-18 carbons. Its NADPH-dependent reductase activity (via the C-terminal domain) allows electron transfer from NADPH to the heme iron of the N-terminal cytochrome P450. CYP120A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410691 [Multi-domain]  Cd Length: 430  Bit Score: 71.45  E-value: 6.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVR---TAKLTPVSAqLQD--IEGKIDr 188
Cdd:cd11068   246 TSGLLSFALYYLLKNPEVLAKARAEVDEVLGDDPPPYEQVAKLRYIRRVLDETLRlwpTAPAFARKP-KEDtvLGGKYP- 323

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1707919429 189 fiIPRETLVLYALGVVLQDPNTW-PSPHKFDPDRFDDE 225
Cdd:cd11068   324 --LKKGDPVLVLLPALHRDPSVWgEDAEEFRPERFLPE 359
CYP306A1-like cd20652
cytochrome P450 306A1 and similar cytochrome P450s; This subfamily is composed of insect and ...
 120-271 7.27e-14

cytochrome P450 306A1 and similar cytochrome P450s; This subfamily is composed of insect and crustacean cytochrome P450s including insect cytochrome P450 306A1 (CYP306A1 or Cyp306a1) and CYP18A1. CYP306A1 functions as a carbon 25-hydroxylase and has an essential role in ecdysteroid biosynthesis during insect development. CYP18A1 is a 26-hydroxylase and plays a key role in steroid hormone inactivation. The CYP306A1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410745 [Multi-domain]  Cd Length: 432  Bit Score: 71.29  E-value: 7.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFGnGP--VTPEKIEQLRYCQHVLCETVRTAKLTPVS---AQLQDIEgkIDRFIIPRE 194
Cdd:cd20652   256 WFLLYMALFPKEQRRIQRELDEVVG-RPdlVTLEDLSSLPYLQACISESQRIRSVVPLGiphGCTEDAV--LAGYRIPKG 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 195 TLVLYALGVVLQDPNTWPSPHKFDPDRF--DDELVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQ 271
Cdd:cd20652   333 SMIIPLLWAVHMDPNLWEEPEEFRPERFldTDGKYLKPEAFIPFqTGKRMCLGDELARMILFLFTARILRKFRIALPDGQ 412
CYP2 cd11026
cytochrome P450 family 2; The cytochrome P450 family 2 (CYP2 or Cyp2) is one of the largest, ...
 120-225 9.84e-14

cytochrome P450 family 2; The cytochrome P450 family 2 (CYP2 or Cyp2) is one of the largest, most diverse CYP families in vertebrates. It includes many subfamilies across vertebrate species but not all subfamilies are found in multiple vertebrate taxonomic classes. The CYP2U and CYP2R genes are present in the vertebrate ancestor and are shared across all vertebrate classes, whereas some subfamilies are lineage-specific, such as CYP2B and CYP2S in mammals. CYP2 enzymes play important roles in drug metabolism. The CYP2 family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410652 [Multi-domain]  Cd Length: 425  Bit Score: 70.67  E-value: 9.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVS---AQLQDIE--GkidrFIIPR 193
Cdd:cd11026   248 WALLLLMKYPHIQEKVQEEIDRVIGrNRTPSLEDRAKMPYTDAVIHEVQRFGDIVPLGvphAVTRDTKfrG----YTIPK 323

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1707919429 194 ETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE 225
Cdd:cd11026   324 GTTVIPNLTSVLRDPKQWETPEEFNPGHFLDE 355
CYP170A1-like cd11049
cytochrome P450 family 170, subfamily A, polypeptide 1-like actinobacterial cytochrome P450s; ...
 114-291 1.13e-13

cytochrome P450 family 170, subfamily A, polypeptide 1-like actinobacterial cytochrome P450s; This subfamily is composed of Streptomyces coelicolor cytochrome P450 170A1 (CYP170A1), Streptomyces avermitilis pentalenene oxygenase, and similar actinobacterial cytochrome P450s. CYP170A1, also called epi-isozizaene 5-monooxygenase (EC 1.14.13.106)/(E)-beta-farnesene synthase (EC 4.2.3.47), catalyzes the two-step allylic oxidation of epi-isozizaene to albaflavenone, which is a sesquiterpenoid antibiotic. Pentalenene oxygenase (EC 1.14.15.32) catalyzes the conversion of pentalenene to pentalen-13-al by stepwise oxidation via pentalen-13-ol, a precursor of the neopentalenolactone antibiotic. The CYP170A1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410673 [Multi-domain]  Cd Length: 415  Bit Score: 70.75  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRtakLTPVSAQL-----QDIEgkIDR 188
Cdd:cd11049   236 TASTLAWAFHLLARHPEVERRLHAELDAVLGGRPATFEDLPRLTYTRRVVTEALR---LYPPVWLLtrrttADVE--LGG 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 189 FIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE--LVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHL 265
Cdd:cd11049   311 HRLPAGTEVAFSPYALHRDPEVYPDPERFDPDRWLPGraAAVPRGAFIPFGaGARKCIGDTFALTELTLALATIASRWRL 390

                         170       180
                  ....*....|....*....|....*.
gi 1707919429 266 LSVEGqvietkyelvTSSREEAWITV 291
Cdd:cd11049   391 RPVPG----------RPVRPRPLATL 406
CYP73 cd11074
cytochrome P450 family 73; Cytochrome P450 family 73 (CYP73 pr Cyp73), also called ...
 97-271 1.89e-13

cytochrome P450 family 73; Cytochrome P450 family 73 (CYP73 pr Cyp73), also called trans-cinnamate 4-monooxygenase (EC 1.14.14.91) or cinnamic acid 4-hydroxylase, catalyzes the regiospecific 4-hydroxylation of cinnamic acid to form precursors of lignin and many other phenolic compounds. It controls the general phenylpropanoid pathway, and controls carbon flux to pigments essential for pollination or UV protection. CYP73 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410697 [Multi-domain]  Cd Length: 434  Bit Score: 70.19  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  97 GTILEDSMIFSLASCIITAKLCT-----WAICFLTTSEEVQKKLYEEINQVFGNGPVTPE-KIEQLRYCQHVLCETVRTA 170
Cdd:cd11074   227 GEINEDNVLYIVENINVAAIETTlwsieWGIAELVNHPEIQKKLRDELDTVLGPGVQITEpDLHKLPYLQAVVKETLRLR 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 171 KLTPVSAQLQDI-EGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE-----LVMKTFSSLGFS-GTQECP 243
Cdd:cd11074   307 MAIPLLVPHMNLhDAKLGGYDIPAESKILVNAWWLANNPAHWKKPEEFRPERFLEEeskveANGNDFRYLPFGvGRRSCP 386

                         170       180
                  ....*....|....*....|....*...
gi 1707919429 244 ELRFAYMVTTVLLSVLVKRLHLLSVEGQ 271
Cdd:cd11074   387 GIILALPILGITIGRLVQNFELLPPPGQ 414
CYP4B_4F-like cd20659
cytochrome P450 family 4, subfamilies B and F, and similar cytochrome P450s; This group is ...
 109-289 2.07e-13

cytochrome P450 family 4, subfamilies B and F, and similar cytochrome P450s; This group is composed of family 4 cytochrome P450s from vertebrate subfamilies A (CYP4A), B (CYP4B), F (CYP4F), T (CYP4T), X (CYP4X), and Z (CYP4Z). Also included are similar proteins from lancelets, tunicates, hemichordates, echinoderms, mollusks, annelid worms, sponges, and choanoflagellates, among others. The CYP4A, CYP4X, and CYP4Z subfamilies are specific to mammals, CYP4T is present in fish, while CYP4B and CYP4F are conserved among vertebrates. CYP4Bs specialize in omega-hydroxylation of short chain fatty acids and also participates in the metabolism of exogenous compounds that are protoxic including valproic acid (C8), 3-methylindole (C9), 4-ipomeanol, 3-methoxy-4-aminoazobenzene, and several aromatic amines. CYP4F enzymes are known for known for omega-hydroxylation of very long fatty acids (VLFA; C18-C26), leukotrienes, prostaglandins, and vitamins with long alkyl side chains. The CYP4B_4F-like group belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410752 [Multi-domain]  Cd Length: 423  Bit Score: 69.89  E-value: 2.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 109 ASCIitaklcTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKID 187
Cdd:cd20659   244 ASGI------SWTLYSLAKHPEHQQKCREEVDEVLGDRdDIEWDDLSKLPYLTMCIKESLRLYPPVPFIARTLTKPITID 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 188 RFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELV--MKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLH 264
Cdd:cd20659   318 GVTLPAGTLIAINIYALHHNPTVWEDPEEFDPERFLPENIkkRDPFAFIPFSaGPRNCIGQNFAMNEMKVVLARILRRFE 397

                         170       180
                  ....*....|....*....|....*
gi 1707919429 265 LLSVEGQVIETKYELVTSSREEAWI 289
Cdd:cd20659   398 LSVDPNHPVEPKPGLVLRSKNGIKL 422
CYP76-like cd11073
cytochrome P450 family 76 and similar cytochrome P450s; Characterized members of the plant ...
 120-259 3.99e-13

cytochrome P450 family 76 and similar cytochrome P450s; Characterized members of the plant cytochrome P450 family 76 (CYP76 or Cyp76) include: Catharanthus roseus CYP76B6, a multifunctional enzyme catalyzing two sequential oxidation steps leading to the formation of 8-oxogeraniol from geraniol; the Brassicaceae-specific CYP76C subfamily of enzymes that are involved in the metabolism of monoterpenols and phenylurea herbicides; and two P450s from Lamiaceae, CYP76AH and CYP76AK, that are involved in the oxidation of abietane diterpenes. CYP76AH produces ferruginol and 11-hydroxyferruginol, while CYP76AK catalyzes oxidations at the C20 position. Also included in this group is Berberis stolonifera Cyp80, also called berbamunine synthase or (S)-N-methylcoclaurine oxidase [C-O phenol-coupling], that catalyzes the phenol oxidation of N-methylcoclaurine to form the bisbenzylisoquinoline alkaloid berbamunine. The CYP76-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410696 [Multi-domain]  Cd Length: 435  Bit Score: 69.10  E-value: 3.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFGNGPVTPEK-IEQLRYCQHVLCETVRtakLTPVSAQL------QDIEgkIDRFIIP 192
Cdd:cd11073   253 WAMAELLRNPEKMAKARAELDEVIGKDKIVEESdISKLPYLQAVVKETLR---LHPPAPLLlprkaeEDVE--VMGYTIP 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1707919429 193 RETLVL---YALGvvlQDPNTWPSPHKFDPDRF-DDELVMK--TFSSLGF-SGTQECPELRFAY-MVTTVLLSVL 259
Cdd:cd11073   328 KGTQVLvnvWAIG---RDPSVWEDPLEFKPERFlGSEIDFKgrDFELIPFgSGRRICPGLPLAErMVHLVLASLL 399
CYP71-like cd11072
cytochrome P450 family 71 and similar cytochrome P450s; The group includes plant cytochrome ...
 114-239 4.35e-13

cytochrome P450 family 71 and similar cytochrome P450s; The group includes plant cytochrome P450 family 71 (CYP71) proteins, as well as some CYPs designated as belonging to a different family including CYP99A1, CYP83B1, and CYP84A1, among others. Characterized CYP71 enzymes include: parsnip (Pastinaca sativa) CYP71AJ4, also called angelicin synthase, that converts (+)-columbianetin to angelicin, an angular furanocumarin; periwinkle (Catharanthus roseus) CYP71D351, also called tabersonine 16-hydroxylase 2, that is involved in the foliar biosynthesis of vindoline; sorghum CYP71E1, also called 4-hydroxyphenylacetaldehyde oxime monooxygenase, that catalyzes the conversion of p-hydroxyphenylacetaldoxime to p-hydroxymandelonitrile; as well as maize CYP71C1, CYP71C2, and CYP71C4, which are monooxygenases catalyzing the oxidation of 3-hydroxyindolin-2-one, indolin-2-one, and indole, respectively. CYPs within a single CYP71 subfamily, such as the C subfamily, usually metabolize similar/related compounds. The CYP71-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410695 [Multi-domain]  Cd Length: 428  Bit Score: 69.03  E-value: 4.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRtakLTPVSAQL------QDIegKI 186
Cdd:cd11072   244 SATTLEWAMTELIRNPRVMKKAQEEVREVVGgKGKVTEEDLEKLKYLKAVIKETLR---LHPPAPLLlprecrEDC--KI 318

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1707919429 187 DRFIIPRETLVL---YALGvvlQDPNTWPSPHKFDPDRFDDelvmktfSSLGFSGT 239
Cdd:cd11072   319 NGYDIPAKTRVIvnaWAIG---RDPKYWEDPEEFRPERFLD-------SSIDFKGQ 364
CYP46A1-like cd20613
cytochrome P450 family 46, subfamily A, polypeptide 1, also called cholesterol 24-hydroxylase, ...
 130-279 7.38e-13

cytochrome P450 family 46, subfamily A, polypeptide 1, also called cholesterol 24-hydroxylase, and similar cytochrome P450s; CYP46A1 is also called cholesterol 24-hydroxylase (EC 1.14.14.25), CH24H, cholesterol 24-monooxygenase, or cholesterol 24S-hydroxylase. It catalyzes the conversion of cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. CYP46A1 is associated with high-order brain functions; increased expression improves cognition while a reduction leads to a poor cognitive performance. It also plays a role in the pathogenesis or progression of neurodegenerative disorders. CYP46A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410706 [Multi-domain]  Cd Length: 429  Bit Score: 68.31  E-value: 7.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 130 EVQKKLYEEINQVFGNGP-VTPEKIEQLRYCQHVLCETVRtakLTPVSAQLQDI---EGKIDRFIIPRETLVL---YALG 202
Cdd:cd20613   266 EILKRLQAEVDEVLGSKQyVEYEDLGKLEYLSQVLKETLR---LYPPVPGTSREltkDIELGGYKIPAGTTVLvstYVMG 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 203 vvlQDPNTWPSPHKFDPDRFDDELVMK--TFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIETKYEL 279
Cdd:cd20613   343 ---RMEEYFEDPLKFDPERFSPEAPEKipSYAYFPFSlGPRSCIGQQFAQIEAKVILAKLLQNFKFELVPGQSFGILEEV 419
CYP71_clan cd20618
Plant cytochrome P450s, clan CYP71; The number of cytochrome P450s (P450s, CYPs) in plants is ...
 83-260 7.98e-13

Plant cytochrome P450s, clan CYP71; The number of cytochrome P450s (P450s, CYPs) in plants is considerably larger than in other taxa. In individual plant genomes, CYPs form the third largest family of plant genes; the two largest gene families code for F-box proteins and receptor-like kinases. CYPs have been classified into families and subfamilies based on homology and phylogenetic criteria; family membership is defined as 40% amino acid sequence identity or higher. However, there is a phenomenon called family creep, where a sequence (below 40% identity) is absorbed into a large family; this is seen in the plant CYP71 and CYP89 families. The plant CYPs have also been classified according to clans; land plants have 11 clans that form two groups: single-family clans (CYP51, CYP74, CYP97, CYP710, CYP711, CYP727, CYP746) and multi-family clans (CYP71, CYP72, CYP85, CYP86). The CYP71 clan has expanded dramatically and represents 50% of all plant CYPs; it includes several families including CYP71, CYP73, CYP76, CYP81, CYP82, CYP89, and CYP93, among others. It belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410711 [Multi-domain]  Cd Length: 429  Bit Score: 67.96  E-value: 7.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  83 FEDDQEVIRFQKNHGTILEDSMIFSLASCII------TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQ 155
Cdd:cd20618   208 DDDDDLLLLLDLDGEGKLSDDNIKALLLDMLaagtdtSAVTIEWAMAELLRHPEVMRKAQEELDSVVGRErLVEESDLPK 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 156 LRYCQHVLCETVRtakLTPVSAQL------QDIegKIDRFIIPRETLVL---YALGvvlQDPNTWPSPHKFDPDRFDDEL 226
Cdd:cd20618   288 LPYLQAVVKETLR---LHPPGPLLlphestEDC--KVAGYDIPAGTRVLvnvWAIG---RDPKVWEDPLEFKPERFLESD 359

