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Conserved domains on  [gi|1708260519|ref|NP_001358701|]
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adenylate kinase 8 isoform 5 [Homo sapiens]

Protein Classification

DD_R_PKA and ADK domain-containing protein( domain architecture ID 13063862)

DD_R_PKA and ADK domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 225-417 8.28e-56

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 183.21  E-value: 8.28e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 304
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 305 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 381
Cdd:cd01428    80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1708260519 382 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 417
Cdd:cd01428   156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
PLN02842 super family cl31938
nucleotide kinase
 58-205 8.04e-27

nucleotide kinase


The actual alignment was detected with superfamily member PLN02842:

Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 112.26  E-value: 8.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  58 ARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDP 137
Cdd:PLN02842   46 AKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDP 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1708260519 138 QTGEIYHTTFdWPPES-EIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVF 205
Cdd:PLN02842  126 VTGKIYHIKN-FPPESeEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSDIMVKIDGNRPKEVVF 193
DD_R_PKA_DPY30-like super family cl02594
dimerization/docking (D/D) domains found in the cAMP-dependent protein kinase regulatory ...
 9-30 6.71e-03

dimerization/docking (D/D) domains found in the cAMP-dependent protein kinase regulatory subunit (PRKAR) and the DPY30/SDC1-like family; This hierarchy includes the dimerization/docking (D/D) domains of type I and type II cAMP-dependent protein kinase (PKA) regulatory (R) subunits, DPY30 from animals and its homologs, SDC1 from yeasts, and similar domains. PKA is a serine/threonine kinase (STK), catalyzing the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of R subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. There are two classes of R subunits, RI and RII; each exists as two isoforms (alpha and beta) from distinct genes. These functionally non-redundant R isoforms allow for specificity in PKA signaling. The R subunit contains an N-terminal D/D domain, a linker with an inhibitory sequence (IS), and two c-AMP binding domains. The D/D domain dimerizes to form a four-helix bundle that serves as a docking site for A-kinase-anchoring proteins (AKAPs), which facilitates the localization of PKA to specific sites in the cell. DPY30, also called dumpy-30, was initially discovered in Caenorhabditis elegans as a key player in X chromosome dosage compensation. Human DPY30 plays a dual function in moderately regulating the methyltransferase activity of SET1/COMPASS (COMplex of Proteins ASsociated with Set1) enzymes and contributing to the recruitment of the complex to chromatin. Yeast SDC1 (suppressor of CDC25 protein 1) is the smallest subunit of COMPASS (COMplex of Proteins ASsociated with Set1) and interacts exclusively with Bre2 at the distal end of the catalytic module. It positively regulates the COMPASS catalytic module by stabilizing the non-canonical Bre2 SPRY domain. DPY30/SDC1 contains a C-terminal helical bundle domain that directly interacts with Ash2L (in human)/Bre2 (in yeast) COMPASS through the DPY30-binding motif (DBM). The DPY30/SDC1 helical bundle domain, also called D/D domain, is formed of two alpha-helices that may be analogous to the D/D domain found in regulatory subunit of PKA.


The actual alignment was detected with superfamily member cd22979:

Pssm-ID: 445844  Cd Length: 45  Bit Score: 34.36  E-value: 6.71e-03
                          10        20
                  ....*....|....*....|..
gi 1708260519   9 RIPPEMPQYGEENHIFELMQAM 30
Cdd:cd22979     1 EIPPEFAAYAEKHRIFELFQDL 22
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 225-417 8.28e-56

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 183.21  E-value: 8.28e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 304
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 305 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 381
Cdd:cd01428    80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1708260519 382 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 417
Cdd:cd01428   156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 225-425 7.23e-40

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 141.80  E-value: 7.23e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 304
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-ANG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 305 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 376
Cdd:COG0563    81 FILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVcdkcGGELVQR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1708260519 377 PKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 425
Cdd:COG0563   161 ADDNEETVRKRLEVYHEQTAPLIDYYrkkGKLVEIDGEGSIEEVTADILAIL 212
PLN02842 PLN02842
nucleotide kinase
 230-423 1.93e-39

