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Conserved domains on  [gi|1758362352|ref|NP_001361598|]
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rab9 effector protein with kelch motifs isoform 2 [Mus musculus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 18656853)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions; similar to Mus musculus Rab9 effector protein with kelch motifs, which is a Rab9 effector required for endosome to trans-Golgi network (TGN) transport

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
13-266 4.76e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 94.45  E-value: 4.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  13 PRKATWYTLtcpGDRPCPRVGHscsyfpPVGDAESGKIFIVGGANPN----QSFSDVHTMDLGTHQWdTATREGLLPRYE 88
Cdd:COG3055    45 PATNTWSEL---APLPGPPRHH------AAAVAQDGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW-TKLAPMPTPRGG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  89 HASFLPScspHSIWVFGGADQSGNRNCLQVMSPEDRTWSTpevTGSPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvedv 168
Cdd:COG3055   115 ATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN--------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 169 klhvFDANTLTWSQPETHgspPSPRHGHVMVAAGTKLFIHGGLAGdkFFDDLHCIDIGDMSWQKLGPtgaVPVGCAAHAA 248
Cdd:COG3055   180 ----GSGFSNTWTTLAPL---PTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGE---LPTPRHGHAA 247

                         250
                  ....*....|....*...
gi 1758362352 249 VAVGHHVYMFGGMTATGA 266
Cdd:COG3055   248 VLTDGKVYVIGGETKPGV 265
Kelch smart00612
Kelch domain;
256-301 2.59e-03

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.61  E-value: 2.59e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1758362352  256 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 301
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
13-266 4.76e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 94.45  E-value: 4.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  13 PRKATWYTLtcpGDRPCPRVGHscsyfpPVGDAESGKIFIVGGANPN----QSFSDVHTMDLGTHQWdTATREGLLPRYE 88
Cdd:COG3055    45 PATNTWSEL---APLPGPPRHH------AAAVAQDGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW-TKLAPMPTPRGG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  89 HASFLPScspHSIWVFGGADQSGNRNCLQVMSPEDRTWSTpevTGSPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvedv 168
Cdd:COG3055   115 ATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN--------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 169 klhvFDANTLTWSQPETHgspPSPRHGHVMVAAGTKLFIHGGLAGdkFFDDLHCIDIGDMSWQKLGPtgaVPVGCAAHAA 248
Cdd:COG3055   180 ----GSGFSNTWTTLAPL---PTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGE---LPTPRHGHAA 247

                         250
                  ....*....|....*...
gi 1758362352 249 VAVGHHVYMFGGMTATGA 266
Cdd:COG3055   248 VLTDGKVYVIGGETKPGV 265
PLN02193 PLN02193
nitrile-specifier protein
 126-294 1.61e-15

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 77.69  E-value: 1.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 126 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 204
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 205 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 284
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                         170
                  ....*....|
gi 1758362352 285 FDTSLPAGRL 294
Cdd:PLN02193  307 FHCSTPGDSF 316
Kelch_3 pfam13415
Galactose oxidase, central domain;
149-201 3.37e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.82  E-value: 3.37e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1758362352 149 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 201
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
256-301 2.59e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.61  E-value: 2.59e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1758362352  256 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 301
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
13-266 4.76e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 94.45  E-value: 4.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  13 PRKATWYTLtcpGDRPCPRVGHscsyfpPVGDAESGKIFIVGGANPN----QSFSDVHTMDLGTHQWdTATREGLLPRYE 88
Cdd:COG3055    45 PATNTWSEL---APLPGPPRHH------AAAVAQDGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW-TKLAPMPTPRGG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  89 HASFLPScspHSIWVFGGADQSGNRNCLQVMSPEDRTWSTpevTGSPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvedv 168
Cdd:COG3055   115 ATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN--------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 169 klhvFDANTLTWSQPETHgspPSPRHGHVMVAAGTKLFIHGGLAGdkFFDDLHCIDIGDMSWQKLGPtgaVPVGCAAHAA 248
Cdd:COG3055   180 ----GSGFSNTWTTLAPL---PTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGE---LPTPRHGHAA 247