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1707919429 227 VMKT----FSSLGF-SGTQECPELRFAYMVTTVLLSVLV 260
Cdd:cd20618   360 IDDVkgqdFELLPFgSGRRMCPGMPLGLRMVQLTLANLL 398
CYP93 cd20655
cytochrome P450 family 93; The cytochrome P450 family 93 (CYP93) is specifically found in ...
 82-260 8.10e-13

cytochrome P450 family 93; The cytochrome P450 family 93 (CYP93) is specifically found in flowering plants and could be classified into ten subfamilies, CYP93A-K. CYP93A appears to be the ancestor that was derived in flowering plants, and the remaining subfamiles show lineage-specific distribution: CYP93B and CYP93C are present in dicots; CYP93F is distributed only in Poaceae; CYP93G and CYP93J are monocot-specific; CYP93E is unique to legumes; CYP93H and CYP93K are only found in Aquilegia coerulea; and CYP93D is Brassicaceae-specific. Members of this family include: Glycyrrhiza echinata CYP93B1, also called licodione synthase (EC 1.14.14.140), that catalyzes the formation of licodione and 2-hydroxynaringenin from (2S)-liquiritigenin and (2S)-naringenin, respectively; and Glycine max CYP93A1, also called 3,9-dihydroxypterocarpan 6A-monooxygenase (EC 1.14.14.93), that is involved in the biosynthesis of the phytoalexin glyceollin. CYP93 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410748 [Multi-domain]  Cd Length: 433  Bit Score: 68.01  E-value: 8.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  82 TFEDDQEVIRFQKNH--GTILEdsmIFsLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEK-IEQLRY 158
Cdd:cd20655   214 AYEDENAEYKITRNHikAFILD---LF-IAGTDTSAATTEWAMAELINNPEVLEKAREEIDSVVGKTRLVQESdLPNLPY 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 159 CQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVL---YALGvvlQDPNTWPSPHKFDPDRF--------DDELV 227
Cdd:cd20655   290 LQAVVKETLRLHPPGPLLVRESTEGCKINGYDIPEKTTLFvnvYAIM---RDPNYWEDPLEFKPERFlassrsgqELDVR 366

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1707919429 228 MKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLV 260
Cdd:cd20655   367 GQHFKLLPFgSGRRGCPGASLAYQVVGTAIAAMV 400
CYP_FUM15-like cd11069
Fusarium verticillioides cytochrome P450 monooxygenase FUM15, and similar cytochrome P450s; ...
 119-283 1.77e-12

Fusarium verticillioides cytochrome P450 monooxygenase FUM15, and similar cytochrome P450s; Fusarium verticillioides cytochrome P450 monooxygenase FUM15, is also called fumonisin biosynthesis cluster protein 15. The FUM15 gene is part of the gene cluster that mediates the biosynthesis of fumonisins B1, B2, B3, and B4, which are carcinogenic mycotoxins. This FUM15-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410692 [Multi-domain]  Cd Length: 437  Bit Score: 67.29  E-value: 1.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICFLTTSEEVQKKLYEEINQVF---GNGPVTPEKIEQLRYCQHVLCETVRtakLTPVSAQL-----QDIegKIDRFI 190
Cdd:cd11069   256 TWALYLLAKHPDVQERLREEIRAALpdpPDGDLSYDDLDRLPYLNAVCRETLR---LYPPVPLTsreatKDT--VIKGVP 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 191 IPRETLVLYALGVVLQDPNTW-PSPHKFDPDRFDDELV------------MKTFSslgfSGTQECPELRFAYMVTTVLLS 257
Cdd:cd11069   331 IPKGTVVLIPPAAINRSPEIWgPDAEEFNPERWLEPDGaaspggagsnyaLLTFL----HGPRSCIGKKFALAEMKVLLA 406

                         170       180
                  ....*....|....*....|....*.
gi 1707919429 258 VLVKRLHLLSVEGQVIETKYELVTSS 283
Cdd:cd11069   407 ALVSRFEFELDPDAEVERPIGIITRP 432
CYP17A1 cd20673
cytochrome P450 family 17, subfamily A, polypeptide 1; Cytochrome P450 17A1 (CYP17A1 or ...
 114-271 3.29e-12

cytochrome P450 family 17, subfamily A, polypeptide 1; Cytochrome P450 17A1 (CYP17A1 or Cyp17a1), also called cytochrome P450c17, steroid 17-alpha-hydroxylase (EC 1.14.14.19)/17,20 lyase (EC 1.14.14.32), or 17-alpha-hydroxyprogesterone aldolase, catalyzes the conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. It is a dual enzyme that catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reactions. Severe mutations on the enzyme cause combined 17-hydroxylase/17,20-lyase deficiency (17OHD); patients with 17OHD synthesize 11-deoxycorticosterone (DOC) which causes hypertension and hypokalemia. Loss of 17,20-lyase activity precludes sex steroid synthesis and leads to sexual infantilism. Included in this group is a second 17A P450 from teleost fish, CYP17A2, that is more efficient in pregnenolone 17-alpha-hydroxylation than CYP17A1, but does not catalyze the lyase reaction. CYP17A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410766 [Multi-domain]  Cd Length: 432  Bit Score: 66.19  E-value: 3.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQV--FGNGPVTPEKiEQLRYCQHVLCETVRtakLTPVSAQL----QDIEGKID 187
Cdd:cd20673   248 TTTVLKWIIAFLLHNPEVQKKIQEEIDQNigFSRTPTLSDR-NHLPLLEATIREVLR---IRPVAPLLiphvALQDSSIG 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 188 RFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE----LVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLVKR 262
Cdd:cd20673   324 EFTIPKGTRVVINLWALHHDEKEWDQPDQFMPERFLDPtgsqLISPSLSYLPFgAGPRVCLGEALARQELFLFMAWLLQR 403


                  ....*....
gi 1707919429 263 LHLLSVEGQ 271
Cdd:cd20673   404 FDLEVPDGG 412
CYP5A1 cd20649
cytochrome P450 family 5, subfamily A, polypeptide 1, also called thromboxane-A synthase; ...
 99-269 3.48e-12

cytochrome P450 family 5, subfamily A, polypeptide 1, also called thromboxane-A synthase; Cytochrome P450 5A1 (CYP5A1), also called thromboxane-A synthase (EC 5.3.99.5) or thromboxane synthetase, converts prostaglandin H2 into thromboxane A2, a biologically active metabolite of arachidonic acid that has been implicated in stroke, asthma, and various cardiovascular diseases, due to its acute and chronic effects in promoting platelet aggregation, vasoconstriction, bronchoconstriction, and proliferation. CYP5A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410742 [Multi-domain]  Cd Length: 457  Bit Score: 66.40  E-value: 3.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  99 ILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINqVFGNGPVTPE--KIEQLRYCQHVLCETVR----TAKL 172
Cdd:cd20649   262 IVGQAFIFLIAGYETTTNTLSFATYLLATHPECQKKLLREVD-EFFSKHEMVDyaNVQELPYLDMVIAETLRmyppAFRF 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 173 TPVSAQLQDIEGKIdrfiIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMK--TFSSLGF-SGTQECPELRFAY 249
Cdd:cd20649   341 AREAAEDCVVLGQR----IPAGAVLEIPVGFLHHDPEHWPEPEKFIPERFTAEAKQRrhPFVYLPFgAGPRSCIGMRLAL 416

                         170       180
                  ....*....|....*....|
gi 1707919429 250 MVTTVLLSVLVKRLHLLSVE 269
Cdd:cd20649   417 LEIKVTLLHILRRFRFQACP 436
CYP2W1 cd20671
cytochrome P450 family 2, subfamily W, polypeptide 1; Cytochrome P450 2W1 (CYP2W1) is ...
 114-270 6.33e-12

cytochrome P450 family 2, subfamily W, polypeptide 1; Cytochrome P450 2W1 (CYP2W1) is expressed during development of the gastrointestinal tract, is silenced after birth in the intestine and colon by epigenetic modifications, but is activated following demethylation in colorectal cancer (CRC). Its expression levels in CRC correlate with the degree of malignancy, are higher in metastases and are predictive of survival. Thus, it is an attractive tumor-specific diagnostic and therapeutic target. CYP2W1 belongs to family 2 of the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410764 [Multi-domain]  Cd Length: 422  Bit Score: 65.59  E-value: 6.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIP 192
Cdd:cd20671   239 TSTTLQWAVLLMMKYPHIQKRVQEEIDRVLGPGcLPNYEDRKALPYTSAVIHEVQRFITLLPHVPRCTAADTQFKGYLIP 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 193 RETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE--LVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVE 269
Cdd:cd20671   319 KGTPVIPLLSSVLLDKTQWETPYQFNPNHFLDAegKFVKKEAFLPFSaGRRVCVGESLARTELFIFFTGLLQKFTFLPPP 398


                  .
gi 1707919429 270 G 270
Cdd:cd20671   399 G 399
PLN02302 PLN02302
ent-kaurenoic acid oxidase
 114-243 7.65e-12

ent-kaurenoic acid oxidase


Pssm-ID: 215171 [Multi-domain]  Cd Length: 490  Bit Score: 65.50  E-value: 7.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEK-----IEQLRYCQHVLCETVRTAKLTPVSAQ--LQDIEgkI 186
Cdd:PLN02302  303 SGHLTMWATIFLQEHPEVLQKAKAEQEEIAKKRPPGQKGltlkdVRKMEYLSQVIDETLRLINISLTVFReaKTDVE--V 380

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1707919429 187 DRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVmKTFSSLGFS-GTQECP 243
Cdd:PLN02302  381 NGYTIPKGWKVLAWFRQVHMDPEVYPNPKEFDPSRWDNYTP-KAGTFLPFGlGSRLCP 437
CYP2K cd20664
cytochrome P450 family 2, subfamily K; Members of CYP2K are present in fish, birds, and ...
 101-225 7.74e-12

cytochrome P450 family 2, subfamily K; Members of CYP2K are present in fish, birds, and amphibians. CYP2K6 from zebrafish has been shown to catalyze the conversion of aflatoxin B1 (AFB1) to its cytotoxic derivative AFB1 exo-8,9-epoxide, while its ortholog in rainbow trout CYP2K1 is also capable of oxidizing lauric acid. In birds, CYP2K is one of the largest CYP2 subfamilies. The CYP2K subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410757 [Multi-domain]  Cd Length: 424  Bit Score: 65.21  E-value: 7.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 101 EDSMIFSLASCI-----ITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPV 175
Cdd:cd20664   223 DDNLTCSVGNLFgagtdTTGTTLRWGLLLMMKYPEIQKKVQEEIDRVIGSRQPQVEHRKNMPYTDAVIHEIQRFANIVPM 302

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1707919429 176 S---AQLQDIegKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE 225
Cdd:cd20664   303 NlphATTRDV--TFRGYFIPKGTYVIPLLTSVLQDKTEWEKPEEFNPEHFLDS 353
PLN02687 PLN02687
flavonoid 3'-monooxygenase
 114-222 9.73e-12

flavonoid 3'-monooxygenase


Pssm-ID: 215371 [Multi-domain]  Cd Length: 517  Bit Score: 65.22  E-value: 9.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRTAKLTPVS-AQLQDIEGKIDRFII 191
Cdd:PLN02687  313 TSSTVEWAIAELIRHPDILKKAQEELDAVVGRDrLVSESDLPQLTYLQAVIKETFRLHPSTPLSlPRMAAEECEINGYHI 392

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1707919429 192 PRETLVLYALGVVLQDPNTWPSPHKFDPDRF 222
Cdd:PLN02687  393 PKGATLLVNVWAIARDPEQWPDPLEFRPDRF 423
CYP_unk cd11083
unknown subfamily of cytochrome P450s; This subfamily is composed of uncharacterized ...
 114-269 1.78e-11

unknown subfamily of cytochrome P450s; This subfamily is composed of uncharacterized cytochrome P450s. Cytochrome P450 (P450, CYP) is a large superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. Their monooxygenase activity relies on the reductive scission of molecular oxygen bound to the P450 heme iron, and the delivery of two electrons to the heme iron during the catalytic cycle.


Pssm-ID: 410704 [Multi-domain]  Cd Length: 421  Bit Score: 63.88  E-value: 1.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTP--EKIEQLRYCQHVLCETVRtakLTPVSAQL-----QDieGKI 186
Cdd:cd11083   238 TANTLAWMLYYLASRPDVQARVREEVDAVLGGARVPPllEALDRLPYLEAVARETLR---LKPVAPLLflepnED--TVV 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 187 DRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF---DDELVMKTFSS-LGF-SGTQECPELRFAYMVTTVLLSVLVK 261
Cdd:cd11083   313 GDIALPAGTPVFLLTRAAGLDAEHFPDPEEFDPERWldgARAAEPHDPSSlLPFgAGPRLCPGRSLALMEMKLVFAMLCR 392


                  ....*...
gi 1707919429 262 RLHLLSVE 269
Cdd:cd11083   393 NFDIELPE 400
CYP2U1 cd20666
cytochrome P450 family 2, subfamily U, polypeptide 1; CYP2U1 is a thymus- and brain-specific ...
 88-250 2.03e-11

cytochrome P450 family 2, subfamily U, polypeptide 1; CYP2U1 is a thymus- and brain-specific cytochrome P450 that catalyzes omega- and (omega-1)-hydroxylation of fatty acids such as arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. Mutations in CYP2U1 are associated with hereditary spastic paraplegia (HSP), a neurological disorder, and pigmentary degenerative maculopathy associated with progressive spastic paraplegia. CYP2U1 belongs to family 2 of the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410759 [Multi-domain]  Cd Length: 426  Bit Score: 64.03  E-value: 2.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  88 EVIRFQKNHG--TILEDSMIFSLASCII-----TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG--PVTPEKiEQLRY 158
Cdd:cd20666   211 HIEEEQKNNAesSFNEDYLFYIIGDLFIagtdtTTNTLLWCLLYMSLYPEVQEKVQAEIDTVIGPDraPSLTDK-AQMPF 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 159 CQHVLCETVRTAKLTPVSAQLQDIEGKIDR-FIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE--LVMKTFSSLG 235
Cdd:cd20666   290 TEATIMEVQRMTVVVPLSIPHMASENTVLQgYTIPKGTVIVPNLWSVHRDPAIWEKPDDFMPSRFLDEngQLIKKEAFIP 369

                         170
                  ....*....|....*.
gi 1707919429 236 FS-GTQECPELRFAYM 250
Cdd:cd20666   370 FGiGRRVCMGEQLAKM 385
CYP2J cd20662
cytochrome P450 family 2, subfamily J; Members of CYP2J are expressed in multiple tissues in ...
 101-242 2.17e-11

cytochrome P450 family 2, subfamily J; Members of CYP2J are expressed in multiple tissues in mice and humans. They function as catalysts of arachidonic acid metabolism and are active in the metabolism of fatty acids to generate bioactive compounds. Human CYP2J2, also called arachidonic acid epoxygenase or albendazole monooxygenase (hydroxylating), is a membrane-bound cytochrome P450 primarily expressed in the heart and plays a significant role in cardiovascular diseases. The CYP2J subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410755 [Multi-domain]  Cd Length: 421  Bit Score: 63.66  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 101 EDSMIFS-----LASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG--PVTPEKiEQLRYCQHVLCETVRTAKLT 173
Cdd:cd20662   223 EENLICStldlfFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQKrqPSLADR-ESMPYTNAVIHEVQRMGNII 301

