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Conserved domains on  [gi|1722218962|ref|NP_001359035|]
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dynein axonemal heavy chain 10 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1912-2238 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


:

Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 673.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1912 YGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYRAVGKIFSG 1991
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1992 LAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFR 2071
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2072 PVVVIVPDLQQICEIMLFSEGFLEAKTLAKKMTVLYKLAREQLSKQYHYDFGLRALKSVLVMAGELKRGSSDLREDVVLM 2151
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2152 RALRDMNLPKFVFEDVPLFLGLISDLFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETMLTRHTTMVVG 2231
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320

                   ....*..
gi 1722218962 2232 PTRGGKS 2238
Cdd:pfam12774  321 PTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
306-876 2.03e-176

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


:

Pssm-ID: 462457  Cd Length: 560  Bit Score: 555.65  E-value: 2.03e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  306 VDILEQCVINWLNQISTAveaqLKKTPQGK--GPLAEIEFWRERNATLSALHEQTKLPIVRKVLDVIKESDSMLVANLQP 383
Cdd:pfam08385    1 LHALESVVIKWTKQIQDV----LKEDSQGRnpGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKA 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  384 VFTELFKFHTEASDNVRFLSTVERYFKNITHGSGFHVVLDTIPAMMSALRMVWIISRHYNKDERMIPLMERIAWEIAERV 463
Cdd:pfam08385   77 LDTELTDALNEAKDNVKYLKTLERPFEDLEELTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQC 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  464 CRVVNLRTLFKENRASAQSKTLEARNTLRLWKKAYFDTRAKIEASGREDRWEFDRKRLFERTDYMATICQDLSDVLQILE 543
Cdd:pfam08385  157 KKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERPWDFSERYIFGRFDAFLERLEKILELFETIE 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  544 EF------YNIFGPELKAVtgdpkrIDDVLCRVDGLVTPMENLTFDPFSIKSSQfWKYVMDEFKIEVLVIEKEAKHFIDE 617
Cdd:pfam08385  237 QFsklekiGGTKGPELEGV------IEEILEEFQEAYKVFKSKTYDILDVSNEG-FDDDYEEFKERIKDLERRLQAFIDQ 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  618 SFKTLRSAEAAFDMLLKFKHIRSREAVNRQMMMKFNDILAQYCKEIDIINKIFVQNLENP-PLYKNHPPVAGAIYWERSL 696
Cdd:pfam08385  310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYNPsPIAKNMPPVAGAIIWARQL 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  697 FFRIKHTILRFQEVQEILDSDRGQEVKQKYLEVGRTMKEYEDRKYEQWMEVTEQVLPALMKKSLLTKSSiateepstlER 776
Cdd:pfam08385  390 FRRIQEPMKRFKEELGLLKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLLVRHP---------ET 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  777 GAVFAINFSPALREIINETKYLEQLGFTVPELARNVALQEDKFLRYTAGIQRMLDHYHMLIGTLNDAESVLLKDHSQELL 856
Cdd:pfam08385  461 GKLLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDID 540
                          570       580
                   ....*....|....*....|
gi 1722218962  857 RVFRSGYKRLNWNSLGIGDY 876
Cdd:pfam08385  541 EKLEPGLTTLTWNSLGIDEY 560
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1372-1777 1.06e-159

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


:

Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 501.02  E-value: 1.06e-159
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1372 LLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWINLNVQILQEGIEGFLRALRKLPRPVRGLSVTYYLEAKMKAFKDSIP 1451
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1452 LLLDLKNEALRDRHWKELMEKTSVFFEM-TETFTLENMFAMELHKHTDVLNEIVTAAIKEVAIEKAVKEILDTWENMKFT 1530
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFDPlSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1531 VVKYCKGTqerGYILGSVDEIIQSLDDNTFNLQSISGSRFVGPFLQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFI 1610
Cdd:pfam08393  161 LVPYKDTG---TFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1611 GGDIRSQLPEEAKKFDNIDKVFKRIMGETLKDPVIKRCCEAPNRLSDLQNVSEGLEKCQKSLNDYLDSKRNAFPRFFFIS 1690
Cdd:pfam08393  238 SEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLS 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1691 DDELLSILG-SSDPLCVQEHMIKMYDNIASLRFNDgdsgEKLVSAMISAEGEVMEFRK-ILRAEGRVEDWMTAVLNEMRR 1768
Cdd:pfam08393  318 NDELLEILSqTKDPTRVQPHLKKCFEGIASLEFDE----NKEITGMISKEGEVVPFSKpPVEAKGNVEEWLNELEEEMRE 393

                   ....*....
gi 1722218962 1769 TNRLITKEA 1777
Cdd:pfam08393  394 TLRDLLKEA 402
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2891-3150 7.96e-118

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


:

Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 374.25  E-value: 7.96e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2891 MNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIE 2970
Cdd:pfam12780    1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2971 NKAMIFLFTDAHVAEEGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGMGPAKESVWQYFVNKSANNLHIVLG 3050
Cdd:pfam12780   81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3051 MSPVGDTLRTWCRNFPGMVNNTGIDWFMPWPPQALHAVAKSFLGyNPMIPAENIENVVKHVVLVHQSVDHYSQQFLQKLR 3130
Cdd:pfam12780  161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLE-DIEIPEELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
                          250       260
                   ....*....|....*....|
gi 1722218962 3131 RSNYVTPKNYLDFINTYSKL 3150
Cdd:pfam12780  240 RKNYVTPKSYLELLRLYKNL 259
DYN1 super family cl34955
Dynein, heavy chain [Cytoskeleton];
1274-4265 1.65e-114

Dynein, heavy chain [Cytoskeleton];


The actual alignment was detected with superfamily member COG5245:

Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 411.69  E-value: 1.65e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1274 SIWSNLFNDSVNVEHALGdIKRTFTELTRgeIMNYRVQIEEFAKRFYSEgPGSVGDDLDKGVELlgvYERELARHEKSRQ 1353
Cdd:COG5245    339 SLESSLFYEFRGGEHLAG-FYSAFGDIKR--ILLFTWSFKKLGTLLPSL-PGYSSGGMDYGEEY---RSLLWELGSEVGD 411
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1354 ELANAEKLFDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWinLNVQILQEGIEGFLRAlRKLPRPVRgL 1433
Cdd:COG5245    412 PDSGPVRKWMRKDLFDAKVRSGVSFGKQEEFVSDIFNITFERIHGMDPTTL--EDDEEDTPALAILLGQ-EEAGRFVK-L 487
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1434 SVTYYLEAKMKAFKDSIPLLLDLKNEALRdrHWKELMEKTSVFFEMTETFTLENMFaMELHKHTDVLNEIVTAAIKEVA- 1512
Cdd:COG5245    488 CKIMRMFSFFNSLEMFSRRTLANRMAIVK--YLSSVVRTGPLFLQRDFFGRMSELL-MARDMFMEVDGVLRLFFGGEWSg 564
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1513 -IEKAVKEILDTWENMKFT--VVKYCKGTQERGYILGSVDEIIQSLDDNTfNLQSISGSRfvgpflqtVHKWEKTLSLIG 1589
Cdd:COG5245    565 iVQLSGIRRAKRCVERQIDdeIREWCSSVLSDDFLEERAVRVERGADGAR-RLRASSGSP--------VLRRLDEYLMMM 635
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1590 EVIeiwmlvqrkwmylesifiggDIRSQLPEEAKKFDNIDKVFKRIMGETLKDPVIKRCCEAPNrLSDLQNVSEGLEKCQ 1669
Cdd:COG5245    636 SLE--------------------DLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVF 694
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1670 KSLNDYLDSKRNAFPRFffISDDELLSILGS-SDPLCVQEHMIKMYDNIASLR-FNDGDSGEKLVSAMISAEGEVMEFRK 1747
Cdd:COG5245    695 MSIEKVLGLRWREVERA--SEVEELMDRVRElENRVYSYRFFVKKIAKEEMKTvFSSRIQKKEPFSLDSEAYVGFFRLYE 772
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1748 ILRAEGRVEDWMTAVLNEMRRTNRLITKEAIFRYCEDRSRVDWMLLYQGMvvlaasqvwWTWEVEDVFhkaqkgeKQAMK 1827
Cdd:COG5245    773 KSIVIRGINRSMGRVLSQYLESVQEALEIEDGSFFVSRHRVRDGGLEKGR---------GCDAWENCF-------DPPLS 836
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1828 NYGRKMHRQIDELVTRitmpLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFDWESQLRFYwDREPDELNIRQCT 1907
Cdd:COG5245    837 EYFRILEKIFPSEEGY----FFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVSISELP-QGLYKRFIKVRSS 911
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1908 GTFGYGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLggapAGPAGTGKTETTKDLAKALGLLCvvtncgEGMDYRAvgK 1987
Cdd:COG5245    912 YRSAEMFAKNTIPFFVFEHSMDTSQHQKLFEAVCDEV----CRFVDTENSRVYGMLVAGKGRIY------DGTEPRS--R 979
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1988 IFSGLAQCGAWGcFDEFNRIDASVLSvISSQIQTIRNAL--IHQLTTFQFEgqEISLDSRMGIFITMNPgyagRTELPES 2065
Cdd:COG5245    980 IEAGPICEEERG-TEESALLDEISRT-ILVDEYLNSDEFrmLEELNSAVVE--HGLKSPSTPVEMIINE----RNIVLEI 1051
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2066 VKALFRPVVVIVPdLQQICEIMlfsegfleaKTLAKKMTVLYKLAREQLSKQYHYDFglRALKSVLvmagelkRGSSDLR 2145
Cdd:COG5245   1052 GRRALDMFLSNIP-FGAIKSRR---------ESLDREIGAFNNEVDGIAREEDELMF--YPMFKSL-------KAKHRML 1112
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2146 EDVV--LMRALRDMNLPkfvfedvplflgLISD-LFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETML 2222
Cdd:COG5245   1113 EEKTeyLNKILSITGLP------------LISDtLRERIDTLDAEWDSFCRISESLKKYESQQVSGLDVAQFVSFLRSVD 1180
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2223 TRHTTMVVGPTRGGKSVVINTLCQaqtklglttklYILNPKAVSVIELYgiLDPTTrDWTdGVLSNIFREINKPTDKKER 2302
Cdd:COG5245   1181 TGAFHAEYFRVFLCKIKHYTDACD-----------YLWHVKSPYVKKKY--FDADM-ELR-QFFLMFNREDMEARLADSK 1245
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2303 KYILFDGdvdalWVENMNSVMDDNRLLTLANGERirlqahcALLFEVGDlqyASPATVSRCGMVYVDPKNLKYRPYWKKW 2382
Cdd:COG5245   1246 MEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRLSTKGVFLDE 1310
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2383 VNQ----IPNKVEQYNLNSLFEKYVPYLMDVIVEGIVdgRQAEKLKTIVPQTDLNMV--------------TQLAKMLDa 2444
Cdd:COG5245   1311 LGDtkryLDECLDFFSCFEEVQKEIDELSMVFCADAL--RFSADLYHIVKERRFSGVlagsdaseslggksIELAAILE- 1387
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2445 lLEGEIEDLDLLECYFLeaLYCSLGASLLEDGRmkfdeyikRLASLSTVDTEGVWANPGELPGQLPTLYDFHFDNKRNQW 2524
Cdd:COG5245   1388 -HKDLIVEMKRGINDVL--KLRIFGDKCRESTP--------RFYLISDGDLIKDLNERSDYEEMLIMMFNISAVITNNGS 1456
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2525 VPWSKLVPEYIHAPErkfiNILVHTVDTTRTTWILEQMVKIKQPVIFVGESGTSKTATTQNFLKnlSEETNIVLMVNFSS 2604
Cdd:COG5245   1457 IAGFELRGERVMLRK----EVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLR--SELITEVKYFNFST 1530
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2605 RTTSMDIQRNLEANVEKRTKD----TYGPPMGKRLLVFMDDMNMPRVDEYGTQQPIALLKLLLEK-GYLYDRGKELncKS 2679
Cdd:COG5245   1531 CTMTPSKLSVLERETEYYPNTgvvrLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERqGFWSSIAVSW--VT 1608
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2680 IRDLGFIAAMGKAGG-GRNEVDPRFISLFSVFNVPFPSEESLHLIYSSILKG------HTSTFHESIVAVSGKLTFCTLA 2752
Cdd:COG5245   1609 ICGIILYGACNPGTDeGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGsylcfdEFNRLSEETMSASVELYLSSKD 1688
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2753 LYKNIVQDlpptpskfHYIFNLRDLSRV---FNGLVLTNPErfQTVAQMVRVWRNECLRVFHDRLISETDKQLVQQHIGS 2829
Cdd:COG5245   1689 KTKFFLQM--------NYGYKPRELTRSlraIFGYAETRID--TPDVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYD 1758
                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2830 LVVEHFKD-DVEVVMRDPILFGD---FQMALhegepriyediQDYEAAKALFQEILEEYNESNTKMNLVLFDDALEHLTR 2905
Cdd:COG5245   1759 FGLRAIREmIAGHIGEAEITFSMilfFGMAC-----------LLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALLHILR 1827
                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2906 VHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIENKAMIFLFTDAHVAE 2985
Cdd:COG5245   1828 SRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVE 1907
                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2986 EGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGMG-PAKESVWQYFVNKSANNLHIVLGMSPVGDTLRTWCRN 3064
Cdd:COG5245   1908 SSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLEkDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIR 1987
                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3065 FPGMVNNTGIDWFMPWPPQALHAVAKSFL------GYNPMIPAE--NIENVVKHVVLVHQSVDHYSQQFLQKLRR-SNYV 3135
Cdd:COG5245   1988 SPALKNRCFIDFKKLWDTEEMSQYANSVEtlsrdgGRVFFINGElgVGKGALISEVFGDDAVVIEGRGFEISMIEgSLGE 2067
                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3136 TPKNYLDFINTYSKLLDEKTQCNIAQCKRLDGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACEALLE-------EIA 3208
Cdd:COG5245   2068 SKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSgtpgerlERE 2147
                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3209 VNTAVAEEKKKLAEEKAMEIEEQNKVIAMEKAEAETTLAEvmpileaAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECI 3288
Cdd:COG5245   2148 VKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLE-------AVLFVYKIKKASLREIRSFIRPPGDLCIEMEDV 2220
                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3289 LIMKGYKELNWKTAKGVMSD----PNFLRSLMEIDFDsiTQSQVKNIKGLLKTLNTTTEEMEAVSKAGLGMLKFVEAVMG 3364
Cdd:COG5245   2221 CDLLGFEAKIWFGEQQSLRRddfiRIIGKYPDEIEFD--LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECN 2298
                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3365 YCDVFREIKPKREKVARLERNFYLTKrelERIQNELAAIQK---ELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKL 3441
Cdd:COG5245   2299 RSKVLEVKIPLREEEKRIDGEAFLVE---DRLTLGKGLSSDlmtFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFV 2375
                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3442 ISGLGSENIRWLNDLDELMHRRVKLLGDCLLCAAFLSYEGafTWEFRDEMVNRIWQNDILEREIPLSQPFR---LESLLT 3518
Cdd:COG5245   2376 SEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIG--TLGFLCRAIEFGMSFIRISKEFRDKEIRRrqfITEGVQ 2453
                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3519 DDVEiSRWGSQglpPDELSVQN-GILTTRASRFPLCIDPQQQALNWIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPF 3597
Cdd:COG5245   2454 KIED-FKEEAC---STDYGLENsRIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDK 2529
                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3598 LFRDVdEYIDPVIDNVLEKNIKVSQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQL 3677
Cdd:COG5245   2530 IIGDA-EALDEEIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEI 2608
                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3678 LSVLVAYERRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEVSEKLKLAEKTAL 3757
Cdd:COG5245   2609 PDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIED 2688
                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3758 DIDRLRDGYRPAARRGAILFFVLSEMALVNSMYQYSLIAFLEVFRLSLKKSlpdSILMKRLRNIMDTLTFSIYNHGCTGL 3837
Cdd:COG5245   2689 RIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWRRMK---SKYLCAIRYMLMSSEWILDHEDRSGF 2765
                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3838 FerHKLLFSFNMTIKieqaegrvpqEELDFFLKGNISLEKskrkkpcawLSDQGWEDIILLSEMfSDNFGQLPDDVENNQ 3917
Cdd:COG5245   2766 I--HRLDVSFLLRTK----------RFVSTLLEDKNYRQV---------LSSCSLYGNDVISHS-CDRFDRDVYRALKHQ 2823
                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3918 TvwqewydldSLEQFPVPLGYDNNITPFQKLLILRCFRVDRVYRAVTDYVTVTMGekyvqppmisfeaIFEQSTPHSPIV 3997
Cdd:COG5245   2824 M---------DNRTHSTILTSNSKTNPYKEYTYNDSWAEAFEVEDSGDLYKFEEG-------------LLELIVGHAPLI 2881
                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3998 FIL--SPGSDPATDLMKLAERSGFGGNRLKFlamgqgqekvalqlletAVARGQWLMLQNCHLLVKWLKD-LEKSLERI- 4073
Cdd:COG5245   2882 YAHkkSLENERNVDRLGSKENEVYAVLNSLF-----------------SRKEKSWFEVYNISLSFGWFKRyVEDVVYPIk 2944
                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4074 -TKPHPDF-RLWLTTDPTKGFPIGILQKSLKVVTEPPNGLKLNMrATYFKISHEMLDQCPHPAFKpLVYVLAFFHAVVQE 4151
Cdd:COG5245   2945 aSRVCGKVkNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRYPFDYTLVIACD-DAFYLSWEHAAVAS 3022
                         2970      2980      2990      3000      3010      3020      3030      3040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4152 RRKFGKIGWNVYYDFNESDFQVCMEILNTYLtkaFQQRDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYMDEYlgdf 4231
Cdd:COG5245   3023 VISAGPKENNEEIYFGDKDFEFKTHLLKNIL---FLNHLNARKWGNNRDLIFTIVYGKKHSLMEDSKVVDKYCRGY---- 3095
                         3050      3060      3070
                   ....*....|....*....|....*....|....
gi 1722218962 4232 ifdtfqpFHFFRNKEVDYKIPVGDEKEKFVEAIE 4265
Cdd:COG5245   3096 -------GAHETSSQILASVPGGDPELVKFHMEE 3122
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4288-4586 5.65e-114