                         250
                  ....*....|....*...
gi 1758362352 249 VAVGHHVYMFGGMTATGA 266
Cdd:COG3055   248 VLTDGKVYVIGGETKPGV 265
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
48-301 2.04e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 84.05  E-value: 2.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  48 GKIFIVGGANPNQSFSDVHTMDLGTHQWDTATREGLLPRYEHASFLPScspHSIWVFGGADQSGNRNCLQ----VMSPED 123
Cdd:COG3055    23 GKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQD---GKLYVFGGFTGANPSSTPLndvyVYDPAT 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 124 RTWSTpevTGSPPSPRTFHTsSAAIGNQLYVFGggerGAQPVEDVKLH-VFDANTLTWSQPethGSPPSPRHGH-VMVAA 201
Cdd:COG3055   100 NTWTK---LAPMPTPRGGAT-ALLLDGKIYVVG----GWDDGGNVAWVeVYDPATGTWTQL---APLPTPRDHLaAAVLP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 202 GTKLFIHGGLAGDKFFDdlHCIDIGDMSWQKLGPTGAVPVGcaahaavavghHVYMFGGMtaTGALNMMYKYHTEKQHWT 281
Cdd:COG3055   169 DGKILVIGGRNGSGFSN--TWTTLAPLPTARAGHAAAVLGG-----------KILVFGGE--SGFSDEVEAYDPATNTWT 233

                         250       260
                  ....*....|....*....|
gi 1758362352 282 VLqfdTSLPAGRLDHSMCVI 301
Cdd:COG3055   234 AL---GELPTPRHGHAAVLT 250
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
125-364 2.71e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 78.27  E-value: 2.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 125 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 202
Cdd:COG3055     2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 203 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 278
Cdd:COG3055    71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 279 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 354
Cdd:COG3055   148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                         250
                  ....*....|...
gi 1758362352 355 GM---NTEGEVYD 364
Cdd:COG3055   214 GEsgfSDEVEAYD 226
PLN02193 PLN02193
nitrile-specifier protein
 126-294 1.61e-15

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 77.69  E-value: 1.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 126 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 204
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 205 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 284
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                         170
                  ....*....|
gi 1758362352 285 FDTSLPAGRL 294
Cdd:PLN02193  307 FHCSTPGDSF 316
PLN02153 PLN02153
epithiospecifier protein
 133-275 7.75e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 71.94  E-value: 7.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 133 GSPPSPRTFHtSSAAIGNQLYVFGGgERGAQPVEDVKLHVFDANTLTWSQPETHGSPPS-PRHGHVMVAAGTKLFIHGGL 211
Cdd:PLN02153   17 GKGPGPRCSH-GIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGR 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1758362352 212 AGDKFFDDLHCIDIGDMSWQ---KLGPTGAvPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHT 275
Cdd:PLN02153   95 DEKREFSDFYSYDTVKNEWTfltKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRT 160
PLN02193 PLN02193
nitrile-specifier protein
 9-263 1.95e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.06  E-value: 1.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352   9 PGDKPRKATWYTLTCPGDRPCPRVGHscsyfppvGDAESG-KIFIVGGA-NPNQSFSD-VHTMDLGTHQWDTATREGLLP 85
Cdd:PLN02193  144 PSTPKLLGKWIKVEQKGEGPGLRCSH--------GIAQVGnKIYSFGGEfTPNQPIDKhLYVFDLETRTWSISPATGDVP 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  86 ryeHASFLPSCS---PHSIWVFGGADQSGNRNCLQVMSPEDRTWS--TPEVTGspPSPRTFHtSSAAIGNQLYVFGGgeR 160
Cdd:PLN02193  216 ---HLSCLGVRMvsiGSTLYVFGGRDASRQYNGFYSFDTTTNEWKllTPVEEG--PTPRSFH-SMAADEENVYVFGG--V 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 161 GAQpvedVKLHVFDANTL---TWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLAGDKFfDDLHCIDIGDMSWQKLGPTG 237
Cdd:PLN02193  288 SAT----ARLKTLDSYNIvdkKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEV-DDVHYYDPVQDKWTQVETFG 362

