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dynein axonemal heavy chain 10 isoform 3 [Homo sapiens]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
AAA_6
pfam12774 Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1912-2238
0e+00
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain]
Cd Length: 327
Bit Score: 673.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1912 YGYEY M G LN GRLVITPLTDR I YLTLTQAL SMY LGGAPAGPAGTGKTET T KDLAKAL GLLC VV T NC GE G M DY RAV G K IF S G 1991
Cdd:pfam12774 1 YGYEY L G NS GRLVITPLTDR C YLTLTQAL HLH LGGAPAGPAGTGKTET V KDLAKAL AKQV VV F NC SD G L DY KSM G R IF K G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1992 LAQCGAWGCFDEFNRID AS VLSV ISS QI Q TI RN AL IHQ L T TF Q FEG Q EI S L DSRM GIFITMNPGYAGRTELP ESV KALFR 2071
Cdd:pfam12774 81 LAQCGAWGCFDEFNRID IE VLSV VAQ QI L TI QQ AL AAN L K TF V FEG S EI K L NPSC GIFITMNPGYAGRTELP DNL KALFR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2072 PV VVI VPD LQQ I C EIMLFSEGF LE AK T LAKK MTV LYKL AR EQLSKQ Y HYDFGLRALKSVLV M AG E LKR GSSD L R EDV V L M 2151
Cdd:pfam12774 161 PV AMM VPD YAL I A EIMLFSEGF SD AK V LAKK LVT LYKL CS EQLSKQ D HYDFGLRALKSVLV T AG S LKR SNPN L N EDV L L L 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2152 RALRDMNLPK F V FE DVPLFLGLISDLFPG LDC P RVR Y PDFND A V E Q V LE E N G YAVLPIQVD KV V Q MF ETML T RH TT M V VG 2231
Cdd:pfam12774 241 RALRDMNLPK L V AD DVPLFLGLISDLFPG VEL P PSD Y GELEE A I E E V CK E L G LQPHDAFIL KV I Q LY ETML V RH GV M L VG 320
....*..
gi 1722218962 2232 PT RG GK S 2238
Cdd:pfam12774 321 PT GS GK T 327
DHC_N1
pfam08385 Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
306-876
2.03e-176
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457
Cd Length: 560
Bit Score: 555.65
E-value: 2.03e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 306 VDI LE QC VI N W LN QI STA veaq LK KTP QG K -- GPLAEIEFW RE R N A T LS ALH EQ T K L P I V R KVL DVIKESD S MLVANLQP 383
Cdd:pfam08385 1 LHA LE SV VI K W TK QI QDV ---- LK EDS QG R np GPLAEIEFW KS R E A N LS SIY EQ L K S P E V K KVL EILEAAK S SYLPAFKA 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 384 VF TEL FKFHT EA S DNV RF L S T V ER Y F KNITHGSGFHVVLDT IP AM M SAL R MV W I ISR H YN KD ERM IP L M E R I AWEIA E RV 463
Cdd:pfam08385 77 LD TEL TDALN EA K DNV KY L K T L ER P F EDLEELTDPPEIIEA IP PL M NTI R LI W S ISR Y YN TS ERM TV L L E K I SNQLI E QC 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 464 CRVVNLRTL F KENRAS A QS K TL E ARNT L RL WK KA Y FD TR A K I E A S G RE DR W E F DRKRL F E R T D YMATICQDLSDVLQIL E 543
Cdd:pfam08385 157 KKYLSPEGI F DGDVEE A LE K LQ E CIEL L EA WK EE Y KK TR E K L E E S P RE RP W D F SERYI F G R F D AFLERLEKILELFETI E 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 544 E F ------ YNIF GPEL KA V tgdpkr I DDV L CRVDGLVTPMENL T F D PFSIKSSQ f WKYVMD EFK IEVLVI E KEAKH FID E 617
Cdd:pfam08385 237 Q F skleki GGTK GPEL EG V ------ I EEI L EEFQEAYKVFKSK T Y D ILDVSNEG - FDDDYE EFK ERIKDL E RRLQA FID Q 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 618 S F KTL RS A E A AF DM L LK F KHIRS R EAVNRQMMM K FN D I L AQYC KE I D IIN KIF VQNLE NP - P LY KN H PPVAGAI Y W E R S L 696
Cdd:pfam08385 310 A F DDA RS T E S AF KL L RI F EFLLE R PIIRGALEE K YT D L L QMFK KE L D AVK KIF DKQKY NP s P IA KN M PPVAGAI I W A R Q L 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 697 F F RI KHTIL RF Q E VQEI L DSDR G QE V KQ KY L E VGRTMK EYE DRK YE Q W MEVT E QVLPALM K KS LL TKSS iateepstl E R 776
Cdd:pfam08385 390 F R RI QEPMK RF K E ELGL L KHAE G KK V IK KY N E LAKKLD EYE RLI YE A W LKEV E EASEGNL K RP LL VRHP --------- E T 460
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 777 G AVFAI NF S P A L REIIN E T KYL EQ LGF TV PE L A R N V AL Q E DKFLR Y TAGIQRMLDH Y HMLIG TL NDA E SV LL KD H SQELL 856
Cdd:pfam08385 461 G KLLSV NF D P Q L LALLR E V KYL QK LGF EI PE S A L N I AL K E ERLRP Y AESLELLVRW Y NKIRS TL LPV E RP LL AP H LKDID 540
570 580
....*....|....*....|
gi 1722218962 857 RVFRS G YKR L N WNSLGI GD Y 876
Cdd:pfam08385 541 EKLEP G LTT L T WNSLGI DE Y 560
DHC_N2
pfam08393 Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1372-1777
1.06e-159
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain]
Cd Length: 402
Bit Score: 501.02
E-value: 1.06e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1372 L LKVQ KE MSG L RMIYE L YEGLKVAK EEW SQTLWIN L N V QI L Q E GI E G FL RA L R KLP RPV R GLS V TYY L EA K MKA FK D S I P 1451
Cdd:pfam08393 1 L EEIK KE LEP L KKLWD L VSEWQESL EEW KNGPFSD L D V EE L E E EL E E FL KE L K KLP KEL R DWD V AEE L KK K IDD FK K S L P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1452 L LL DL K N E ALR D RHWK E L M E KTSVF F EM - T E T FTL ENMFAME LHK HTDVLN EI VTA A I KE VA IEKA V K E I LDT W EN M K F T 1530
Cdd:pfam08393 81 L IE DL R N P ALR E RHWK Q L S E ILGFD F DP l S E F FTL GDLLDLN LHK YEEEIE EI SEQ A S KE YS IEKA L K K I EEE W KT M E F E 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1531 V V K Y CKGT qer GY IL GSV DEI IQS LDD NTFN LQS ISG S RF V G PF LQT V HK WEK T LSL IG E VIEI W ML VQRKW M YLE S IF I 1610
Cdd:pfam08393 161 L V P Y KDTG --- TF IL KGW DEI QEL LDD HLVK LQS MKS S PY V K PF EEE V SE WEK K LSL LQ E ILDE W LK VQRKW L YLE P IF S 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1611 GG DIR S QLPEEAK K F D N I DK VF K R IM GETL KDP VIKRC C EA P NR L SD L QNVS E G LEK C QKSLN D YL DS KR N AFPRF F F I S 1690
Cdd:pfam08393 238 SE DIR K QLPEEAK R F Q N V DK EW K K IM KKAV KDP NVLEA C NI P GL L EK L EELN E L LEK I QKSLN E YL EK KR L AFPRF Y F L S 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1691 D DELL S IL G - SS DP LC VQ E H MI K MYDN IASL R F ND gdsg E K LVSA MIS A EGEV ME F R K - ILR A E G R VE D W MTAVLN EMR R 1768
Cdd:pfam08393 318 N DELL E IL S q TK DP TR VQ P H LK K CFEG IASL E F DE ---- N K EITG MIS K EGEV VP F S K p PVE A K G N VE E W LNELEE EMR E 393
....*....
gi 1722218962 1769 T N R LIT KEA 1777
Cdd:pfam08393 394 T L R DLL KEA 402
AAA_8
pfam12780 P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2891-3150
7.96e-118
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain]
Cd Length: 259
Bit Score: 374.25
E-value: 7.96e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2891 M N LVLF D DALEHL T R VH RI I R MD RGHALLVGVGGSG K QSL SR LAAF T A SC E V F E I LLS R G Y SE N S FREDLK SLYL K L GI E 2970
Cdd:pfam12780 1 M D LVLF R DALEHL C R IC RI L R QP RGHALLVGVGGSG R QSL TK LAAF I A GY E L F Q I EVT R N Y DM N E FREDLK KVLK K A GI K 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2971 N K AMI FL FT D AHVA EE G FLE L INN M L T SG I VP A LF SE EEKE S I LSQIGQE A LK Q GMGPAK E S V WQ YFV NKSA NNLHIVL G 3050
Cdd:pfam12780 81 G K PTV FL LS D TQII EE S FLE D INN L L N SG E VP N LF TD EEKE E I IESVRDD A KA Q NIEDSR E A V YN YFV KRCR NNLHIVL C 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3051 MSPVG DTL R TWC R N FP GM VN NTG IDWF MP WP PQ AL H AVA KS FL G y NPM IP A E NIE NVVK HV V L VH Q SV DHY S QQ F LQK L R 3130
Cdd:pfam12780 161 MSPVG EAF R NRL R M FP SL VN CCT IDWF NE WP EE AL L AVA EK FL E - DIE IP E E LKS NVVK VF V Y VH S SV EDM S KK F YEE L K 239
250 260
....*....|....*....|
gi 1722218962 3131 R S NYVTPK N YL DFINT Y SK L 3150
Cdd:pfam12780 240 R K NYVTPK S YL ELLRL Y KN L 259
DYN1 super family
cl34955 Dynein, heavy chain [Cytoskeleton];
1274-4265
1.65e-114
Dynein, heavy chain [Cytoskeleton];
COG5245 :Pssm-ID: 227570 [Multi-domain]
Cd Length: 3164
Bit Score: 411.69
E-value: 1.65e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1274 S IW S N LF NDSVNV EH AL G d IKRT F TELT R ge I MNYRVQIEEFAKRFY S E g PG SVGDDL D K G V E L lgv YERELARHEKSRQ 1353
Cdd:COG5245 339 S LE S S LF YEFRGG EH LA G - FYSA F GDIK R -- I LLFTWSFKKLGTLLP S L - PG YSSGGM D Y G E E Y --- RSLLWELGSEVGD 411
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1354 ELANAEKLFDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQ T LW in LNVQILQEGIEGF L RA l RKLP R P V R g L 1433
Cdd:COG5245 412 PDSGPVRKWMRKDLFDAKVRSGVSFGKQEEFVSDIFNITFERIHGMDP T TL -- EDDEEDTPALAIL L GQ - EEAG R F V K - L 487
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1434 SVTYYLEAKMKAFKDSIPLL L DLKNEALR dr HWKELMEKTSV F FEMTETFTLENMF a M ELHKHTD V LNEIVTAAIK E VA - 1512
Cdd:COG5245 488 CKIMRMFSFFNSLEMFSRRT L ANRMAIVK -- YLSSVVRTGPL F LQRDFFGRMSELL - M ARDMFME V DGVLRLFFGG E WS g 564
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1513 - IEKAVKEILDTWENMKFT -- VVKY C KGTQERGYILGSVDEIIQSL D DNT f N L QSI SGS R fvgpflqt V HKWEKTLSLIG 1589
Cdd:COG5245 565 i VQLSGIRRAKRCVERQID de IREW C SSVLSDDFLEERAVRVERGA D GAR - R L RAS SGS P -------- V LRRLDEYLMMM 635
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1590 EVI eiwmlvqrkwmylesifigg D IRSQL P EEAKKFDNIDKVFKR I MGETLKDPVIKRCCEAPN r LS DL QNVSEGLEKCQ 1669
Cdd:COG5245 636 SLE -------------------- D LMPLI P HAVHRKMSLVSGVRG I YKRVVSGCEAINTILEDV - GD DL DLFYKEMDQVF 694
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1670 K S LNDY L DSKRNAFP R F ff ISDD EL LSILGS - SDPLCVQEHMI K MYDNIASLR - F NDGDSGEKLV S AMIS A EGEVMEFRK 1747
Cdd:COG5245 695 M S IEKV L GLRWREVE R A -- SEVE EL MDRVRE l ENRVYSYRFFV K KIAKEEMKT v F SSRIQKKEPF S LDSE A YVGFFRLYE 772
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1748 ILRAEGRVEDW M TA VL NEMRRTNRLITKEAIFRYCED R S RV DWML L YQ G M vvlaasqvw WTWEV E DV F hkaqkge KQAMK 1827
Cdd:COG5245 773 KSIVIRGINRS M GR VL SQYLESVQEALEIEDGSFFVS R H RV RDGG L EK G R --------- GCDAW E NC F ------- DPPLS 836