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


:

Pssm-ID: 465677  Cd Length: 301  Bit Score: 365.02  E-value: 5.65e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4288 TQAARDMWAHLLELQPQT--GESSSGISRDDYIGQVAKEIENKMPKVFDLDQVRKRLGTG-LSPTSVVLLQELERFNKLV 4364
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSdsGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPVGyEDPLNTVLLQEIERFNKLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4365 VRMTKSLAELQRALAGEVGMSNELDDVARSLFIGHIPNIWRRLAPDTLKSLGNWMVYFLRRFSQYMLWV-TESEPSVMWL 4443
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLdDEGPPKVFWL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4444 SGLHIPESYLTALVQATCRKNGWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIEKGCLIKSKPKVLVV 4523
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1722218962 4524 DLPILKIIPIEAHRLKLQ-NTFRTPVYTTSMRRNAmgvGLVFEADLFTTRHISHWVLQGVCLTL 4586
Cdd:pfam18199  241 PLPVIHLKPVESDKKKLDeNTYECPVYKTSERHST---NFVFSVDLPTDKPPDHWILRGVALLL 301
 
Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1912-2238 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 673.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1912 YGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYRAVGKIFSG 1991
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1992 LAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFR 2071
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2072 PVVVIVPDLQQICEIMLFSEGFLEAKTLAKKMTVLYKLAREQLSKQYHYDFGLRALKSVLVMAGELKRGSSDLREDVVLM 2151
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2152 RALRDMNLPKFVFEDVPLFLGLISDLFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETMLTRHTTMVVG 2231
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320

                   ....*..
gi 1722218962 2232 PTRGGKS 2238
Cdd:pfam12774  321 PTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
306-876 2.03e-176

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 555.65  E-value: 2.03e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  306 VDILEQCVINWLNQISTAveaqLKKTPQGK--GPLAEIEFWRERNATLSALHEQTKLPIVRKVLDVIKESDSMLVANLQP 383
Cdd:pfam08385    1 LHALESVVIKWTKQIQDV----LKEDSQGRnpGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKA 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  384 VFTELFKFHTEASDNVRFLSTVERYFKNITHGSGFHVVLDTIPAMMSALRMVWIISRHYNKDERMIPLMERIAWEIAERV 463
Cdd:pfam08385   77 LDTELTDALNEAKDNVKYLKTLERPFEDLEELTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQC 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  464 CRVVNLRTLFKENRASAQSKTLEARNTLRLWKKAYFDTRAKIEASGREDRWEFDRKRLFERTDYMATICQDLSDVLQILE 543
Cdd:pfam08385  157 KKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERPWDFSERYIFGRFDAFLERLEKILELFETIE 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  544 EF------YNIFGPELKAVtgdpkrIDDVLCRVDGLVTPMENLTFDPFSIKSSQfWKYVMDEFKIEVLVIEKEAKHFIDE 617
Cdd:pfam08385  237 QFsklekiGGTKGPELEGV------IEEILEEFQEAYKVFKSKTYDILDVSNEG-FDDDYEEFKERIKDLERRLQAFIDQ 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  618 SFKTLRSAEAAFDMLLKFKHIRSREAVNRQMMMKFNDILAQYCKEIDIINKIFVQNLENP-PLYKNHPPVAGAIYWERSL 696
Cdd:pfam08385  310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYNPsPIAKNMPPVAGAIIWARQL 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  697 FFRIKHTILRFQEVQEILDSDRGQEVKQKYLEVGRTMKEYEDRKYEQWMEVTEQVLPALMKKSLLTKSSiateepstlER 776
Cdd:pfam08385  390 FRRIQEPMKRFKEELGLLKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLLVRHP---------ET 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  777 GAVFAINFSPALREIINETKYLEQLGFTVPELARNVALQEDKFLRYTAGIQRMLDHYHMLIGTLNDAESVLLKDHSQELL 856
Cdd:pfam08385  461 GKLLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDID 540
                          570       580
                   ....*....|....*....|
gi 1722218962  857 RVFRSGYKRLNWNSLGIGDY 876
Cdd:pfam08385  541 EKLEPGLTTLTWNSLGIDEY 560
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1372-1777 1.06e-159

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 501.02  E-value: 1.06e-159
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1372 LLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWINLNVQILQEGIEGFLRALRKLPRPVRGLSVTYYLEAKMKAFKDSIP 1451
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1452 LLLDLKNEALRDRHWKELMEKTSVFFEM-TETFTLENMFAMELHKHTDVLNEIVTAAIKEVAIEKAVKEILDTWENMKFT 1530
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFDPlSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1531 VVKYCKGTqerGYILGSVDEIIQSLDDNTFNLQSISGSRFVGPFLQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFI 1610
Cdd:pfam08393  161 LVPYKDTG---TFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1611 GGDIRSQLPEEAKKFDNIDKVFKRIMGETLKDPVIKRCCEAPNRLSDLQNVSEGLEKCQKSLNDYLDSKRNAFPRFFFIS 1690
Cdd:pfam08393  238 SEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLS 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1691 DDELLSILG-SSDPLCVQEHMIKMYDNIASLRFNDgdsgEKLVSAMISAEGEVMEFRK-ILRAEGRVEDWMTAVLNEMRR 1768
Cdd:pfam08393  318 NDELLEILSqTKDPTRVQPHLKKCFEGIASLEFDE----NKEITGMISKEGEVVPFSKpPVEAKGNVEEWLNELEEEMRE 393

                   ....*....
gi 1722218962 1769 TNRLITKEA 1777
Cdd:pfam08393  394 TLRDLLKEA 402
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2891-3150 7.96e-118

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 374.25  E-value: 7.96e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2891 MNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIE 2970
Cdd:pfam12780    1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2971 NKAMIFLFTDAHVAEEGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGMGPAKESVWQYFVNKSANNLHIVLG 3050
Cdd:pfam12780   81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3051 MSPVGDTLRTWCRNFPGMVNNTGIDWFMPWPPQALHAVAKSFLGyNPMIPAENIENVVKHVVLVHQSVDHYSQQFLQKLR 3130
Cdd:pfam12780  161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLE-DIEIPEELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
                          250       260
                   ....*....|....*....|
gi 1722218962 3131 RSNYVTPKNYLDFINTYSKL 3150
Cdd:pfam12780  240 RKNYVTPKSYLELLRLYKNL 259
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1274-4265 1.65e-114