                         250       260
                  ....*....|....*....|....*.
gi 1758362352 238 AVPVGCAAHAAVAVGHHVYMFGGMTA 263
Cdd:PLN02193  363 VRPSERSVFASAAVGKHIVIFGGEIA 388
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
13-168 1.78e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 55.16  E-value: 1.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  13 PRKATWYTLtcpGDRPCPRVGHSCSYFPpvgdaeSGKIFIVGGANpnqsfsdvhtmdlGTHQWDTATREGLLP--RYEHA 90
Cdd:COG3055   144 PATGTWTQL---APLPTPRDHLAAAVLP------DGKILVIGGRN-------------GSGFSNTWTTLAPLPtaRAGHA 201

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1758362352  91 SFLPScspHSIWVFGGadQSGNRNCLQVMSPEDRTWSTpevTGSPPSPRTFHTSsAAIGNQLYVFGGGERGAQPVEDV 168
Cdd:COG3055   202 AAVLG---GKILVFGG--ESGFSDEVEAYDPATNTWTA---LGELPTPRHGHAA-VLTDGKVYVIGGETKPGVRTPLV 270
PLN02153 PLN02153
epithiospecifier protein
 25-260 2.18e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 55.38  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  25 GDRPCPRVGHSCSYfppVGDaesgKIFIVGGA-NPNQSF-SDVHTMDLGTHQWDTATREGLLPRYEHASFLPSCSPHSIW 102
Cdd:PLN02153   17 GKGPGPRCSHGIAV---VGD----KLYSFGGElKPNEHIdKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 103 VFGGADQSGNRNCLQVMSPEDRTW---STPEVTGSPPSpRTFHtSSAAIGNQLYVFGGGERGAQPVEDVKLHVFDANTLT 179
Cdd:PLN02153   90 IFGGRDEKREFSDFYSYDTVKNEWtflTKLDEEGGPEA-RTFH-SMASDENHVYVFGGVSKGGLMKTPERFRTIEAYNIA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 180 ---WSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLA--------GDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAA 248
Cdd:PLN02153  168 dgkWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFAtsilpggkSDYESNAVQFFDPASGKWTEVETTGAKPSARSVFAH 247

                         250
                  ....*....|..
gi 1758362352 249 VAVGHHVYMFGG 260
Cdd:PLN02153  248 AVVGKYIIIFGG 259
PLN02153 PLN02153
epithiospecifier protein
 34-242 4.02e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 54.22  E-value: 4.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  34 HSCSYFPPVGD------------AESGKIFIVGGANPNQSFSDVHTMDLGTHQWDTATREGLLPRYEHASFLPSCSPHS- 100
Cdd:PLN02153   60 HTWSIAPANGDvprisclgvrmvAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEGGPEARTFHSMASDENh 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 101 IWVFGGADQSGNRN------CLQVMSPEDRTWSTPEVTGSPPSPRTFHTSSAAIGNQLYVFGGGER----GAQPVEDVKL 170
Cdd:PLN02153  140 VYVFGGVSKGGLMKtperfrTIEAYNIADGKWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSilpgGKSDYESNAV 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 171 HVFDANTLTWSQPETHGSPPSPRHGHVMVAAGTKLFIHGG---------LAGDKFFDDLHCIDIGDMSWQKLGPTG--AV 239
Cdd:PLN02153  220 QFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGGevwpdlkghLGPGTLSNEGYALDTETLVWEKLGECGepAM 299