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1707919429 174 PVSAQLQ-DIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF-DDELVMKTFSSLGFS-GTQEC 242
Cdd:cd20662   302 PLNVPREvAVDTKLAGFHLPKGTMILTNLTALHRDPKEWATPDTFNPGHFlENGQFKKREAFLPFSmGKRAC 373
CYP72_clan cd11052
Plant cytochrome P450s, clan CYP72; CYPs have been classified into families and subfamilies ...
 114-263 4.51e-11

Plant cytochrome P450s, clan CYP72; CYPs have been classified into families and subfamilies based on homology and phylogenetic criteria; family membership is defined as 40% amino acid sequence identity or higher. The plant CYPs have also been classified according to clans; land plants have 11 clans that form two groups: single-family clans (CYP51, CYP74, CYP97, CYP710, CYP711, CYP727, CYP746) and multi-family clans (CYP71, CYP72, CYP85, CYP86). The CYP72 clan is associated with the metabolism of a diversity of fairly hydrophobic compounds including fatty acids and isoprenoids, with the catabolism of hormones (brassinosteroids and gibberellin, GA) and with the biosynthesis of cytokinins. This clan includes: CYP734 enzymes that are involved in brassinosteroid (BRs) catabolism and regulation of BRs homeostasis; CYP714 enzymes that are involved in the biosynthesis of gibberellins (GAs) and the mechanism to control their bioactive endogenous levels; and CYP72 family enzymes, among others. The CYP72 clan belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410675 [Multi-domain]  Cd Length: 427  Bit Score: 62.74  E-value: 4.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRtakLTPVSAQLQ-----DIegKIDR 188
Cdd:cd11052   248 TALLLTWTTMLLAIHPEWQEKAREEVLEVCGKDKPPSDSLSKLKTVSMVINESLR---LYPPAVFLTrkakeDI--KLGG 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 189 FIIPRETLVLYALGVVLQDPNTWPS-PHKFDPDRFDDELVMKTFSSLGF----SGTQECPELRFAYMVTTVLLSVLVKRL 263
Cdd:cd11052   323 LVIPKGTSIWIPVLALHHDEEIWGEdANEFNPERFADGVAKAAKHPMAFlpfgLGPRNCIGQNFATMEAKIVLAMILQRF 402
PLN02183 PLN02183
ferulate 5-hydroxylase
 81-243 7.43e-11

ferulate 5-hydroxylase


Pssm-ID: 165828 [Multi-domain]  Cd Length: 516  Bit Score: 62.56  E-value: 7.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  81 STFEDDQEVIRFQKNH-GTILEDSMIF---SLASCIitaklcTWAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQ 155
Cdd:PLN02183  289 NESDDLQNSIKLTRDNiKAIIMDVMFGgteTVASAI------EWAMAELMKSPEDLKRVQQELADVVGlNRRVEESDLEK 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 156 LRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVL---YALGvvlQDPNTWPSPHKFDPDRFDDELVM---- 228
Cdd:PLN02183  363 LTYLKCTLKETLRLHPPIPLLLHETAEDAEVAGYFIPKRSRVMinaWAIG---RDKNSWEDPDTFKPSRFLKPGVPdfkg 439

                         170
                  ....*....|....*.
gi 1707919429 229 KTFSSLGF-SGTQECP 243
Cdd:PLN02183  440 SHFEFIPFgSGRRSCP 455
CYP21 cd20674
cytochrome P450 21, also called steroid 21-hydroxylase; Cytochrome P450 21 (CYP21 or Cyp21), ...
 62-266 8.56e-11

cytochrome P450 21, also called steroid 21-hydroxylase; Cytochrome P450 21 (CYP21 or Cyp21), also called steroid 21-hydroxylase (EC 1.14.14.16) or cytochrome P-450c21 or CYP21A2 (in humans), catalyzes the 21-hydroxylation of steroids such as progesterone and 17-alpha-hydroxyprogesterone (17-alpha-OH-progesterone) to form 11-deoxycorticosterone and 11-deoxycortisol, respectively. It is required for the adrenal synthesis of mineralocorticoids and glucocorticoids. Deficiency of this CYP is involved in ~95% of cases of human congenital adrenal hyperplasia, a disorder of adrenal steroidogenesis. There are two CYP21 genes in the human genome, CYP21A1 (a pseudogene) and CYP21A2 (the functional gene). Deficiencies in steroid 21-hydroxylase activity lead to a type of congenital adrenal hyperplasia, which has three clinical forms: a severe form with concurrent defects in both cortisol and aldosterone biosynthesis; a form with adequate aldosterone biosynthesis; and a mild, non-classic form that can be asymptomatic or associated with signs of postpubertal androgen excess without cortisol deficiency. CYP21A2 is also the major autoantigen in autoimmune Addison disease. Cyp21 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410767 [Multi-domain]  Cd Length: 424  Bit Score: 62.05  E-value: 8.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  62 LSQHMLGFAMKSVTQMVMGS-TFEDDQEVirfQKNHGTILEDSMIFSLASCII-----TAKLCTWAICFLTTSEEVQKKL 135
Cdd:cd20674   187 LRQHKESLVAGQWRDMTDYMlQGLGQPRG---EKGMGQLLEGHVHMAVVDLFIggtetTASTLSWAVAFLLHHPEIQDRL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 136 YEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDI-EGKIDRFIIPRETLVLYALGVVLQDPNTWPS 213
Cdd:cd20674   264 QEELDRVLGPGaSPSYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTrDSSIAGYDIPKGTVVIPNLQGAHLDETVWEQ 343

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1707919429 214 PHKFDPDRFDDElVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLL 266
Cdd:cd20674   344 PHEFRPERFLEP-GAANRALLPFGcGARVCLGEPLARLELFVFLARLLQAFTLL 396
CYP1B1-like cd20675
cytochrome P450 family 1, subfamily B, polypeptide 1 and similar cytochrome P450s; Cytochrome ...
 119-225 1.20e-10

cytochrome P450 family 1, subfamily B, polypeptide 1 and similar cytochrome P450s; Cytochrome P450 1B1 (CYP1B1) is expressed in liver and extrahepatic tissues where it carries out the metabolism of numerous xenobiotics, including metabolic activation of polycyclic aromatic hydrocarbons. It is also important in regulating endogenous metabolic pathways, including the metabolism of steroid hormones, fatty acids, melatonin, and vitamins. CYP1B1 is overexpressed in a wide variety of tumors and is associated with angiogenesis. It is also associated with adipogenesis, obesity, hypertension, and atherosclerosis. It is therefore a target for the treatment of metabolic diseases and cancer. Also included in this subfamily are CYP1C proteins from fish, birds and amphibians. The CYP1B1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410768 [Multi-domain]  Cd Length: 434  Bit Score: 61.56  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICFLTTSEEVQKKLYEEINQVFGNGPV-TPEKIEQLRYCQHVLCETVRTAKLTPVS---AQLQDIEgkIDRFIIPRE 194
Cdd:cd20675   256 QWILLLLVRYPDVQARLQEELDRVVGRDRLpCIEDQPNLPYVMAFLYEAMRFSSFVPVTiphATTADTS--ILGYHIPKD 333

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1707919429 195 TLVLYALGVVLQDPNTWPSPHKFDPDRFDDE 225
Cdd:cd20675   334 TVVFVNQWSVNHDPQKWPNPEVFDPTRFLDE 364
CypX COG2124
Cytochrome P450 [Secondary metabolites biosynthesis, transport and catabolism, Defense ...
 114-294 1.41e-10

Cytochrome P450 [Secondary metabolites biosynthesis, transport and catabolism, Defense mechanisms]; Cytochrome P450 is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441727 [Multi-domain]  Cd Length: 400  Bit Score: 61.45  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEinqvfgngpvtPEKIEQ-----LRYCQHVLCeTVRTAKltpvsaqlQDIEgkIDR 188
Cdd:COG2124   242 TANALAWALYALLRHPEQLARLRAE-----------PELLPAaveetLRLYPPVPL-LPRTAT--------EDVE--LGG 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 189 FIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRfddelvmKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLS 267
Cdd:COG2124   300 VTIPAGDRVLLSLAAANRDPRVFPDPDRFDPDR-------PPNAHLPFGgGPHRCLGAALARLEARIALATLLRRFPDLR 372

                         170       180
                  ....*....|....*....|....*...
gi 1707919429 268 -VEGQVIETKYELVTSSREEAWITVSKR 294
Cdd:COG2124   373 lAPPEELRWRPSLTLRGPKSLPVRLRPR 400
CYP81 cd20653
cytochrome P450 family 81; The only characterized member of the cytochrome P450 family 81 ...
 120-260 1.67e-10

cytochrome P450 family 81; The only characterized member of the cytochrome P450 family 81 (CYP81 or Cyp81) is CYP81E1, also called isoflavone 2'-hydroxylase, that catalyzes the hydroxylation of isoflavones, daidzein, and formononetin, to yield 2'-hydroxyisoflavones, 2'-hydroxydaidzein, and 2'-hydroxyformononetin, respectively. It is involved in the biosynthesis of isoflavonoid-derived antimicrobial compounds of legumes. CYP81 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410746 [Multi-domain]  Cd Length: 420  Bit Score: 61.08  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFGNGPVTPEK-IEQLRYCQHVLCETVRtakLTPVSAQL------QDIegKIDRFIIP 192
Cdd:cd20653   249 WAMSNLLNHPEVLKKAREEIDTQVGQDRLIEESdLPKLPYLQNIISETLR---LYPAAPLLvphessEDC--KIGGYDIP 323

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1707919429 193 RETLVLYALGVVLQDPNTWPSPHKFDPDRFDDElVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLV 260
Cdd:cd20653   324 RGTMLLVNAWAIHRDPKLWEDPTKFKPERFEGE-EREGYKLIPFgLGRRACPGAGLAQRVVGLALGSLI 391
CYP2R1 cd20661
cytochrome P450 2R1; CYP2R1, also called vitamin D 25-hydroxylase (EC 1.14.14.24), is a ...
 98-279 2.05e-10

cytochrome P450 2R1; CYP2R1, also called vitamin D 25-hydroxylase (EC 1.14.14.24), is a microsomal enzyme that is required for the activation of vitamin D; it catalyzes the initial step converting vitamin D into 25-hydroxyvitamin D (25(OH)D), the major circulating metabolite of vitamin D. The 1alpha-hydroxylation of 25(OH)D by CYP27B1 generates the fully active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)2D). Mutations in the CYP2R1 gene are associated with an atypical form of vitamin D-deficiency rickets, which has been classified as vitamin D dependent rickets type 1B. CYP2R1 belongs to family 2 of the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410754 [Multi-domain]  Cd Length: 436  Bit Score: 60.98  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  98 TILEDSMIFSLASCII-----TAKLCTWAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAK 171
Cdd:cd20661   233 TFSMENLIFSVGELIIagtetTTNVLRWAILFMALYPNIQGQVQKEIDLVVGpNGMPSFEDKCKMPYTEAVLHEVLRFCN 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 172 LTPVSAQLQDIEGKIDR-FIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE--LVMKTFSSLGFS-GTQECPELRF 247
Cdd:cd20661   313 IVPLGIFHATSKDAVVRgYSIPKGTTVITNLYSVHFDEKYWSDPEVFHPERFLDSngQFAKKEAFVPFSlGRRHCLGEQL 392

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1707919429 248 AYMVTTVLLSVLVKRLHLLSVEGQVIETKYEL 279
Cdd:cd20661   393 ARMEMFLFFTALLQRFHLHFPHGLIPDLKPKL 424
PLN02936 PLN02936
epsilon-ring hydroxylase
 114-294 2.42e-10

epsilon-ring hydroxylase


Pssm-ID: 178524 [Multi-domain]  Cd Length: 489  Bit Score: 60.96  E-value: 2.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPV---SAQLQDIEGKidRFI 190
Cdd:PLN02936  294 TGSVLTWTLYLLSKNPEALRKAQEELDRVLQGRPPTYEDIKELKYLTRCINESMRLYPHPPVlirRAQVEDVLPG--GYK 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 191 IPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGF------SGTQECPELRFAYMVTTVLLSVLVKRLH 264
Cdd:PLN02936  372 VNAGQDIMISVYNIHRSPEVWERAEEFVPERFDLDGPVPNETNTDFryipfsGGPRKCVGDQFALLEAIVALAVLLQRLD 451

                         170       180       190
                  ....*....|....*....|....*....|
gi 1707919429 265 LLSVEGQVIETKYELVTSSREEAWITVSKR 294
Cdd:PLN02936  452 LELVPDQDIVMTTGATIHTTNGLYMTVSRR 481
CYP58-like cd11062
cytochrome P450 family 58-like fungal cytochrome P450s; This group includes Fusarium ...
 114-269 2.48e-10

cytochrome P450 family 58-like fungal cytochrome P450s; This group includes Fusarium sporotrichioides cytochrome P450 58 (CYP58, also known as Tri4 and trichodiene oxygenase), and similar fungal proteins. CYP58 catalyzes the oxygenation of trichodiene during the biosynthesis of trichothecenes, which are sesquiterpenoid toxins that act by inhibiting protein biosynthesis. The CYP58-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410685 [Multi-domain]  Cd Length: 425  Bit Score: 60.73  E-value: 2.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVF--GNGPVTPEKIEQLRYCQHVLCETVRTAklTPVSAQLQDI---EG-KID 187
Cdd:cd11062   240 TARTLSVATFHLLSNPEILERLREELKTAMpdPDSPPSLAELEKLPYLTAVIKEGLRLS--YGVPTRLPRVvpdEGlYYK 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 188 RFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF---DDELVMKTFsSLGFS-GTQECPELRFAYMVTTVLLSVLVKRL 263
Cdd:cd11062   318 GWVIPPGTPVSMSSYFVHHDEEIFPDPHEFRPERWlgaAEKGKLDRY-LVPFSkGSRSCLGINLAYAELYLALAALFRRF 396


                  ....*.
gi 1707919429 264 HLLSVE 269
Cdd:cd11062   397 DLELYE 402
PLN02738 PLN02738
carotene beta-ring hydroxylase
 101-262 3.66e-10

carotene beta-ring hydroxylase


Pssm-ID: 215393 [Multi-domain]  Cd Length: 633  Bit Score: 60.31  E-value: 3.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 101 EDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPV----S 176
Cdd:PLN02738  394 DDLMTMLIAGHETSAAVLTWTFYLLSKEPSVVAKLQEEVDSVLGDRFPTIEDMKKLKYTTRVINESLRLYPQPPVlirrS 473

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 177 AQlQDIEGKidrFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF-----DDELVMKTFSSLGF-SGTQECPELRFAYM 250
Cdd:PLN02738  474 LE-NDMLGG---YPIKRGEDIFISVWNLHRSPKHWDDAEKFNPERWpldgpNPNETNQNFSYLPFgGGPRKCVGDMFASF 549

