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Conserved domains on  [gi|1708260594|ref|NP_001358703|]
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adenylate kinase 8 isoform 2 [Homo sapiens]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 10106414)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 66-258 1.09e-57

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 182.82  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 145
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 146 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 222
Cdd:cd01428    80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1708260594 223 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 258
Cdd:cd01428   156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 66-258 1.09e-57

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 182.82  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 145
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 146 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 222
Cdd:cd01428    80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1708260594 223 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 258
Cdd:cd01428   156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 66-266 1.70e-41

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 141.80  E-value: 1.70e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 145
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-ANG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 146 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 217
Cdd:COG0563    81 FILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVcdkcGGELVQR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1708260594 218 PKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 266
Cdd:COG0563   161 ADDNEETVRKRLEVYHEQTAPLIDYYrkkGKLVEIDGEGSIEEVTADILAIL 212
PLN02842 PLN02842
nucleotide kinase
 71-264 5.85e-41

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 147.70  E-value: 5.85e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  71 GPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHG 150
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 151 VPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMD 230
Cdd:PLN02842   84 YPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKARLITRPDDTEEKVKARLQ 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1708260594 231 LFYRNSADLEQLYGSAI-TLNGDQDPYTVFEYIES 264
Cdd:PLN02842  164 IYKKNAEAILSTYSDIMvKIDGNRPKEVVFEEISS 198
ADK pfam00406
Adenylate kinase;
69-243 1.46e-39

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 135.90  E-value: 1.46e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  69 LLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGWVL 148
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC-KNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 149 HGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTM----EIQARLLQNPKDA 221
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPgkddVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|..
gi 1708260594 222 EEQVKLKMDLFYRNSADLEQLY 243
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYY 181
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 65-259 1.50e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 61.76  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  65 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQK 144
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 145 GWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRidpvtgeryhlmykppptmEIQARLlqnpKDAEEQ 224
Cdd:TIGR01360  84 GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRA-------------------ETSGRV----DDNEKT 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1708260594 225 VKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVF 259
Cdd:TIGR01360 141 IKKRLETYYKATEPVIAYYetkGKLRKINAEGTVDDVF 178
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 66-258 1.09e-57

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 182.82  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 145
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 146 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 222
Cdd:cd01428    80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1708260594 223 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 258
Cdd:cd01428   156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 66-266 1.70e-41

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 141.80  E-value: 1.70e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 145
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-ANG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 146 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 217
Cdd:COG0563    81 FILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVcdkcGGELVQR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1708260594 218 PKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 266
Cdd:COG0563   161 ADDNEETVRKRLEVYHEQTAPLIDYYrkkGKLVEIDGEGSIEEVTADILAIL 212
PLN02842 PLN02842
nucleotide kinase
 71-264 5.85e-41

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 147.70  E-value: 5.85e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  71 GPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHG 150
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 151 VPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMD 230
Cdd:PLN02842   84 YPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKARLITRPDDTEEKVKARLQ 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1708260594 231 LFYRNSADLEQLYGSAI-TLNGDQDPYTVFEYIES 264
Cdd:PLN02842  164 IYKKNAEAILSTYSDIMvKIDGNRPKEVVFEEISS 198
ADK pfam00406
Adenylate kinase;
69-243 1.46e-39

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 135.90  E-value: 1.46e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  69 LLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGWVL 148
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC-KNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 149 HGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTM----EIQARLLQNPKDA 221
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPgkddVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|..
gi 1708260594 222 EEQVKLKMDLFYRNSADLEQLY 243
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYY 181
adk PRK00279
adenylate kinase; Reviewed
 66-264 5.34e-33

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 119.87  E-value: 5.34e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 145
Cdd:PRK00279    2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDC-KNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 146 WVLHGVPRDLDQAHLLNR----LGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 217
Cdd:PRK00279   81 FLLDGFPRTIPQAEALDEmlkeLGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKcdvcGEELIQR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1708260594 218 PKDAEEQVKLKMDLFYRNSADLEQLYGSA---ITLNGDQDPYTVFEYIES 264
Cdd:PRK00279  161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKgklKKIDGTGSIDEVFADILK 210
PRK14530 PRK14530
adenylate kinase; Provisional
 65-266 2.46e-30