                  ...
gi 1758362352 240 PVG 242
Cdd:PLN02153  300 PRG 302
Kelch_3 pfam13415
Galactose oxidase, central domain;
149-201 3.37e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.82  E-value: 3.37e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1758362352 149 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 201
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
145-224 1.97e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.16  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 145 SAAIGNQLYVFGGGERGA-----QPVEDVklHVFDANTLTWSQPETHgsppSPRH--GHVMVAA-GTKLFIHGGLAG--- 213
Cdd:PRK14131   80 AAFIDGKLYVFGGIGKTNsegspQVFDDV--YKYDPKTNSWQKLDTR----SPVGlaGHVAVSLhNGKAYITGGVNKnif 153

                          90
                  ....*....|.
gi 1758362352 214 DKFFDDLHCID 224
Cdd:PRK14131  154 DGYFEDLAAAG 164
PRK14131 PRK14131
N-acetylneuraminate epimerase;
41-265 3.44e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.39  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  41 PVGDAESGKIFIVGG------ANPNQSFSDVHTMDLGTHQW---DTATREGLLPryeHASFlpscSPHS--IWVFGGADQ 109
Cdd:PRK14131   78 AVAAFIDGKLYVFGGigktnsEGSPQVFDDVYKYDPKTNSWqklDTRSPVGLAG---HVAV----SLHNgkAYITGGVNK 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 110 S-------------GNRNCLQV-------MSPEDRTWST------PE-----VTGSPPSPRTFHTSSAAIGNQLYVFGG- 157
Cdd:PRK14131  151 NifdgyfedlaaagKDKTPKDKindayfdKKPEDYFFNKevlsydPStnqwkNAGESPFLGTAGSAVVIKGNKLWLINGe 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 158 ---GERGAQpvedVKLHVFDANTLTW-SQPETHGSPPSPR------------HGHVMVAAGT------------KLFIHG 209
Cdd:PRK14131  231 ikpGLRTDA----VKQGKFTGNNLKWqKLPDLPPAPGGSSqegvagafagysNGVLLVAGGAnfpgarenyqngKLYAHE 306

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1758362352 210 GLAgDKFFDDLHCIDIGDmsWQKLGptgAVPVGCAAHAAVAVGHHVYMFGGMTATG 265
Cdd:PRK14131  307 GLK-KSWSDEIYALVNGK--WQKVG---ELPQGLAYGVSVSWNNGVLLIGGETAGG 356
Kelch_6 pfam13964
Kelch motif;
138-193 3.85e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.78  E-value: 3.85e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1758362352 138 PRTFHtSSAAIGNQLYVFGGGERGAQPVEdvKLHVFDANTLTWsqpETHGSPPSPR 193
Cdd:pfam13964   1 PRTFH-SVVSVGGYIYVFGGYTNASPALN--KLEVYNPLTKSW---EELPPLPTPR 50
PHA03098 PHA03098
kelch-like protein; Provisional
 50-236 4.08e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 45.53  E-value: 4.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352  50 IFIVGGANP-NQSFSDVHTMDLGTHQWdtatreGLLPRYEHASFLPSCS--PHSIWVFGGADQSGNRNCLQVMSPEDRTW 126
Cdd:PHA03098  297 IYFIGGMNKnNLSVNSVVSYDTKTKSW------NKVPELIYPRKNPGVTvfNNRIYVIGGIYNSISLNTVESWKPGESKW 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 127 stpevTGSPP--SPRtFHTSSAAIGNQLYVFGGGERGAQPVEDVKlhVFDANTLTWSqpeTHGSPPSPRHGHVMVAAGTK 204
Cdd:PHA03098  371 -----REEPPliFPR-YNPCVVNVNNLIYVIGGISKNDELLKTVE--CFSLNTNKWS---KGSPLPISHYGGCAIYHDGK 439