                         170
                  ....*....|..
gi 1707919429 251 VTTVLLSVLVKR 262
Cdd:PLN02738  550 ENVVATAMLVRR 561
CYP75 cd20657
cytochrome P450 family 75; The cytochrome P450 family 75 (CYP75) play important roles in the ...
 120-222 3.81e-10

cytochrome P450 family 75; The cytochrome P450 family 75 (CYP75) play important roles in the biosynthesis of colored class of flavonoids, anthocyanins, which confer a diverse range of colors to flowers from orange to red to violet and blue. The number of hydroxyl groups on the B-ring of anthocyanidins, the chromophores and precursors of anthocyanins, impact the anthocyanin color - the more the bluer. The hydroxylation pattern is determined by CYP75 proteins: flavonoid 3'-hydroxylase (F3'H, EC 1.14.14.82) and and flavonoid 3',5'-hydroxylase (F3'5'H, EC 1.14.14.81), which belong to CYP75B and CYP75A subfamilies, respectively. Both enzymes have broad substrate specificity and catalyze the hydroxylation of flavanones, dihydroflavonols, flavonols and flavones. F3'H catalyzes the 3'-hydroxylation of the flavonoid B-ring to the 3',4'-hydroxylated state. F3'5'H catalysis leads to trihydroxylated delphinidin-based anthocyanins that tend to have violet/blue colours. CYP75 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410750 [Multi-domain]  Cd Length: 438  Bit Score: 60.13  E-value: 3.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEG-KIDRFIIPRETLV 197
Cdd:cd20657   250 WALAELIRHPDILKKAQEEMDQVIGrDRRLLESDIPNLPYLQAICKETFRLHPSTPLNLPRIASEAcEVDGYYIPKGTRL 329

                          90       100
                  ....*....|....*....|....*
gi 1707919429 198 LYALGVVLQDPNTWPSPHKFDPDRF 222
Cdd:cd20657   330 LVNIWAIGRDPDVWENPLEFKPERF 354
CYP98 cd20656
cytochrome P450 family 98; Cytochrome P450 family 98 (CYP98) monooxygenases catalyze the ...
 114-259 3.88e-10

cytochrome P450 family 98; Cytochrome P450 family 98 (CYP98) monooxygenases catalyze the meta-hydroxylation step in the phenylpropanoid biosynthetic pathway. CYP98A3, also called p-coumaroylshikimate/quinate 3'-hydroxylase, catalyzes 3'-hydroxylation of p-coumaric esters of shikimic/quinic acids to form lignin monomers. CYP98A8, also called p-coumarate 3-hydroxylase, acts redundantly with CYP98A9 as tricoumaroylspermidine meta-hydroxylase. CYP98 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410749 [Multi-domain]  Cd Length: 432  Bit Score: 60.19  E-value: 3.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPE-KIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEG-KIDRFII 191
Cdd:cd20656   246 TAISVEWAMAEMIRNPRVQEKAQEELDRVVGSDRVMTEaDFPQLPYLQCVVKEALRLHPPTPLMLPHKASENvKIGGYDI 325

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1707919429 192 PRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELV-MK--TFSSLGF-SGTQECPELRFAY-MVTTVLLSVL 259
Cdd:cd20656   326 PKGANVHVNVWAIARDPAVWKNPLEFRPERFLEEDVdIKghDFRLLPFgAGRRVCPGAQLGInLVTLMLGHLL 398
CYP27A1 cd20646
cytochrome P450 family 27, subfamily A, polypeptide 1, also called vitamin D(3) 25-hydroxylase; ...
 108-262 4.82e-10

cytochrome P450 family 27, subfamily A, polypeptide 1, also called vitamin D(3) 25-hydroxylase; Cytochrome P450 27A1 (CYP27A1, EC 1.14.15.15) is also called CYP27, cholestanetriol 26-monooxygenase, sterol 26-hydroxylase, 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase, cytochrome P-450C27/25, sterol 27-hydroxylase, or vitamin D(3) 25-hydroxylase. It catalyzes the first step in the oxidation of the side chain of sterol intermediates, the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, and the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. It also hydroxylates vitamin D3 at the 25-position, as well as cholesterol at positions 24 and 25. CYP27A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410739 [Multi-domain]  Cd Length: 430  Bit Score: 59.67  E-value: 4.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 108 LASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPV-TPEKIEQLRYCQHVLCETVRTAKLTPVSAQL-QDIEGK 185
Cdd:cd20646   243 LAGVDTTSNTLSWALYHLARDPEIQERLYQEVISVCPGDRIpTAEDIAKMPLLKAVIKETLRLYPVVPGNARViVEKEVV 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 186 IDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF--DDELVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKR 262
Cdd:cd20646   323 VGDYLFPKNTLFHLCHYAVSHDETNFPEPERFKPERWlrDGGLKHHPFGSIPFGyGVRACVGRRIAELEMYLALSRLIKR 402
PLN02290 PLN02290
cytokinin trans-hydroxylase
 92-262 5.52e-10

cytokinin trans-hydroxylase


Pssm-ID: 215164 [Multi-domain]  Cd Length: 516  Bit Score: 59.83  E-value: 5.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  92 FQKNHGTILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVR--- 168
Cdd:PLN02290  310 FNLNLQLIMDECKTFFFAGHETTALLLTWTLMLLASNPTWQDKVRAEVAEVCGGETPSVDHLSKLTLLNMVINESLRlyp 389

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 169 TAKLTPVSAqLQDIegKIDRFIIPRETLVLYALGVVLQDPNTW-PSPHKFDPDRFddelVMKTFSSLGF-----SGTQEC 242
Cdd:PLN02290  390 PATLLPRMA-FEDI--KLGDLHIPKGLSIWIPVLAIHHSEELWgKDANEFNPDRF----AGRPFAPGRHfipfaAGPRNC 462

                         170       180
                  ....*....|....*....|
gi 1707919429 243 PELRFAYMVTTVLLSVLVKR 262
Cdd:PLN02290  463 IGQAFAMMEAKIILAMLISK 482
CYP52 cd11063
cytochrome P450 family 52; Cytochrome P450 52 (CYP52), also called P450ALK, monooxygenases ...
 114-238 8.38e-10

cytochrome P450 family 52; Cytochrome P450 52 (CYP52), also called P450ALK, monooxygenases catalyze the first hydroxylation step in the assimilation of alkanes and fatty acids by filamentous fungi. The number of CYP52 proteins depend on the fungal species: for example, Candida tropicalis has seven, Candida maltose has eight, and Yarrowia lipolytica has twelve. The CYP52 family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410686 [Multi-domain]  Cd Length: 419  Bit Score: 59.11  E-value: 8.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGP-VTPEKIEQLRYCQHVLCETVRtakLTPVSAQ-----LQD------ 181
Cdd:cd11063   232 TASLLSFLFYELARHPEVWAKLREEVLSLFGPEPtPTYEDLKNMKYLRAVINETLR---LYPPVPLnsrvaVRDttlprg 308

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 182 --IEGKIDRFiIPRETLVLYALGVVLQDPNTW-PSPHKFDPDRFDDeLVMKTFSSLGFSG 238
Cdd:cd11063   309 ggPDGKSPIF-VPKGTRVLYSVYAMHRRKDIWgPDAEEFRPERWED-LKRPGWEYLPFNG 366
CYP2D cd20663
cytochrome P450 family 2, subfamily D; Members of CYP2D are present in mammals, birds, ...
 109-225 1.03e-09

cytochrome P450 family 2, subfamily D; Members of CYP2D are present in mammals, birds, reptiles, and amphibians. The hominin CYP2D subfamily consists of a functional CYP2D6 and two paralogs, CYP2D7 and CYP2D8, that are often not functional in some species. Human CYP2D6 has a high affinity for alkaloids and can detoxify them. It is also responsible for metabolizing about 25% of commonly used drugs, such as antidepressants, beta-blockers, and antiarrhythmics. The CYP2D subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410756 [Multi-domain]  Cd Length: 428  Bit Score: 58.94  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 109 ASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPvTPEKIEQLR--YCQHVLCETVRTAKLTPVSA---QLQDIE 183
Cdd:cd20663   241 AGMVTTSTTLSWALLLMILHPDVQRRVQQEIDEVIGQVR-RPEMADQARmpYTNAVIHEVQRFGDIVPLGVphmTSRDIE 319

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1707919429 184 gkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE 225
Cdd:cd20663   320 --VQGFLIPKGTTLITNLSSVLKDETVWEKPLRFHPEHFLDA 359
CYP82 cd20654
cytochrome P450 family 82; Cytochrome P450 family 82 (CYP82 or Cyp82) genes specifically ...
 119-285 1.19e-09

cytochrome P450 family 82; Cytochrome P450 family 82 (CYP82 or Cyp82) genes specifically reside in dicots and are usually induced by distinct environmental stresses. Characterized members include: Glycine max CYP82A3 that is induced by infection, salinity and drought stresses, and is involved in the jasmonic acid and ethylene signaling pathway, enhancing plant resistance; Arabidopsis thaliana CYP82G1 that catalyzes the breakdown of the C(20)-precursor (E,E)-geranyllinalool to the insect-induced C(16)-homoterpene (E,E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene (TMTT); and Papaver somniferum CYP82N4, also called methyltetrahydroprotoberberine 14-monooxygenase, and CYP82Y1, also called N-methylcanadine 1-hydroxylase. CYP82N4 catalyzes the conversion of N-methylated protoberberine alkaloids N-methylstylopine and N-methylcanadine into protopine and allocryptopine, respectively, in the biosynthesis of isoquinoline alkaloid sanguinarine. CYP82Y1 catalyzes the 1-hydroxylation of N-methylcanadine to 1-hydroxy-N-methylcanadine, the first committed step in the formation of noscapine. CYP82 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410747 [Multi-domain]  Cd Length: 447  Bit Score: 58.78  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEK-IEQLRYCQHVLCETVRTAKLTPVSAQLQDIEG-KIDRFIIPRETL 196
Cdd:cd20654   262 TWALSLLLNNPHVLKKAQEELDTHVGKDRWVEESdIKNLVYLQAIVKETLRLYPPGPLLGPREATEDcTVGGYHVPKGTR 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 197 VLYALGVVLQDPNTWPSPHKFDPDRF-----DDELVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLvkrLHllsveg 270
Cdd:cd20654   342 LLVNVWKIQRDPNVWSDPLEFKPERFltthkDIDVRGQNFELIPFgSGRRSCPGVSFGLQVMHLTLARL---LH------ 412

                         170
                  ....*....|....*
gi 1707919429 271 qvietKYELVTSSRE 285
Cdd:cd20654   413 -----GFDIKTPSNE 422
CYP86A cd11064
cytochrome P450 family 86, subfamily A; This subfamily includes several Arabidopsis thaliana ...
 119-280 1.20e-09

cytochrome P450 family 86, subfamily A; This subfamily includes several Arabidopsis thaliana cytochrome P450s (CYP86A1, CYP86A2, CYP86A4, among others), Petunia x hybrida CYP86A22, and Vicia sativa CYP94A1 and CYP94A2. They are P450-dependent fatty acid omega-hydroxylases that catalyze the omega-hydroxylation of various fatty acids. CYP86A2 acts on saturated and unsaturated fatty acids with chain lengths from C12 to C18; CYP86A22 prefers substrates with chain lengths of C16 and C18; and CYP94A1 acts on various fatty acids from 10 to 18 carbons. They play roles in the biosynthesis of extracellular lipids, cutin synthesis, and plant defense. The CYP86A subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410687 [Multi-domain]  Cd Length: 432  Bit Score: 58.37  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICFLTTSEEVQKKLYEEINQV----FGNGPV--TPEKIEQLRYCQHVLCETVRtakLTPVSAqlqdIEGKI------ 186
Cdd:cd11064   251 TWFFWLLSKNPRVEEKIREELKSKlpklTTDESRvpTYEELKKLVYLHAALSESLR---LYPPVP----FDSKEavnddv 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 187 --DRFIIPRETLVL---YALGVVlqdPNTW-PSPHKFDPDRF-DDELVMKTFSSLGFS----GTQECPELRFAYMVTTVL 255
Cdd:cd11064   324 lpDGTFVKKGTRIVysiYAMGRM---ESIWgEDALEFKPERWlDEDGGLRPESPYKFPafnaGPRICLGKDLAYLQMKIV 400

                         170       180
                  ....*....|....*....|....*
gi 1707919429 256 LSVLVKRLHLLSVEGQVIETKYELV 280
Cdd:cd11064   401 AAAILRRFDFKVVPGHKVEPKMSLT 425
CYP78 cd11076
cytochrome P450 family 78; Characterized cytochrome P450 family 78 (CYP78 or Cyp78) proteins ...
 100-243 1.98e-09

cytochrome P450 family 78; Characterized cytochrome P450 family 78 (CYP78 or Cyp78) proteins include: CYP78A5, which is expressed in leaf, flora and embryo, and has been reported to stimulate plant organ growth in Arabidopsis thaliana and to regulate plant architecture, ripening time, and fruit mass in tomato; Glycine max CYP78A10 that functions in regulating seed size/weight and pod number; and Physcomitrella patens CYP78A27 or CYP78A28, which together, are essential in bud formation. The CYP78 family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410699 [Multi-domain]  Cd Length: 426  Bit Score: 57.72  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 100 LEDS-MIFSLASCII-----TAKLCTWAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRtakL 172
Cdd:cd11076   220 LSDSdMIAVLWEMIFrgtdtVAILTEWIMARMVLHPDIQSKAQAEIDAAVGgSRRVADSDVAKLPYLQAVVKETLR---L 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 173 TP----VS-AQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLG-------F-SGT 239
Cdd:cd11076   297 HPpgplLSwARLAIHDVTVGGHVVPAGTTAMVNMWAITHDPHVWEDPLEFKPERFVAAEGGADVSVLGsdlrlapFgAGR 376


                  ....
gi 1707919429 240 QECP 243
Cdd:cd11076   377 RVCP 380
CYP503A1-like cd11041
cytochrome P450 family 503, subfamily A, polypeptide 1 and similar cytochrome P450s; This ...
 104-243 2.50e-09

cytochrome P450 family 503, subfamily A, polypeptide 1 and similar cytochrome P450s; This family is composed of predominantly fungal cytochrome P450s (CYPs) with similarity to Fusarium fujikuroi Cytochrome P450 503A1 (CYP503A1, also called ent-kaurene oxidase or cytochrome P450-4), Aspergillus nidulans austinol synthesis protein I (ausI), Alternaria alternata tentoxin synthesis protein 1 (TES1), and Acanthamoeba polyphaga mimivirus cytochrome P450 51 (CYP51, also called P450-LIA1 or sterol 14-alpha demethylase). Ent-kaurene oxidase catalyzes three successive oxidations of the 4-methyl group of ent-kaurene to form kaurenoic acid, an intermediate in gibberellin biosynthesis. AusI and TES1 are cytochrome P450 monooxygenases that mediate the biosynthesis of the meroterpenoids, austinol and dehydroaustinol, and the phytotoxin tentoxin, respectively. P450-LIA1 catalyzes the 14-alpha demethylation of obtusifoliol and functions in steroid biosynthesis. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410667 [Multi-domain]  Cd Length: 441  Bit Score: 57.69  E-value: 2.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 104 MIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQ---L 179
Cdd:cd11041   233 LALSFAAIHTTSMTLTHVLLDLAAHPEYIEPLREEIRSVLAEhGGWTKAALNKLKKLDSFMKESQRLNPLSLVSLRrkvL 312