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 411.69  E-value: 1.65e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1274 SIWSNLFNDSVNVEHALGdIKRTFTELTRgeIMNYRVQIEEFAKRFYSEgPGSVGDDLDKGVELlgvYERELARHEKSRQ 1353
Cdd:COG5245    339 SLESSLFYEFRGGEHLAG-FYSAFGDIKR--ILLFTWSFKKLGTLLPSL-PGYSSGGMDYGEEY---RSLLWELGSEVGD 411
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1354 ELANAEKLFDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWinLNVQILQEGIEGFLRAlRKLPRPVRgL 1433
Cdd:COG5245    412 PDSGPVRKWMRKDLFDAKVRSGVSFGKQEEFVSDIFNITFERIHGMDPTTL--EDDEEDTPALAILLGQ-EEAGRFVK-L 487
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1434 SVTYYLEAKMKAFKDSIPLLLDLKNEALRdrHWKELMEKTSVFFEMTETFTLENMFaMELHKHTDVLNEIVTAAIKEVA- 1512
Cdd:COG5245    488 CKIMRMFSFFNSLEMFSRRTLANRMAIVK--YLSSVVRTGPLFLQRDFFGRMSELL-MARDMFMEVDGVLRLFFGGEWSg 564
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1513 -IEKAVKEILDTWENMKFT--VVKYCKGTQERGYILGSVDEIIQSLDDNTfNLQSISGSRfvgpflqtVHKWEKTLSLIG 1589
Cdd:COG5245    565 iVQLSGIRRAKRCVERQIDdeIREWCSSVLSDDFLEERAVRVERGADGAR-RLRASSGSP--------VLRRLDEYLMMM 635
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1590 EVIeiwmlvqrkwmylesifiggDIRSQLPEEAKKFDNIDKVFKRIMGETLKDPVIKRCCEAPNrLSDLQNVSEGLEKCQ 1669
Cdd:COG5245    636 SLE--------------------DLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVF 694
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1670 KSLNDYLDSKRNAFPRFffISDDELLSILGS-SDPLCVQEHMIKMYDNIASLR-FNDGDSGEKLVSAMISAEGEVMEFRK 1747
Cdd:COG5245    695 MSIEKVLGLRWREVERA--SEVEELMDRVRElENRVYSYRFFVKKIAKEEMKTvFSSRIQKKEPFSLDSEAYVGFFRLYE 772
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1748 ILRAEGRVEDWMTAVLNEMRRTNRLITKEAIFRYCEDRSRVDWMLLYQGMvvlaasqvwWTWEVEDVFhkaqkgeKQAMK 1827
Cdd:COG5245    773 KSIVIRGINRSMGRVLSQYLESVQEALEIEDGSFFVSRHRVRDGGLEKGR---------GCDAWENCF-------DPPLS 836
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1828 NYGRKMHRQIDELVTRitmpLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFDWESQLRFYwDREPDELNIRQCT 1907
Cdd:COG5245    837 EYFRILEKIFPSEEGY----FFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVSISELP-QGLYKRFIKVRSS 911
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1908 GTFGYGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLggapAGPAGTGKTETTKDLAKALGLLCvvtncgEGMDYRAvgK 1987
Cdd:COG5245    912 YRSAEMFAKNTIPFFVFEHSMDTSQHQKLFEAVCDEV----CRFVDTENSRVYGMLVAGKGRIY------DGTEPRS--R 979
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1988 IFSGLAQCGAWGcFDEFNRIDASVLSvISSQIQTIRNAL--IHQLTTFQFEgqEISLDSRMGIFITMNPgyagRTELPES 2065
Cdd:COG5245    980 IEAGPICEEERG-TEESALLDEISRT-ILVDEYLNSDEFrmLEELNSAVVE--HGLKSPSTPVEMIINE----RNIVLEI 1051
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2066 VKALFRPVVVIVPdLQQICEIMlfsegfleaKTLAKKMTVLYKLAREQLSKQYHYDFglRALKSVLvmagelkRGSSDLR 2145
Cdd:COG5245   1052 GRRALDMFLSNIP-FGAIKSRR---------ESLDREIGAFNNEVDGIAREEDELMF--YPMFKSL-------KAKHRML 1112
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2146 EDVV--LMRALRDMNLPkfvfedvplflgLISD-LFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETML 2222
Cdd:COG5245   1113 EEKTeyLNKILSITGLP------------LISDtLRERIDTLDAEWDSFCRISESLKKYESQQVSGLDVAQFVSFLRSVD 1180
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2223 TRHTTMVVGPTRGGKSVVINTLCQaqtklglttklYILNPKAVSVIELYgiLDPTTrDWTdGVLSNIFREINKPTDKKER 2302
Cdd:COG5245   1181 TGAFHAEYFRVFLCKIKHYTDACD-----------YLWHVKSPYVKKKY--FDADM-ELR-QFFLMFNREDMEARLADSK 1245
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2303 KYILFDGdvdalWVENMNSVMDDNRLLTLANGERirlqahcALLFEVGDlqyASPATVSRCGMVYVDPKNLKYRPYWKKW 2382
Cdd:COG5245   1246 MEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRLSTKGVFLDE 1310
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2383 VNQ----IPNKVEQYNLNSLFEKYVPYLMDVIVEGIVdgRQAEKLKTIVPQTDLNMV--------------TQLAKMLDa 2444
Cdd:COG5245   1311 LGDtkryLDECLDFFSCFEEVQKEIDELSMVFCADAL--RFSADLYHIVKERRFSGVlagsdaseslggksIELAAILE- 1387
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2445 lLEGEIEDLDLLECYFLeaLYCSLGASLLEDGRmkfdeyikRLASLSTVDTEGVWANPGELPGQLPTLYDFHFDNKRNQW 2524
Cdd:COG5245   1388 -HKDLIVEMKRGINDVL--KLRIFGDKCRESTP--------RFYLISDGDLIKDLNERSDYEEMLIMMFNISAVITNNGS 1456
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2525 VPWSKLVPEYIHAPErkfiNILVHTVDTTRTTWILEQMVKIKQPVIFVGESGTSKTATTQNFLKnlSEETNIVLMVNFSS 2604
Cdd:COG5245   1457 IAGFELRGERVMLRK----EVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLR--SELITEVKYFNFST 1530
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2605 RTTSMDIQRNLEANVEKRTKD----TYGPPMGKRLLVFMDDMNMPRVDEYGTQQPIALLKLLLEK-GYLYDRGKELncKS 2679
Cdd:COG5245   1531 CTMTPSKLSVLERETEYYPNTgvvrLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERqGFWSSIAVSW--VT 1608
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2680 IRDLGFIAAMGKAGG-GRNEVDPRFISLFSVFNVPFPSEESLHLIYSSILKG------HTSTFHESIVAVSGKLTFCTLA 2752
Cdd:COG5245   1609 ICGIILYGACNPGTDeGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGsylcfdEFNRLSEETMSASVELYLSSKD 1688
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2753 LYKNIVQDlpptpskfHYIFNLRDLSRV---FNGLVLTNPErfQTVAQMVRVWRNECLRVFHDRLISETDKQLVQQHIGS 2829
Cdd:COG5245   1689 KTKFFLQM--------NYGYKPRELTRSlraIFGYAETRID--TPDVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYD 1758
                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2830 LVVEHFKD-DVEVVMRDPILFGD---FQMALhegepriyediQDYEAAKALFQEILEEYNESNTKMNLVLFDDALEHLTR 2905
Cdd:COG5245   1759 FGLRAIREmIAGHIGEAEITFSMilfFGMAC-----------LLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALLHILR 1827
                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2906 VHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIENKAMIFLFTDAHVAE 2985
Cdd:COG5245   1828 SRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVE 1907
                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2986 EGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGMG-PAKESVWQYFVNKSANNLHIVLGMSPVGDTLRTWCRN 3064
Cdd:COG5245   1908 SSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLEkDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIR 1987
                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3065 FPGMVNNTGIDWFMPWPPQALHAVAKSFL------GYNPMIPAE--NIENVVKHVVLVHQSVDHYSQQFLQKLRR-SNYV 3135
Cdd:COG5245   1988 SPALKNRCFIDFKKLWDTEEMSQYANSVEtlsrdgGRVFFINGElgVGKGALISEVFGDDAVVIEGRGFEISMIEgSLGE 2067
                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3136 TPKNYLDFINTYSKLLDEKTQCNIAQCKRLDGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACEALLE-------EIA 3208
Cdd:COG5245   2068 SKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSgtpgerlERE 2147
                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3209 VNTAVAEEKKKLAEEKAMEIEEQNKVIAMEKAEAETTLAEvmpileaAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECI 3288
Cdd:COG5245   2148 VKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLE-------AVLFVYKIKKASLREIRSFIRPPGDLCIEMEDV 2220
                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3289 LIMKGYKELNWKTAKGVMSD----PNFLRSLMEIDFDsiTQSQVKNIKGLLKTLNTTTEEMEAVSKAGLGMLKFVEAVMG 3364
Cdd:COG5245   2221 CDLLGFEAKIWFGEQQSLRRddfiRIIGKYPDEIEFD--LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECN 2298
                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3365 YCDVFREIKPKREKVARLERNFYLTKrelERIQNELAAIQK---ELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKL 3441
Cdd:COG5245   2299 RSKVLEVKIPLREEEKRIDGEAFLVE---DRLTLGKGLSSDlmtFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFV 2375
                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3442 ISGLGSENIRWLNDLDELMHRRVKLLGDCLLCAAFLSYEGafTWEFRDEMVNRIWQNDILEREIPLSQPFR---LESLLT 3518
Cdd:COG5245   2376 SEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIG--TLGFLCRAIEFGMSFIRISKEFRDKEIRRrqfITEGVQ 2453
                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3519 DDVEiSRWGSQglpPDELSVQN-GILTTRASRFPLCIDPQQQALNWIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPF 3597
Cdd:COG5245   2454 KIED-FKEEAC---STDYGLENsRIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDK 2529
                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3598 LFRDVdEYIDPVIDNVLEKNIKVSQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQL 3677
Cdd:COG5245   2530 IIGDA-EALDEEIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEI 2608
                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3678 LSVLVAYERRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEVSEKLKLAEKTAL 3757
Cdd:COG5245   2609 PDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIED 2688
                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3758 DIDRLRDGYRPAARRGAILFFVLSEMALVNSMYQYSLIAFLEVFRLSLKKSlpdSILMKRLRNIMDTLTFSIYNHGCTGL 3837
Cdd:COG5245   2689 RIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWRRMK---SKYLCAIRYMLMSSEWILDHEDRSGF 2765
                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3838 FerHKLLFSFNMTIKieqaegrvpqEELDFFLKGNISLEKskrkkpcawLSDQGWEDIILLSEMfSDNFGQLPDDVENNQ 3917
Cdd:COG5245   2766 I--HRLDVSFLLRTK----------RFVSTLLEDKNYRQV---------LSSCSLYGNDVISHS-CDRFDRDVYRALKHQ 2823
                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3918 TvwqewydldSLEQFPVPLGYDNNITPFQKLLILRCFRVDRVYRAVTDYVTVTMGekyvqppmisfeaIFEQSTPHSPIV 3997
Cdd:COG5245   2824 M---------DNRTHSTILTSNSKTNPYKEYTYNDSWAEAFEVEDSGDLYKFEEG-------------LLELIVGHAPLI 2881
                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3998 FIL--SPGSDPATDLMKLAERSGFGGNRLKFlamgqgqekvalqlletAVARGQWLMLQNCHLLVKWLKD-LEKSLERI- 4073
Cdd:COG5245   2882 YAHkkSLENERNVDRLGSKENEVYAVLNSLF-----------------SRKEKSWFEVYNISLSFGWFKRyVEDVVYPIk 2944
                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4074 -TKPHPDF-RLWLTTDPTKGFPIGILQKSLKVVTEPPNGLKLNMrATYFKISHEMLDQCPHPAFKpLVYVLAFFHAVVQE 4151
Cdd:COG5245   2945 aSRVCGKVkNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRYPFDYTLVIACD-DAFYLSWEHAAVAS 3022
                         2970      2980      2990      3000      3010      3020      3030      3040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4152 RRKFGKIGWNVYYDFNESDFQVCMEILNTYLtkaFQQRDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYMDEYlgdf 4231
Cdd:COG5245   3023 VISAGPKENNEEIYFGDKDFEFKTHLLKNIL---FLNHLNARKWGNNRDLIFTIVYGKKHSLMEDSKVVDKYCRGY---- 3095
                         3050      3060      3070
                   ....*....|....*....|....*....|....
gi 1722218962 4232 ifdtfqpFHFFRNKEVDYKIPVGDEKEKFVEAIE 4265
Cdd:COG5245   3096 -------GAHETSSQILASVPGGDPELVKFHMEE 3122
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4288-4586 5.65e-114