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 112.96  E-value: 2.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  65 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLK----EAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQD 140
Cdd:PRK14530    4 PRILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRankqMDISDMDTEYDTPGEYMDAGELVPDAVVNEIVEEALSDAD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 141 ciqkGWVLHGVPRDLDQAHLLNRLGyNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQ 216
Cdd:PRK14530   84 ----GFVLDGYPRNLEQAEYLESIT-DLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVcdecGGELIQ 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1708260594 217 NPKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 266
Cdd:PRK14530  159 RDDDTEETVRERLDVFEENTEPVIEHYrdqGVLVEVDGEQTPDEVWADIQDAI 211
adk PRK02496
adenylate kinase; Provisional
 66-266 1.20e-23

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 94.43  E-value: 1.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 145
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDA-ANG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 146 WVLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSIMERLTLR-RIDpvtgeryhlmykppptmeiqarllqnpkD 220
Cdd:PRK02496   82 WILDGFPRKVTQAAFLDELlqeiGQSGERVVNLDVPDDVVVERLLARgRKD----------------------------D 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1708260594 221 AEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 266
Cdd:PRK02496  134 TEEVIRRRLEVYREQTAPLIDYYrdrQKLLTIDGNQSVEAVTTELKAAL 182
PLN02674 PLN02674
adenylate kinase
 39-236 6.68e-23

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 94.18  E-value: 6.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  39 DQPCVDVFYQALTYVQSNHRTNApftpRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFE 118
Cdd:PLN02674   10 DVPSVDLMTELLRRMKCSSKPDK----RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 119 KEMAVPDSLLMKVLSQRLDQQDCiQKGWVLHGVPRDLDQAH----LLNRLGYNPNRVffLNVPF-DSIM-ERLTLRRIDP 192
Cdd:PLN02674   86 KGELVSDDLVVGIIDEAMKKPSC-QKGFILDGFPRTVVQAQkldeMLAKQGAKIDKV--LNFAIdDAILeERITGRWIHP 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1708260594 193 VTGERYHLMYKPPPTMEIQ----ARLLQNPKDAEEQVKLKMDLFYRNS 236
Cdd:PLN02674  163 SSGRTYHTKFAPPKVPGVDdvtgEPLIQRKDDTAAVLKSRLEAFHKQT 210
PRK14528 PRK14528
adenylate kinase; Provisional
 66-190 1.14e-17

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 78.51  E-value: 1.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 145
Cdd:PRK14528    3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADC-KNG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1708260594 146 WVLHGVPRDLDQA----HLLNRLGYNPNRVFFLNVPFDSIMERLTLRRI 190
Cdd:PRK14528   82 FLLDGFPRTVEQAdaldALLKNEGKSIDKAINLEVPDGELLKRLLGRAE 130
PRK13808 PRK13808
adenylate kinase; Provisional
 66-164 6.37e-16

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 76.46  E-value: 6.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQkG 145
Cdd:PRK13808    2 RLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-G 80

                          90
                  ....*....|....*....
gi 1708260594 146 WVLHGVPRDLDQAHLLNRL 164
Cdd:PRK13808   81 FILDGFPRTVPQAEALDAL 99
PRK14526 PRK14526
adenylate kinase; Provisional
 66-273 1.38e-15

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 73.35  E-value: 1.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 145
Cdd:PRK14526    2 KLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-NDN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 146 WVLHGVPRDLDQAHLLNRLGYNPNRVFFLnVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQNPKDA 221
Cdd:PRK14526   81 FILDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGIcdvcKGDLYQRKDDK 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1708260594 222 EEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEyIESGIINPLPKK 273
Cdd:PRK14526  160 EESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDE-VKKKLIEIISKK 210
PRK14527 PRK14527
adenylate kinase; Provisional
 67-266 1.47e-15