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707919429 180 QDIeGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF------DDELVMKTFSS-----LGFS-GTQECP 243
Cdd:cd11041   313 KDV-TLSDGLTLPKGTRIAVPAHAIHRDPDIYPDPETFDGFRFyrlreqPGQEKKHQFVStspdfLGFGhGRHACP 387
CYP64-like cd11065
cytochrome P450 family 64-like fungal cytochrome P450s; This group includes Aspergillus flavus ...
 130-222 3.63e-09

cytochrome P450 family 64-like fungal cytochrome P450s; This group includes Aspergillus flavus cytochrome P450 64 (CYP64), also called O-methylsterigmatocystin (OMST) oxidoreductase or aflatoxin B synthase or aflatoxin biosynthesis protein Q, and similar fungal cytochrome P450s. CYP64 converts OMST to aflatoxin B1 and converts dihydro-O-methylsterigmatocystin (DHOMST) to aflatoxin B2 in the aflatoxin biosynthesis pathway. The CYP64-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410688 [Multi-domain]  Cd Length: 425  Bit Score: 57.20  E-value: 3.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 130 EVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRTAKLTPVS---AQLQDIEgkIDRFIIPRETLVLYALGVVL 205
Cdd:cd11065   255 EVQKKAQEELDRVVGPDrLPTFEDRPNLPYVNAIVKEVLRWRPVAPLGiphALTEDDE--YEGYFIPKGTTVIPNAWAIH 332

                          90
                  ....*....|....*..
gi 1707919429 206 QDPNTWPSPHKFDPDRF 222
Cdd:cd11065   333 HDPEVYPDPEEFDPERY 349
CYP59-like cd11051
cytochrome P450 family 59 and similar cytochrome P450s; This family is composed of Aspergillus ...
 114-222 6.38e-09

cytochrome P450 family 59 and similar cytochrome P450s; This family is composed of Aspergillus nidulans cytochrome P450 59 (CYP59), also called sterigmatocystin biosynthesis P450 monooxygenase stcS, and similar fungal proteins. CYP59 is required for the conversion of versicolorin A to sterigmatocystin. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410674 [Multi-domain]  Cd Length: 403  Bit Score: 56.11  E-value: 6.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGP--------VTPEKIEQLRYCQHVLCETVR------TAKLTPVSAQL 179
Cdd:cd11051   201 TSSTLCWAFYLLSKHPEVLAKVRAEHDEVFGPDPsaaaellrEGPELLNQLPYTTAVIKETLRlfppagTARRGPPGVGL 280

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1707919429 180 QDIEGKIdrfiIPRETLVLYALGVVLQ-DPNTWPSPHKFDPDRF 222
Cdd:cd11051   281 TDRDGKE----YPTDGCIVYVCHHAIHrDPEYWPRPDEFIPERW 320
PLN02655 PLN02655
ent-kaurene oxidase
 98-225 8.85e-09

ent-kaurene oxidase


Pssm-ID: 215354 [Multi-domain]  Cd Length: 466  Bit Score: 55.90  E-value: 8.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  98 TILEDSMIFSLASCIITAKLCT-----WAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRT--- 169
Cdd:PLN02655  257 HLTDEQLMMLVWEPIIEAADTTlvtteWAMYELAKNPDKQERLYREIREVCGDERVTEEDLPNLPYLNAVFHETLRKysp 336

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1707919429 170 AKLTPVSAQLQDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE 225
Cdd:PLN02655  337 VPLLPPRFVHEDTT--LGGYDIPAGTQIAINIYGCNMDKKRWENPEEWDPERFLGE 390
CYP_GliC-like cd20615
cytochrome P450 monooxygenases similar to gliotoxin biosynthesis protein C; This subfamily is ...
 102-291 9.24e-09

cytochrome P450 monooxygenases similar to gliotoxin biosynthesis protein C; This subfamily is composed of cytochrome P450 monooxygenases that are part of gene clusters involved in the biosynthesis of various compounds such as mycotoxins and alkaloids, including Aspergillus fumigatus gliotoxin biosynthesis protein (GliC), Penicillium rubens roquefortine/meleagrin synthesis protein R (RoqR), Aspergillus oryzae aspirochlorine biosynthesis protein C (AclC), Aspergillus terreus bimodular acetylaranotin synthesis protein ataTC, Kluyveromyces lactis pulcherrimin biosynthesis cluster protein 2 (PUL2), and Aspergillus nidulans aspyridones biosynthesis protein B (ApdB). The GliC-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410708 [Multi-domain]  Cd Length: 409  Bit Score: 55.76  E-value: 9.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 102 DSMIFslASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEKIEQ----LRYCqhvLCETVRTAKLTPVS 176
Cdd:cd20615   221 DEMLF--ANLDVTTGVLSWNLVFLAANPAVQEKLREEISAAREQsGYPMEDYILStdtlLAYC---VLESLRLRPLLAFS 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 177 -AQLQDIEGKIDRFIIPRETLVL---YALGVvlQDPNTWPSPHKFDPDRFDDEL---VMKTFSSLGFsGTQECPELRFAY 249
Cdd:cd20615   296 vPESSPTDKIIGGYRIPANTPVVvdtYALNI--NNPFWGPDGEAYRPERFLGISptdLRYNFWRFGF-GPRKCLGQHVAD 372

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1707919429 250 MVTTVLLSVLVKRLHL-LSVEGQVIETKYElvtssrEEAWITV 291
Cdd:cd20615   373 VILKALLAHLLEQYELkLPDQGENEEDTFE------GLPWIWV 409
CYP2A cd20668
cytochrome P450 family 2, subfamily A; Cytochrome P450 family 2, subfamily A (CYP2A) includes ...
 130-225 2.01e-08

cytochrome P450 family 2, subfamily A; Cytochrome P450 family 2, subfamily A (CYP2A) includes CYP2A1, 2A2, and 2A3 in rats; CYP2A4, 2A5, 2A12, 2A20p, 2A21p, 2A22, and 2A23p in mice; CYP2A6, 2A7, 2A13, 2A18P in humans; CYP2A8, 2A9, 2A14, 2A15, 2A16, and 2A17 in hamsters; CYP2A10 and 2A11 in rabbits; and CYP2A19 in pigs. CYP2A enzymes metabolize numerous xenobiotic compounds, including coumarin, aflatoxin B1, nicotine, cotinine, 1,3-butadiene, and acetaminophen, among others, as well as endogenous compounds, including testosterone, progesterone, and other steroid hormones. Human CYP2A6 is responsible for the systemic clearance of nicotine, while CYP2A13 activates the nicotine-derived procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) into DNA-altering compounds that cause lung cancer. The CYP2A subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410761 [Multi-domain]  Cd Length: 425  Bit Score: 54.80  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 130 EVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVS-AQLQDIEGKIDRFIIPRETLVLYALGVVLQD 207
Cdd:cd20668   258 EVEAKVHEEIDRVIGrNRQPKFEDRAKMPYTEAVIHEIQRFGDVIPMGlARRVTKDTKFRDFFLPKGTEVFPMLGSVLKD 337

                          90
                  ....*....|....*...
gi 1707919429 208 PNTWPSPHKFDPDRFDDE 225
Cdd:cd20668   338 PKFFSNPKDFNPQHFLDD 355
CYP2G cd20670
cytochrome P450 family 2, subfamily G; CYP2G1 is uniquely expressed in the olfactory mucosa of ...
 120-225 2.82e-08

cytochrome P450 family 2, subfamily G; CYP2G1 is uniquely expressed in the olfactory mucosa of rats and rabbits and may have important functions for the olfactory chemosensory system. It is involved in the metabolism of sex steroids and xenobiotic compounds. In cynomolgus monkeys, CYP2G2 is a functional drug-metabolizing enzyme in nasal mucosa. In humans, two different CYP2G genes, CYP2GP1 and CYP2GP2, are pseudogenes because of loss-of-function deletions/mutations. The CYP2G subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410763 [Multi-domain]  Cd Length: 425  Bit Score: 54.55  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFGNG--PVTPEKIeQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDR-FIIPRETL 196
Cdd:cd20670   248 YGFLLLMKYPEVEAKIHEEINQVIGPHrlPSVDDRV-KMPYTDAVIHEIQRLTDIVPLGVPHNVIRDTQFRgYLLPKGTD 326

                          90       100
                  ....*....|....*....|....*....
gi 1707919429 197 VLYALGVVLQDPNTWPSPHKFDPDRFDDE 225
Cdd:cd20670   327 VFPLLGSVLKDPKYFRYPEAFYPQHFLDE 355
CYP1A cd20676
cytochrome P450 family 1, subfamily A; Cytochrome P450 family 1, subfamily A (CYP1A) consists ...
 113-222 2.97e-08

cytochrome P450 family 1, subfamily A; Cytochrome P450 family 1, subfamily A (CYP1A) consists of two human members, CYP1A1 and CYP1A2, which overlap in their activities. CYP1A2 is the highly expressed cytochrome enzyme in the human liver, while CYP1A1 is mostly found in extrahepatic tissues. Known common substrates include aromatic compounds such as polycyclic aromatic hydrocarbons, arachidonic acid and eicosapentoic acid, as well as melatonin and 6-hydroxylate melatonin. In addition, CYP1A1 activates procarcinogens into carcinogens via epoxides, and metabolizes heterocyclic aromatic amines of industrial origin. CYP1A2 metabolizes numerous natural products that result in toxic products, such as the transformation of methyleugenol to 1'-hydroxymethyleugenol, estragole to reactive metabolites, and oxidation of nephrotoxins. It also plays an important role in the metabolism of several clinical drugs including analgesics, antipyretics, antipsychotics, antidepressants, anti-inflammatory, and cardiovascular drugs. The CYP1A subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410769 [Multi-domain]  Cd Length: 437  Bit Score: 54.25  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 113 ITAKLCtWAICFLTTSEEVQKKLYEEINQVFG--NGPVTPEKIeQLRYCQHVLCETVRTAKLTPVS---AQLQDIegKID 187
Cdd:cd20676   253 VTTALS-WSLMYLVTYPEIQKKIQEELDEVIGreRRPRLSDRP-QLPYLEAFILETFRHSSFVPFTiphCTTRDT--SLN 328

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1707919429 188 RFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF 222
Cdd:cd20676   329 GYYIPKDTCVFINQWQVNHDEKLWKDPSSFRPERF 363
CYP714 cd20640
cytochrome P450 family 714; Cytochrome P450 family 714 (CYP714) belongs to the plant CYP72 ...
 114-262 3.35e-08

cytochrome P450 family 714; Cytochrome P450 family 714 (CYP714) belongs to the plant CYP72 clan, which is generally associated with the metabolism of a diversity of fairly hydrophobic compounds including fatty acids and isoprenoids, with the catabolism of hormones (brassinosteroids and gibberellin, GA) and with the biosynthesis of cytokinins. CYP714 enzymes are involved in the biosynthesis of gibberellins (GAs) and the mechanism to control their bioactive endogenous levels. They contribute to the production of diverse GA compounds through various oxidations of C and D rings in both monocots and eudicots. CYP714B1 and CYP714B2 encode the enzyme GA 13-oxidase, which is required for GA1 biosynthesis, while CYP714D1 encodes GA 16a,17-epoxidase, which inactivates the non-13-hydroxy GAs in rice. Arabidopsis CYP714A1 is an inactivation enzyme that catalyzes the conversion of GA12 to 16-carboxylated GA12 (16-carboxy-16beta,17-dihydro GA12). CYP714 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410733 [Multi-domain]  Cd Length: 426  Bit Score: 54.34  E-value: 3.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRtakLTPVSA-----QLQDIegKIDR 188
Cdd:cd20640   246 TAVTAAWCLMLLALHPEWQDRVRAEVLEVCKGGPPDADSLSRMKTVTMVIQETLR---LYPPAAfvsreALRDM--KLGG 320

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1707919429 189 FIIPRETLVLYALGVVLQDPNTW-PSPHKFDPDRFDD---ELVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLVKR 262
Cdd:cd20640   321 LVVPKGVNIWVPVSTLHLDPEIWgPDANEFNPERFSNgvaAACKPPHSYMPFgAGARTCLGQNFAMAELKVLVSLILSK 399
CYP2C-like cd20665
cytochrome P450 family 2, subfamily C, and similar cytochrome P450s; This CYP2C-like group ...
 130-225 3.84e-08

cytochrome P450 family 2, subfamily C, and similar cytochrome P450s; This CYP2C-like group includes CYP2C, and similar CYPs including mammalian CYP2E1, also called 4-nitrophenol 2-hydroxylase, as well as chicken CYP2H1 and CYP2H2. The CYP2C subfamily is composed of four human members (CYP2C8, CYP2C9, CYP2C18, CYP2C19) that metabolize approximately 20% of clinically used drugs, and all four exhibit genetic polymorphisms that results in toxicity or altered efficacy of some drugs in affected individuals. CYP2E1 participates in the metabolism of endogenous substrates, including acetone and fatty acids, and exogenous compounds such as anesthetics, ethanol, nicotine, acetaminophen, aspartame, and chlorzoxazone, among others. The CYP2C-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410758 [Multi-domain]  Cd Length: 425  Bit Score: 53.80  E-value: 3.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 130 EVQKKLYEEINQVFG--NGPVTPEKIeQLRYCQHVLCETVRTAKLTPVS---AQLQDIegKIDRFIIPRETLVLYALGVV 204
Cdd:cd20665   258 EVTAKVQEEIDRVIGrhRSPCMQDRS-HMPYTDAVIHEIQRYIDLVPNNlphAVTCDT--KFRNYLIPKGTTVITSLTSV 334

                          90       100
                  ....*....|....*....|.
gi 1707919429 205 LQDPNTWPSPHKFDPDRFDDE 225
Cdd:cd20665   335 LHDDKEFPNPEKFDPGHFLDE 355
CYP709 cd20641
cytochrome P450 family 709; Cytochrome P450 family 709 (CYP709) belongs to the plant CYP72 ...
 97-265 1.21e-07

cytochrome P450 family 709; Cytochrome P450 family 709 (CYP709) belongs to the plant CYP72 clan, which is generally associated with the metabolism of a diversity of fairly hydrophobic compounds including fatty acids and isoprenoids, with the catabolism of hormones (brassinosteroids and gibberellin, GA) and with the biosynthesis of cytokinins. Arabidopsis thaliana CYP709B3 is involved in abscisic acid (ABA) and salt stress response. CYP709 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410734 [Multi-domain]  Cd Length: 431  Bit Score: 52.45  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  97 GTILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEI-NQVFGNGPVTPEKIEQLRYCQHVLCETVR------- 168
Cdd:cd20641   234 DEIIDECKTFFFAGHETTSNLLTWTMFLLSLHPDWQEKLREEVfRECGKDKIPDADTLSKLKLMNMVLMETLRlygpvin 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 169 TAKLTPVSAQLQDIEgkidrfiIPRETLVLYALGVVLQDPNTWPS-PHKFDPDRFDDELVMKTF---SSLGFS-GTQECP 243
Cdd:cd20641   314 IARRASEDMKLGGLE-------IPKGTTIIIPIAKLHRDKEVWGSdADEFNPLRFANGVSRAAThpnALLSFSlGPRACI 386

                         170       180
                  ....*....|....*....|..
gi 1707919429 244 ELRFAYMVTTVLLSVLVKRLHL 265
Cdd:cd20641   387 GQNFAMIEAKTVLAMILQRFSF 408
PLN00110 PLN00110
flavonoid 3',5'-hydroxylase (F3'5'H); Provisional
 120-260 1.21e-07

flavonoid 3',5'-hydroxylase (F3'5'H); Provisional


Pssm-ID: 177725  Cd Length: 504  Bit Score: 52.55  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLTP-----VSAQLQDIEGkidrFIIPR 193
Cdd:PLN00110  311 WSLAEMLKNPSILKRAHEEMDQVIGrNRRLVESDLPKLPYLQAICKESFRKHPSTPlnlprVSTQACEVNG----YYIPK 386