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1828 N Y G R KMHRQIDELVTR itmp LSKNDR K KYNTVLI I DVHARD I VDSFIRGSILEAREFDWE S QLRFY w DREPDELNIRQCT 1907
Cdd:COG5245 837 E Y F R ILEKIFPSEEGY ---- FFDEVL K RLDPGHE I KSRIEE I IRMVTVKYDFCLEVLGSV S ISELP - QGLYKRFIKVRSS 911
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1908 GTFGYGYEYMGLNGRLVITPLTDRIYLT L TQ A LSMYL ggap AGPAG T GKTETTKD L AKAL G LLC vvtncg E G MDY R A vg K 1987
Cdd:COG5245 912 YRSAEMFAKNTIPFFVFEHSMDTSQHQK L FE A VCDEV ---- CRFVD T ENSRVYGM L VAGK G RIY ------ D G TEP R S -- R 979
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1988 I FS G LAQCGAW G c FD E FNRI D ASVLS v I SSQIQTIRNAL -- IHQ L TTFQF E gq EISLDSRMGIFITM N P gyag R TELP E S 2065
Cdd:COG5245 980 I EA G PICEEER G - TE E SALL D EISRT - I LVDEYLNSDEF rm LEE L NSAVV E -- HGLKSPSTPVEMII N E ---- R NIVL E I 1051
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2066 VKALFRPVVVIV P d LQQ I CEIM lfsegflea KT L AKKMTVLYKLAREQLSKQYHYD F gl RALKSV L vmagelk RGSSDLR 2145
Cdd:COG5245 1052 GRRALDMFLSNI P - FGA I KSRR --------- ES L DREIGAFNNEVDGIAREEDELM F -- YPMFKS L ------- KAKHRML 1112
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2146 E DVV -- L MRA L RDMN LP kfvfedvplflg LISD - L FPGL D CPRVRYPD F NDAV E QVLEENGYA V LPIQ V DKV V QMFETML 2222
Cdd:COG5245 1113 E EKT ey L NKI L SITG LP ------------ LISD t L RERI D TLDAEWDS F CRIS E SLKKYESQQ V SGLD V AQF V SFLRSVD 1180
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2223 T RHTTMVVGPTRGG K SVVINTL C Q aqtklglttkl Y ILNP K AVS V IEL Y gi L D PTT r DWT d GVLSNIF RE INKPTDKKER 2302
Cdd:COG5245 1181 T GAFHAEYFRVFLC K IKHYTDA C D ----------- Y LWHV K SPY V KKK Y -- F D ADM - ELR - QFFLMFN RE DMEARLADSK 1245
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2303 KYILFDG dvdal W VE NMNSVMDDNR L LTLAN GE R irlqahc ALLFEVGD lqy ASPAT V S RC GMV Y VDPKN L KYRPYWKKW 2382
Cdd:COG5245 1246 MEYEVER ----- Y VE KTKAEVSSLK L ELSSV GE G ------- QVVVSNLG --- SIGDK V G RC LVE Y DSISR L STKGVFLDE 1310
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2383 VNQ ---- IPNKVEQYNLNSLFE K YVPY L MD V IVEGIV dg R QAEK L KT IV PQTDLNM V -------------- TQ LA KM L D a 2444
Cdd:COG5245 1311 LGD tkry LDECLDFFSCFEEVQ K EIDE L SM V FCADAL -- R FSAD L YH IV KERRFSG V lagsdaseslggks IE LA AI L E - 1387
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2445 l LEGE I EDLDLLECYF L ea LYCSL G ASLL E DGR mkfdeyik R LASL S TV D TEGVWANPGELPGQ L PTLYDFHFDNKR N QW 2524
Cdd:COG5245 1388 - HKDL I VEMKRGINDV L -- KLRIF G DKCR E STP -------- R FYLI S DG D LIKDLNERSDYEEM L IMMFNISAVITN N GS 1456
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2525 VPWSK L VP E YIHAPE rkfi NILVH T V DT TRTTWILEQMVKIKQPV I FV G ES G TS K TATTQNF L K nl SE ETNI V LMV NFS S 2604
Cdd:COG5245 1457 IAGFE L RG E RVMLRK ---- EVVIP T S DT GFVDSFSNEALNTLRSY I YC G PP G SG K EMLMCPS L R -- SE LITE V KYF NFS T 1530
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2605 R T TSMDIQRN LE ANV E KRTKD ---- T Y GP P MG K R L LV F M D DM N M P RVD EY GTQQP I AL L KL L L E K - G YLYDRGKEL nc KS 2679
Cdd:COG5245 1531 C T MTPSKLSV LE RET E YYPNT gvvr L Y PK P VV K D L VL F C D EI N L P YGF EY YPPTV I VF L RP L V E R q G FWSSIAVSW -- VT 1608
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2680 I RDLGFIA A MGKAGG - GR NEVDP RFI SLFSVFNVPF P SEE SL HL IY SSI L K G ------ HTSTFH E SIVAV S GK L TFCTLA 2752
Cdd:COG5245 1609 I CGIILYG A CNPGTD e GR VKYYE RFI RKPVFVFCCY P ELA SL RN IY EAV L M G sylcfd EFNRLS E ETMSA S VE L YLSSKD 1688
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2753 LY K NIV Q D lpptpskf H Y IFNL R D L S R V --- FN G LVL T NPE rf QTVAQMVRV W RN E CL R VFH DRL ISETDKQLVQ Q HIGS 2829
Cdd:COG5245 1689 KT K FFL Q M -------- N Y GYKP R E L T R S lra IF G YAE T RID -- TPDVSLIID W YC E AI R EKI DRL VQQKESSTSR Q DLYD 1758
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2830 LVVEHFKD - DVEVVMRDP I L F GD --- F Q MA L hegepriyedi QDYEAAKALFQ E ILEEYNE S NTKMNL V LFD DAL E H LT R 2905
Cdd:COG5245 1759 FGLRAIRE m IAGHIGEAE I T F SM ilf F G MA C ----------- LLKKDLAVFVE E VRKIFGS S HLDVEA V AYK DAL L H IL R 1827
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2906 VH R IIRMDR GH AL L V GV GGS G KQSLSRLAAFTASCEVF EI LLS R GYSENS FR ED LK SLY L KLG I ENKAMIFLFTDAHVA E 2985
Cdd:COG5245 1828 SR R GLLVVG GH GV L K GV LIR G ACDAREFVCWLNPRNMR EI FGH R DELTGD FR DS LK VQD L RRN I HGGRECLFIFESIPV E 1907
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2986 EG FLE LI N NM L TSGIVPA LFS EE E KES I LSQIGQEALKQGMG - PAKESVWQY F VNKSAN NL HI V LGMSPVG DT LRTWCRN 3064
Cdd:COG5245 1908 SS FLE DF N PL L DNNRFLC LFS GN E RIR I PENLRFVFESTSLE k DTEATLTRV F LVYMEE NL PV V FSACCSQ DT SVLAGIR 1987
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3065 F P GMV N NTG ID WFMP W PPQALHAV A K S FL ------ G YNPM I PA E -- NIENVVKHV V LVHQS V DHYSQQ F LQKLRR - S NYV 3135
Cdd:COG5245 1988 S P ALK N RCF ID FKKL W DTEEMSQY A N S VE tlsrdg G RVFF I NG E lg VGKGALISE V FGDDA V VIEGRG F EISMIE g S LGE 2067
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3136 TPKNYLDFINT Y SKLLDEKTQCNIAQCKR L DG G LD K LK E ATIQLD EL NQK L AEQKIV L AE K SAACEAL L E ------- E IA 3208
Cdd:COG5245 2068 SKIKFIGGLKV Y DARCVIYIEELDCTNVN L VE G VR K YN E YGRGMG EL KEQ L SNTVVI L GV K EKNADDA L S gtpgerl E RE 2147
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3209 V NTAVA E EKKKLAEEKAM E IEEQNKVIAME K AEAETTLA E vmpilea A K L ELQ K LD K SDVT EIRSF AK PP KQVQTVC E CI 3288
Cdd:COG5245 2148 V KSVFV E APRDMLFLLEE E VRKRKGSVMKF K SSKKPAVL E ------- A V L FVY K IK K ASLR EIRSF IR PP GDLCIEM E DV 2220
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3289 LIMK G YKELN W KTAKGVMSD ---- PNFLRSLM EI D FD si TQSQVKNIKGLLKTLNT T TEEMEAV SKA GLGMLKFVEAVMG 3364
Cdd:COG5245 2221 CDLL G FEAKI W FGEQQSLRR ddfi RIIGKYPD EI E FD -- LEARRFREARECSDPSF T GSILNRA SKA CGPLKRWLVRECN 2298
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3365 YCD V FREIK P K RE KVA R LERNFY L TK rel E R IQNELAAIQK --- ELETLGAK Y EAA IL EKQKLQEEAEIMERRLIAADKL 3441
Cdd:COG5245 2299 RSK V LEVKI P L RE EEK R IDGEAF L VE --- D R LTLGKGLSSD lmt FKLRRRSY Y SLD IL RVHGKIADMDTVHKDVLRSIFV 2375
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3442 ISG L GS E NIR W LNDLD E LMHRR V K L L GD CLLCAAFLS Y E G af T WE F RDEMVNRIWQNDILER E IPLSQPF R --- LESLLT 3518
Cdd:COG5245 2376 SEI L IN E DSE W GGVFS E VPKLM V E L D GD GHPSSCLHP Y I G -- T LG F LCRAIEFGMSFIRISK E FRDKEIR R rqf ITEGVQ 2453
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3519 DDVE i SRWGSQ glp PDELSVQ N - G I LTTRASRFPLCI DP QQQALNWIKRKEEKNNLRVA SF NDPD F LKQ L EMSIKY G TPF 3597
Cdd:COG5245 2454 KIED - FKEEAC --- STDYGLE N s R I RKDLQDLTAVLN DP SSKIVTSQRQMYDEKKAILG SF REME F AFG L SQARRE G SDK 2529
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3598 LFR D V d E YI D PV I DNVLEKNI K VSQGRQFIILGDK E VDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLK G L E DQL 3677
Cdd:COG5245 2530 IIG D A - E AL D EE I GRLIKEEF K SNLSEVKVMINPP E IVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVL G C E TEI 2608
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3678 LSV L VAYERRE L EEQREH L IQETSENKNL L KD L EDS LL RE L AT S TG NM LDNVDLVHT L EET K SKAT E VS E KLKLAEKTAL 3757
Cdd:COG5245 2609 PDA L EKLVSGP L FVHEKA L NALKACGSLF L WV L ARY LL AK L ML S IS NM EQTDEIAVL L HNL K KSRK E IE E EESESMEIED 2688
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3758 D ID R L RDG Y RPAAR R GAILFFVLSEMALVNS MY QY S LIAFLEV F RLSLKKS lpd S ILMKRL R NIMDTLTFSIYNHGCT G L 3837
Cdd:COG5245 2689 R ID A L KSE Y NASVK R LESIRVEIAMFDEKAL MY NK S ICELSSE F EKWRRMK --- S KYLCAI R YMLMSSEWILDHEDRS G F 2765
2650 2660 2670 2680 2690 2700 2710 2720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3838 F er H K L LF SF NMTI K ieqaegrvpq EELDFF L KGNISLEK skrkkpcaw LS DQGWEDIILL S EM f S D N F GQLPDDVENN Q 3917
Cdd:COG5245 2766 I -- H R L DV SF LLRT K ---------- RFVSTL L EDKNYRQV --------- LS SCSLYGNDVI S HS - C D R F DRDVYRALKH Q 2823
2730 2740 2750 2760 2770 2780 2790 2800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3918 T vwqewydld SLEQFPVP L GYDNNIT P FQKLLILRCFRVDRVYRAVT D YVTVTM G ekyvqppmisfea IF E QSTP H S P IV 3997
Cdd:COG5245 2824 M --------- DNRTHSTI L TSNSKTN P YKEYTYNDSWAEAFEVEDSG D LYKFEE G ------------- LL E LIVG H A P LI 2881
2810 2820 2830 2840 2850 2860 2870 2880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3998 FIL -- S PGSDPAT D LMKLA E RSGFGGNRLK F lamgqgqekvalqllet AVARGQ W LMLQ N CH L LVK W L K D - L E KSLER I - 4073
Cdd:COG5245 2882 YAH kk S LENERNV D RLGSK E NEVYAVLNSL F ----------------- SRKEKS W FEVY N IS L SFG W F K R y V E DVVYP I k 2944
2890 2900 2910 2920 2930 2940 2950 2960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4074 - TKPHPDF - RL W LTTDPTKGF PI GI L QKSLKV V TEPPNGLKLNM r A TYFK I SHEML D QCPHP A FK p LVYV L AFF HA V V QE 4151
Cdd:COG5245 2945 a SRVCGKV k NM W TSMVDADML PI QL L IAIDSF V SSTYPETGCGY - A DLVE I DRYPF D YTLVI A CD - DAFY L SWE HA A V AS 3022
2970 2980 2990 3000 3010 3020 3030 3040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4152 RRKF G KIGW N VYYD F NES DF QVCMEI L NTY L tka F QQRDPRIP WG SLKY LI GEVM YG GRAIDSF D RRILTI Y MDE Y lgdf 4231
Cdd:COG5245 3023 VISA G PKEN N EEIY F GDK DF EFKTHL L KNI L --- F LNHLNARK WG NNRD LI FTIV YG KKHSLME D SKVVDK Y CRG Y ---- 3095
3050 3060 3070
....*....|....*....|....*....|....