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 148.09  E-value: 1.93e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 230 GPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHG 309
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 310 VPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMD 389
Cdd:PLN02842   84 YPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKARLITRPDDTEEKVKARLQ 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1708260519 390 LFYRNSADLEQLYGSAI-TLNGDQDPYTVFEYIES 423
Cdd:PLN02842  164 IYKKNAEAILSTYSDIMvKIDGNRPKEVVFEEISS 198
ADK pfam00406
Adenylate kinase;
228-402 3.58e-38

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 136.67  E-value: 3.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 228 LLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGWVL 307
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC-KNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 308 HGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTM----EIQARLLQNPKDA 380
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPgkddVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|..
gi 1708260519 381 EEQVKLKMDLFYRNSADLEQLY 402
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYY 181
PLN02842 PLN02842
nucleotide kinase
 58-205 8.04e-27

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 112.26  E-value: 8.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  58 ARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDP 137
Cdd:PLN02842   46 AKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDP 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1708260519 138 QTGEIYHTTFdWPPES-EIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVF 205
Cdd:PLN02842  126 VTGKIYHIKN-FPPESeEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSDIMVKIDGNRPKEVVF 193
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 57-204 7.25e-24

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 7.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  57 EARRLYLQRKTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL---GITPRHVIVLSAPDTVLIERNLGK 133
Cdd:cd01428    47 KAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKGFILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGR 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1708260519 134 RIDPQTGEIYHTTFDWPPESEIQNRlmvPEDisELETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDV 204
Cdd:cd01428   126 RICPVSGRVYHLGKDDVTGEPLSQR---SDD--NEETIKKRLEvYKEQTAPLIDYYKKkgKLVEIDGSGDIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 68-213 2.58e-23

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 96.92  E-value: 2.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  68 VPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRI-QTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTT 146
Cdd:TIGR01351  58 VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALdALLEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLK 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1708260519 147 FDWPPESEIQN----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVFYQALTYVQ 213
Cdd:TIGR01351 138 FNPPKVPGCDDctgeLLVQREDDTE-EVVKKRLEvYKEQTEPLIDYYKKrgILVQIDGNGPIDEVWKRILEALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 68-205 7.89e-21

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 90.19  E-value: 7.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  68 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL----GITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 143
Cdd:COG0563    59 VPDEIVIGLVKERLAQPDC-ANGFILDGFPRTVAQAEALDELlaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATY 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1708260519 144 HTTFDWPPESEI----QNRLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVF 205
Cdd:COG0563   138 HVKFNPPKVEGVcdkcGGELVQRADDNE-ETVRKRLEvYHEQTAPLIDYYRKkgKLVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
66-190 9.62e-18

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 9.62e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  66 KTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQAL---RIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEI 142
Cdd:pfam00406  53 ELVPDEVVVGLVKERLEQNDC-KNGFLLDGFPRTVPQAEaleELLERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRS 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1708260519 143 YHTTFDwPPESEIQN-----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK 190
Cdd:pfam00406 132 YHLEFN-PPKVPGKDdvtgePLVQRSDDNE-ETVKKRLEtYHKQTKPLIDYYKK 183
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 224-418 3.90e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 61.76  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 224 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQK 303
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 304 GWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRidpvtgeryhlmykppptmEIQARLlqnpKDAEEQ 383
Cdd:TIGR01360  84 GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRA-------------------ETSGRV----DDNEKT 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1708260519 384 VKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVF 418
Cdd:TIGR01360 141 IKKRLETYYKATEPVIAYYetkGKLRKINAEGTVDDVF 178
DD_AK8 cd22979
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 8 (AK8) and similar ...
 9-30 6.71e-03

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 8 (AK8) and similar proteins; AK8 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 8, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. It also displays broad nucleoside diphosphate kinase activity. AK8 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438548  Cd Length: 45  Bit Score: 34.36  E-value: 6.71e-03
                          10        20
                  ....*....|....*....|..
gi 1708260519   9 RIPPEMPQYGEENHIFELMQAM 30
Cdd:cd22979     1 EIPPEFAAYAEKHRIFELFQDL 22
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 225-417 8.28e-56