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707919429 194 ETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKT------FSSLGF-SGTQECPELRFAYMVTTVLLSVLV 260
Cdd:PLN00110  387 NTRLSVNIWAIGRDPDVWENPEEFRPERFLSEKNAKIdprgndFELIPFgAGRRICAGTRMGIVLVEYILGTLV 460
PLN02196 PLN02196
abscisic acid 8'-hydroxylase
 71-267 1.25e-07

abscisic acid 8'-hydroxylase


Pssm-ID: 177847 [Multi-domain]  Cd Length: 463  Bit Score: 52.63  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  71 MKSVTQMVMGSTFEDDQEVIRFQKNHGTIledSMIFslASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGP--- 147
Cdd:PLN02196  242 NGSSHNDLLGSFMGDKEGLTDEQIADNII---GVIF--AARDTTASVLTWILKYLAENPSVLEAVTEEQMAIRKDKEege 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 148 -VTPEKIEQLRYCQHVLCETVRTAKLTPVSAQ--LQDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDD 224
Cdd:PLN02196  317 sLTWEDTKKMPLTSRVIQETLRVASILSFTFReaVEDVE--YEGYLIPKGWKVLPLFRNIHHSADIFSDPGKFDPSRFEV 394

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1707919429 225 ELVMKTFSSLGfSGTQECPELRFAYMVTTVLLSVLVK--RLHLLS 267
Cdd:PLN02196  395 APKPNTFMPFG-NGTHSCPGNELAKLEISVLIHHLTTkyRWSIVG 438
CYP27C1 cd20647
cytochrome P450 family 27, subfamily C, polypeptide 1, also called all-trans retinol 3, ...
 108-265 1.43e-07

cytochrome P450 family 27, subfamily C, polypeptide 1, also called all-trans retinol 3,4-desaturase; Cytochrome P450 27C1 (CYP27C1) is also called all-trans retinol 3,4-desaturase. It catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4-didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4-didehydroretinal). CYP27C1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410740 [Multi-domain]  Cd Length: 433  Bit Score: 52.23  E-value: 1.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 108 LASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKI 186
Cdd:cd20647   247 LAGVDTTSFTLSWATYLLARHPEVQQQVYEEIVRNLGkRVVPTAEDVPKLPLIRALLKETLRLFPVLPGNGRVTQDDLIV 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 187 DRFIIPRET-LVLYALGVVLQDPNtWPSPHKFDPDRF---DDELVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVK 261
Cdd:cd20647   327 GGYLIPKGTqLALCHYSTSYDEEN-FPRAEEFRPERWlrkDALDRVDNFGSIPFGyGIRSCIGRRIAELEIHLALIQLLQ 405


                  ....
gi 1707919429 262 RLHL 265
Cdd:cd20647   406 NFEI 409
CYP11B cd20644
cytochrome P450 family 11, subfamily B subfamily; Cytochrome P450 11B (CYP11B) enzymes ...
 125-280 1.65e-07

cytochrome P450 family 11, subfamily B subfamily; Cytochrome P450 11B (CYP11B) enzymes catalyze the final steps in the production of glucocorticoids and mineralocorticoids that takes place in the adrenal gland. There are two human CYP11B isoforms: Cyb11B1 (11-beta-hydroxylase or P45011beta), which catalyzes the final step of cortisol synthesis by a one-step reaction from 11-deoxycortisol; and CYP11B2 (aldosterone synthase or P450aldo), which catalyzes three steps in the synthesis of aldosterone. The CYP11B subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410737 [Multi-domain]  Cd Length: 428  Bit Score: 52.15  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 125 LTTSEEVQKKLYEEINQVFGNGPVTPEKIEQ-LRYCQHVLCETVRtakLTPVSAQLQDIEGK---IDRFIIPRETLV--- 197
Cdd:cd20644   259 LARNPDVQQILRQESLAAAAQISEHPQKALTeLPLLKAALKETLR---LYPVGITVQRVPSSdlvLQNYHIPAGTLVqvf 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 198 LYALGvvlQDPNTWPSPHKFDPDRF-DDELVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIET 275
Cdd:cd20644   336 LYSLG---RSAALFPRPERYDPQRWlDIRGSGRNFKHLAFGfGMRQCLGRRLAEAEMLLLLMHVLKNFLVETLSQEDIKT 412


                  ....*
gi 1707919429 276 KYELV 280
Cdd:cd20644   413 VYSFI 417
CYP72 cd20642
cytochrome P450 family 72; Cytochrome P450 family 72 (CYP72) belongs to the plant CYP72 clan, ...
 94-262 2.24e-07

cytochrome P450 family 72; Cytochrome P450 family 72 (CYP72) belongs to the plant CYP72 clan, which is generally associated with the metabolism of a diversity of fairly hydrophobic compounds including fatty acids and isoprenoids, with the catabolism of hormones (brassinosteroids and gibberellin, GA) and with the biosynthesis of cytokinins. Characterized members, among others, include: Catharanthus roseus cytochrome P450 72A1 (CYP72A1), also called secologanin synthase (EC 1.3.3.9), that catalyzes the conversion of loganin into secologanin, the precursor of monoterpenoid indole alkaloids and ipecac alkaloids; Medicago truncatula CYP72A67 that catalyzes a key oxidative step in hemolytic sapogenin biosynthesis; and Arabidopsis thaliana CYP72C1, an atypical CYP that acts on brassinolide precursors and functions as a brassinosteroid-inactivating enzyme. This family also includes Panax ginseng CYP716A47 that catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis. CYP72 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410735 [Multi-domain]  Cd Length: 431  Bit Score: 51.51  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  94 KNHGTILEDSM----IFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRt 169
Cdd:cd20642   226 KNGGMSTEDVIeeckLFYFAGQETTSVLLVWTMVLLSQHPDWQERAREEVLQVFGNNKPDFEGLNHLKVVTMILYEVLR- 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 170 akLTPVSAQLQDI---EGKIDRFIIPRETLVLYALGVVLQDPNTW-PSPHKFDPDRFDDELVMKT---FSSLGFS-GTQE 241
Cdd:cd20642   305 --LYPPVIQLTRAihkDTKLGDLTLPAGVQVSLPILLVHRDPELWgDDAKEFNPERFAEGISKATkgqVSYFPFGwGPRI 382

                         170       180
                  ....*....|....*....|.
gi 1707919429 242 CPELRFAYMVTTVLLSVLVKR 262
Cdd:cd20642   383 CIGQNFALLEAKMALALILQR 403
CYP74 cd11071
cytochrome P450 family 74; The cytochrome P450 74 (CYP74) family controls several enzymatic ...
 128-225 2.39e-07

cytochrome P450 family 74; The cytochrome P450 74 (CYP74) family controls several enzymatic conversions of fatty acid hydroperoxides to bioactive oxylipins in plants, some invertebrates, and bacteria. It includes two dehydrases, namely allene oxide synthase (AOS) and divinyl ether synthase (DES), and two isomerases, hydroperoxide lyase (HPL) and epoxyalcohol synthase (EAS). AOS (EC 4.2.1.92, also called hydroperoxide dehydratase), such as Arabidopsis thaliana CYP74A acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides. DES (EC 4.2.1.121), also called colneleate synthase or CYP74D, catalyzes the selective removal of pro-R hydrogen at C-8 in the biosynthesis of colneleic acid. The linolenate HPL, Arabidopsis thaliana CYP74B2, is required for the synthesis of the green leaf volatiles (GLVs) hexanal and trans-2-hexenal. The fatty acid HPL, Solanum lycopersicum CYP74B, is involved in the biosynthesis of traumatin and C6 aldehydes. The epoxyalcohol synthase Ranunculus japonicus CYP74A88 (also known as RjEAS) specifically converts linoleic acid 9- and 13-hydroperoxides to oxiranyl carbinols 9,10-epoxy-11-hydroxy-12-octadecenoic acid and 11-hydroxy-12,13-epoxy-9-octadecenoic acid, respectively. The CYP74 family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410694 [Multi-domain]  Cd Length: 424  Bit Score: 51.49  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 128 SEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAklTPVSAQLQ------DIEGKIDRFIIPRETLVLYA 200
Cdd:cd11071   256 GEELHARLAEEIRSALGsEGGLTLAALEKMPLLKSVVYETLRLH--PPVPLQYGrarkdfVIESHDASYKIKKGELLVGY 333

                          90       100
                  ....*....|....*....|....*
gi 1707919429 201 LGVVLQDPNTWPSPHKFDPDRFDDE 225
Cdd:cd11071   334 QPLATRDPKVFDNPDEFVPDRFMGE 358
CYP11A1 cd20643
cytochrome P450 family 11, subfamily A, polypeptide 1, also called cholesterol side-chain ...
 120-276 3.05e-07

cytochrome P450 family 11, subfamily A, polypeptide 1, also called cholesterol side-chain cleavage enzyme; Cytochrome P450 11A1 (CYP11A1, EC 1.14.15.6) is also called cholesterol side-chain cleavage enzyme, cholesterol desmolase, or cytochrome P450(scc). It catalyzes the side-chain cleavage reaction of cholesterol to form pregnenolone, the precursor of all steroid hormones. Missense or nonsense mutations of the CYP11A1 gene cause mild to severe early-onset adrenal failure depending on the severity of the enzyme dysfunction/deficiency. CYP11A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410736 [Multi-domain]  Cd Length: 425  Bit Score: 51.25  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEI----NQVFGNgPVTPEKIEQLRYCqhVLCETVRtakLTPVSAQLQ-----DIegKIDRFI 190
Cdd:cd20643   256 WTLYELARNPNVQEMLRAEVlaarQEAQGD-MVKMLKSVPLLKA--AIKETLR---LHPVAVSLQryiteDL--VLQNYH 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 191 IPRETLV---LYALGvvlQDPNTWPSPHKFDPDRFddeLVMKT--FSSLGFS-GTQECPELRFAYMVTTVLLsvlvkrLH 264
Cdd:cd20643   328 IPAGTLVqvgLYAMG---RDPTVFPKPEKYDPERW---LSKDIthFRNLGFGfGPRQCLGRRIAETEMQLFL------IH 395

                         170
                  ....*....|..
gi 1707919429 265 LLsvEGQVIETK 276
Cdd:cd20643   396 ML--ENFKIETQ 405
PTZ00404 PTZ00404
cytochrome P450; Provisional
 98-294 4.88e-07

cytochrome P450; Provisional


Pssm-ID: 173595 [Multi-domain]  Cd Length: 482  Bit Score: 50.49  E-value: 4.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  98 TILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGP-VTPEKIEQLRYCQHVLCETVRTAKLTPVS 176
Cdd:PTZ00404  283 SILATILDFFLAGVDTSATSLEWMVLMLCNYPEIQEKAYNEIKSTVNGRNkVLLSDRQSTPYTVAIIKETLRYKPVSPFG 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 177 ---AQLQDIEGKIDRFiIPRETLVL---YALGvvlQDPNTWPSPHKFDPDRFDDELVMKTFssLGFS-GTQECPELRFAY 249
Cdd:PTZ00404  363 lprSTSNDIIIGGGHF-IPKDAQILinyYSLG---RNEKYFENPEQFDPSRFLNPDSNDAF--MPFSiGPRNCVGQQFAQ 436

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1707919429 250 MVTTVLLSVLVKRLHLLSVEGQVI-ETKYELVTSSREEAWITVSKR 294
Cdd:PTZ00404  437 DELYLAFSNIILNFKLKSIDGKKIdETEEYGLTLKPNKFKVLLEKR 482
PLN02971 PLN02971
tryptophan N-hydroxylase
 120-285 5.52e-07

tryptophan N-hydroxylase


Pssm-ID: 166612 [Multi-domain]  Cd Length: 543  Bit Score: 50.42  E-value: 5.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFGNGPVTPEK-IEQLRYCQHVLCETVRtakLTPVSA------QLQDIegKIDRFIIP 192
Cdd:PLN02971  349 WAMAEMINKPEILHKAMEEIDRVVGKERFVQESdIPKLNYVKAIIREAFR---LHPVAAfnlphvALSDT--TVAGYHIP 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 193 RETLVL---YALGvvlQDPNTWPSPHKFDPDRFDDEL--VMKTFSSLGF----SGTQECPELRFAYMVTTVLLSVLVKRL 263
Cdd:PLN02971  424 KGSQVLlsrYGLG---RNPKVWSDPLSFKPERHLNECseVTLTENDLRFisfsTGKRGCAAPALGTAITTMMLARLLQGF 500

                         170       180
                  ....*....|....*....|..
gi 1707919429 264 HLLSVEGqviETKYELVTSSRE 285
Cdd:PLN02971  501 KWKLAGS---ETRVELMESSHD 519
CYP61_CYP710 cd11082
C-22 sterol desaturase subfamily, such as fungal cytochrome P450 61 and plant cytochrome P450 ...
 114-260 5.56e-07

C-22 sterol desaturase subfamily, such as fungal cytochrome P450 61 and plant cytochrome P450 710; C-22 sterol desaturase (EC 1.14.19.41), also called sterol 22-desaturase, is required for the formation of the C-22 double bond in the sterol side chain of delta22-unsaturated sterols, which are present specifically in fungi and plants. This enzyme is also called cytochrome P450 61 (CYP61) in fungi and cytochrome P450 710 (CYP710) in plants. The CYP61/CYP710 subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410703 [Multi-domain]  Cd Length: 415  Bit Score: 50.32  E-value: 5.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLcTWAICFLTTSEEVQKKLYEEINQVFGNG--PVTPEKIEQLRYCQHVLCETVR---TAKLTP--VSAQLQDIEGki 186
Cdd:cd11082   237 TSSL-VWALQLLADHPDVLAKVREEQARLRPNDepPLTLDLLEEMKYTRQVVKEVLRyrpPAPMVPhiAKKDFPLTED-- 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 187 drFIIPRETLVLYALGVVLQDPntWPSPHKFDPDRFD-----DELVMKTFSSLGfSGTQECPELRFA---YMVTTVLLSV 258
Cdd:cd11082   314 --YTVPKGTIVIPSIYDSCFQG--FPEPDKFDPDRFSperqeDRKYKKNFLVFG-AGPHQCVGQEYAinhLMLFLALFST 388


                  ..
gi 1707919429 259 LV 260
Cdd:cd11082   389 LV 390
CYP_fungal cd11059
unknown subfamily of fungal cytochrome P450s; This subfamily is composed of uncharacterized ...
 119-268 5.62e-07

unknown subfamily of fungal cytochrome P450s; This subfamily is composed of uncharacterized fungal cytochrome P450s. Cytochrome P450 (P450, CYP) is a large superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. Their monooxygenase activity relies on the reductive scission of molecular oxygen bound to the P450 heme iron, and the delivery of two electrons to the heme iron during the catalytic cycle.