gi 1722218962 4232 ifdtfqp FHFFRNKEVDYKI P V GD EKEKFVEAI E 4265
Cdd:COG5245 3096 ------- GAHETSSQILASV P G GD PELVKFHME E 3122
Dynein_C
pfam18199 Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4288-4586
5.65e-114
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677
Cd Length: 301
Bit Score: 365.02
E-value: 5.65e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4288 T QAARDMWAH LL E LQP QT -- G ESSS G I SR DDYIGQV AK E I EN K M P KV FD LDQVRKRLGT G - LS P TSV VLLQE L ERFNKL V 4364
Cdd:pfam18199 1 T NETNELLST LL S LQP RS ds G GGGG G S SR EEIVLEL AK D I LE K L P EP FD IEEAEEKYPV G y ED P LNT VLLQE I ERFNKL L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4365 VRMTK SL AE LQ R A LA G E V G MS N EL DDV A R SL FI G HI P NI W RRLAPDT LK S LG N W MVYF L R R FS Q YML W V - T E SE P S V M WL 4443
Cdd:pfam18199 81 KVIRR SL QD LQ K A IK G L V V MS S EL EEL A N SL LN G KV P ES W AKKSYPS LK P LG S W IRDL L E R LK Q LQD W L d D E GP P K V F WL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4444 SG LHI P ESY LTA LV Q ATC RKNGWP L D RSTLFTQ VTK FQDAD EV N E RAGQ G CF V S GL Y LEGA D WD IEK GCL IK S K PK V L VV 4523
Cdd:pfam18199 161 SG FFF P QAF LTA VL Q NYA RKNGWP I D KLSFDFE VTK KVSPE EV T E PPED G VY V H GL F LEGA R WD RKN GCL VE S E PK E L FS 240
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1722218962 4524 D LP ILKII P I E AHRL KL Q - NT FRT PVY T TS M R RNA mgv GL VF EA DL F T TRHIS HW V L Q GV C L T L 4586
Cdd:pfam18199 241 P LP VIHLK P V E SDKK KL D e NT YEC PVY K TS E R HST --- NF VF SV DL P T DKPPD HW I L R GV A L L L 301
Name
Accession
Description
Interval
E-value
AAA_6
pfam12774 Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1912-2238
0e+00
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain]
Cd Length: 327
Bit Score: 673.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1912 YGYEY M G LN GRLVITPLTDR I YLTLTQAL SMY LGGAPAGPAGTGKTET T KDLAKAL GLLC VV T NC GE G M DY RAV G K IF S G 1991
Cdd:pfam12774 1 YGYEY L G NS GRLVITPLTDR C YLTLTQAL HLH LGGAPAGPAGTGKTET V KDLAKAL AKQV VV F NC SD G L DY KSM G R IF K G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1992 LAQCGAWGCFDEFNRID AS VLSV ISS QI Q TI RN AL IHQ L T TF Q FEG Q EI S L DSRM GIFITMNPGYAGRTELP ESV KALFR 2071
Cdd:pfam12774 81 LAQCGAWGCFDEFNRID IE VLSV VAQ QI L TI QQ AL AAN L K TF V FEG S EI K L NPSC GIFITMNPGYAGRTELP DNL KALFR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2072 PV VVI VPD LQQ I C EIMLFSEGF LE AK T LAKK MTV LYKL AR EQLSKQ Y HYDFGLRALKSVLV M AG E LKR GSSD L R EDV V L M 2151
Cdd:pfam12774 161 PV AMM VPD YAL I A EIMLFSEGF SD AK V LAKK LVT LYKL CS EQLSKQ D HYDFGLRALKSVLV T AG S LKR SNPN L N EDV L L L 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2152 RALRDMNLPK F V FE DVPLFLGLISDLFPG LDC P RVR Y PDFND A V E Q V LE E N G YAVLPIQVD KV V Q MF ETML T RH TT M V VG 2231
Cdd:pfam12774 241 RALRDMNLPK L V AD DVPLFLGLISDLFPG VEL P PSD Y GELEE A I E E V CK E L G LQPHDAFIL KV I Q LY ETML V RH GV M L VG 320
....*..
gi 1722218962 2232 PT RG GK S 2238
Cdd:pfam12774 321 PT GS GK T 327
DHC_N1
pfam08385 Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
306-876
2.03e-176
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457
Cd Length: 560
Bit Score: 555.65
E-value: 2.03e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 306 VDI LE QC VI N W LN QI STA veaq LK KTP QG K -- GPLAEIEFW RE R N A T LS ALH EQ T K L P I V R KVL DVIKESD S MLVANLQP 383
Cdd:pfam08385 1 LHA LE SV VI K W TK QI QDV ---- LK EDS QG R np GPLAEIEFW KS R E A N LS SIY EQ L K S P E V K KVL EILEAAK S SYLPAFKA 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 384 VF TEL FKFHT EA S DNV RF L S T V ER Y F KNITHGSGFHVVLDT IP AM M SAL R MV W I ISR H YN KD ERM IP L M E R I AWEIA E RV 463
Cdd:pfam08385 77 LD TEL TDALN EA K DNV KY L K T L ER P F EDLEELTDPPEIIEA IP PL M NTI R LI W S ISR Y YN TS ERM TV L L E K I SNQLI E QC 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 464 CRVVNLRTL F KENRAS A QS K TL E ARNT L RL WK KA Y FD TR A K I E A S G RE DR W E F DRKRL F E R T D YMATICQDLSDVLQIL E 543
Cdd:pfam08385 157 KKYLSPEGI F DGDVEE A LE K LQ E CIEL L EA WK EE Y KK TR E K L E E S P RE RP W D F SERYI F G R F D AFLERLEKILELFETI E 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 544 E F ------ YNIF GPEL KA V tgdpkr I DDV L CRVDGLVTPMENL T F D PFSIKSSQ f WKYVMD EFK IEVLVI E KEAKH FID E 617
Cdd:pfam08385 237 Q F skleki GGTK GPEL EG V ------ I EEI L EEFQEAYKVFKSK T Y D ILDVSNEG - FDDDYE EFK ERIKDL E RRLQA FID Q 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 618 S F KTL RS A E A AF DM L LK F KHIRS R EAVNRQMMM K FN D I L AQYC KE I D IIN KIF VQNLE NP - P LY KN H PPVAGAI Y W E R S L 696
Cdd:pfam08385 310 A F DDA RS T E S AF KL L RI F EFLLE R PIIRGALEE K YT D L L QMFK KE L D AVK KIF DKQKY NP s P IA KN M PPVAGAI I W A R Q L 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 697 F F RI KHTIL RF Q E VQEI L DSDR G QE V KQ KY L E VGRTMK EYE DRK YE Q W MEVT E QVLPALM K KS LL TKSS iateepstl E R 776
Cdd:pfam08385 390 F R RI QEPMK RF K E ELGL L KHAE G KK V IK KY N E LAKKLD EYE RLI YE A W LKEV E EASEGNL K RP LL VRHP --------- E T 460
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 777 G AVFAI NF S P A L REIIN E T KYL EQ LGF TV PE L A R N V AL Q E DKFLR Y TAGIQRMLDH Y HMLIG TL NDA E SV LL KD H SQELL 856
Cdd:pfam08385 461 G KLLSV NF D P Q L LALLR E V KYL QK LGF EI PE S A L N I AL K E ERLRP Y AESLELLVRW Y NKIRS TL LPV E RP LL AP H LKDID 540
570 580
....*....|....*....|
gi 1722218962 857 RVFRS G YKR L N WNSLGI GD Y 876
Cdd:pfam08385 541 EKLEP G LTT L T WNSLGI DE Y 560
DHC_N2
pfam08393 Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1372-1777
1.06e-159
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain]
Cd Length: 402
Bit Score: 501.02
E-value: 1.06e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1372 L LKVQ KE MSG L RMIYE L YEGLKVAK EEW SQTLWIN L N V QI L Q E GI E G FL RA L R KLP RPV R GLS V TYY L EA K MKA FK D S I P 1451
Cdd:pfam08393 1 L EEIK KE LEP L KKLWD L VSEWQESL EEW KNGPFSD L D V EE L E E EL E E FL KE L K KLP KEL R DWD V AEE L KK K IDD FK K S L P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1452 L LL DL K N E ALR D RHWK E L M E KTSVF F EM - T E T FTL ENMFAME LHK HTDVLN EI VTA A I KE VA IEKA V K E I LDT W EN M K F T 1530
Cdd:pfam08393 81 L IE DL R N P ALR E RHWK Q L S E ILGFD F DP l S E F FTL GDLLDLN LHK YEEEIE EI SEQ A S KE YS IEKA L K K I EEE W KT M E F E 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1531 V V K Y CKGT qer GY IL GSV DEI IQS LDD NTFN LQS ISG S RF V G PF LQT V HK WEK T LSL IG E VIEI W ML VQRKW M YLE S IF I 1610
Cdd:pfam08393 161 L V P Y KDTG --- TF IL KGW DEI QEL LDD HLVK LQS MKS S PY V K PF EEE V SE WEK K LSL LQ E ILDE W LK VQRKW L YLE P IF S 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1611 GG DIR S QLPEEAK K F D N I DK VF K R IM GETL KDP VIKRC C EA P NR L SD L QNVS E G LEK C QKSLN D YL DS KR N AFPRF F F I S 1690
Cdd:pfam08393 238 SE DIR K QLPEEAK R F Q N V DK EW K K IM KKAV KDP NVLEA C NI P GL L EK L EELN E L LEK I QKSLN E YL EK KR L AFPRF Y F L S 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1691 D DELL S IL G - SS DP LC VQ E H MI K MYDN IASL R F ND gdsg E K LVSA MIS A EGEV ME F R K - ILR A E G R VE D W MTAVLN EMR R 1768
Cdd:pfam08393 318 N DELL E IL S q TK DP TR VQ P H LK K CFEG IASL E F DE ---- N K EITG MIS K EGEV VP F S K p PVE A K G N VE E W LNELEE EMR E 393
....*....