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 365.02  E-value: 5.65e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4288 TQAARDMWAHLLELQPQT--GESSSGISRDDYIGQVAKEIENKMPKVFDLDQVRKRLGTG-LSPTSVVLLQELERFNKLV 4364
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSdsGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPVGyEDPLNTVLLQEIERFNKLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4365 VRMTKSLAELQRALAGEVGMSNELDDVARSLFIGHIPNIWRRLAPDTLKSLGNWMVYFLRRFSQYMLWV-TESEPSVMWL 4443
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLdDEGPPKVFWL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4444 SGLHIPESYLTALVQATCRKNGWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIEKGCLIKSKPKVLVV 4523
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1722218962 4524 DLPILKIIPIEAHRLKLQ-NTFRTPVYTTSMRRNAmgvGLVFEADLFTTRHISHWVLQGVCLTL 4586
Cdd:pfam18199  241 PLPVIHLKPVESDKKKLDeNTYECPVYKTSERHST---NFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3524-3745 4.55e-102

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 327.48  E-value: 4.55e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3524 SRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQQQALNWIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPFLFRDVD 3603
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3604 EYIDPVIDNVLEKNIKVSQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVA 3683
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1722218962 3684 YERRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEV 3745
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3165-3442 5.09e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 5.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3165 LDGGLDKLKEATIQLDELNQKL--AEQKIVLAEKSAacEALLEEIAVNTAVAEEKKKLAEEKAMEIE----EQNKVIAmE 3238
Cdd:TIGR02169  690 LSSLQSELRRIENRLDELSQELsdASRKIGEIEKEI--EQLEQEEEKLKERLEELEEDLSSLEQEIEnvksELKELEA-R 766
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3239 KAEAETTLAEVMpiLEAAKLElQKLDKSDVTEIRSFAKPPKQVQTVCECILImkgykELNWKTAKgVMSDPNFLRSLMEI 3318
Cdd:TIGR02169  767 IEELEEDLHKLE--EALNDLE-ARLSHSRIPEIQAELSKLEEEVSRIEARLR-----EIEQKLNR-LTLEKEYLEKEIQE 837
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3319 DFDSI--TQSQVKNIKGLLKTLNTTTEEMEAvskaglgmlkfveavmgycdvfrEIKPKREKVARLERNFYLTKRELERI 3396
Cdd:TIGR02169  838 LQEQRidLKEQIKSIEKEIENLNGKKEELEE-----------------------ELEELEAALRDLESRLGDLKKERDEL 894
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1722218962 3397 QNELAAIQKELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKLI 3442
Cdd:TIGR02169  895 EAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPK 940
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
3170-3458 9.49e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 42.36  E-value: 9.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3170 DKLKEATIQLDELNQKLAEQKIVLAEKSaaceaLLEEIAvntavaeekkklaeekamEIEEQNKVIAMEKAEAETTLAEV 3249
Cdd:PRK03918   473 EKERKLRKELRELEKVLKKESELIKLKE-----LAEQLK------------------ELEEKLKKYNLEELEKKAEEYEK 529
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3250 MpileaaKLELQKLDKsdvtEIRSFAKPPKQVQTV-CECILIMKGYKELNWKTAkgvmsdpNFLRSLMEIDFDSItqsqv 3328
Cdd:PRK03918   530 L------KEKLIKLKG----EIKSLKKELEKLEELkKKLAELEKKLDELEEELA-------ELLKELEELGFESV----- 587
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3329 knikgllKTLNTTTEEMEAVSKaglgmlKFVEAVmgycDVFREIKPKREKVARLERNFYLTKRELERIQNELAAIQKELE 3408
Cdd:PRK03918   588 -------EELEERLKELEPFYN------EYLELK----DAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE 650
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1722218962 3409 TLGAKYEAAilEKQKLQEEAEIMERRLIAADKLISGLGS---ENIRWLNDLDE 3458
Cdd:PRK03918   651 ELEKKYSEE--EYEELREEYLELSRELAGLRAELEELEKrreEIKKTLEKLKE 701
 
Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1912-2238 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 673.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1912 YGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYRAVGKIFSG 1991
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1992 LAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFR 2071
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2072 PVVVIVPDLQQICEIMLFSEGFLEAKTLAKKMTVLYKLAREQLSKQYHYDFGLRALKSVLVMAGELKRGSSDLREDVVLM 2151
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2152 RALRDMNLPKFVFEDVPLFLGLISDLFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETMLTRHTTMVVG 2231
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320

                   ....*..
gi 1722218962 2232 PTRGGKS 2238
Cdd:pfam12774  321 PTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
306-876 2.03e-176

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 555.65  E-value: 2.03e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  306 VDILEQCVINWLNQISTAveaqLKKTPQGK--GPLAEIEFWRERNATLSALHEQTKLPIVRKVLDVIKESDSMLVANLQP 383
Cdd:pfam08385    1 LHALESVVIKWTKQIQDV----LKEDSQGRnpGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKA 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  384 VFTELFKFHTEASDNVRFLSTVERYFKNITHGSGFHVVLDTIPAMMSALRMVWIISRHYNKDERMIPLMERIAWEIAERV 463
Cdd:pfam08385   77 LDTELTDALNEAKDNVKYLKTLERPFEDLEELTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQC 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  464 CRVVNLRTLFKENRASAQSKTLEARNTLRLWKKAYFDTRAKIEASGREDRWEFDRKRLFERTDYMATICQDLSDVLQILE 543
Cdd:pfam08385  157 KKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERPWDFSERYIFGRFDAFLERLEKILELFETIE 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  544 EF------YNIFGPELKAVtgdpkrIDDVLCRVDGLVTPMENLTFDPFSIKSSQfWKYVMDEFKIEVLVIEKEAKHFIDE 617
Cdd:pfam08385  237 QFsklekiGGTKGPELEGV------IEEILEEFQEAYKVFKSKTYDILDVSNEG-FDDDYEEFKERIKDLERRLQAFIDQ 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  618 SFKTLRSAEAAFDMLLKFKHIRSREAVNRQMMMKFNDILAQYCKEIDIINKIFVQNLENP-PLYKNHPPVAGAIYWERSL 696
Cdd:pfam08385  310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYNPsPIAKNMPPVAGAIIWARQL 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  697 FFRIKHTILRFQEVQEILDSDRGQEVKQKYLEVGRTMKEYEDRKYEQWMEVTEQVLPALMKKSLLTKSSiateepstlER 776
Cdd:pfam08385  390 FRRIQEPMKRFKEELGLLKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLLVRHP---------ET 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962  777 GAVFAINFSPALREIINETKYLEQLGFTVPELARNVALQEDKFLRYTAGIQRMLDHYHMLIGTLNDAESVLLKDHSQELL 856
Cdd:pfam08385  461 GKLLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDID 540
                          570       580
                   ....*....|....*....|
gi 1722218962  857 RVFRSGYKRLNWNSLGIGDY 876
Cdd:pfam08385  541 EKLEPGLTTLTWNSLGIDEY 560
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1372-1777 1.06e-159