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 183.21  E-value: 8.28e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 304
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 305 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 381
Cdd:cd01428    80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1708260519 382 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 417
Cdd:cd01428   156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 225-425 7.23e-40

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 141.80  E-value: 7.23e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 304
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-ANG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 305 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 376
Cdd:COG0563    81 FILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVcdkcGGELVQR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1708260519 377 PKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 425
Cdd:COG0563   161 ADDNEETVRKRLEVYHEQTAPLIDYYrkkGKLVEIDGEGSIEEVTADILAIL 212
PLN02842 PLN02842
nucleotide kinase
 230-423 1.93e-39

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 148.09  E-value: 1.93e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 230 GPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHG 309
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 310 VPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMD 389
Cdd:PLN02842   84 YPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKARLITRPDDTEEKVKARLQ 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1708260519 390 LFYRNSADLEQLYGSAI-TLNGDQDPYTVFEYIES 423
Cdd:PLN02842  164 IYKKNAEAILSTYSDIMvKIDGNRPKEVVFEEISS 198
ADK pfam00406
Adenylate kinase;
228-402 3.58e-38

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 136.67  E-value: 3.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 228 LLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGWVL 307
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC-KNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 308 HGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTM----EIQARLLQNPKDA 380
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPgkddVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|..
gi 1708260519 381 EEQVKLKMDLFYRNSADLEQLY 402
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYY 181
adk PRK00279
adenylate kinase; Reviewed
 225-423 1.26e-31

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 119.87  E-value: 1.26e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 304
Cdd:PRK00279    2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDC-KNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 305 WVLHGVPRDLDQAHLLNR----LGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 376
Cdd:PRK00279   81 FLLDGFPRTIPQAEALDEmlkeLGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKcdvcGEELIQR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1708260519 377 PKDAEEQVKLKMDLFYRNSADLEQLYGSA---ITLNGDQDPYTVFEYIES 423
Cdd:PRK00279  161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKgklKKIDGTGSIDEVFADILK 210
PRK14530 PRK14530
adenylate kinase; Provisional
 224-425 7.74e-29

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 112.57  E-value: 7.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 224 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLK----EAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQD 299
Cdd:PRK14530    4 PRILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRankqMDISDMDTEYDTPGEYMDAGELVPDAVVNEIVEEALSDAD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 300 ciqkGWVLHGVPRDLDQAHLLNRLGyNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQ 375
Cdd:PRK14530   84 ----GFVLDGYPRNLEQAEYLESIT-DLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVcdecGGELIQ 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1708260519 376 NPKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 425
Cdd:PRK14530  159 RDDDTEETVRERLDVFEENTEPVIEHYrdqGVLVEVDGEQTPDEVWADIQDAI 211
PLN02842 PLN02842
nucleotide kinase
 58-205 8.04e-27

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 112.26  E-value: 8.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  58 ARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDP 137
Cdd:PLN02842   46 AKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDP 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1708260519 138 QTGEIYHTTFdWPPES-EIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVF 205
Cdd:PLN02842  126 VTGKIYHIKN-FPPESeEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSDIMVKIDGNRPKEVVF 193
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 57-204 7.25e-24

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 7.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  57 EARRLYLQRKTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL---GITPRHVIVLSAPDTVLIERNLGK 133
Cdd:cd01428    47 KAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKGFILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGR 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1708260519 134 RIDPQTGEIYHTTFDWPPESEIQNRlmvPEDisELETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDV 204
Cdd:cd01428   126 RICPVSGRVYHLGKDDVTGEPLSQR---SDD--NEETIKKRLEvYKEQTAPLIDYYKKkgKLVEIDGSGDIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 68-213 2.58e-23