gi 1722218962 1769 T N R LIT KEA 1777
Cdd:pfam08393 394 T L R DLL KEA 402
AAA_8
pfam12780 P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2891-3150
7.96e-118
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain]
Cd Length: 259
Bit Score: 374.25
E-value: 7.96e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2891 M N LVLF D DALEHL T R VH RI I R MD RGHALLVGVGGSG K QSL SR LAAF T A SC E V F E I LLS R G Y SE N S FREDLK SLYL K L GI E 2970
Cdd:pfam12780 1 M D LVLF R DALEHL C R IC RI L R QP RGHALLVGVGGSG R QSL TK LAAF I A GY E L F Q I EVT R N Y DM N E FREDLK KVLK K A GI K 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2971 N K AMI FL FT D AHVA EE G FLE L INN M L T SG I VP A LF SE EEKE S I LSQIGQE A LK Q GMGPAK E S V WQ YFV NKSA NNLHIVL G 3050
Cdd:pfam12780 81 G K PTV FL LS D TQII EE S FLE D INN L L N SG E VP N LF TD EEKE E I IESVRDD A KA Q NIEDSR E A V YN YFV KRCR NNLHIVL C 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3051 MSPVG DTL R TWC R N FP GM VN NTG IDWF MP WP PQ AL H AVA KS FL G y NPM IP A E NIE NVVK HV V L VH Q SV DHY S QQ F LQK L R 3130
Cdd:pfam12780 161 MSPVG EAF R NRL R M FP SL VN CCT IDWF NE WP EE AL L AVA EK FL E - DIE IP E E LKS NVVK VF V Y VH S SV EDM S KK F YEE L K 239
250 260
....*....|....*....|
gi 1722218962 3131 R S NYVTPK N YL DFINT Y SK L 3150
Cdd:pfam12780 240 R K NYVTPK S YL ELLRL Y KN L 259
DYN1
COG5245 Dynein, heavy chain [Cytoskeleton];
1274-4265
1.65e-114
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain]
Cd Length: 3164
Bit Score: 411.69
E-value: 1.65e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1274 S IW S N LF NDSVNV EH AL G d IKRT F TELT R ge I MNYRVQIEEFAKRFY S E g PG SVGDDL D K G V E L lgv YERELARHEKSRQ 1353
Cdd:COG5245 339 S LE S S LF YEFRGG EH LA G - FYSA F GDIK R -- I LLFTWSFKKLGTLLP S L - PG YSSGGM D Y G E E Y --- RSLLWELGSEVGD 411
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1354 ELANAEKLFDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQ T LW in LNVQILQEGIEGF L RA l RKLP R P V R g L 1433
Cdd:COG5245 412 PDSGPVRKWMRKDLFDAKVRSGVSFGKQEEFVSDIFNITFERIHGMDP T TL -- EDDEEDTPALAIL L GQ - EEAG R F V K - L 487
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1434 SVTYYLEAKMKAFKDSIPLL L DLKNEALR dr HWKELMEKTSV F FEMTETFTLENMF a M ELHKHTD V LNEIVTAAIK E VA - 1512
Cdd:COG5245 488 CKIMRMFSFFNSLEMFSRRT L ANRMAIVK -- YLSSVVRTGPL F LQRDFFGRMSELL - M ARDMFME V DGVLRLFFGG E WS g 564
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1513 - IEKAVKEILDTWENMKFT -- VVKY C KGTQERGYILGSVDEIIQSL D DNT f N L QSI SGS R fvgpflqt V HKWEKTLSLIG 1589
Cdd:COG5245 565 i VQLSGIRRAKRCVERQID de IREW C SSVLSDDFLEERAVRVERGA D GAR - R L RAS SGS P -------- V LRRLDEYLMMM 635
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1590 EVI eiwmlvqrkwmylesifigg D IRSQL P EEAKKFDNIDKVFKR I MGETLKDPVIKRCCEAPN r LS DL QNVSEGLEKCQ 1669
Cdd:COG5245 636 SLE -------------------- D LMPLI P HAVHRKMSLVSGVRG I YKRVVSGCEAINTILEDV - GD DL DLFYKEMDQVF 694
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1670 K S LNDY L DSKRNAFP R F ff ISDD EL LSILGS - SDPLCVQEHMI K MYDNIASLR - F NDGDSGEKLV S AMIS A EGEVMEFRK 1747
Cdd:COG5245 695 M S IEKV L GLRWREVE R A -- SEVE EL MDRVRE l ENRVYSYRFFV K KIAKEEMKT v F SSRIQKKEPF S LDSE A YVGFFRLYE 772
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1748 ILRAEGRVEDW M TA VL NEMRRTNRLITKEAIFRYCED R S RV DWML L YQ G M vvlaasqvw WTWEV E DV F hkaqkge KQAMK 1827
Cdd:COG5245 773 KSIVIRGINRS M GR VL SQYLESVQEALEIEDGSFFVS R H RV RDGG L EK G R --------- GCDAW E NC F ------- DPPLS 836
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1828 N Y G R KMHRQIDELVTR itmp LSKNDR K KYNTVLI I DVHARD I VDSFIRGSILEAREFDWE S QLRFY w DREPDELNIRQCT 1907
Cdd:COG5245 837 E Y F R ILEKIFPSEEGY ---- FFDEVL K RLDPGHE I KSRIEE I IRMVTVKYDFCLEVLGSV S ISELP - QGLYKRFIKVRSS 911
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1908 GTFGYGYEYMGLNGRLVITPLTDRIYLT L TQ A LSMYL ggap AGPAG T GKTETTKD L AKAL G LLC vvtncg E G MDY R A vg K 1987
Cdd:COG5245 912 YRSAEMFAKNTIPFFVFEHSMDTSQHQK L FE A VCDEV ---- CRFVD T ENSRVYGM L VAGK G RIY ------ D G TEP R S -- R 979
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1988 I FS G LAQCGAW G c FD E FNRI D ASVLS v I SSQIQTIRNAL -- IHQ L TTFQF E gq EISLDSRMGIFITM N P gyag R TELP E S 2065
Cdd:COG5245 980 I EA G PICEEER G - TE E SALL D EISRT - I LVDEYLNSDEF rm LEE L NSAVV E -- HGLKSPSTPVEMII N E ---- R NIVL E I 1051
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2066 VKALFRPVVVIV P d LQQ I CEIM lfsegflea KT L AKKMTVLYKLAREQLSKQYHYD F gl RALKSV L vmagelk RGSSDLR 2145
Cdd:COG5245 1052 GRRALDMFLSNI P - FGA I KSRR --------- ES L DREIGAFNNEVDGIAREEDELM F -- YPMFKS L ------- KAKHRML 1112
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2146 E DVV -- L MRA L RDMN LP kfvfedvplflg LISD - L FPGL D CPRVRYPD F NDAV E QVLEENGYA V LPIQ V DKV V QMFETML 2222
Cdd:COG5245 1113 E EKT ey L NKI L SITG LP ------------ LISD t L RERI D TLDAEWDS F CRIS E SLKKYESQQ V SGLD V AQF V SFLRSVD 1180
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2223 T RHTTMVVGPTRGG K SVVINTL C Q aqtklglttkl Y ILNP K AVS V IEL Y gi L D PTT r DWT d GVLSNIF RE INKPTDKKER 2302
Cdd:COG5245 1181 T GAFHAEYFRVFLC K IKHYTDA C D ----------- Y LWHV K SPY V KKK Y -- F D ADM - ELR - QFFLMFN RE DMEARLADSK 1245
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2303 KYILFDG dvdal W VE NMNSVMDDNR L LTLAN GE R irlqahc ALLFEVGD lqy ASPAT V S RC GMV Y VDPKN L KYRPYWKKW 2382
Cdd:COG5245 1246 MEYEVER ----- Y VE KTKAEVSSLK L ELSSV GE G ------- QVVVSNLG --- SIGDK V G RC LVE Y DSISR L STKGVFLDE 1310
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2383 VNQ ---- IPNKVEQYNLNSLFE K YVPY L MD V IVEGIV dg R QAEK L KT IV PQTDLNM V -------------- TQ LA KM L D a 2444
Cdd:COG5245 1311 LGD tkry LDECLDFFSCFEEVQ K EIDE L SM V FCADAL -- R FSAD L YH IV KERRFSG V lagsdaseslggks IE LA AI L E - 1387
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2445 l LEGE I EDLDLLECYF L ea LYCSL G ASLL E DGR mkfdeyik R LASL S TV D TEGVWANPGELPGQ L PTLYDFHFDNKR N QW 2524
Cdd:COG5245 1388 - HKDL I VEMKRGINDV L -- KLRIF G DKCR E STP -------- R FYLI S DG D LIKDLNERSDYEEM L IMMFNISAVITN N GS 1456
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2525 VPWSK L VP E YIHAPE rkfi NILVH T V DT TRTTWILEQMVKIKQPV I FV G ES G TS K TATTQNF L K nl SE ETNI V LMV NFS S 2604
Cdd:COG5245 1457 IAGFE L RG E RVMLRK ---- EVVIP T S DT GFVDSFSNEALNTLRSY I YC G PP G SG K EMLMCPS L R -- SE LITE V KYF NFS T 1530
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2605 R T TSMDIQRN LE ANV E KRTKD ---- T Y GP P MG K R L LV F M D DM N M P RVD EY GTQQP I AL L KL L L E K - G YLYDRGKEL nc KS 2679
Cdd:COG5245 1531 C T MTPSKLSV LE RET E YYPNT gvvr L Y PK P VV K D L VL F C D EI N L P YGF EY YPPTV I VF L RP L V E R q G FWSSIAVSW -- VT 1608
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2680 I RDLGFIA A MGKAGG - GR NEVDP RFI SLFSVFNVPF P SEE SL HL IY SSI L K G ------ HTSTFH E SIVAV S GK L TFCTLA 2752
Cdd:COG5245 1609 I CGIILYG A CNPGTD e GR VKYYE RFI RKPVFVFCCY P ELA SL RN IY EAV L M G sylcfd EFNRLS E ETMSA S VE L YLSSKD 1688
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2753 LY K NIV Q D lpptpskf H Y IFNL R D L S R V --- FN G LVL T NPE rf QTVAQMVRV W RN E CL R VFH DRL ISETDKQLVQ Q HIGS 2829
Cdd:COG5245 1689 KT K FFL Q M -------- N Y GYKP R E L T R S lra IF G YAE T RID -- TPDVSLIID W YC E AI R EKI DRL VQQKESSTSR Q DLYD 1758
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2830 LVVEHFKD - DVEVVMRDP I L F GD --- F Q MA L hegepriyedi QDYEAAKALFQ E ILEEYNE S NTKMNL V LFD DAL E H LT R 2905
Cdd:COG5245 1759 FGLRAIRE m IAGHIGEAE I T F SM ilf F G MA C ----------- LLKKDLAVFVE E VRKIFGS S HLDVEA V AYK DAL L H IL R 1827
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2906 VH R IIRMDR GH AL L V GV GGS G KQSLSRLAAFTASCEVF EI LLS R GYSENS FR ED LK SLY L KLG I ENKAMIFLFTDAHVA E 2985
Cdd:COG5245 1828 SR R GLLVVG GH GV L K GV LIR G ACDAREFVCWLNPRNMR EI FGH R DELTGD FR DS LK VQD L RRN I HGGRECLFIFESIPV E 1907
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2986 EG FLE LI N NM L TSGIVPA LFS EE E KES I LSQIGQEALKQGMG - PAKESVWQY F VNKSAN NL HI V LGMSPVG DT LRTWCRN 3064
Cdd:COG5245 1908 SS FLE DF N PL L DNNRFLC LFS GN E RIR I PENLRFVFESTSLE k DTEATLTRV F LVYMEE NL PV V FSACCSQ DT SVLAGIR 1987
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3065 F P GMV N NTG ID WFMP W PPQALHAV A K S FL ------ G YNPM I PA E -- NIENVVKHV V LVHQS V DHYSQQ F LQKLRR - S NYV 3135
Cdd:COG5245 1988 S P ALK N RCF ID FKKL W DTEEMSQY A N S VE tlsrdg G RVFF I NG E lg VGKGALISE V FGDDA V VIEGRG F EISMIE g S LGE 2067
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3136 TPKNYLDFINT Y SKLLDEKTQCNIAQCKR L DG G LD K LK E ATIQLD EL NQK L AEQKIV L AE K SAACEAL L E ------- E IA 3208
Cdd:COG5245 2068 SKIKFIGGLKV Y DARCVIYIEELDCTNVN L VE G VR K YN E YGRGMG EL KEQ L SNTVVI L GV K EKNADDA L S gtpgerl E RE 2147
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3209 V NTAVA E EKKKLAEEKAM E IEEQNKVIAME K AEAETTLA E vmpilea A K L ELQ K LD K SDVT EIRSF AK PP KQVQTVC E CI 3288
Cdd:COG5245 2148 V KSVFV E APRDMLFLLEE E VRKRKGSVMKF K SSKKPAVL E ------- A V L FVY K IK K ASLR EIRSF IR PP GDLCIEM E DV 2220
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3289 LIMK G YKELN W KTAKGVMSD ---- PNFLRSLM EI D FD si TQSQVKNIKGLLKTLNT T TEEMEAV SKA GLGMLKFVEAVMG 3364
Cdd:COG5245 2221 CDLL G FEAKI W FGEQQSLRR ddfi RIIGKYPD EI E FD -- LEARRFREARECSDPSF T GSILNRA SKA CGPLKRWLVRECN 2298
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3365 YCD V FREIK P K RE KVA R LERNFY L TK rel E R IQNELAAIQK --- ELETLGAK Y EAA IL EKQKLQEEAEIMERRLIAADKL 3441
Cdd:COG5245 2299 RSK V LEVKI P L RE EEK R IDGEAF L VE --- D R LTLGKGLSSD lmt FKLRRRSY Y SLD IL RVHGKIADMDTVHKDVLRSIFV 2375
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3442 ISG L GS E NIR W LNDLD E LMHRR V K L L GD CLLCAAFLS Y E G af T WE F RDEMVNRIWQNDILER E IPLSQPF R --- LESLLT 3518
Cdd:COG5245 2376 SEI L IN E DSE W GGVFS E VPKLM V E L D GD GHPSSCLHP Y I G -- T LG F LCRAIEFGMSFIRISK E FRDKEIR R rqf ITEGVQ 2453
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3519 DDVE i SRWGSQ glp PDELSVQ N - G I LTTRASRFPLCI DP QQQALNWIKRKEEKNNLRVA SF NDPD F LKQ L EMSIKY G TPF 3597
Cdd:COG5245 2454 KIED - FKEEAC --- STDYGLE N s R I RKDLQDLTAVLN DP SSKIVTSQRQMYDEKKAILG SF REME F AFG L SQARRE G SDK 2529
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3598 LFR D V d E YI D PV I DNVLEKNI K VSQGRQFIILGDK E VDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLK G L E DQL 3677
Cdd:COG5245 2530 IIG D A - E AL D EE I GRLIKEEF K SNLSEVKVMINPP E IVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVL G C E TEI 2608
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3678 LSV L VAYERRE L EEQREH L IQETSENKNL L KD L EDS LL RE L AT S TG NM LDNVDLVHT L EET K SKAT E VS E KLKLAEKTAL 3757
Cdd:COG5245 2609 PDA L EKLVSGP L FVHEKA L NALKACGSLF L WV L ARY LL AK L ML S IS NM EQTDEIAVL L HNL K KSRK E IE E EESESMEIED 2688
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3758 D ID R L RDG Y RPAAR R GAILFFVLSEMALVNS MY QY S LIAFLEV F RLSLKKS lpd S ILMKRL R NIMDTLTFSIYNHGCT G L 3837
Cdd:COG5245 2689 R ID A L KSE Y NASVK R LESIRVEIAMFDEKAL MY NK S ICELSSE F EKWRRMK --- S KYLCAI R YMLMSSEWILDHEDRS G F 2765
2650 2660 2670 2680 2690 2700 2710 2720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3838 F er H K L LF SF NMTI K ieqaegrvpq EELDFF L KGNISLEK skrkkpcaw LS DQGWEDIILL S EM f S D N F GQLPDDVENN Q 3917
Cdd:COG5245 2766 I -- H R L DV SF LLRT K ---------- RFVSTL L EDKNYRQV --------- LS SCSLYGNDVI S HS - C D R F DRDVYRALKH Q 2823
2730 2740 2750 2760 2770 2780 2790 2800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3918 T vwqewydld SLEQFPVP L GYDNNIT P FQKLLILRCFRVDRVYRAVT D YVTVTM G ekyvqppmisfea IF E QSTP H S P IV 3997
Cdd:COG5245 2824 M --------- DNRTHSTI L TSNSKTN P YKEYTYNDSWAEAFEVEDSG D LYKFEE G ------------- LL E LIVG H A P LI 2881
2810 2820 2830 2840 2850 2860 2870 2880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3998 FIL -- S PGSDPAT D LMKLA E RSGFGGNRLK F lamgqgqekvalqllet AVARGQ W LMLQ N CH L LVK W L K D - L E KSLER I - 4073
Cdd:COG5245 2882 YAH kk S LENERNV D RLGSK E NEVYAVLNSL F ----------------- SRKEKS W FEVY N IS L SFG W F K R y V E DVVYP I k 2944
2890 2900 2910 2920 2930 2940 2950 2960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4074 - TKPHPDF - RL W LTTDPTKGF PI GI L QKSLKV V TEPPNGLKLNM r A TYFK I SHEML D QCPHP A FK p LVYV L AFF HA V V QE 4151
Cdd:COG5245 2945 a SRVCGKV k NM W TSMVDADML PI QL L IAIDSF V SSTYPETGCGY - A DLVE I DRYPF D YTLVI A CD - DAFY L SWE HA A V AS 3022
2970 2980 2990 3000 3010 3020 3030 3040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4152 RRKF G KIGW N VYYD F NES DF QVCMEI L NTY L tka F QQRDPRIP WG SLKY LI GEVM YG GRAIDSF D RRILTI Y MDE Y lgdf 4231
Cdd:COG5245 3023 VISA G PKEN N EEIY F GDK DF EFKTHL L KNI L --- F LNHLNARK WG NNRD LI FTIV YG KKHSLME D SKVVDK Y CRG Y ---- 3095
3050 3060 3070
....*....|....*....|....*....|....