Pssm-ID: 410682 [Multi-domain]  Cd Length: 422  Bit Score: 50.38  E-value: 5.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICfltTSEEVQKKLYEEINQVFGN--GPVTPEKIEQLRYCQHVLCETVRTAklTPVSAQLQ---DIEGK-IDRFIIP 192
Cdd:cd11059   245 IWELS---RPPNLQEKLREELAGLPGPfrGPPDLEDLDKLPYLNAVIRETLRLY--PPIPGSLPrvvPEGGAtIGGYYIP 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 193 RETLVL---YALGvvlQDPNTWPSPHKFDPDRF-----DDELVMKT-FSSLGfSGTQECPELRFAYMVTTVLLSVLVKRL 263
Cdd:cd11059   320 GGTIVStqaYSLH---RDPEVFPDPEEFDPERWldpsgETAREMKRaFWPFG-SGSRMCIGMNLALMEMKLALAAIYRNY 395


                  ....*
gi 1707919429 264 HLLSV 268
Cdd:cd11059   396 RTSTT 400
CYP7_CYP8-like cd11040
cytochrome P450s similar to cytochrome P450 family 7, subfamily A, polypeptide 1, cytochrome ...
 114-225 9.27e-07

cytochrome P450s similar to cytochrome P450 family 7, subfamily A, polypeptide 1, cytochrome P450 family 7, subfamily B, polypeptide 1, cytochrome P450 family 8, subfamily A, polypeptide 1; This family is composed of cytochrome P450s (CYPs) with similarity to the human P450s CYP7A1, CYP7B1, CYP8B1, CYP39A1 and prostacyclin synthase (CYP8A1). CYP7A1, CYP7B1, CYP8B1, and CYP39A1 are involved in the catabolism of cholesterol to bile acids (BAs) in two major pathways. CYP7A1 (cholesterol 7alpha-hydroxylase) and CYP8B1 (sterol 12-alpha-hydroxylase) function in the classic (or neutral) pathway, which leads to two bile acids: cholic acid (CA) and chenodeoxycholic acid (CDCA). CYP7B1 and CYP39A1 are 7-alpha-hydroxylases involved in the alternative (or acidic) pathway, which leads mainly to the formation of CDCA. Prostacyclin synthase (CYP8A1) catalyzes the isomerization of prostaglandin H2 to prostacyclin (or prostaglandin I2), a potent mediator of vasodilation and anti-platelet aggregation. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410666 [Multi-domain]  Cd Length: 432  Bit Score: 49.67  E-value: 9.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKI---EQLRYCQH---VLCETVRTAkLTPVSA--QLQDIEGk 185
Cdd:cd11040   239 TIPAAFWLLAHILSDPELLERIREEIEPAVTPDSGTNAILdltDLLTSCPLldsTYLETLRLH-SSSTSVrlVTEDTVL- 316

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1707919429 186 IDRFIIPRETLVLYALGVVLQDPNTW-PSPHKFDPDRFDDE 225
Cdd:cd11040   317 GGGYLLRKGSLVMIPPRLLHMDPEIWgPDPEEFDPERFLKK 357
PLN03112 PLN03112
cytochrome P450 family protein; Provisional
 120-264 3.29e-06

cytochrome P450 family protein; Provisional


Pssm-ID: 215583 [Multi-domain]  Cd Length: 514  Bit Score: 48.28  E-value: 3.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEG-KIDRFIIPRETLV 197
Cdd:PLN03112  318 WAMAEVIKNPRVLRKIQEELDSVVGrNRMVQESDLVHLNYLRCVVRETFRMHPAGPFLIPHESLRAtTINGYYIPAKTRV 397

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1707919429 198 L---YALGvvlQDPNTWPSPHKFDPDRF--DDELVMKT-----FSSLGFS-GTQECPElrfAYMVTTVLLSVLVKRLH 264
Cdd:PLN03112  398 FintHGLG---RNTKIWDDVEEFRPERHwpAEGSRVEIshgpdFKILPFSaGKRKCPG---APLGVTMVLMALARLFH 469
PLN02966 PLN02966
cytochrome P450 83A1
 61-248 4.04e-06

cytochrome P450 83A1


Pssm-ID: 178550 [Multi-domain]  Cd Length: 502  Bit Score: 47.82  E-value: 4.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  61 PLSQHMLGFAMKSVTQMVMGSTFEDDqevirfqkNHGTILEDSMIfslASCIITAKLCTWAICFLTTSEEVQKKLYEEIN 140
Cdd:PLN02966  263 PETESMIDLLMEIYKEQPFASEFTVD--------NVKAVILDIVV---AGTDTAAAAVVWGMTYLMKYPQVLKKAQAEVR 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 141 QVF---GNGPVTPEKIEQLRYCQHVLCETVRTAKLTPV---SAQLQDIegKIDRFIIPRETLVLYALGVVLQDPNTW-PS 213
Cdd:PLN02966  332 EYMkekGSTFVTEDDVKNLPYFRALVKETLRIEPVIPLlipRACIQDT--KIAGYDIPAGTTVNVNAWAVSRDEKEWgPN 409

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1707919429 214 PHKFDPDRFDDELVMKTFSSLGF----SGTQECPELRFA 248
Cdd:PLN02966  410 PDEFRPERFLEKEVDFKGTDYEFipfgSGRRMCPGMRLG 448
CYP4F cd20679
cytochrome P450 family 4, subfamily F; Cytochrome P450 family 4, subfamily F (CYP4F) enzymes ...
 114-280 4.35e-06

cytochrome P450 family 4, subfamily F; Cytochrome P450 family 4, subfamily F (CYP4F) enzymes are known for known for omega-hydroxylation of very long fatty acids (VLFA; C18-C26), leukotrienes, prostaglandins, and vitamins with long alkyl side chains. The CYP4F subfamily show diverse specificities among its members: CYP4F2 and CYP4F3 metabolize pro- and anti-inflammatory leukotrienes; CYP4F8 and CYP4F12 metabolize prostaglandins, endoperoxides and arachidonic acid; CYP4F11 and CYP4F12 metabolize VLFA and are unique in the CYP4F subfamily since they also hydroxylate xenobiotics such as benzphetamine, ethylmorphine, erythromycin, and ebastine. CYP4F belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410772 [Multi-domain]  Cd Length: 442  Bit Score: 47.76  E-value: 4.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVF-GNGPvtpEKIE-----QLRYCQHVLCETVRTAKLTPVSAQ--LQDIEGK 185
Cdd:cd20679   260 TASGLSWILYNLARHPEYQERCRQEVQELLkDREP---EEIEwddlaQLPFLTMCIKESLRLHPPVTAISRccTQDIVLP 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 186 IDRfIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVmKTFSSLGF----SGTQECPELRFAYMVTTVLLSVLVK 261
Cdd:cd20679   337 DGR-VIPKGIICLISIYGTHHNPTVWPDPEVYDPFRFDPENS-QGRSPLAFipfsAGPRNCIGQTFAMAEMKVVLALTLL 414

                         170
                  ....*....|....*....
gi 1707919429 262 RLHLLSvEGQVIETKYELV 280
Cdd:cd20679   415 RFRVLP-DDKEPRRKPELI 432
CYP27B1 cd20648
cytochrome P450 family 27, subfamily B, polypeptide 1, also called calcidiol 1-monooxygenase; ...
 119-248 5.19e-06

cytochrome P450 family 27, subfamily B, polypeptide 1, also called calcidiol 1-monooxygenase; Cytochrome p450 27B1 (CYP27B1) is also called calcidiol 1-monooxygenase (EC 1.14.15.18), 25-hydroxyvitamin D(3) 1-alpha-hydroxylase (VD3 1A hydroxylase), 25-hydroxyvitamin D-1 alpha hydroxylase, 25-OHD-1 alpha-hydroxylase, 25-hydroxycholecalciferol 1-hydroxylase, or 25-hydroxycholecalciferol 1-monooxygenase. It catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3 or calcitriol), and of 24,25-dihydroxyvitamin D3 (24,25(OH)(2)D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)(3)D3). It is also active with 25-hydroxy-24-oxo-vitamin D3, and has an important role in normal bone growth, calcium metabolism, and tissue differentiation. CYP27B1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410741 [Multi-domain]  Cd Length: 430  Bit Score: 47.44  E-value: 5.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICFLTTSEEVQKKLYEEINQVFGNGPV-TPEKIEQLRYCQHVLCETVRTAKLTPVSAQL---QDIEgkIDRFIIPRE 194
Cdd:cd20648   255 SWSLYELSRHPDVQTALHREITAALKDNSVpSAADVARMPLLKAVVKEVLRLYPVIPGNARVipdRDIQ--VGEYIIPKK 332

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1707919429 195 TLVLYALGVVLQDPNTWPSPHKFDPDRF-DDELVMKTFSSLGFS-GTQECPELRFA 248
Cdd:cd20648   333 TLITLCHYATSRDENQFPDPNSFRPERWlGKGDTHHPYASLPFGfGKRSCIGRRIA 388
CYP2B cd20672
cytochrome P450 family 2, subfamily B; The human cytochrome P450 family 2, subfamily B (CYP2B) ...
 131-224 6.34e-06

cytochrome P450 family 2, subfamily B; The human cytochrome P450 family 2, subfamily B (CYP2B) consists of only one functional member CYP2B6, which shows broad substrate specificity and plays a key role in the metabolism of many clinical drugs, environmental toxins, and endogenous compounds. Rodents have multiple functional CYP2B proteins; mouse subfamily members include CYP2B9, 2B10, 2B13, 2B19, and 2B23. CYP2B enzymes are highly inducible by chemicals that interact with the constitutive androstane receptor (CAR) and/or pregnane X receptor (PXR), such as rifampicin and phenobarbital. The CYP2B subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410765 [Multi-domain]  Cd Length: 425  Bit Score: 47.08  E-value: 6.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 131 VQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDR-FIIPRETLVLYALGVVLQDP 208
Cdd:cd20672   259 VAEKVQKEIDQVIGsHRLPTLDDRAKMPYTDAVIHEIQRFSDLIPIGVPHRVTKDTLFRgYLLPKNTEVYPILSSALHDP 338

                          90
                  ....*....|....*.
gi 1707919429 209 NTWPSPHKFDPDRFDD 224
Cdd:cd20672   339 QYFEQPDTFNPDHFLD 354
CYP39A1 cd20635
cytochrome P450 family 39, subfamily A, polypeptide 1; Cytochrome P450 39A1 (CYP39A1) is also ...
 120-250 9.68e-06

cytochrome P450 family 39, subfamily A, polypeptide 1; Cytochrome P450 39A1 (CYP39A1) is also called 24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.26) or oxysterol 7-alpha-hydroxylase. It is involved in the metabolism of bile acids and has a preference for 24-hydroxycholesterol, converting it into the 7-alpha-hydroxylated product. It may play a role in the alternative bile acid synthesis pathway in the liver. CYP39A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410728  Cd Length: 410  Bit Score: 46.54  E-value: 9.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFGNG-----PVTPEKIEQLRYCQHVLCETVR-------TAKLT-PVsaqlqdiegKI 186
Cdd:cd20635   232 WTLAFILSHPSVYKKVMEEISSVLGKAgkdkiKISEDDLKKMPYIKRCVLEAIRlrspgaiTRKVVkPI---------KI 302

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1707919429 187 DRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDD-----ELVMKTFSSLGfSGTQECPELRFAYM 250
Cdd:cd20635   303 KNYTIPAGDMLMLSPYWAHRNPKYFPDPELFKPERWKKadlekNVFLEGFVAFG-GGRYQCPGRWFALM 370
CYP79 cd20658
cytochrome P450 family 79; Cytochrome P450 family 79 (CYP79) enzymes catalyze the first ...
 120-260 1.25e-05

cytochrome P450 family 79; Cytochrome P450 family 79 (CYP79) enzymes catalyze the first committed step in the biosynthesis of the core structure of glucosinolates, the conversion of amino acids to the corresponding aldoximes. Glucosinolates are amino acid-derived natural plant products that function in the defense against herbivores and microorganisms. Arabidopsis thaliana contains seven family members: CYP79B2 and CYP79B3, which metabolize trytophan; CYP79F1 and CYP79F2, which metabolize chain-elongated methionine derivatives with respectively 1-6 or 5-6 additional methylene groups in the side chain; CYP79A2 that metabolizes phenylalanine; and CYP79C1 and CYP79C2, with unknown function. CYP79 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410751 [Multi-domain]  Cd Length: 444  Bit Score: 46.21  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 120 WAICFLTTSEEVQKKLYEEINQVFGNGPVTPEK-IEQLRYCQHVLCETVRtakLTPVSA------QLQDIegKIDRFIIP 192
Cdd:cd20658   259 WALAEMLNQPEILRKATEELDRVVGKERLVQESdIPNLNYVKACAREAFR---LHPVAPfnvphvAMSDT--TVGGYFIP 333

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1707919429 193 RETLVL---YALGvvlQDPNTWPSPHKFDPDRF--DDELVMKTFSSLGF----SGTQECPELRFAYMVTTVLLSVLV 260
Cdd:cd20658   334 KGSHVLlsrYGLG---RNPKVWDDPLKFKPERHlnEDSEVTLTEPDLRFisfsTGRRGCPGVKLGTAMTVMLLARLL 407
PLN00168 PLN00168
Cytochrome P450; Provisional
 90-222 1.36e-05

Cytochrome P450; Provisional


Pssm-ID: 215086 [Multi-domain]  Cd Length: 519  Bit Score: 46.10  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  90 IRFQKNHGTILEDSMIFSLASCIITAKLCT------WAICFLTTSEEVQKKLYEEINQVFGNGP--VTPEKIEQLRYCQH 161
Cdd:PLN00168  292 IRLPEDGDRALTDDEIVNLCSEFLNAGTDTtstalqWIMAELVKNPSIQSKLHDEIKAKTGDDQeeVSEEDVHKMPYLKA 371

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707919429 162 VLCETVRtaKLTPVSAQL-----QDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF 222
Cdd:PLN00168  372 VVLEGLR--KHPPAHFVLphkaaEDME--VGGYLIPKGATVNFMVAEMGRDEREWERPMEFVPERF 433
P450_pinF1-like cd20629
cytochrome P450-pinF1 and similar cytochrome P450s; This subfamily is composed of bacterial ...
 154-271 1.48e-05

cytochrome P450-pinF1 and similar cytochrome P450s; This subfamily is composed of bacterial CYPs similar to Agrobacterium tumefaciens plant-inducible cytochrome P450-pinF1, which is not essential for virulence but may be involved in the detoxification of plant protective agents at the site of wounding. The P450-pinF1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410722 [Multi-domain]  Cd Length: 353  Bit Score: 45.75  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 154 EQLRYCQHVLCeTVRTAkltpvsaqLQDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRfddelvmKTFSS 233
Cdd:cd20629   242 EGLRWEPPVAS-VPRMA--------LRDVE--LDGVTIPAGSLLDLSVGSANRDEDVYPDPDVFDIDR-------KPKPH 303

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1707919429 234 LGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQ 271
Cdd:cd20629   304 LVFGgGAHRCLGEHLARVELREALNALLDRLPNLRLDPD 342
CYPBJ-4-like cd20614
cytochrome P450 BJ-4 homolog and similar cytochrome P450s; This group is composed of mostly ...
 114-264 1.62e-05

cytochrome P450 BJ-4 homolog and similar cytochrome P450s; This group is composed of mostly uncharacterized proteins including Sinorhizobium fredii CYPBJ-4 homolog. It belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410707 [Multi-domain]  Cd Length: 406  Bit Score: 45.90  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVfGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQ--LQDIEgkIDRFII 191
Cdd:cd20614   224 TASIMAWMVIMLAEHPAVWDALCDEAAAA-GDVPRTPAELRRFPLAEALFRETLRLHPPVPFVFRrvLEEIE--LGGRRI 300

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1707919429 192 PRETLVLYALGVVLQDPNTWPSPHKFDPDRF-DDELVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLVKRLH 264
Cdd:cd20614   301 PAGTHLGIPLLLFSRDPELYPDPDRFRPERWlGRDRAPNPVELLQFgGGPHFCLGYHVACVELVQFIVALARELG 375
CYP19A1 cd20616
cytochrome P450 family 19, subfamily A, polypeptide 1; CYP19A1, also called aromatase or ...
 130-275 1.93e-05

cytochrome P450 family 19, subfamily A, polypeptide 1; CYP19A1, also called aromatase or estrogen synthetase (EC 1.14.14.14), catalyzes the formation of aromatic C18 estrogens from C19 androgens. The CYP19A1 subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410709 [Multi-domain]  Cd Length: 414  Bit Score: 45.81  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 130 EVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRT---AKLTPVSAQLQDIegkIDRFIIPRETLVLYALGVVLQ 206
Cdd:cd20616   256 EVEEAILKEIQTVLGERDIQNDDLQKLKVLENFINESMRYqpvVDFVMRKALEDDV---IDGYPVKKGTNIILNIGRMHR 332