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 501.02  E-value: 1.06e-159
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1372 LLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWINLNVQILQEGIEGFLRALRKLPRPVRGLSVTYYLEAKMKAFKDSIP 1451
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1452 LLLDLKNEALRDRHWKELMEKTSVFFEM-TETFTLENMFAMELHKHTDVLNEIVTAAIKEVAIEKAVKEILDTWENMKFT 1530
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFDPlSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1531 VVKYCKGTqerGYILGSVDEIIQSLDDNTFNLQSISGSRFVGPFLQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFI 1610
Cdd:pfam08393  161 LVPYKDTG---TFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1611 GGDIRSQLPEEAKKFDNIDKVFKRIMGETLKDPVIKRCCEAPNRLSDLQNVSEGLEKCQKSLNDYLDSKRNAFPRFFFIS 1690
Cdd:pfam08393  238 SEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLS 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1691 DDELLSILG-SSDPLCVQEHMIKMYDNIASLRFNDgdsgEKLVSAMISAEGEVMEFRK-ILRAEGRVEDWMTAVLNEMRR 1768
Cdd:pfam08393  318 NDELLEILSqTKDPTRVQPHLKKCFEGIASLEFDE----NKEITGMISKEGEVVPFSKpPVEAKGNVEEWLNELEEEMRE 393

                   ....*....
gi 1722218962 1769 TNRLITKEA 1777
Cdd:pfam08393  394 TLRDLLKEA 402
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2891-3150 7.96e-118

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 374.25  E-value: 7.96e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2891 MNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIE 2970
Cdd:pfam12780    1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2971 NKAMIFLFTDAHVAEEGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGMGPAKESVWQYFVNKSANNLHIVLG 3050
Cdd:pfam12780   81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3051 MSPVGDTLRTWCRNFPGMVNNTGIDWFMPWPPQALHAVAKSFLGyNPMIPAENIENVVKHVVLVHQSVDHYSQQFLQKLR 3130
Cdd:pfam12780  161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLE-DIEIPEELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
                          250       260
                   ....*....|....*....|
gi 1722218962 3131 RSNYVTPKNYLDFINTYSKL 3150
Cdd:pfam12780  240 RKNYVTPKSYLELLRLYKNL 259
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1274-4265 1.65e-114