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 96.92  E-value: 2.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  68 VPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRI-QTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTT 146
Cdd:TIGR01351  58 VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALdALLEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLK 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1708260519 147 FDWPPESEIQN----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVFYQALTYVQ 213
Cdd:TIGR01351 138 FNPPKVPGCDDctgeLLVQREDDTE-EVVKKRLEvYKEQTEPLIDYYKKrgILVQIDGNGPIDEVWKRILEALK 210
adk PRK02496
adenylate kinase; Provisional
 225-425 2.32e-22

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 93.66  E-value: 2.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 304
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDA-ANG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 305 WVLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSIMERLTLR-RIDpvtgeryhlmykppptmeiqarllqnpkD 379
Cdd:PRK02496   82 WILDGFPRKVTQAAFLDELlqeiGQSGERVVNLDVPDDVVVERLLARgRKD----------------------------D 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1708260519 380 AEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 425
Cdd:PRK02496  134 TEEVIRRRLEVYREQTAPLIDYYrdrQKLLTIDGNQSVEAVTTELKAAL 182
PLN02674 PLN02674
adenylate kinase
 198-395 4.11e-22

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 94.57  E-value: 4.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 198 DQPCVDVFYQALTYVQSNHRTNApftpRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFE 277
Cdd:PLN02674   10 DVPSVDLMTELLRRMKCSSKPDK----RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 278 KEMAVPDSLLMKVLSQRLDQQDCiQKGWVLHGVPRDLDQAH----LLNRLGYNPNRVffLNVPF-DSIM-ERLTLRRIDP 351
Cdd:PLN02674   86 KGELVSDDLVVGIIDEAMKKPSC-QKGFILDGFPRTVVQAQkldeMLAKQGAKIDKV--LNFAIdDAILeERITGRWIHP 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1708260519 352 VTGERYHLMYKPPPTMEIQ----ARLLQNPKDAEEQVKLKMDLFYRNS 395
Cdd:PLN02674  163 SSGRTYHTKFAPPKVPGVDdvtgEPLIQRKDDTAAVLKSRLEAFHKQT 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 68-205 7.89e-21

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 90.19  E-value: 7.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  68 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL----GITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 143
Cdd:COG0563    59 VPDEIVIGLVKERLAQPDC-ANGFILDGFPRTVAQAEALDELlaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATY 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1708260519 144 HTTFDWPPESEI----QNRLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVF 205
Cdd:COG0563   138 HVKFNPPKVEGVcdkcGGELVQRADDNE-ETVRKRLEvYHEQTAPLIDYYRKkgKLVEIDGEGSIEEVT 205
adk PRK00279
adenylate kinase; Reviewed
 68-205 5.17e-18

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 82.12  E-value: 5.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  68 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQAL----RIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 143
Cdd:PRK00279   59 VPDEIVIGLVKERLAQPDC-KNGFLLDGFPRTIPQAEaldeMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTY 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1708260519 144 HTTFDWPPESEIQNR----LMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVF 205
Cdd:PRK00279  138 HVKFNPPKVEGKCDVcgeeLIQRADDNE-ETVRKRLEvYHKQTAPLIDYYKKkgKLKKIDGTGSIDEVF 205
ADK pfam00406
Adenylate kinase;
66-190 9.62e-18

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 9.62e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  66 KTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQAL---RIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEI 142
Cdd:pfam00406  53 ELVPDEVVVGLVKERLEQNDC-KNGFLLDGFPRTVPQAEaleELLERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRS 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1708260519 143 YHTTFDwPPESEIQN-----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK 190
Cdd:pfam00406 132 YHLEFN-PPKVPGKDdvtgePLVQRSDDNE-ETVKKRLEtYHKQTKPLIDYYKK 183
PRK14528 PRK14528
adenylate kinase; Provisional
 225-349 5.01e-17

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 78.90  E-value: 5.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 304
Cdd:PRK14528    3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADC-KNG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1708260519 305 WVLHGVPRDLDQA----HLLNRLGYNPNRVFFLNVPFDSIMERLTLRRI 349
Cdd:PRK14528   82 FLLDGFPRTVEQAdaldALLKNEGKSIDKAINLEVPDGELLKRLLGRAE 130
PRK13808 PRK13808
adenylate kinase; Provisional
 225-323 3.21e-15