gi 1722218962 4232 ifdtfqp FHFFRNKEVDYKI P V GD EKEKFVEAI E 4265
Cdd:COG5245 3096 ------- GAHETSSQILASV P G GD PELVKFHME E 3122
Dynein_C
pfam18199 Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4288-4586
5.65e-114
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677
Cd Length: 301
Bit Score: 365.02
E-value: 5.65e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4288 T QAARDMWAH LL E LQP QT -- G ESSS G I SR DDYIGQV AK E I EN K M P KV FD LDQVRKRLGT G - LS P TSV VLLQE L ERFNKL V 4364
Cdd:pfam18199 1 T NETNELLST LL S LQP RS ds G GGGG G S SR EEIVLEL AK D I LE K L P EP FD IEEAEEKYPV G y ED P LNT VLLQE I ERFNKL L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4365 VRMTK SL AE LQ R A LA G E V G MS N EL DDV A R SL FI G HI P NI W RRLAPDT LK S LG N W MVYF L R R FS Q YML W V - T E SE P S V M WL 4443
Cdd:pfam18199 81 KVIRR SL QD LQ K A IK G L V V MS S EL EEL A N SL LN G KV P ES W AKKSYPS LK P LG S W IRDL L E R LK Q LQD W L d D E GP P K V F WL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4444 SG LHI P ESY LTA LV Q ATC RKNGWP L D RSTLFTQ VTK FQDAD EV N E RAGQ G CF V S GL Y LEGA D WD IEK GCL IK S K PK V L VV 4523
Cdd:pfam18199 161 SG FFF P QAF LTA VL Q NYA RKNGWP I D KLSFDFE VTK KVSPE EV T E PPED G VY V H GL F LEGA R WD RKN GCL VE S E PK E L FS 240
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1722218962 4524 D LP ILKII P I E AHRL KL Q - NT FRT PVY T TS M R RNA mgv GL VF EA DL F T TRHIS HW V L Q GV C L T L 4586
Cdd:pfam18199 241 P LP VIHLK P V E SDKK KL D e NT YEC PVY K TS E R HST --- NF VF SV DL P T DKPPD HW I L R GV A L L L 301
AAA_9
pfam12781 ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3524-3745
4.55e-102
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain]
Cd Length: 222
Bit Score: 327.48
E-value: 4.55e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3524 SR W GS QGLP P DELS VQ N G I LT T RAS R F PL C IDPQ Q QA LN WIK RK E EK N N L R V A SF N D PD FLK Q LE MS I KY G T P F L FR DV D 3603
Cdd:pfam12781 1 RE W NI QGLP N DELS IE N A I IV T NSR R W PL L IDPQ G QA NK WIK NM E KD N G L K V T SF T D KN FLK T LE NA I RF G K P L L IE DV G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3604 E YI DP VI D N VL E K N I KVSQ GR QF I I LGDKEVDY DS NFRLYL N TKL A NP R Y S P S V FG K AMV IN Y TVT LK GLEDQLL SVL V A 3683
Cdd:pfam12781 81 E EL DP IL D P VL L K E I FKGG GR KV I K LGDKEVDY NP NFRLYL T TKL P NP H Y P P E V AA K VTL IN F TVT RS GLEDQLL GIV V K 160
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1722218962 3684 Y ER RE LEEQR EH LI Q E TS ENK NL LK D LED S LL RE L AT S T GN M LD NVD L VH TLE ET K SKAT E V 3745
Cdd:pfam12781 161 K ER PD LEEQR NE LI K E IA ENK KQ LK E LED K LL EL L SS S E GN I LD DEE L IE TLE TS K KTSE E I 222
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3165-3442
5.09e-03
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 43.13
E-value: 5.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3165 L DGGLDK L KEATIQ LDEL N Q K L -- A EQ KI VLA EK SA ac E A L LE E IAVNTAVA EE KKKLAEEKAM EIE ---- E QNKVI A m E 3238
Cdd:TIGR02169 690 L SSLQSE L RRIENR LDEL S Q E L sd A SR KI GEI EK EI -- E Q L EQ E EEKLKERL EE LEEDLSSLEQ EIE nvks E LKELE A - R 766
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3239 KA E A E TT L AEVM pi LEAAK LE l QK L DK S DVT EI RSFAKPPKQVQTVC E CI L I mkgyk E LNW K TAK g VMSDPNF L RSLMEI 3318
Cdd:TIGR02169 767 IE E L E ED L HKLE -- EALND LE - AR L SH S RIP EI QAELSKLEEEVSRI E AR L R ----- E IEQ K LNR - LTLEKEY L EKEIQE 837
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3319 DFDSI -- TQS Q V K N I KGLLKT LN TTT EE M E A vskaglgmlkfveavmgycdvfr E IKPKREKVAR LE RNFYLT K R E LERI 3396
Cdd:TIGR02169 838 LQEQR id LKE Q I K S I EKEIEN LN GKK EE L E E ----------------------- E LEELEAALRD LE SRLGDL K K E RDEL 894
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1722218962 3397 QNE L AAIQKEL E T L G A KY E AAILEKQK L QEEA E IM E RR L IAADKLI 3442
Cdd:TIGR02169 895 EAQ L RELERKI E E L E A QI E KKRKRLSE L KAKL E AL E EE L SEIEDPK 940
PRK03918
PRK03918 DNA double-strand break repair ATPase Rad50;
3170-3458
9.49e-03
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain]
Cd Length: 880
Bit Score: 42.36
E-value: 9.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3170 D K LKEATIQ L D EL NQK L AEQKIVLAE K S aacea L L E EIA vntavaeekkklaeekam E I EE QN K VIAM E KA E AETTLA E V 3249
Cdd:PRK03918 473 E K ERKLRKE L R EL EKV L KKESELIKL K E ----- L A E QLK ------------------ E L EE KL K KYNL E EL E KKAEEY E K 529
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3250 M pileaa K LE L Q KL DK sdvt EI R S FA K PPKQVQTV - CECILIM K GYK EL NWKT A kgvmsdp NF L RS L M E ID F D S I tqsqv 3328
Cdd:PRK03918 530 L ------ K EK L I KL KG ---- EI K S LK K ELEKLEEL k KKLAELE K KLD EL EEEL A ------- EL L KE L E E LG F E S V ----- 587
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3329 knikgll KT L NTTTE E M E AVSK aglgml KFV E AV mgyc D VFR E IKPKREKVAR LE RNFYLTKR EL ERIQNE L AAIQ KELE 3408
Cdd:PRK03918 588 ------- EE L EERLK E L E PFYN ------ EYL E LK ---- D AEK E LEREEKELKK LE EELDKAFE EL AETEKR L EELR KELE 650
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1722218962 3409 T L GA KY EAA il E KQK L Q EE AEIME R R L IAADKLISG L GS --- E NIRW L ND L D E 3458
Cdd:PRK03918 651 E L EK KY SEE -- E YEE L R EE YLELS R E L AGLRAELEE L EK rre E IKKT L EK L K E 701
Name
Accession
Description
Interval
E-value
AAA_6
pfam12774 Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1912-2238
0e+00
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain]
Cd Length: 327
Bit Score: 673.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1912 YGYEY M G LN GRLVITPLTDR I YLTLTQAL SMY LGGAPAGPAGTGKTET T KDLAKAL GLLC VV T NC GE G M DY RAV G K IF S G 1991
Cdd:pfam12774 1 YGYEY L G NS GRLVITPLTDR C YLTLTQAL HLH LGGAPAGPAGTGKTET V KDLAKAL AKQV VV F NC SD G L DY KSM G R IF K G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1992 LAQCGAWGCFDEFNRID AS VLSV ISS QI Q TI RN AL IHQ L T TF Q FEG Q EI S L DSRM GIFITMNPGYAGRTELP ESV KALFR 2071
Cdd:pfam12774 81 LAQCGAWGCFDEFNRID IE VLSV VAQ QI L TI QQ AL AAN L K TF V FEG S EI K L NPSC GIFITMNPGYAGRTELP DNL KALFR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2072 PV VVI VPD LQQ I C EIMLFSEGF LE AK T LAKK MTV LYKL AR EQLSKQ Y HYDFGLRALKSVLV M AG E LKR GSSD L R EDV V L M 2151
Cdd:pfam12774 161 PV AMM VPD YAL I A EIMLFSEGF SD AK V LAKK LVT LYKL CS EQLSKQ D HYDFGLRALKSVLV T AG S LKR SNPN L N EDV L L L 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2152 RALRDMNLPK F V FE DVPLFLGLISDLFPG LDC P RVR Y PDFND A V E Q V LE E N G YAVLPIQVD KV V Q MF ETML T RH TT M V VG 2231
Cdd:pfam12774 241 RALRDMNLPK L V AD DVPLFLGLISDLFPG VEL P PSD Y GELEE A I E E V CK E L G LQPHDAFIL KV I Q LY ETML V RH GV M L VG 320
....*..