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 72.90  E-value: 1.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  67 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKgw 146
Cdd:PRK14527    9 VIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV-- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 147 VLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSIMERLTLRridpvtgeryhlmykppptmeiqARLLQNPKDAE 222
Cdd:PRK14527   87 IFDGFPRTLAQAEALDRLleelGARLLAVVLLEVPDEELIRRIVER-----------------------ARQEGRSDDNE 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1708260594 223 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 266
Cdd:PRK14527  144 ETVRRRQQVYREQTQPLVDYYearGHLKRVDGLGTPDEVYARILKAL 190
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 66-243 2.51e-15

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 73.29  E-value: 2.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQ-QDCIQK 144
Cdd:PTZ00088    8 KIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKvTDDCFK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 145 GWVLHGVPRDLDQAhllNRLGYNPNRVFFLNV--PFDSIMERLTLRRIDPVTGERYHLM------YKPPPTMEIQ----- 211
Cdd:PTZ00088   88 GFILDGFPRNLKQC---KELGKITNIDLFVNIylPRNILIKKLLGRRICNTCNRNFNIAhirsdpYDMPPILPPAdcegc 164

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1708260594 212 ---ARLLQNPKDAEEQVKLKMDLFYRNSADLEQLY 243
Cdd:PTZ00088  165 kgnPKLQKRSDDTEEIVAHRLNTYESTNSPIIQFF 199
AAA_17 pfam13207
AAA domain;
70-189 1.74e-12

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 63.03  E-value: 1.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  70 LGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTtfGELIQPFFEKEMAVPDSLLMKVLSQRLDqQDCIQKGWVLH 149
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIA-EEAGEGGVIVD 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1708260594 150 GVPRDLDQAHLLNRL------GYNPNRVFFLNVPFDSIMERLTLRR 189
Cdd:pfam13207  78 GHPRIKTPAGYLPGLpvevlrELKPDAIILLEADPEEILERRLKDR 123
PRK14531 PRK14531
adenylate kinase; Provisional
 66-188 9.90e-12

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 62.14  E-value: 9.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLdqQDCIQKG 145
Cdd:PRK14531    4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALNSGG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1708260594 146 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLR 188
Cdd:PRK14531   82 WLLDGFPRTVAQAEalepLLEELKQPIEAVVLLELDDAVLIERLLAR 128
PRK14529 PRK14529
adenylate kinase; Provisional
 66-161 1.36e-11

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 62.43  E-value: 1.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  66 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDciQKG 145
Cdd:PRK14529    2 NILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDG--KNG 79

                          90
                  ....*....|....*.
gi 1708260594 146 WVLHGVPRDLDQAHLL 161
Cdd:PRK14529   80 WLLDGFPRNKVQAEKL 95
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 65-259 1.50e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 61.76  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  65 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQK 144
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 145 GWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRidpvtgeryhlmykppptmEIQARLlqnpKDAEEQ 224
Cdd:TIGR01360  84 GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRA-------------------ETSGRV----DDNEKT 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1708260594 225 VKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVF 259
Cdd:TIGR01360 141 IKKRLETYYKATEPVIAYYetkGKLRKINAEGTVDDVF 178
PRK14532 PRK14532
adenylate kinase; Provisional
 67-243 3.42e-11

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 60.99  E-value: 3.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  67 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGW 146
Cdd:PRK14532    3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEA-AGGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594 147 VLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRridpvtgeryhlmykppptMEIQARllqnPKDAE 222
Cdd:PRK14532   82 IFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERIVKR-------------------FEEQGR----PDDNP 138

                         170       180
                  ....*....|....*....|.
gi 1708260594 223 EQVKLKMDLFYRNSADLEQLY 243
Cdd:PRK14532  139 EVFVTRLDAYNAQTAPLLPYY 159
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 67-188 8.00e-10

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 57.00  E-value: 8.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1708260594  67 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADR-TTFGELIQPFFEKEMAVPDSLLMKVLSQRLdQQDCIQKG 145
Cdd:TIGR01359   2 VFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAI-QEDGSSKK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1708260594 146 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLR 188
Cdd:TIGR01359  81 FLIDGFPRNEENLEAWEKLmdnKVNFKFVLFFDCPEETMIKRLLKR 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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