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1707919429 207 DPNtWPSPHKFDPDRFDDELVMKTFSSLGFsGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIET 275
Cdd:cd20616   333 LEF-FPKPNEFTLENFEKNVPSRYFQPFGF-GPRSCVGKYIAMVMMKAILVTLLRRFQVCTLQGRCVEN 399
CYP1D1 cd20677
cytochrome P450 family 1, subfamily D, polypeptide 1; The cytochrome P450 1D1 (CYP1D1) gene is ...
 112-274 2.40e-05

cytochrome P450 family 1, subfamily D, polypeptide 1; The cytochrome P450 1D1 (CYP1D1) gene is pseudogenized in humans because of five nonsense mutations in the putative coding region. However, in other organisms including cynomolgus monkey, CYP1D1 is a functional drug-metabolizing enzyme that is highly expressed in the liver. CYP1D1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410770 [Multi-domain]  Cd Length: 435  Bit Score: 45.47  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 112 IITAKLctWAICFLTTSEEVQKKLYEEINQVFGNGPVTP-EKIEQLRYCQHVLCETVRTAKLTPVS-AQLQDIEGKIDRF 189
Cdd:cd20677   252 ISTALQ--WSLLYLIKYPEIQDKIQEEIDEKIGLSRLPRfEDRKSLHYTEAFINEVFRHSSFVPFTiPHCTTADTTLNGY 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 190 IIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE-------LVMKTfssLGFS-GTQECPELRFAYMVTTVLLSVLVK 261
Cdd:cd20677   330 FIPKDTCVFINMYQVNHDETLWKDPDLFMPERFLDEngqlnksLVEKV---LIFGmGVRKCLGEDVARNEIFVFLTTILQ 406

                         170
                  ....*....|...
gi 1707919429 262 RLHLLSVEGQVIE 274
Cdd:cd20677   407 QLKLEKPPGQKLD 419
Cyp2F cd20669
cytochrome P450 family 2, subfamily F; Cytochrome P450 family 2, subfamily F (CYP2F) members ...
 130-225 6.48e-05

cytochrome P450 family 2, subfamily F; Cytochrome P450 family 2, subfamily F (CYP2F) members are selectively expressed in lung tissues. They are responsible for the bioactivation of several pneumotoxic and carcinogenic chemicals such as benzene, styrene, naphthalene, and 1,1-dichloroethylene. CYP2F1 and CYP2F3 selectively catalyzes the 3-methyl dehydrogenation of 3-methylindole, forming toxic reactive intermediates that can form adducts with proteins and DNA. The CYP2F subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410762 [Multi-domain]  Cd Length: 425  Bit Score: 43.98  E-value: 6.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 130 EVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVS---AQLQDIEGKidRFIIPRETLVLYALGVVL 205
Cdd:cd20669   258 KVAARVQEEIDRVVGrNRLPTLEDRARMPYTDAVIHEIQRFADIIPMSlphAVTRDTNFR--GFLIPKGTDVIPLLNSVH 335

                          90       100
                  ....*....|....*....|
gi 1707919429 206 QDPNTWPSPHKFDPDRFDDE 225
Cdd:cd20669   336 YDPTQFKDPQEFNPEHFLDD 355
CYP24A1 cd20645
cytochrome P450 family 24, subfamily A, polypeptide 1, also called vitamin D(3) 24-hydroxylase; ...
 114-285 7.19e-05

cytochrome P450 family 24, subfamily A, polypeptide 1, also called vitamin D(3) 24-hydroxylase; Cytochrome P450 24A1 (CYP24A1, EC 1.14.15.16) is also called 1,25-dihydroxyvitamin D(3) 24-hydroxylase (24-OHase), vitamin D(3) 24-hydroxylase, or cytochrome P450-CC24. It catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3) or 1,25(OH)2D3). CYP24A1 regulates vitamin D activity through its hydroxylation of calcitriol, the physiologically active vitamin D hormone, which controls gene-expression and signal-transduction processes associated with calcium homeostasis, cellular growth, and the maintenance of heart, muscle, immune, and skin function. CYP24A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410738 [Multi-domain]  Cd Length: 419  Bit Score: 44.03  E-value: 7.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQV-FGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIP 192
Cdd:cd20645   242 TANSLLWILYNLSRNPQAQQKLLQEIQSVlPANQTPRAEDLKNMPYLKACLKESMRLTPSVPFTSRTLDKDTVLGDYLLP 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 193 RETLVL---YALGVvlqDPNTWPSPHKFDPDRF-DDELVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLS 267
Cdd:cd20645   322 KGTVLMinsQALGS---SEEYFEDGRQFKPERWlQEKHSINPFAHVPFGiGKRMCIGRRLAELQLQLALCWIIQKYQIVA 398

                         170
                  ....*....|....*....
gi 1707919429 268 VEGQVIETKYE-LVTSSRE 285
Cdd:cd20645   399 TDNEPVEMLHSgILVPSRE 417
PLN03141 PLN03141
3-epi-6-deoxocathasterone 23-monooxygenase; Provisional
 156-273 8.77e-05

3-epi-6-deoxocathasterone 23-monooxygenase; Provisional


Pssm-ID: 215600 [Multi-domain]  Cd Length: 452  Bit Score: 43.57  E-value: 8.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 156 LRYCQHVLCETVRTAKLTP--VSAQLQDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDElVMKTFSS 233
Cdd:PLN03141  314 LPFTQNVITETLRMGNIINgvMRKAMKDVE--IKGYLIPKGWCVLAYFRSVHLDEENYDNPYQFNPWRWQEK-DMNNSSF 390

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1707919429 234 LGFSGTQE-CPELRFAYMVTTVLLSVLVKRLHLLSVEGQVI 273
Cdd:PLN03141  391 TPFGGGQRlCPGLDLARLEASIFLHHLVTRFRWVAEEDTIV 431
CYP26C1 cd20636
cytochrome P450 family 26, subfamily C, polypeptide 1; Cytochrome P450 26C1 (CYP26C1) is a ...
 104-238 1.76e-04

cytochrome P450 family 26, subfamily C, polypeptide 1; Cytochrome P450 26C1 (CYP26C1) is a retinoic acid-metabolizing cytochrome that plays key roles in retinoic acid (RA) metabolism. It effectively metabolizes all-trans retinoic acid (atRA), 9-cis-retinoic acid (9-cis-RA), 13-cis-retinoic acid, and 4-oxo-atRA with the highest intrinsic clearance toward 9-cis-RA. RA is a critical signaling molecule that regulates gene transcription and the cell cycle. Loss of function mutations in the CYP26C1 gene cause type IV focal facial dermal dysplasia (FFDD), a rare syndrome characterized by facial lesions resembling aplasia cutis. CYP26C1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410729 [Multi-domain]  Cd Length: 431  Bit Score: 42.51  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 104 MIFslASCIITAKLCTWAICFLTTSEEVQKKLYEEINQ-----VFGNGP--VTPEKIEQLRYCQHVLCETVRTakLTPVS 176
Cdd:cd20636   235 LIF--AAFSTTASASTSLVLLLLQHPSAIEKIRQELVShglidQCQCCPgaLSLEKLSRLRYLDCVVKEVLRL--LPPVS 310

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1707919429 177 A----QLQDIEgkIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFD---DELVMKTFSSLGFSG 238
Cdd:cd20636   311 GgyrtALQTFE--LDGYQIPKGWSVMYSIRDTHETAAVYQNPEGFDPDRFGverEESKSGRFNYIPFGG 377
CYP60B-like cd11058
cytochrome P450 family 60, subfamily B and similar cytochrome P450s; This family is composed ...
 99-225 2.04e-04

cytochrome P450 family 60, subfamily B and similar cytochrome P450s; This family is composed of fungal cytochrome P450s including: Aspergillus nidulans cytochrome P450 60B (CYP60B), also called versicolorin B desaturase, which catalyzes the conversion of versicolorin B to versicolorin A during sterigmatocystin biosynthesis; Fusarium sporotrichioides cytochrome P450 65A1 (CYP65A1), also called isotrichodermin C-15 hydroxylase, which catalyzes the hydroxylation at C-15 of isotricodermin in trichothecene biosynthesis; and Penicillium aethiopicum P450 monooxygenase vrtK, also called viridicatumtoxin synthesis protein K, which catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to produce viridicatumtoxin, a tetracycline-like fungal meroterpenoid. The CYP60B-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410681 [Multi-domain]  Cd Length: 419  Bit Score: 42.57  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  99 ILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEKIEQLRYCQHVLCETVRtakLT-PVS 176
Cdd:cd11058   218 LEANASLLIIAGSETTATALSGLTYYLLKNPEVLRKLVDEIRSAFSSeDDITLDSLAQLPYLNAVIQEALR---LYpPVP 294

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1707919429 177 AQLQDI---EGK-IDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE 225
Cdd:cd11058   295 AGLPRVvpaGGAtIDGQFVPGGTSVSVSQWAAYRSPRNFHDPDEFIPERWLGD 347
CYP_PhacA-like cd11066
fungal cytochrome P450s similar to Aspergillus nidulans phenylacetate 2-hydroxylase; This ...
 119-225 2.36e-04

fungal cytochrome P450s similar to Aspergillus nidulans phenylacetate 2-hydroxylase; This group includes Aspergillus nidulans phenylacetate 2-hydroxylase (encoded by the phacA gene) and similar fungal cytochrome P450s. PhacA catalyzes the ortho-hydroxylation of phenylacetate, the first step of A. nidulans phenylacetate catabolism. The PhacA-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410689 [Multi-domain]  Cd Length: 434  Bit Score: 42.30  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 119 TWAICFLTTS--EEVQKKLYEEINQVFGNG------PVTPEKIEqlrYCQHVLCETVR---TAKLTPVSAQLQDIEgkID 187
Cdd:cd11066   249 NHLIGHLSHPpgQEIQEKAYEEILEAYGNDedawedCAAEEKCP---YVVALVKETLRyftVLPLGLPRKTTKDIV--YN 323

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1707919429 188 RFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE 225
Cdd:cd11066   324 GAVIPAGTILFMNAWAANHDPEHFGDPDEFIPERWLDA 361
CYP26A1 cd20638
cytochrome P450 family 26, subfamily A, polypeptide 1; Cytochrome P450s 26A1 (CYP26A1) is a ...
 114-263 8.36e-04

cytochrome P450 family 26, subfamily A, polypeptide 1; Cytochrome P450s 26A1 (CYP26A1) is a retinoic acid-metabolizing cytochrome that plays key roles in retinoic acid (RA) metabolism. It is the main all-trans-retinoic acid (atRA) hydroxylase that catalyzes the formation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. RA is a critical signaling molecule that regulates gene transcription and the cell cycle. CYP26A1 has been shown to upregulate fascin and promote the malignant behavior of breast carcinoma cells. It belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410731 [Multi-domain]  Cd Length: 432  Bit Score: 40.57  E-value: 8.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEIN-QVFGNGPVTPEK------IEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKI 186
Cdd:cd20638   246 TASAATSLIMFLGLHPEVLQKVRKELQeKGLLSTKPNENKelsmevLEQLKYTGCVIKETLRLSPPVPGGFRVALKTFEL 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 187 DRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKT--FSSLGF-SGTQECPELRFAymvtTVLLSVLVKRL 263
Cdd:cd20638   326 NGYQIPKGWNVIYSICDTHDVADIFPNKDEFNPDRFMSPLPEDSsrFSFIPFgGGSRSCVGKEFA----KVLLKIFTVEL 401
CYP26B1 cd20637
cytochrome P450 family 26, subfamily B, polypeptide 1; Cytochrome P450 26B1 (CYP26B1) is a ...
 70-283 2.39e-03

cytochrome P450 family 26, subfamily B, polypeptide 1; Cytochrome P450 26B1 (CYP26B1) is a retinoic acid-metabolizing cytochrome that plays key roles in retinoic acid (RA) metabolism. It is an all-trans-retinoic acid (atRA) hydroxylase that catalyzes the formation of similar metabolites as CYP26A1. RA is a critical signaling molecule that regulates gene transcription and the cell cycle. In rats, CYP26B1 regulates sex-specific timing of meiotic initiation, independent of RA signaling. CYP26B1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410730 [Multi-domain]  Cd Length: 430  Bit Score: 39.06  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429  70 AMKSVTQMVMGSTFEDDQEV-IRFQKNHGTIL------EDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEI--- 139
Cdd:cd20637   191 AIREKLQGTQGKDYADALDIlIESAKEHGKELtmqelkDSTIELIFAAFATTASASTSLIMQLLKHPGVLEKLREELrsn 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 140 ----NQVFGNGPVTPEKIEQLRYCQHVLCETVRTakLTPVSA----QLQDIEgkIDRFIIPRETLVLYAL------GVVL 205
Cdd:cd20637   271 gilhNGCLCEGTLRLDTISSLKYLDCVIKEVLRL--FTPVSGgyrtALQTFE--LDGFQIPKGWSVLYSIrdthdtAPVF 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 206 QDPNTwpsphkFDPDRFDDElvmktfsslgfsgTQECPELRFAYM-----VTTVLLSVLVKR-LHLLSVEgQVIETKYEL 279
Cdd:cd20637   347 KDVDA------FDPDRFGQE-------------RSEDKDGRFHYLpfgggVRTCLGKQLAKLfLKVLAVE-LASTSRFEL 406


                  ....
gi 1707919429 280 VTSS 283
Cdd:cd20637   407 ATRT 410
CYP4B-like cd20678
cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, ...
 114-266 8.75e-03

cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z; This group is composed of family 4 cytochrome P450s from subfamilies A (CYP4A), B (CYP4B), T (CYP4T), X (CYP4X), and Z (CYP4Z). The CYP4A, CYP4X, and CYP4Z subfamilies are specific to mammals, CYP4T is present in fish, while CYP4B is conserved among vertebrates. CYP4As are known for catalyzing arachidonic acid to 20-HETE (20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid), and some can also metabolize lauric and palmitic acid. CYP4Bs specialize in omega-hydroxylation of short chain fatty acids and also participates in the metabolism of exogenous compounds that are protoxic including valproic acid (C8), 3-methylindole (C9), 4-ipomeanol, 3-methoxy-4-aminoazobenzene, and several aromatic amines. CYP4X1 is expressed at high levels in the mammalian brain and may play a role in regulating fat metabolism. CYP4Z1 is a fatty acid hydroxylase that is unique among human CYPs in that it is predominantly expressed in the mammary gland. Monophyly was not found with the CYP4T and CYP4B subfamilies, and further consideration should be given to their nomenclature. The CYP4B-like group belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.


Pssm-ID: 410771 [Multi-domain]  Cd Length: 436  Bit Score: 37.26  E-value: 8.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 114 TAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRtakLTP----VSAQLQDIEGKIDR 188
Cdd:cd20678   255 TASGISWILYCLALHPEHQQRCREEIREILGDGdSITWEHLDQMPYTTMCIKEALR---LYPpvpgISRELSKPVTFPDG 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707919429 189 FIIPRETLV---LYALGvvlQDPNTWPSPHKFDPDRFDDELVMK--TFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKR 262
Cdd:cd20678   332 RSLPAGITVslsIYGLH---HNPAVWPNPEVFDPLRFSPENSSKrhSHAFLPFSaGPRNCIGQQFAMNEMKVAVALTLLR 408


                  ....
gi 1707919429 263 LHLL 266
Cdd:cd20678   409 FELL 412
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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