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Conserved domains on  [gi|1758362348|ref|NP_001361588|]
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protein ABHD14A isoform b [Mus musculus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
45-259 3.13e-17

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 77.73  E-value: 3.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348  45 LTRGNSRIFYREVLPIQQArraeVVFLHGKAFNSHTWEQLgtLQLLSERgYRAVAIDLPGDPEhfvapmrlclllflgfg 124
Cdd:COG0596     7 VTVDGVRLHYREAGPDGPP----VVLLHGLPGSSYEWRPL--IPALAAG-YRVIAPDLRGHGR----------------- 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348 125 nSAPSEEVSTEAGRVELLERVFQDLQVQNTVLVSPSLSGSYALPFLMQNHHQLRGFVPIAPTSTRNYAQ----------- 193
Cdd:COG0596    63 -SDKPAGGYTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPlrrpglapeal 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348 194 -------------EQFGAVKTPTLILYGELDHTLARESLQQL-RHLPNHSVVKLHDAGHACYLHKPEAFHLALLAFLDHL 259
Cdd:COG0596   142 aallralartdlrERLARITVPTLVIWGEKDPIVPPALARRLaELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
45-259 3.13e-17

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 77.73  E-value: 3.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348  45 LTRGNSRIFYREVLPIQQArraeVVFLHGKAFNSHTWEQLgtLQLLSERgYRAVAIDLPGDPEhfvapmrlclllflgfg 124
Cdd:COG0596     7 VTVDGVRLHYREAGPDGPP----VVLLHGLPGSSYEWRPL--IPALAAG-YRVIAPDLRGHGR----------------- 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348 125 nSAPSEEVSTEAGRVELLERVFQDLQVQNTVLVSPSLSGSYALPFLMQNHHQLRGFVPIAPTSTRNYAQ----------- 193
Cdd:COG0596    63 -SDKPAGGYTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPlrrpglapeal 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348 194 -------------EQFGAVKTPTLILYGELDHTLARESLQQL-RHLPNHSVVKLHDAGHACYLHKPEAFHLALLAFLDHL 259
Cdd:COG0596   142 aallralartdlrERLARITVPTLVIWGEKDPIVPPALARRLaELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
45-259 3.13e-17

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 77.73  E-value: 3.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348  45 LTRGNSRIFYREVLPIQQArraeVVFLHGKAFNSHTWEQLgtLQLLSERgYRAVAIDLPGDPEhfvapmrlclllflgfg 124
Cdd:COG0596     7 VTVDGVRLHYREAGPDGPP----VVLLHGLPGSSYEWRPL--IPALAAG-YRVIAPDLRGHGR----------------- 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348 125 nSAPSEEVSTEAGRVELLERVFQDLQVQNTVLVSPSLSGSYALPFLMQNHHQLRGFVPIAPTSTRNYAQ----------- 193
Cdd:COG0596    63 -SDKPAGGYTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPlrrpglapeal 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348 194 -------------EQFGAVKTPTLILYGELDHTLARESLQQL-RHLPNHSVVKLHDAGHACYLHKPEAFHLALLAFLDHL 259
Cdd:COG0596   142 aallralartdlrERLARITVPTLVIWGEKDPIVPPALARRLaELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
46-257 1.07e-12

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 65.41  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348  46 TRGNSRIFYREVLPIQQARRAeVVFLHGkaFNSHTWEQLGTLQLLSERGYRAVAIDLPGDPEhfvapmrlclllflgfgN 125
Cdd:COG2267    10 TRDGLRLRGRRWRPAGSPRGT-VVLVHG--LGEHSGRYAELAEALAAAGYAVLAFDLRGHGR-----------------S 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348 126 SAPSEEVSTEAGRVELLERVFQDLQVQN---TVLVSPSLSGSYALPFLMQNHHQLRGFVPIAPTSTRN------------ 190
Cdd:COG2267    70 DGPRGHVDSFDDYVDDLRAALDALRARPglpVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRADpllgpsarwlra 149
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1758362348 191 -YAQEQFGAVKTPTLILYGELDHTLARESLQQL--RHLPNHSVVKLHDAGHACYLHKP-EAFHLALLAFLD 257
Cdd:COG2267   150 lRLAEALARIDVPVLVLHGGADRVVPPEAARRLaaRLSPDVELVLLPGARHELLNEPArEEVLAAILAWLE 220
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
57-239 3.39e-06

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 46.88  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348  57 VLPIQQARRAEVVFLHGkAFNSHTWEQlGTLQLLSERGYRAVAIDLPGDPEHfvapmrlclllflgfgnSAPSEEVSTEA 136
Cdd:COG0412    21 ARPAGGGPRPGVVVLHE-IFGLNPHIR-DVARRLAAAGYVVLAPDLYGRGGP-----------------GDDPDEARALM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362348 137 GRVELlERVFQDLQ-----VQNTVLVSP--------SLSGSYALpFLMQNHHQLRGFVPIAPTSTRNYAQEQFGAVKTPT 203
Cdd:COG0412    82 GALDP-ELLAADLRaaldwLKAQPEVDAgrvgvvgfCFGGGLAL-LAAARGPDLAAAVSFYGGLPADDLLDLAARIKAPV 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1758362348 204 LILYGELDHTLARESLQQLR-----HLPNHSVVKLHDAGHA 239
Cdd:COG0412   160 LLLYGEKDPLVPPEQVAALEaalaaAGVDVELHVYPGAGHG 200
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
190-260 1.11e-04

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 42.24  E-value: 1.11e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1758362348 190 NYAQEQFGAVKTPTLILYGELDHTLARESLQQL-RHL--PNHSVVKLHDAGH-ACYLHKPEAFHLALLAFLDHLP 260
Cdd:COG1647   171 REVRRDLPKITAPTLIIQSRKDEVVPPESARYIyERLgsPDKELVWLEDSGHvITLDKDREEVAEEILDFLERLA 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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