gi 1722218962 2232 PT RG GK S 2238
Cdd:pfam12774 321 PT GS GK T 327
DHC_N1
pfam08385 Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
306-876
2.03e-176
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457
Cd Length: 560
Bit Score: 555.65
E-value: 2.03e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 306 VDI LE QC VI N W LN QI STA veaq LK KTP QG K -- GPLAEIEFW RE R N A T LS ALH EQ T K L P I V R KVL DVIKESD S MLVANLQP 383
Cdd:pfam08385 1 LHA LE SV VI K W TK QI QDV ---- LK EDS QG R np GPLAEIEFW KS R E A N LS SIY EQ L K S P E V K KVL EILEAAK S SYLPAFKA 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 384 VF TEL FKFHT EA S DNV RF L S T V ER Y F KNITHGSGFHVVLDT IP AM M SAL R MV W I ISR H YN KD ERM IP L M E R I AWEIA E RV 463
Cdd:pfam08385 77 LD TEL TDALN EA K DNV KY L K T L ER P F EDLEELTDPPEIIEA IP PL M NTI R LI W S ISR Y YN TS ERM TV L L E K I SNQLI E QC 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 464 CRVVNLRTL F KENRAS A QS K TL E ARNT L RL WK KA Y FD TR A K I E A S G RE DR W E F DRKRL F E R T D YMATICQDLSDVLQIL E 543
Cdd:pfam08385 157 KKYLSPEGI F DGDVEE A LE K LQ E CIEL L EA WK EE Y KK TR E K L E E S P RE RP W D F SERYI F G R F D AFLERLEKILELFETI E 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 544 E F ------ YNIF GPEL KA V tgdpkr I DDV L CRVDGLVTPMENL T F D PFSIKSSQ f WKYVMD EFK IEVLVI E KEAKH FID E 617
Cdd:pfam08385 237 Q F skleki GGTK GPEL EG V ------ I EEI L EEFQEAYKVFKSK T Y D ILDVSNEG - FDDDYE EFK ERIKDL E RRLQA FID Q 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 618 S F KTL RS A E A AF DM L LK F KHIRS R EAVNRQMMM K FN D I L AQYC KE I D IIN KIF VQNLE NP - P LY KN H PPVAGAI Y W E R S L 696
Cdd:pfam08385 310 A F DDA RS T E S AF KL L RI F EFLLE R PIIRGALEE K YT D L L QMFK KE L D AVK KIF DKQKY NP s P IA KN M PPVAGAI I W A R Q L 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 697 F F RI KHTIL RF Q E VQEI L DSDR G QE V KQ KY L E VGRTMK EYE DRK YE Q W MEVT E QVLPALM K KS LL TKSS iateepstl E R 776
Cdd:pfam08385 390 F R RI QEPMK RF K E ELGL L KHAE G KK V IK KY N E LAKKLD EYE RLI YE A W LKEV E EASEGNL K RP LL VRHP --------- E T 460
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 777 G AVFAI NF S P A L REIIN E T KYL EQ LGF TV PE L A R N V AL Q E DKFLR Y TAGIQRMLDH Y HMLIG TL NDA E SV LL KD H SQELL 856
Cdd:pfam08385 461 G KLLSV NF D P Q L LALLR E V KYL QK LGF EI PE S A L N I AL K E ERLRP Y AESLELLVRW Y NKIRS TL LPV E RP LL AP H LKDID 540
570 580
....*....|....*....|
gi 1722218962 857 RVFRS G YKR L N WNSLGI GD Y 876
Cdd:pfam08385 541 EKLEP G LTT L T WNSLGI DE Y 560
DHC_N2
pfam08393 Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1372-1777
1.06e-159
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain]
Cd Length: 402
Bit Score: 501.02
E-value: 1.06e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1372 L LKVQ KE MSG L RMIYE L YEGLKVAK EEW SQTLWIN L N V QI L Q E GI E G FL RA L R KLP RPV R GLS V TYY L EA K MKA FK D S I P 1451
Cdd:pfam08393 1 L EEIK KE LEP L KKLWD L VSEWQESL EEW KNGPFSD L D V EE L E E EL E E FL KE L K KLP KEL R DWD V AEE L KK K IDD FK K S L P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1452 L LL DL K N E ALR D RHWK E L M E KTSVF F EM - T E T FTL ENMFAME LHK HTDVLN EI VTA A I KE VA IEKA V K E I LDT W EN M K F T 1530
Cdd:pfam08393 81 L IE DL R N P ALR E RHWK Q L S E ILGFD F DP l S E F FTL GDLLDLN LHK YEEEIE EI SEQ A S KE YS IEKA L K K I EEE W KT M E F E 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1531 V V K Y CKGT qer GY IL GSV DEI IQS LDD NTFN LQS ISG S RF V G PF LQT V HK WEK T LSL IG E VIEI W ML VQRKW M YLE S IF I 1610
Cdd:pfam08393 161 L V P Y KDTG --- TF IL KGW DEI QEL LDD HLVK LQS MKS S PY V K PF EEE V SE WEK K LSL LQ E ILDE W LK VQRKW L YLE P IF S 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1611 GG DIR S QLPEEAK K F D N I DK VF K R IM GETL KDP VIKRC C EA P NR L SD L QNVS E G LEK C QKSLN D YL DS KR N AFPRF F F I S 1690
Cdd:pfam08393 238 SE DIR K QLPEEAK R F Q N V DK EW K K IM KKAV KDP NVLEA C NI P GL L EK L EELN E L LEK I QKSLN E YL EK KR L AFPRF Y F L S 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1691 D DELL S IL G - SS DP LC VQ E H MI K MYDN IASL R F ND gdsg E K LVSA MIS A EGEV ME F R K - ILR A E G R VE D W MTAVLN EMR R 1768
Cdd:pfam08393 318 N DELL E IL S q TK DP TR VQ P H LK K CFEG IASL E F DE ---- N K EITG MIS K EGEV VP F S K p PVE A K G N VE E W LNELEE EMR E 393
....*....
gi 1722218962 1769 T N R LIT KEA 1777
Cdd:pfam08393 394 T L R DLL KEA 402
AAA_8
pfam12780 P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2891-3150
7.96e-118
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain]
Cd Length: 259
Bit Score: 374.25
E-value: 7.96e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2891 M N LVLF D DALEHL T R VH RI I R MD RGHALLVGVGGSG K QSL SR LAAF T A SC E V F E I LLS R G Y SE N S FREDLK SLYL K L GI E 2970
Cdd:pfam12780 1 M D LVLF R DALEHL C R IC RI L R QP RGHALLVGVGGSG R QSL TK LAAF I A GY E L F Q I EVT R N Y DM N E FREDLK KVLK K A GI K 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2971 N K AMI FL FT D AHVA EE G FLE L INN M L T SG I VP A LF SE EEKE S I LSQIGQE A LK Q GMGPAK E S V WQ YFV NKSA NNLHIVL G 3050
Cdd:pfam12780 81 G K PTV FL LS D TQII EE S FLE D INN L L N SG E VP N LF TD EEKE E I IESVRDD A KA Q NIEDSR E A V YN YFV KRCR NNLHIVL C 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3051 MSPVG DTL R TWC R N FP GM VN NTG IDWF MP WP PQ AL H AVA KS FL G y NPM IP A E NIE NVVK HV V L VH Q SV DHY S QQ F LQK L R 3130
Cdd:pfam12780 161 MSPVG EAF R NRL R M FP SL VN CCT IDWF NE WP EE AL L AVA EK FL E - DIE IP E E LKS NVVK VF V Y VH S SV EDM S KK F YEE L K 239
250 260
....*....|....*....|
gi 1722218962 3131 R S NYVTPK N YL DFINT Y SK L 3150
Cdd:pfam12780 240 R K NYVTPK S YL ELLRL Y KN L 259
DYN1
COG5245 Dynein, heavy chain [Cytoskeleton];
1274-4265
1.65e-114
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain]
Cd Length: 3164
Bit Score: 411.69
E-value: 1.65e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1274 S IW S N LF NDSVNV EH AL G d IKRT F TELT R ge I MNYRVQIEEFAKRFY S E g PG SVGDDL D K G V E L lgv YERELARHEKSRQ 1353
Cdd:COG5245 339 S LE S S LF YEFRGG EH LA G - FYSA F GDIK R -- I LLFTWSFKKLGTLLP S L - PG YSSGGM D Y G E E Y --- RSLLWELGSEVGD 411
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1354 ELANAEKLFDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQ T LW in LNVQILQEGIEGF L RA l RKLP R P V R g L 1433
Cdd:COG5245 412 PDSGPVRKWMRKDLFDAKVRSGVSFGKQEEFVSDIFNITFERIHGMDP T TL -- EDDEEDTPALAIL L GQ - EEAG R F V K - L 487
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1434 SVTYYLEAKMKAFKDSIPLL L DLKNEALR dr HWKELMEKTSV F FEMTETFTLENMF a M ELHKHTD V LNEIVTAAIK E VA - 1512
Cdd:COG5245 488 CKIMRMFSFFNSLEMFSRRT L ANRMAIVK -- YLSSVVRTGPL F LQRDFFGRMSELL - M ARDMFME V DGVLRLFFGG E WS g 564
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1513 - IEKAVKEILDTWENMKFT -- VVKY C KGTQERGYILGSVDEIIQSL D DNT f N L QSI SGS R fvgpflqt V HKWEKTLSLIG 1589
Cdd:COG5245 565 i VQLSGIRRAKRCVERQID de IREW C SSVLSDDFLEERAVRVERGA D GAR - R L RAS SGS P -------- V LRRLDEYLMMM 635
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1590 EVI eiwmlvqrkwmylesifigg D IRSQL P EEAKKFDNIDKVFKR I MGETLKDPVIKRCCEAPN r LS DL QNVSEGLEKCQ 1669
Cdd:COG5245 636 SLE -------------------- D LMPLI P HAVHRKMSLVSGVRG I YKRVVSGCEAINTILEDV - GD DL DLFYKEMDQVF 694
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1670 K S LNDY L DSKRNAFP R F ff ISDD EL LSILGS - SDPLCVQEHMI K MYDNIASLR - F NDGDSGEKLV S AMIS A EGEVMEFRK 1747
Cdd:COG5245 695 M S IEKV L GLRWREVE R A -- SEVE EL MDRVRE l ENRVYSYRFFV K KIAKEEMKT v F SSRIQKKEPF S LDSE A YVGFFRLYE 772
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1748 ILRAEGRVEDW M TA VL NEMRRTNRLITKEAIFRYCED R S RV DWML L YQ G M vvlaasqvw WTWEV E DV F hkaqkge KQAMK 1827
Cdd:COG5245 773 KSIVIRGINRS M GR VL SQYLESVQEALEIEDGSFFVS R H RV RDGG L EK G R --------- GCDAW E NC F ------- DPPLS 836
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1828 N Y G R KMHRQIDELVTR itmp LSKNDR K KYNTVLI I DVHARD I VDSFIRGSILEAREFDWE S QLRFY w DREPDELNIRQCT 1907
Cdd:COG5245 837 E Y F R ILEKIFPSEEGY ---- FFDEVL K RLDPGHE I KSRIEE I IRMVTVKYDFCLEVLGSV S ISELP - QGLYKRFIKVRSS 911
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1908 GTFGYGYEYMGLNGRLVITPLTDRIYLT L TQ A LSMYL ggap AGPAG T GKTETTKD L AKAL G LLC vvtncg E G MDY R A vg K 1987
Cdd:COG5245 912 YRSAEMFAKNTIPFFVFEHSMDTSQHQK L FE A VCDEV ---- CRFVD T ENSRVYGM L VAGK G RIY ------ D G TEP R S -- R 979
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1988 I FS G LAQCGAW G c FD E FNRI D ASVLS v I SSQIQTIRNAL -- IHQ L TTFQF E gq EISLDSRMGIFITM N P gyag R TELP E S 2065
Cdd:COG5245 980 I EA G PICEEER G - TE E SALL D EISRT - I LVDEYLNSDEF rm LEE L NSAVV E -- HGLKSPSTPVEMII N E ---- R NIVL E I 1051
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2066 VKALFRPVVVIV P d LQQ I CEIM lfsegflea KT L AKKMTVLYKLAREQLSKQYHYD F gl RALKSV L vmagelk RGSSDLR 2145
Cdd:COG5245 1052 GRRALDMFLSNI P - FGA I KSRR --------- ES L DREIGAFNNEVDGIAREEDELM F -- YPMFKS L ------- KAKHRML 1112
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2146 E DVV -- L MRA L RDMN LP kfvfedvplflg LISD - L FPGL D CPRVRYPD F NDAV E QVLEENGYA V LPIQ V DKV V QMFETML 2222
Cdd:COG5245 1113 E EKT ey L NKI L SITG LP ------------ LISD t L RERI D TLDAEWDS F CRIS E SLKKYESQQ V SGLD V AQF V SFLRSVD 1180
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2223 T RHTTMVVGPTRGG K SVVINTL C Q aqtklglttkl Y ILNP K AVS V IEL Y gi L D PTT r DWT d GVLSNIF RE INKPTDKKER 2302
Cdd:COG5245 1181 T GAFHAEYFRVFLC K IKHYTDA C D ----------- Y LWHV K SPY V KKK Y -- F D ADM - ELR - QFFLMFN RE DMEARLADSK 1245
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2303 KYILFDG dvdal W VE NMNSVMDDNR L LTLAN GE R irlqahc ALLFEVGD lqy ASPAT V S RC GMV Y VDPKN L KYRPYWKKW 2382
Cdd:COG5245 1246 MEYEVER ----- Y VE KTKAEVSSLK L ELSSV GE G ------- QVVVSNLG --- SIGDK V G RC LVE Y DSISR L STKGVFLDE 1310
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2383 VNQ ---- IPNKVEQYNLNSLFE K YVPY L MD V IVEGIV dg R QAEK L KT IV PQTDLNM V -------------- TQ LA KM L D a 2444
Cdd:COG5245 1311 LGD tkry LDECLDFFSCFEEVQ K EIDE L SM V FCADAL -- R FSAD L YH IV KERRFSG V lagsdaseslggks IE LA AI L E - 1387
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2445 l LEGE I EDLDLLECYF L ea LYCSL G ASLL E DGR mkfdeyik R LASL S TV D TEGVWANPGELPGQ L PTLYDFHFDNKR N QW 2524
Cdd:COG5245 1388 - HKDL I VEMKRGINDV L -- KLRIF G DKCR E STP -------- R FYLI S DG D LIKDLNERSDYEEM L IMMFNISAVITN N GS 1456