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 76.46  E-value: 3.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQkG 304
Cdd:PRK13808    2 RLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-G 80

                          90
                  ....*....|....*....
gi 1708260519 305 WVLHGVPRDLDQAHLLNRL 323
Cdd:PRK13808   81 FILDGFPRTVPQAEALDAL 99
PRK14526 PRK14526
adenylate kinase; Provisional
 225-432 4.04e-15

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 73.73  E-value: 4.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 304
Cdd:PRK14526    2 KLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-NDN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 305 WVLHGVPRDLDQAHLLNRLGYNPNRVFFLnVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQNPKDA 380
Cdd:PRK14526   81 FILDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGIcdvcKGDLYQRKDDK 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1708260519 381 EEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEyIESGIINPLPKK 432
Cdd:PRK14526  160 EESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDE-VKKKLIEIISKK 210
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 225-402 7.66e-15

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 73.68  E-value: 7.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQ-QDCIQK 303
Cdd:PTZ00088    8 KIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKvTDDCFK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 304 GWVLHGVPRDLDQAhllNRLGYNPNRVFFLNV--PFDSIMERLTLRRIDPVTGERYHLM------YKPPPTMEIQ----- 370
Cdd:PTZ00088   88 GFILDGFPRNLKQC---KELGKITNIDLFVNIylPRNILIKKLLGRRICNTCNRNFNIAhirsdpYDMPPILPPAdcegc 164

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1708260519 371 ---ARLLQNPKDAEEQVKLKMDLFYRNSADLEQLY 402
Cdd:PTZ00088  165 kgnPKLQKRSDDTEEIVAHRLNTYESTNSPIIQFF 199
PRK14527 PRK14527
adenylate kinase; Provisional
 226-425 8.11e-15

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 72.52  E-value: 8.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 226 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKgw 305
Cdd:PRK14527    9 VIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV-- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 306 VLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSIMERLTLRridpvtgeryhlmykppptmeiqARLLQNPKDAE 381
Cdd:PRK14527   87 IFDGFPRTLAQAEALDRLleelGARLLAVVLLEVPDEELIRRIVER-----------------------ARQEGRSDDNE 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1708260519 382 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 425
Cdd:PRK14527  144 ETVRRRQQVYREQTQPLVDYYearGHLKRVDGLGTPDEVYARILKAL 190
adk PRK02496
adenylate kinase; Provisional
 68-179 1.67e-12

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 65.54  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  68 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQA----LRIQTLGITPRHVIVLSAPDTVLIERNLGK-RIDPQtgei 142
Cdd:PRK02496   60 VPDQLVLDLVQERLQQPDA-ANGWILDGFPRKVTQAafldELLQEIGQSGERVVNLDVPDDVVVERLLARgRKDDT---- 134

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1708260519 143 yhttfdwppESEIQNRLMVPEDiselETAqKLLEYHR 179
Cdd:PRK02496  135 ---------EEVIRRRLEVYRE----QTA-PLIDYYR 157
PRK14530 PRK14530
adenylate kinase; Provisional
 68-188 2.03e-12

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 65.96  E-value: 2.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  68 VPSALLVQLIQERLAEEDcikqGWILDGIPETREQALRIQtlGITPRHVIV-LSAPDTVLIERNLGKRIDPQTGEIYHTT 146
Cdd:PRK14530   66 VPDAVVNEIVEEALSDAD----GFVLDGYPRNLEQAEYLE--SITDLDVVLyLDVSEEELVDRLTGRRVCPDCGANYHVE 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1708260519 147 FDWPPESEIQN----RLMVPEDISElETAQKLLE-YHRNIVRVIPSY 188
Cdd:PRK14530  140 FNQPEEEGVCDecggELIQRDDDTE-ETVRERLDvFEENTEPVIEHY 185
AAA_17 pfam13207
AAA domain;
229-348 7.41e-12