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 411.69  E-value: 1.65e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1274 SIWSNLFNDSVNVEHALGdIKRTFTELTRgeIMNYRVQIEEFAKRFYSEgPGSVGDDLDKGVELlgvYERELARHEKSRQ 1353
Cdd:COG5245    339 SLESSLFYEFRGGEHLAG-FYSAFGDIKR--ILLFTWSFKKLGTLLPSL-PGYSSGGMDYGEEY---RSLLWELGSEVGD 411
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1354 ELANAEKLFDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWinLNVQILQEGIEGFLRAlRKLPRPVRgL 1433
Cdd:COG5245    412 PDSGPVRKWMRKDLFDAKVRSGVSFGKQEEFVSDIFNITFERIHGMDPTTL--EDDEEDTPALAILLGQ-EEAGRFVK-L 487
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1434 SVTYYLEAKMKAFKDSIPLLLDLKNEALRdrHWKELMEKTSVFFEMTETFTLENMFaMELHKHTDVLNEIVTAAIKEVA- 1512
Cdd:COG5245    488 CKIMRMFSFFNSLEMFSRRTLANRMAIVK--YLSSVVRTGPLFLQRDFFGRMSELL-MARDMFMEVDGVLRLFFGGEWSg 564
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1513 -IEKAVKEILDTWENMKFT--VVKYCKGTQERGYILGSVDEIIQSLDDNTfNLQSISGSRfvgpflqtVHKWEKTLSLIG 1589
Cdd:COG5245    565 iVQLSGIRRAKRCVERQIDdeIREWCSSVLSDDFLEERAVRVERGADGAR-RLRASSGSP--------VLRRLDEYLMMM 635
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1590 EVIeiwmlvqrkwmylesifiggDIRSQLPEEAKKFDNIDKVFKRIMGETLKDPVIKRCCEAPNrLSDLQNVSEGLEKCQ 1669
Cdd:COG5245    636 SLE--------------------DLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVF 694
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1670 KSLNDYLDSKRNAFPRFffISDDELLSILGS-SDPLCVQEHMIKMYDNIASLR-FNDGDSGEKLVSAMISAEGEVMEFRK 1747
Cdd:COG5245    695 MSIEKVLGLRWREVERA--SEVEELMDRVRElENRVYSYRFFVKKIAKEEMKTvFSSRIQKKEPFSLDSEAYVGFFRLYE 772
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1748 ILRAEGRVEDWMTAVLNEMRRTNRLITKEAIFRYCEDRSRVDWMLLYQGMvvlaasqvwWTWEVEDVFhkaqkgeKQAMK 1827
Cdd:COG5245    773 KSIVIRGINRSMGRVLSQYLESVQEALEIEDGSFFVSRHRVRDGGLEKGR---------GCDAWENCF-------DPPLS 836
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1828 NYGRKMHRQIDELVTRitmpLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFDWESQLRFYwDREPDELNIRQCT 1907
Cdd:COG5245    837 EYFRILEKIFPSEEGY----FFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVSISELP-QGLYKRFIKVRSS 911
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1908 GTFGYGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLggapAGPAGTGKTETTKDLAKALGLLCvvtncgEGMDYRAvgK 1987
Cdd:COG5245    912 YRSAEMFAKNTIPFFVFEHSMDTSQHQKLFEAVCDEV----CRFVDTENSRVYGMLVAGKGRIY------DGTEPRS--R 979
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 1988 IFSGLAQCGAWGcFDEFNRIDASVLSvISSQIQTIRNAL--IHQLTTFQFEgqEISLDSRMGIFITMNPgyagRTELPES 2065
Cdd:COG5245    980 IEAGPICEEERG-TEESALLDEISRT-ILVDEYLNSDEFrmLEELNSAVVE--HGLKSPSTPVEMIINE----RNIVLEI 1051
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2066 VKALFRPVVVIVPdLQQICEIMlfsegfleaKTLAKKMTVLYKLAREQLSKQYHYDFglRALKSVLvmagelkRGSSDLR 2145
Cdd:COG5245   1052 GRRALDMFLSNIP-FGAIKSRR---------ESLDREIGAFNNEVDGIAREEDELMF--YPMFKSL-------KAKHRML 1112
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2146 EDVV--LMRALRDMNLPkfvfedvplflgLISD-LFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETML 2222
Cdd:COG5245   1113 EEKTeyLNKILSITGLP------------LISDtLRERIDTLDAEWDSFCRISESLKKYESQQVSGLDVAQFVSFLRSVD 1180
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2223 TRHTTMVVGPTRGGKSVVINTLCQaqtklglttklYILNPKAVSVIELYgiLDPTTrDWTdGVLSNIFREINKPTDKKER 2302
Cdd:COG5245   1181 TGAFHAEYFRVFLCKIKHYTDACD-----------YLWHVKSPYVKKKY--FDADM-ELR-QFFLMFNREDMEARLADSK 1245
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2303 KYILFDGdvdalWVENMNSVMDDNRLLTLANGERirlqahcALLFEVGDlqyASPATVSRCGMVYVDPKNLKYRPYWKKW 2382
Cdd:COG5245   1246 MEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRLSTKGVFLDE 1310
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2383 VNQ----IPNKVEQYNLNSLFEKYVPYLMDVIVEGIVdgRQAEKLKTIVPQTDLNMV--------------TQLAKMLDa 2444
Cdd:COG5245   1311 LGDtkryLDECLDFFSCFEEVQKEIDELSMVFCADAL--RFSADLYHIVKERRFSGVlagsdaseslggksIELAAILE- 1387
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2445 lLEGEIEDLDLLECYFLeaLYCSLGASLLEDGRmkfdeyikRLASLSTVDTEGVWANPGELPGQLPTLYDFHFDNKRNQW 2524
Cdd:COG5245   1388 -HKDLIVEMKRGINDVL--KLRIFGDKCRESTP--------RFYLISDGDLIKDLNERSDYEEMLIMMFNISAVITNNGS 1456
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2525 VPWSKLVPEYIHAPErkfiNILVHTVDTTRTTWILEQMVKIKQPVIFVGESGTSKTATTQNFLKnlSEETNIVLMVNFSS 2604
Cdd:COG5245   1457 IAGFELRGERVMLRK----EVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLR--SELITEVKYFNFST 1530
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2605 RTTSMDIQRNLEANVEKRTKD----TYGPPMGKRLLVFMDDMNMPRVDEYGTQQPIALLKLLLEK-GYLYDRGKELncKS 2679
Cdd:COG5245   1531 CTMTPSKLSVLERETEYYPNTgvvrLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERqGFWSSIAVSW--VT 1608
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2680 IRDLGFIAAMGKAGG-GRNEVDPRFISLFSVFNVPFPSEESLHLIYSSILKG------HTSTFHESIVAVSGKLTFCTLA 2752
Cdd:COG5245   1609 ICGIILYGACNPGTDeGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGsylcfdEFNRLSEETMSASVELYLSSKD 1688
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2753 LYKNIVQDlpptpskfHYIFNLRDLSRV---FNGLVLTNPErfQTVAQMVRVWRNECLRVFHDRLISETDKQLVQQHIGS 2829
Cdd:COG5245   1689 KTKFFLQM--------NYGYKPRELTRSlraIFGYAETRID--TPDVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYD 1758
                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2830 LVVEHFKD-DVEVVMRDPILFGD---FQMALhegepriyediQDYEAAKALFQEILEEYNESNTKMNLVLFDDALEHLTR 2905
Cdd:COG5245   1759 FGLRAIREmIAGHIGEAEITFSMilfFGMAC-----------LLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALLHILR 1827
                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2906 VHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIENKAMIFLFTDAHVAE 2985
Cdd:COG5245   1828 SRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVE 1907
                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2986 EGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGMG-PAKESVWQYFVNKSANNLHIVLGMSPVGDTLRTWCRN 3064
Cdd:COG5245   1908 SSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLEkDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIR 1987
                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3065 FPGMVNNTGIDWFMPWPPQALHAVAKSFL------GYNPMIPAE--NIENVVKHVVLVHQSVDHYSQQFLQKLRR-SNYV 3135
Cdd:COG5245   1988 SPALKNRCFIDFKKLWDTEEMSQYANSVEtlsrdgGRVFFINGElgVGKGALISEVFGDDAVVIEGRGFEISMIEgSLGE 2067
                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3136 TPKNYLDFINTYSKLLDEKTQCNIAQCKRLDGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACEALLE-------EIA 3208
Cdd:COG5245   2068 SKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSgtpgerlERE 2147
                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3209 VNTAVAEEKKKLAEEKAMEIEEQNKVIAMEKAEAETTLAEvmpileaAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECI 3288
Cdd:COG5245   2148 VKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLE-------AVLFVYKIKKASLREIRSFIRPPGDLCIEMEDV 2220
                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3289 LIMKGYKELNWKTAKGVMSD----PNFLRSLMEIDFDsiTQSQVKNIKGLLKTLNTTTEEMEAVSKAGLGMLKFVEAVMG 3364
Cdd:COG5245   2221 CDLLGFEAKIWFGEQQSLRRddfiRIIGKYPDEIEFD--LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECN 2298
                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3365 YCDVFREIKPKREKVARLERNFYLTKrelERIQNELAAIQK---ELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKL 3441
Cdd:COG5245   2299 RSKVLEVKIPLREEEKRIDGEAFLVE---DRLTLGKGLSSDlmtFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFV 2375
                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3442 ISGLGSENIRWLNDLDELMHRRVKLLGDCLLCAAFLSYEGafTWEFRDEMVNRIWQNDILEREIPLSQPFR---LESLLT 3518
Cdd:COG5245   2376 SEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIG--TLGFLCRAIEFGMSFIRISKEFRDKEIRRrqfITEGVQ 2453
                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3519 DDVEiSRWGSQglpPDELSVQN-GILTTRASRFPLCIDPQQQALNWIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPF 3597
Cdd:COG5245   2454 KIED-FKEEAC---STDYGLENsRIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDK 2529
                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3598 LFRDVdEYIDPVIDNVLEKNIKVSQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQL 3677
Cdd:COG5245   2530 IIGDA-EALDEEIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEI 2608
                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3678 LSVLVAYERRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEVSEKLKLAEKTAL 3757
Cdd:COG5245   2609 PDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIED 2688
                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3758 DIDRLRDGYRPAARRGAILFFVLSEMALVNSMYQYSLIAFLEVFRLSLKKSlpdSILMKRLRNIMDTLTFSIYNHGCTGL 3837
Cdd:COG5245   2689 RIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWRRMK---SKYLCAIRYMLMSSEWILDHEDRSGF 2765
                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3838 FerHKLLFSFNMTIKieqaegrvpqEELDFFLKGNISLEKskrkkpcawLSDQGWEDIILLSEMfSDNFGQLPDDVENNQ 3917
Cdd:COG5245   2766 I--HRLDVSFLLRTK----------RFVSTLLEDKNYRQV---------LSSCSLYGNDVISHS-CDRFDRDVYRALKHQ 2823
                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3918 TvwqewydldSLEQFPVPLGYDNNITPFQKLLILRCFRVDRVYRAVTDYVTVTMGekyvqppmisfeaIFEQSTPHSPIV 3997
Cdd:COG5245   2824 M---------DNRTHSTILTSNSKTNPYKEYTYNDSWAEAFEVEDSGDLYKFEEG-------------LLELIVGHAPLI 2881
                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3998 FIL--SPGSDPATDLMKLAERSGFGGNRLKFlamgqgqekvalqlletAVARGQWLMLQNCHLLVKWLKD-LEKSLERI- 4073
Cdd:COG5245   2882 YAHkkSLENERNVDRLGSKENEVYAVLNSLF-----------------SRKEKSWFEVYNISLSFGWFKRyVEDVVYPIk 2944
                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4074 -TKPHPDF-RLWLTTDPTKGFPIGILQKSLKVVTEPPNGLKLNMrATYFKISHEMLDQCPHPAFKpLVYVLAFFHAVVQE 4151
Cdd:COG5245   2945 aSRVCGKVkNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRYPFDYTLVIACD-DAFYLSWEHAAVAS 3022
                         2970      2980      2990      3000      3010      3020      3030      3040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4152 RRKFGKIGWNVYYDFNESDFQVCMEILNTYLtkaFQQRDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYMDEYlgdf 4231
Cdd:COG5245   3023 VISAGPKENNEEIYFGDKDFEFKTHLLKNIL---FLNHLNARKWGNNRDLIFTIVYGKKHSLMEDSKVVDKYCRGY---- 3095
                         3050      3060      3070
                   ....*....|....*....|....*....|....
gi 1722218962 4232 ifdtfqpFHFFRNKEVDYKIPVGDEKEKFVEAIE 4265
Cdd:COG5245   3096 -------GAHETSSQILASVPGGDPELVKFHMEE 3122
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4288-4586 5.65e-114

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 365.02  E-value: 5.65e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4288 TQAARDMWAHLLELQPQT--GESSSGISRDDYIGQVAKEIENKMPKVFDLDQVRKRLGTG-LSPTSVVLLQELERFNKLV 4364
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSdsGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPVGyEDPLNTVLLQEIERFNKLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4365 VRMTKSLAELQRALAGEVGMSNELDDVARSLFIGHIPNIWRRLAPDTLKSLGNWMVYFLRRFSQYMLWV-TESEPSVMWL 4443
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLdDEGPPKVFWL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4444 SGLHIPESYLTALVQATCRKNGWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIEKGCLIKSKPKVLVV 4523
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1722218962 4524 DLPILKIIPIEAHRLKLQ-NTFRTPVYTTSMRRNAmgvGLVFEADLFTTRHISHWVLQGVCLTL 4586
Cdd:pfam18199  241 PLPVIHLKPVESDKKKLDeNTYECPVYKTSERHST---NFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3524-3745 4.55e-102

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 327.48  E-value: 4.55e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3524 SRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQQQALNWIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPFLFRDVD 3603
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3604 EYIDPVIDNVLEKNIKVSQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVA 3683
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1722218962 3684 YERRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEV 3745
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
2536-2715 2.77e-87

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 283.13  E-value: 2.77e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2536 HAPERKFINILVHTVDTTRTTWILEQMVKIKQPVIFVGESGTSKTATTQNFLKNLSEETNIVLMVNFSSRTTSMDIQRNL 2615
Cdd:pfam12775    1 IPPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEKYLPLFINFSAQTTSNQTQDII 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2616 EANVEKRTKDTYGPPMGKRLLVFMDDMNMPRVDEYGTQQPIALLKLLLEKGYLYDRgKELNCKSIRDLGFIAAMGKAGGG 2695
Cdd:pfam12775   81 ESKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDR-KKLTFKEIVDVQFVAAMGPPGGG 159
                          170       180
                   ....*....|....*....|
gi 1722218962 2696 RNEVDPRFISLFSVFNVPFP 2715
Cdd:pfam12775  160 RNDITPRLLRHFNVFNITFP 179
AAA_lid_11 pfam18198
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ...
4135-4282 1.77e-66

Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.