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2525 VPWSK L VP E YIHAPE rkfi NILVH T V DT TRTTWILEQMVKIKQPV I FV G ES G TS K TATTQNF L K nl SE ETNI V LMV NFS S 2604
Cdd:COG5245 1457 IAGFE L RG E RVMLRK ---- EVVIP T S DT GFVDSFSNEALNTLRSY I YC G PP G SG K EMLMCPS L R -- SE LITE V KYF NFS T 1530
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2605 R T TSMDIQRN LE ANV E KRTKD ---- T Y GP P MG K R L LV F M D DM N M P RVD EY GTQQP I AL L KL L L E K - G YLYDRGKEL nc KS 2679
Cdd:COG5245 1531 C T MTPSKLSV LE RET E YYPNT gvvr L Y PK P VV K D L VL F C D EI N L P YGF EY YPPTV I VF L RP L V E R q G FWSSIAVSW -- VT 1608
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2680 I RDLGFIA A MGKAGG - GR NEVDP RFI SLFSVFNVPF P SEE SL HL IY SSI L K G ------ HTSTFH E SIVAV S GK L TFCTLA 2752
Cdd:COG5245 1609 I CGIILYG A CNPGTD e GR VKYYE RFI RKPVFVFCCY P ELA SL RN IY EAV L M G sylcfd EFNRLS E ETMSA S VE L YLSSKD 1688
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2753 LY K NIV Q D lpptpskf H Y IFNL R D L S R V --- FN G LVL T NPE rf QTVAQMVRV W RN E CL R VFH DRL ISETDKQLVQ Q HIGS 2829
Cdd:COG5245 1689 KT K FFL Q M -------- N Y GYKP R E L T R S lra IF G YAE T RID -- TPDVSLIID W YC E AI R EKI DRL VQQKESSTSR Q DLYD 1758
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2830 LVVEHFKD - DVEVVMRDP I L F GD --- F Q MA L hegepriyedi QDYEAAKALFQ E ILEEYNE S NTKMNL V LFD DAL E H LT R 2905
Cdd:COG5245 1759 FGLRAIRE m IAGHIGEAE I T F SM ilf F G MA C ----------- LLKKDLAVFVE E VRKIFGS S HLDVEA V AYK DAL L H IL R 1827
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2906 VH R IIRMDR GH AL L V GV GGS G KQSLSRLAAFTASCEVF EI LLS R GYSENS FR ED LK SLY L KLG I ENKAMIFLFTDAHVA E 2985
Cdd:COG5245 1828 SR R GLLVVG GH GV L K GV LIR G ACDAREFVCWLNPRNMR EI FGH R DELTGD FR DS LK VQD L RRN I HGGRECLFIFESIPV E 1907
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2986 EG FLE LI N NM L TSGIVPA LFS EE E KES I LSQIGQEALKQGMG - PAKESVWQY F VNKSAN NL HI V LGMSPVG DT LRTWCRN 3064
Cdd:COG5245 1908 SS FLE DF N PL L DNNRFLC LFS GN E RIR I PENLRFVFESTSLE k DTEATLTRV F LVYMEE NL PV V FSACCSQ DT SVLAGIR 1987
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3065 F P GMV N NTG ID WFMP W PPQALHAV A K S FL ------ G YNPM I PA E -- NIENVVKHV V LVHQS V DHYSQQ F LQKLRR - S NYV 3135
Cdd:COG5245 1988 S P ALK N RCF ID FKKL W DTEEMSQY A N S VE tlsrdg G RVFF I NG E lg VGKGALISE V FGDDA V VIEGRG F EISMIE g S LGE 2067
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3136 TPKNYLDFINT Y SKLLDEKTQCNIAQCKR L DG G LD K LK E ATIQLD EL NQK L AEQKIV L AE K SAACEAL L E ------- E IA 3208
Cdd:COG5245 2068 SKIKFIGGLKV Y DARCVIYIEELDCTNVN L VE G VR K YN E YGRGMG EL KEQ L SNTVVI L GV K EKNADDA L S gtpgerl E RE 2147
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3209 V NTAVA E EKKKLAEEKAM E IEEQNKVIAME K AEAETTLA E vmpilea A K L ELQ K LD K SDVT EIRSF AK PP KQVQTVC E CI 3288
Cdd:COG5245 2148 V KSVFV E APRDMLFLLEE E VRKRKGSVMKF K SSKKPAVL E ------- A V L FVY K IK K ASLR EIRSF IR PP GDLCIEM E DV 2220
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3289 LIMK G YKELN W KTAKGVMSD ---- PNFLRSLM EI D FD si TQSQVKNIKGLLKTLNT T TEEMEAV SKA GLGMLKFVEAVMG 3364
Cdd:COG5245 2221 CDLL G FEAKI W FGEQQSLRR ddfi RIIGKYPD EI E FD -- LEARRFREARECSDPSF T GSILNRA SKA CGPLKRWLVRECN 2298
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3365 YCD V FREIK P K RE KVA R LERNFY L TK rel E R IQNELAAIQK --- ELETLGAK Y EAA IL EKQKLQEEAEIMERRLIAADKL 3441
Cdd:COG5245 2299 RSK V LEVKI P L RE EEK R IDGEAF L VE --- D R LTLGKGLSSD lmt FKLRRRSY Y SLD IL RVHGKIADMDTVHKDVLRSIFV 2375
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3442 ISG L GS E NIR W LNDLD E LMHRR V K L L GD CLLCAAFLS Y E G af T WE F RDEMVNRIWQNDILER E IPLSQPF R --- LESLLT 3518
Cdd:COG5245 2376 SEI L IN E DSE W GGVFS E VPKLM V E L D GD GHPSSCLHP Y I G -- T LG F LCRAIEFGMSFIRISK E FRDKEIR R rqf ITEGVQ 2453
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3519 DDVE i SRWGSQ glp PDELSVQ N - G I LTTRASRFPLCI DP QQQALNWIKRKEEKNNLRVA SF NDPD F LKQ L EMSIKY G TPF 3597
Cdd:COG5245 2454 KIED - FKEEAC --- STDYGLE N s R I RKDLQDLTAVLN DP SSKIVTSQRQMYDEKKAILG SF REME F AFG L SQARRE G SDK 2529
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3598 LFR D V d E YI D PV I DNVLEKNI K VSQGRQFIILGDK E VDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLK G L E DQL 3677
Cdd:COG5245 2530 IIG D A - E AL D EE I GRLIKEEF K SNLSEVKVMINPP E IVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVL G C E TEI 2608
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3678 LSV L VAYERRE L EEQREH L IQETSENKNL L KD L EDS LL RE L AT S TG NM LDNVDLVHT L EET K SKAT E VS E KLKLAEKTAL 3757
Cdd:COG5245 2609 PDA L EKLVSGP L FVHEKA L NALKACGSLF L WV L ARY LL AK L ML S IS NM EQTDEIAVL L HNL K KSRK E IE E EESESMEIED 2688
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3758 D ID R L RDG Y RPAAR R GAILFFVLSEMALVNS MY QY S LIAFLEV F RLSLKKS lpd S ILMKRL R NIMDTLTFSIYNHGCT G L 3837
Cdd:COG5245 2689 R ID A L KSE Y NASVK R LESIRVEIAMFDEKAL MY NK S ICELSSE F EKWRRMK --- S KYLCAI R YMLMSSEWILDHEDRS G F 2765
2650 2660 2670 2680 2690 2700 2710 2720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3838 F er H K L LF SF NMTI K ieqaegrvpq EELDFF L KGNISLEK skrkkpcaw LS DQGWEDIILL S EM f S D N F GQLPDDVENN Q 3917
Cdd:COG5245 2766 I -- H R L DV SF LLRT K ---------- RFVSTL L EDKNYRQV --------- LS SCSLYGNDVI S HS - C D R F DRDVYRALKH Q 2823
2730 2740 2750 2760 2770 2780 2790 2800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3918 T vwqewydld SLEQFPVP L GYDNNIT P FQKLLILRCFRVDRVYRAVT D YVTVTM G ekyvqppmisfea IF E QSTP H S P IV 3997
Cdd:COG5245 2824 M --------- DNRTHSTI L TSNSKTN P YKEYTYNDSWAEAFEVEDSG D LYKFEE G ------------- LL E LIVG H A P LI 2881
2810 2820 2830 2840 2850 2860 2870 2880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3998 FIL -- S PGSDPAT D LMKLA E RSGFGGNRLK F lamgqgqekvalqllet AVARGQ W LMLQ N CH L LVK W L K D - L E KSLER I - 4073
Cdd:COG5245 2882 YAH kk S LENERNV D RLGSK E NEVYAVLNSL F ----------------- SRKEKS W FEVY N IS L SFG W F K R y V E DVVYP I k 2944
2890 2900 2910 2920 2930 2940 2950 2960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4074 - TKPHPDF - RL W LTTDPTKGF PI GI L QKSLKV V TEPPNGLKLNM r A TYFK I SHEML D QCPHP A FK p LVYV L AFF HA V V QE 4151
Cdd:COG5245 2945 a SRVCGKV k NM W TSMVDADML PI QL L IAIDSF V SSTYPETGCGY - A DLVE I DRYPF D YTLVI A CD - DAFY L SWE HA A V AS 3022
2970 2980 2990 3000 3010 3020 3030 3040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4152 RRKF G KIGW N VYYD F NES DF QVCMEI L NTY L tka F QQRDPRIP WG SLKY LI GEVM YG GRAIDSF D RRILTI Y MDE Y lgdf 4231
Cdd:COG5245 3023 VISA G PKEN N EEIY F GDK DF EFKTHL L KNI L --- F LNHLNARK WG NNRD LI FTIV YG KKHSLME D SKVVDK Y CRG Y ---- 3095
3050 3060 3070
....*....|....*....|....*....|....
gi 1722218962 4232 ifdtfqp FHFFRNKEVDYKI P V GD EKEKFVEAI E 4265
Cdd:COG5245 3096 ------- GAHETSSQILASV P G GD PELVKFHME E 3122
Dynein_C
pfam18199 Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4288-4586
5.65e-114
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677
Cd Length: 301
Bit Score: 365.02
E-value: 5.65e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4288 T QAARDMWAH LL E LQP QT -- G ESSS G I SR DDYIGQV AK E I EN K M P KV FD LDQVRKRLGT G - LS P TSV VLLQE L ERFNKL V 4364
Cdd:pfam18199 1 T NETNELLST LL S LQP RS ds G GGGG G S SR EEIVLEL AK D I LE K L P EP FD IEEAEEKYPV G y ED P LNT VLLQE I ERFNKL L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4365 VRMTK SL AE LQ R A LA G E V G MS N EL DDV A R SL FI G HI P NI W RRLAPDT LK S LG N W MVYF L R R FS Q YML W V - T E SE P S V M WL 4443
Cdd:pfam18199 81 KVIRR SL QD LQ K A IK G L V V MS S EL EEL A N SL LN G KV P ES W AKKSYPS LK P LG S W IRDL L E R LK Q LQD W L d D E GP P K V F WL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4444 SG LHI P ESY LTA LV Q ATC RKNGWP L D RSTLFTQ VTK FQDAD EV N E RAGQ G CF V S GL Y LEGA D WD IEK GCL IK S K PK V L VV 4523
Cdd:pfam18199 161 SG FFF P QAF LTA VL Q NYA RKNGWP I D KLSFDFE VTK KVSPE EV T E PPED G VY V H GL F LEGA R WD RKN GCL VE S E PK E L FS 240
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1722218962 4524 D LP ILKII P I E AHRL KL Q - NT FRT PVY T TS M R RNA mgv GL VF EA DL F T TRHIS HW V L Q GV C L T L 4586
Cdd:pfam18199 241 P LP VIHLK P V E SDKK KL D e NT YEC PVY K TS E R HST --- NF VF SV DL P T DKPPD HW I L R GV A L L L 301
AAA_9
pfam12781 ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3524-3745
4.55e-102
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain]
Cd Length: 222
Bit Score: 327.48
E-value: 4.55e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3524 SR W GS QGLP P DELS VQ N G I LT T RAS R F PL C IDPQ Q QA LN WIK RK E EK N N L R V A SF N D PD FLK Q LE MS I KY G T P F L FR DV D 3603
Cdd:pfam12781 1 RE W NI QGLP N DELS IE N A I IV T NSR R W PL L IDPQ G QA NK WIK NM E KD N G L K V T SF T D KN FLK T LE NA I RF G K P L L IE DV G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3604 E YI DP VI D N VL E K N I KVSQ GR QF I I LGDKEVDY DS NFRLYL N TKL A NP R Y S P S V FG K AMV IN Y TVT LK GLEDQLL SVL V A 3683
Cdd:pfam12781 81 E EL DP IL D P VL L K E I FKGG GR KV I K LGDKEVDY NP NFRLYL T TKL P NP H Y P P E V AA K VTL IN F TVT RS GLEDQLL GIV V K 160
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1722218962 3684 Y ER RE LEEQR EH LI Q E TS ENK NL LK D LED S LL RE L AT S T GN M LD NVD L VH TLE ET K SKAT E V 3745
Cdd:pfam12781 161 K ER PD LEEQR NE LI K E IA ENK KQ LK E LED K LL EL L SS S E GN I LD DEE L IE TLE TS K KTSE E I 222
AAA_7
pfam12775 P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
2536-2715
2.77e-87
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain]
Cd Length: 179
Bit Score: 283.13
E-value: 2.77e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2536 HA P ERK F IN ILV H TVDT T R T T WI L EQMV K IKQ PV IF VG ES GT S KT ATT QN F L KN L SE E TNIV L MV NFS SR TTS MDI Q RNL 2615
Cdd:pfam12775 1 IP P DVP F SE ILV P TVDT V R Y T YL L DLLL K NGK PV LL VG PT GT G KT VII QN L L RK L DK E KYLP L FI NFS AQ TTS NQT Q DII 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2616 E ANV EKR T K DT YGPP M GK R L L VF M DD M NMP R VD E YG T Q Q PI A LL KLL L EK G YL YDR g K E L NC K S I R D LG F I AAMG KA GGG 2695
Cdd:pfam12775 81 E SKL EKR R K GV YGPP G GK K L V VF I DD L NMP A VD T YG A Q P PI E LL RQW L DY G GW YDR - K K L TF K E I V D VQ F V AAMG PP GGG 159
170 180
....*....|....*....|
gi 1722218962 2696 RN EVD PR FISL F S VFN VP FP 2715
Cdd:pfam12775 160 RN DIT PR LLRH F N VFN IT FP 179
AAA_lid_11
pfam18198 Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ...