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 62.64  E-value: 7.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 229 LGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTtfGELIQPFFEKEMAVPDSLLMKVLSQRLDqQDCIQKGWVLH 308
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIA-EEAGEGGVIVD 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1708260519 309 GVPRDLDQAHLLNRL------GYNPNRVFFLNVPFDSIMERLTLRR 348
Cdd:pfam13207  78 GHPRIKTPAGYLPGLpvevlrELKPDAIILLEADPEEILERRLKDR 123
PRK14529 PRK14529
adenylate kinase; Provisional
 225-320 3.66e-11

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 62.43  E-value: 3.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDciQKG 304
Cdd:PRK14529    2 NILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDG--KNG 79

                          90
                  ....*....|....*.
gi 1708260519 305 WVLHGVPRDLDQAHLL 320
Cdd:PRK14529   80 WLLDGFPRNKVQAEKL 95
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 224-418 3.90e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 61.76  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 224 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQK 303
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 304 GWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRidpvtgeryhlmykppptmEIQARLlqnpKDAEEQ 383
Cdd:TIGR01360  84 GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRA-------------------ETSGRV----DDNEKT 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1708260519 384 VKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVF 418
Cdd:TIGR01360 141 IKKRLETYYKATEPVIAYYetkGKLRKINAEGTVDDVF 178
PRK14531 PRK14531
adenylate kinase; Provisional
 225-347 4.42e-11

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 61.75  E-value: 4.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 225 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLdqQDCIQKG 304
Cdd:PRK14531    4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALNSGG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1708260519 305 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLR 347
Cdd:PRK14531   82 WLLDGFPRTVAQAEalepLLEELKQPIEAVVLLELDDAVLIERLLAR 128
PRK14532 PRK14532
adenylate kinase; Provisional
 226-402 8.65e-11

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 60.99  E-value: 8.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 226 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGW 305
Cdd:PRK14532    3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEA-AGGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 306 VLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRridpvtgeryhlmykppptMEIQARllqnPKDAE 381
Cdd:PRK14532   82 IFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERIVKR-------------------FEEQGR----PDDNP 138

                         170       180
                  ....*....|....*....|.
gi 1708260519 382 EQVKLKMDLFYRNSADLEQLY 402
Cdd:PRK14532  139 EVFVTRLDAYNAQTAPLLPYY 159
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 226-347 1.83e-09

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 57.00  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 226 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADR-TTFGELIQPFFEKEMAVPDSLLMKVLSQRLdQQDCIQKG 304
Cdd:TIGR01359   2 VFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAI-QEDGSSKK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1708260519 305 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLR 347
Cdd:TIGR01359  81 FLIDGFPRNEENLEAWEKLmdnKVNFKFVLFFDCPEETMIKRLLKR 126
PRK14528 PRK14528
adenylate kinase; Provisional
 28-159 3.41e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 56.17  E-value: 3.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  28 QAMWLCKHLNSSLLTLENlILNEFSYTAT----EARRLYLQRKTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQA 103
Cdd:PRK14528   17 QAKILCERLSIPQISTGD-ILREAVKNQTamgiEAKRYMDAGDLVPDSVVIGIIKDRIREADC-KNGFLLDGFPRTVEQA 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 104 LR----IQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEiyhttfdwPPESEIQNRL 159
Cdd:PRK14528   95 DAldalLKNEGKSIDKAINLEVPDGELLKRLLGRAEIEGRAD--------DNEATIKNRL 146
PLN02674 PLN02674
adenylate kinase
 68-204 2.09e-08

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 54.89  E-value: 2.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  68 VPSALLVQLIQERLAEEDCIKqGWILDGIPETREQALRIQTL----GITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 143
Cdd:PLN02674   90 VSDDLVVGIIDEAMKKPSCQK-GFILDGFPRTVVQAQKLDEMlakqGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTY 168