Pssm-ID: 465676  Cd Length: 139  Bit Score: 221.94  E-value: 1.77e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 4135 FKPLVYVLAFFHAVVQERRKFGKIGWNVYYDFNESDFQVCMEILNTYLTKAfqqrDPRIPWGSLKYLIGEVMYGGRAIDS 4214
Cdd:pfam18198    1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEY----DEKIPWDALRYLIGEINYGGRVTDD 76
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1722218962 4215 FDRRILTIYMDEYLGDFIFDtfQPFHFFrnkEVDYKIPVGDEKEKFVEAIEALPLANTPEVFGLHPNA 4282
Cdd:pfam18198   77 WDRRLLNTYLEEFFNPEVLE--EDFKFS---PSLYYIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
Dynein_heavy pfam03028
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ...
3991-4104 1.89e-55

Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.


Pssm-ID: 460782  Cd Length: 115  Bit Score: 189.58  E-value: 1.89e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3991 TPHSPIVFILSPGSDPATDLMKLAERSGFGgNRLKFLAMGQGQEKVALQLLETAVARGQWLMLQNCHLLVKWLKDLEKSL 4070
Cdd:pfam03028    1 SPTTPLIFILSPGSDPTADLEKLAKKLGFG-GKLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPELEKIL 79
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1722218962 4071 ERI--TKPHPDFRLWLTTDPTKGFPIGILQKSLKVV 4104
Cdd:pfam03028   80 EELpeETLHPDFRLWLTSEPSPKFPISILQNSIKIT 115
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
3163-3496 2.68e-55

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 198.37  E-value: 2.68e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3163 KRLDGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACEALLEEIAVNTAVAEEKKKLAEEKAMEIEEQNKVIAMEKAEA 3242
Cdd:pfam12777    1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3243 ETTLAEVMPILEAAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECILIM-----KGYKELNWKTAKGVMSDPN-FLRSLM 3316
Cdd:pfam12777   81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILmapggKIPKDKSWKAAKIMMAKVDgFLDSLI 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3317 EIDFDSITQSQVKNIKGLLKTLNTTTEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKREKVARLERNFYLTKRELERI 3396
Cdd:pfam12777  161 KFDKEHIHEACLKAFKPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAAI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3397 QNELAAIQKELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKLISGLGSENIRWLNDLDELMHRRVKLLGDCLLCAAF 3476
Cdd:pfam12777  241 KAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISAF 320
                          330       340
                   ....*....|....*....|
gi 1722218962 3477 LSYEGAFTWEFRDEMVNRIW 3496
Cdd:pfam12777  321 ISYLGFFTKKYRNELLDKFW 340
Dynein_AAA_lid pfam17852
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ...
2395-2528 4.40e-23

Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.


Pssm-ID: 465532 [Multi-domain]  Cd Length: 126  Bit Score: 97.35  E-value: 4.40e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2395 LNSLFEKYVPYLMDVIvegivdgrqAEKLKTIVPQTDLNMVTQLAKMLDALLEGEIED-----------LDLLECYFLEA 2463
Cdd:pfam17852    1 LEPLFEWLVPPALEFV---------RKNCKEIVPTSDLNLVQSLCRLLESLLDEVLEYngvhplspdklKEYLEKLFLFA 71
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1722218962 2464 LYCSLGASLLEDGRMKFDEYIKRLASLStvdtegvwanpgELPGQL-PTLYDFHFDNKRNQWVPWS 2528
Cdd:pfam17852   72 LVWSIGGTLDEDSRKKFDEFLRELFSGL------------DLPPPEkGTVYDYFVDLEKGEWVPWS 125
AAA_lid_1 pfam17857
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
2751-2849 2.66e-16

AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.


Pssm-ID: 465535 [Multi-domain]  Cd Length: 100  Bit Score: 77.28  E-value: 2.66e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2751 LALYKNIVQDLPPTPSKFHYIFNLRDLSRVFNGLVLTNPERFQTVAQMVRVWRNECLRVFHDRLISETDKQLVQQhIGSL 2830
Cdd:pfam17857    6 LAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK-IQMA 84
                           90
                   ....*....|....*....
gi 1722218962 2831 VVEHFKDDVEvvmrDPILF 2849
Cdd:pfam17857   85 SLKKFFDDIE----DELEF 99
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2568-2707 1.97e-07

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 53.07  E-value: 1.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 2568 PVIFVGESGTSKTATTQNFLKNLSEETniVLMVNFSSRTTSMDI--QRNLEANVEKRTKDTYGPPMGKRLLVFMDDMNMP 2645
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSNRP--VFYVQLTRDTTEEDLfgRRNIDPGGASWVDGPLVRAAREGEIAVLDEINRA 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1722218962 2646 RVDEYGTQQPiallklLLEKGYLY--DRGKELNCKSiRDLGFIAAMGKAGGGRNEVDPRFISLF 2707
Cdd:pfam07728   79 NPDVLNSLLS------LLDERRLLlpDGGELVKAAP-DGFRLIATMNPLDRGLNELSPALRSRF 135
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
3371-3442 1.21e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.82  E-value: 1.21e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1722218962 3371 EIKPKREKVARLERnfyltkrELERIQNELAAIQKELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKLI 3442
Cdd:COG3883     17 QIQAKQKELSELQA-------ELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEI 81
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3165-3442 5.09e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 5.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3165 LDGGLDKLKEATIQLDELNQKL--AEQKIVLAEKSAacEALLEEIAVNTAVAEEKKKLAEEKAMEIE----EQNKVIAmE 3238
Cdd:TIGR02169  690 LSSLQSELRRIENRLDELSQELsdASRKIGEIEKEI--EQLEQEEEKLKERLEELEEDLSSLEQEIEnvksELKELEA-R 766
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3239 KAEAETTLAEVMpiLEAAKLElQKLDKSDVTEIRSFAKPPKQVQTVCECILImkgykELNWKTAKgVMSDPNFLRSLMEI 3318
Cdd:TIGR02169  767 IEELEEDLHKLE--EALNDLE-ARLSHSRIPEIQAELSKLEEEVSRIEARLR-----EIEQKLNR-LTLEKEYLEKEIQE 837
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3319 DFDSI--TQSQVKNIKGLLKTLNTTTEEMEAvskaglgmlkfveavmgycdvfrEIKPKREKVARLERNFYLTKRELERI 3396
Cdd:TIGR02169  838 LQEQRidLKEQIKSIEKEIENLNGKKEELEE-----------------------ELEELEAALRDLESRLGDLKKERDEL 894
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1722218962 3397 QNELAAIQKELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKLI 3442
Cdd:TIGR02169  895 EAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPK 940
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
3370-3435 7.32e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.20  E-value: 7.32e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1722218962 3370 REIKPKREKVARLERNFYLTKRELERIQNELAAIQKELETLGAKYEAAILEKQKLQEEAEIMERRL 3435
Cdd:COG4372     52 EELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEEL 117
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
3170-3458 9.49e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 42.36  E-value: 9.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3170 DKLKEATIQLDELNQKLAEQKIVLAEKSaaceaLLEEIAvntavaeekkklaeekamEIEEQNKVIAMEKAEAETTLAEV 3249
Cdd:PRK03918   473 EKERKLRKELRELEKVLKKESELIKLKE-----LAEQLK------------------ELEEKLKKYNLEELEKKAEEYEK 529
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3250 MpileaaKLELQKLDKsdvtEIRSFAKPPKQVQTV-CECILIMKGYKELNWKTAkgvmsdpNFLRSLMEIDFDSItqsqv 3328
Cdd:PRK03918   530 L------KEKLIKLKG----EIKSLKKELEKLEELkKKLAELEKKLDELEEELA-------ELLKELEELGFESV----- 587
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722218962 3329 knikgllKTLNTTTEEMEAVSKaglgmlKFVEAVmgycDVFREIKPKREKVARLERNFYLTKRELERIQNELAAIQKELE 3408
Cdd:PRK03918   588 -------EELEERLKELEPFYN------EYLELK----DAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE 650
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1722218962 3409 TLGAKYEAAilEKQKLQEEAEIMERRLIAADKLISGLGS---ENIRWLNDLDE 3458
Cdd:PRK03918   651 ELEKKYSEE--EYEELREEYLELSRELAGLRAELEELEKrreEIKKTLEKLKE 701
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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