4135-4282
1.77e-66
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.
Pssm-ID: 465676
Cd Length: 139
Bit Score: 221.94
E-value: 1.77e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4135 F K P L VYV L A FFHAVVQERRKFG KI GWN VY Y D FNESD FQVCMEI L NT YL TKA fqqr D PR IPW GS L K YLIGE VM YGGR AI D S 4214
Cdd:pfam18198 1 W K K L LFG L C FFHAVVQERRKFG PL GWN IP Y E FNESD LRISVQQ L QM YL DEY ---- D EK IPW DA L R YLIGE IN YGGR VT D D 76
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1722218962 4215 F DRR I L TI Y MD E YLGDFIFD tf QP F H F F rnk EVD Y K IP VGDEK E KFV E A IE A LPL ANT PEVFGLHPNA 4282
Cdd:pfam18198 77 W DRR L L NT Y LE E FFNPEVLE -- ED F K F S --- PSL Y Y IP PDGDL E DYL E Y IE S LPL VDS PEVFGLHPNA 139
Dynein_heavy
pfam03028 Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ...
3991-4104
1.89e-55
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Pssm-ID: 460782
Cd Length: 115
Bit Score: 189.58
E-value: 1.89e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3991 T P HS P IV FILSPGSDP AT DL M KLA ERS GFG g NR L KFLAM GQGQ EKV A LQ L L E T A VAR G Q W LM LQNCHL LVK W LKD LEK S L 4070
Cdd:pfam03028 1 S P TT P LI FILSPGSDP TA DL E KLA KKL GFG - GK L HSISL GQGQ GPI A EK L I E E A AKE G G W VL LQNCHL ALS W MPE LEK I L 79
90 100 110
....*....|....*....|....*....|....*.
gi 1722218962 4071 E RI -- TKP HPDFRLWLT TD P TKG FPI G ILQ K S L K VV 4104
Cdd:pfam03028 80 E EL pe ETL HPDFRLWLT SE P SPK FPI S ILQ N S I K IT 115
MT
pfam12777 Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
3163-3496
2.68e-55
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain]
Cd Length: 344
Bit Score: 198.37
E-value: 2.68e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3163 K RL DG GL D KL KEATI Q L D E L NQ KLA E Q KIV L AE K SAACEA L LEEIAVNTAVAEEK K KL A E E KAMEIEEQN K VIAMEKAEA 3242
Cdd:pfam12777 1 E RL EN GL L KL HSTAA Q V D D L KA KLA A Q EAE L KQ K NEDADK L IQVVGIEADKVSKE K AI A D E EEQKVAVIM K EVKEKQKAC 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3243 E TT LA EVM P I L E AA KLE L QK L D K SDV TE IR SF AK PP KQ V QT V CECIL I M ----- K GY K ELN WK T AK GV M SDPN - FL R SL M 3316
Cdd:pfam12777 81 E ED LA KAE P A L L AA QAA L DT L N K NNL TE LK SF GS PP DA V SN V SAAVM I L mapgg K IP K DKS WK A AK IM M AKVD g FL D SL I 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3317 EI D FDS I TQSQV K NI K GL L KTLNTTT E EMEAV S K A GL G MLKFVEAVMGYCD VF REIK PKR EKVARLERNFYLTKRE L ER I 3396
Cdd:pfam12777 161 KF D KEH I HEACL K AF K PY L GDPEFDP E FIASK S T A AA G LCSWCINIVRFYE VF CDVA PKR QALEEANADLAAAQEK L AA I 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3397 QNEL A AIQKE L ET L G A KY E A A ILE K Q K L Q E EA EIME R RLIA A DK L IS GL G SENIRW LNDLDELMHRRVK L L GD C LL CA AF 3476
Cdd:pfam12777 241 KAKI A ELNAN L AK L T A AF E K A TAD K I K C Q Q EA DATA R TILL A NR L VG GL A SENIRW ADAVENFKQQERT L C GD I LL IS AF 320
330 340
....*....|....*....|
gi 1722218962 3477 L SY E G A FT WEF R D E MVNRI W 3496
Cdd:pfam12777 321 I SY L G F FT KKY R N E LLDKF W 340
Dynein_AAA_lid
pfam17852 Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ...
2395-2528
4.40e-23
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.
Pssm-ID: 465532 [Multi-domain]
Cd Length: 126
Bit Score: 97.35
E-value: 4.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2395 L NS LFE KY VP YLMDVI vegivdgrq AEKL K T IVP QT DLN M V TQ L AKM L DA LL EGEI E D ----------- LDL LE CY FL E A 2463
Cdd:pfam17852 1 L EP LFE WL VP PALEFV --------- RKNC K E IVP TS DLN L V QS L CRL L ES LL DEVL E Y ngvhplspdkl KEY LE KL FL F A 71
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1722218962 2464 L YC S L G AS L L ED G R M KFDE YIKR L A S LS tvdtegvwanpg E LP GQL - P T L YD FHF D NKRNQ WVPWS 2528
Cdd:pfam17852 72 L VW S I G GT L D ED S R K KFDE FLRE L F S GL ------------ D LP PPE k G T V YD YFV D LEKGE WVPWS 125
AAA_lid_1
pfam17857 AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
2751-2849
2.66e-16
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
Pssm-ID: 465535 [Multi-domain]
Cd Length: 100
Bit Score: 77.28
E-value: 2.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2751 LA LYKN I VQDLP PT PS KFHYIFNLRD LSRV F N G LVLTNP E RFQTVAQMV R V W RN E CL RV FH D RLIS E T D KQ L VQQ h I GSL 2830
Cdd:pfam17857 6 LA FHQK I AATFL PT AI KFHYIFNLRD FANI F Q G ILFSSA E CLKSPLDLI R L W LH E SE RV YG D KMVD E K D FD L FDK - I QMA 84
90
....*....|....*....
gi 1722218962 2831 VVEH F K DD V E vvmr D PIL F 2849
Cdd:pfam17857 85 SLKK F F DD I E ---- D ELE F 99
AAA_5
pfam07728 AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2568-2707
1.97e-07
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain]
Cd Length: 135
Bit Score: 53.07
E-value: 1.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2568 P V IF VG ES GT S KT ATTQNFLKN LS EET ni V LM V NFSSR TT SM D I -- Q RN LEANVEKRTKDTYGPPMGKRLLVFM D DM N MP 2645
Cdd:pfam07728 1 G V LL VG PP GT G KT ELAERLAAA LS NRP -- V FY V QLTRD TT EE D L fg R RN IDPGGASWVDGPLVRAAREGEIAVL D EI N RA 78
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1722218962 2646 RV D EYGTQQP iallkl LL EKGY L Y -- D R G KELNCKS i RDLGF IA A M GKAGG G R NE VD P RFI S L F 2707
Cdd:pfam07728 79 NP D VLNSLLS ------ LL DERR L L lp D G G ELVKAAP - DGFRL IA T M NPLDR G L NE LS P ALR S R F 135
CwlO1
COG3883 Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
3371-3442
1.21e-03
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain]
Cd Length: 379
Bit Score: 44.82
E-value: 1.21e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1722218962 3371 E I KP K REKVAR L ER nfyltkr ELE RI Q N EL A A I Q K ELE T L GAK Y EAAIL E KQK LQ E E AEIMERRLIA A DKL I 3442
Cdd:COG3883 17 Q I QA K QKELSE L QA ------- ELE AA Q A EL D A L Q A ELE E L NEE Y NELQA E LEA LQ A E IDKLQAEIAE A EAE I 81
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3165-3442
5.09e-03
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 43.13
E-value: 5.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3165 L DGGLDK L KEATIQ LDEL N Q K L -- A EQ KI VLA EK SA ac E A L LE E IAVNTAVA EE KKKLAEEKAM EIE ---- E QNKVI A m E 3238
Cdd:TIGR02169 690 L SSLQSE L RRIENR LDEL S Q E L sd A SR KI GEI EK EI -- E Q L EQ E EEKLKERL EE LEEDLSSLEQ EIE nvks E LKELE A - R 766
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3239 KA E A E TT L AEVM pi LEAAK LE l QK L DK S DVT EI RSFAKPPKQVQTVC E CI L I mkgyk E LNW K TAK g VMSDPNF L RSLMEI 3318
Cdd:TIGR02169 767 IE E L E ED L HKLE -- EALND LE - AR L SH S RIP EI QAELSKLEEEVSRI E AR L R ----- E IEQ K LNR - LTLEKEY L EKEIQE 837
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3319 DFDSI -- TQS Q V K N I KGLLKT LN TTT EE M E A vskaglgmlkfveavmgycdvfr E IKPKREKVAR LE RNFYLT K R E LERI 3396
Cdd:TIGR02169 838 LQEQR id LKE Q I K S I EKEIEN LN GKK EE L E E ----------------------- E LEELEAALRD LE SRLGDL K K E RDEL 894
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1722218962 3397 QNE L AAIQKEL E T L G A KY E AAILEKQK L QEEA E IM E RR L IAADKLI 3442
Cdd:TIGR02169 895 EAQ L RELERKI E E L E A QI E KKRKRLSE L KAKL E AL E EE L SEIEDPK 940
COG4372
COG4372 Uncharacterized protein, contains DUF3084 domain [Function unknown];
3370-3435
7.32e-03
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain]
Cd Length: 370
Bit Score: 42.20
E-value: 7.32e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1722218962 3370 R E IKPK RE KVAR LE RNFYLTKR ELE RIQN EL AAIQKE L ETLG A KYEA A IL E KQK LQEEAE IMERR L 3435
Cdd:COG4372 52 E E LEQA RE ELEQ LE EELEQARS ELE QLEE EL EELNEQ L QAAQ A ELAQ A QE E LES LQEEAE ELQEE L 117
PRK03918
PRK03918 DNA double-strand break repair ATPase Rad50;
3170-3458
9.49e-03
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain]
Cd Length: 880
Bit Score: 42.36
E-value: 9.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3170 D K LKEATIQ L D EL NQK L AEQKIVLAE K S aacea L L E EIA vntavaeekkklaeekam E I EE QN K VIAM E KA E AETTLA E V 3249
Cdd:PRK03918 473 E K ERKLRKE L R EL EKV L KKESELIKL K E ----- L A E QLK ------------------ E L EE KL K KYNL E EL E KKAEEY E K 529
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3250 M pileaa K LE L Q KL DK sdvt EI R S FA K PPKQVQTV - CECILIM K GYK EL NWKT A kgvmsdp NF L RS L M E ID F D S I tqsqv 3328
Cdd:PRK03918 530 L ------ K EK L I KL KG ---- EI K S LK K ELEKLEEL k KKLAELE K KLD EL EEEL A ------- EL L KE L E E LG F E S V ----- 587
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3329 knikgll KT L NTTTE E M E AVSK aglgml KFV E AV mgyc D VFR E IKPKREKVAR LE RNFYLTKR EL ERIQNE L AAIQ KELE 3408
Cdd:PRK03918 588 ------- EE L EERLK E L E PFYN ------ EYL E LK ---- D AEK E LEREEKELKK LE EELDKAFE EL AETEKR L EELR KELE 650
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1722218962 3409 T L GA KY EAA il E KQK L Q EE AEIME R R L IAADKLISG L GS --- E NIRW L ND L D E 3458
Cdd:PRK03918 651 E L EK KY SEE -- E YEE L R EE YLELS R E L AGLRAELEE L EK rre E IKKT L EK L K E 701
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