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1708260519 144 HTTFDwPP----------ESEIQNRlmvpEDISELeTAQKLLEYHRNIVRVIPSYPK--ILKVISADQPCVDV 204
Cdd:PLN02674  169 HTKFA-PPkvpgvddvtgEPLIQRK----DDTAAV-LKSRLEAFHKQTEPVIDYYAKkgVVANLHAEKPPKEV 235
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 25-151 1.21e-05

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 46.33  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  25 ELMQAMWLCKHLNSSlltleNLILNEFSYTAT---EARRLYLQRKTVPSALLVQLIQERLAE-EDCIKQGWILDGIPETR 100
Cdd:PTZ00088   24 EILSKKENLKHINMG-----NILREEIKAKTTigkEIQKVVTSGNLVPDNLVIAIVKDEIAKvTDDCFKGFILDGFPRNL 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1708260519 101 EQALRIQTLgITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYH------TTFDWPP 151
Cdd:PTZ00088   99 KQCKELGKI-TNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNiahirsDPYDMPP 154
PRK14527 PRK14527
adenylate kinase; Provisional
 68-133 4.92e-05

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 44.01  E-value: 4.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  68 VPSALLVQLIQERLAEEDCIKQgwILDGIPETREQA----LRIQTLGITPRHVIVLSAPDTVLIERNLGK 133
Cdd:PRK14527   65 VPDELILALIRDELAGMEPVRV--IFDGFPRTLAQAealdRLLEELGARLLAVVLLEVPDEELIRRIVER 132
AAA_17 pfam13207
AAA domain;
68-134 1.09e-04

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 41.84  E-value: 1.09e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1708260519  68 VPSALLVQLIQERLAEEdCIKQGWILDGIPETREQALRIQTL------GITPRHVIVLSAPDTVLIERNLGKR 134
Cdd:pfam13207  52 EPQKELQKLAAERIAEE-AGEGGVIVDGHPRIKTPAGYLPGLpvevlrELKPDAIILLEADPEEILERRLKDR 123
PRK14529 PRK14529
adenylate kinase; Provisional
 68-135 1.62e-03

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 39.70  E-value: 1.62e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1708260519  68 VPSALLVQLIQERLAEEDciKQGWILDGIPETREQALR----IQTLGITPRHVIVLSAPDTVLIERNLGKRI 135
Cdd:PRK14529   59 VPDDITIPMILETLKQDG--KNGWLLDGFPRNKVQAEKlweaLQKEGMKLDYVIEILLPREVAKNRIMGRRL 128
DD_AK8 cd22979
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 8 (AK8) and similar ...
 9-30 6.71e-03

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 8 (AK8) and similar proteins; AK8 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 8, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. It also displays broad nucleoside diphosphate kinase activity. AK8 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438548  Cd Length: 45  Bit Score: 34.36  E-value: 6.71e-03
                          10        20
                  ....*....|....*....|..
gi 1708260519   9 RIPPEMPQYGEENHIFELMQAM 30
Cdd:cd22979     1 EIPPEFAAYAEKHRIFELFQDL 22
PRK14531 PRK14531
adenylate kinase; Provisional
 28-180 9.42e-03

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 37.10  E-value: 9.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519  28 QAMWLCKHLNSSLLTLENLILNEF---SYTATEARRLYLQRKTVPSALLVQLIQERLAEEDciKQGWILDGIPETREQAL 104
Cdd:PRK14531   18 QAARLCAAHGLRHLSTGDLLRSEVaagSALGQEAEAVMNRGELVSDALVLAIVESQLKALN--SGGWLLDGFPRTVAQAE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260519 105 R----IQTLGITPRHVIVLSAPDTVLIERNLGK-RIDPQtgeiyhttfdwppESEIQNRLMVPEDiselETAqKLLEYHR 179
Cdd:PRK14531   96 AleplLEELKQPIEAVVLLELDDAVLIERLLARgRADDN-------------EAVIRNRLEVYRE----KTA-PLIDHYR 157


                  .
gi 1708260519 180 N 180
Cdd:PRK14531  158 Q 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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