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1758362352 205 LFIHGGLA---GDKFFDDLHCIDIGDMSWQKLGPT 236
Cdd:PHA03098  440 IYVIGGISyidNIKVYNIVESYNPVTNKWTELSSL 474
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 190-221 4.22e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.54  E-value: 4.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1758362352 190 PSPRHGHVMVAAGTKLFIHGG--LAGDKFFDDLH 221
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGytGGEGQPSDDVY 34
Kelch_4 pfam13418
Galactose oxidase, central domain;
192-235 8.66e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 8.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1758362352 192 PRHGHVMVA-AGTKLFIHGGLAGD-KFFDDLHCIDIGDMSWQKLGP 235
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGS 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 192-235 9.74e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 9.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1758362352 192 PRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSWQKLGP 235
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
PLN02772 PLN02772
guanylate kinase
 144-215 9.77e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 40.98  E-value: 9.77e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1758362352 144 SSAAIGNQLYVFGGGERGAQPVEDVKLhvFDANTLTWSQPETHGSPPSPRHGH--VMVAAGTKLFIHGGLAGDK 215
Cdd:PLN02772   29 TSVTIGDKTYVIGGNHEGNTLSIGVQI--LDKITNNWVSPIVLGTGPKPCKGYsaVVLNKDRILVIKKGSAPDD 100
Kelch_3 pfam13415
Galactose oxidase, central domain;
99-147 2.07e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 2.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1758362352  99 HSIWVFGGADQSGNR--NCLQVMSPEDRTWSTpevTGSPPSPRTFHTSSAA 147
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTNTWTQ---IGDLPPPRSGHSATYI 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
30-75 2.48e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.67  E-value: 2.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1758362352  30 PRVGHSCSYFPpvgdaeSGKIFIVGGAN-PNQSFSDVHTMDLGTHQW 75
Cdd:pfam13418   1 PRAYHTSTSIP------DDTIYLFGGEGeDGTLLSDLWVFDLSTNEW 41
Kelch smart00612
Kelch domain;
256-301 2.59e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.61  E-value: 2.59e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1758362352  256 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 301
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 30-75 3.76e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.90  E-value: 3.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1758362352  30 PRVGHSCSYFPpvgdaesGKIFIVGGANPNQSFSDVHTMDLGTHQW 75
Cdd:pfam01344   1 RRSGAGVVVVG-------GKIYVIGGFDGNQSLNSVEVYDPETNTW 39
Kelch_4 pfam13418
Galactose oxidase, central domain;
138-182 4.67e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 4.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1758362352 138 PRTFHTSSAAIGNQLYVFGGGERGAQPVEDvkLHVFDANTLTWSQ 182
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSD--LWVFDLSTNEWTR 43
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 30-80 7.54e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 34.23  E-value: 7.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1758362352  30 PRVGHSCSYfppvgdaESGKIFIVGGA--NPNQSFSDVHTMDLGTHQWDTATR 80
Cdd:pfam07646   1 PRYPHASSV-------PGGKLYVVGGSdgLGDLSSSDVLVYDPETNVWTEVPR 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
145-242 8.45e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 38.07  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758362352 145 SAAIGNQLYVfGGGERGaqpvedVKLHVFDANTLTWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLaGDK-------FF 217
Cdd:PRK14131   34 GAIDNNTVYV-GLGSAG------TSWYKLDLNAPSKGWTKIAAFPGGPREQAVAAFIDGKLYVFGGI-GKTnsegspqVF 105

                          90       100
                  ....*....|....*....|....*
gi 1758362352 218 DDLHCIDIGDMSWQKLgPTGAvPVG 242
Cdd:PRK14131  106 DDVYKYDPKTNSWQKL-DTRS-PVG 128
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 138-182 9.22e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 33.74  E-value: 9.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1758362352 138 PRTFHtSSAAIGNQLYVFGGGeRGAQPVEDVklHVFDANTLTWSQ 182
Cdd:pfam01344   1 RRSGA-GVVVVGGKIYVIGGF-DGNQSLNSV--EVYDPETNTWSK 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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