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phenylalanine--tRNA ligase, mitochondrial isoform 3 [Homo sapiens]
phenylalanine--tRNA ligase( domain architecture ID 1006086)
phenylalanine--tRNA ligase catalyzes the synthesis of phenylalanyl-tRNA (Phe)
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
PLN02788 super family | cl33567 | phenylalanine-tRNA synthetase |
1-218 | 8.28e-115 | ||||
phenylalanine-tRNA synthetase The actual alignment was detected with superfamily member PLN02788: Pssm-ID: 215422 [Multi-domain] Cd Length: 402 Bit Score: 333.27 E-value: 8.28e-115
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Name | Accession | Description | Interval | E-value | ||||
PLN02788 | PLN02788 | phenylalanine-tRNA synthetase |
1-218 | 8.28e-115 | ||||
phenylalanine-tRNA synthetase Pssm-ID: 215422 [Multi-domain] Cd Length: 402 Bit Score: 333.27 E-value: 8.28e-115
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pheS_mito | TIGR00469 | phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA ... |
3-216 | 9.55e-90 | ||||
phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA synthetases, the mitochondrial form demonstrated from yeast is monomeric. It is similar to but longer than the alpha subunit (PheS) of the alpha 2 beta 2 form found in Bacteria, Archaea, and eukaryotes, and shares the characteristic motifs of class II aminoacyl-tRNA ligases. This model models the experimental example from Saccharomyces cerevisiae (designated MSF1) and its orthologs from other eukaryotic species. [Protein synthesis, tRNA aminoacylation] Pssm-ID: 129561 [Multi-domain] Cd Length: 460 Bit Score: 271.56 E-value: 9.55e-90
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PheRS_alpha_core | cd00496 | Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class ... |
1-106 | 9.19e-48 | ||||
Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. Pssm-ID: 238277 [Multi-domain] Cd Length: 218 Bit Score: 156.17 E-value: 9.19e-48
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PheS | COG0016 | Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; ... |
10-111 | 6.53e-33 | ||||
Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase alpha subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases Pssm-ID: 439787 [Multi-domain] Cd Length: 339 Bit Score: 120.93 E-value: 6.53e-33
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FDX-ACB | smart00896 | Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ... |
126-218 | 1.01e-32 | ||||
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold, consisting of an alpha+beta sandwich with anti-parallel beta-sheets (beta-alpha-beta x2). Pssm-ID: 214893 [Multi-domain] Cd Length: 93 Bit Score: 113.67 E-value: 1.01e-32
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tRNA-synt_2d | pfam01409 | tRNA synthetases class II core domain (F); Other tRNA synthetase sub-families are too ... |
10-111 | 3.44e-31 | ||||
tRNA synthetases class II core domain (F); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain. Pssm-ID: 396130 [Multi-domain] Cd Length: 245 Bit Score: 114.21 E-value: 3.44e-31
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Name | Accession | Description | Interval | E-value | ||||
PLN02788 | PLN02788 | phenylalanine-tRNA synthetase |
1-218 | 8.28e-115 | ||||
phenylalanine-tRNA synthetase Pssm-ID: 215422 [Multi-domain] Cd Length: 402 Bit Score: 333.27 E-value: 8.28e-115
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pheS_mito | TIGR00469 | phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA ... |
3-216 | 9.55e-90 | ||||
phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA synthetases, the mitochondrial form demonstrated from yeast is monomeric. It is similar to but longer than the alpha subunit (PheS) of the alpha 2 beta 2 form found in Bacteria, Archaea, and eukaryotes, and shares the characteristic motifs of class II aminoacyl-tRNA ligases. This model models the experimental example from Saccharomyces cerevisiae (designated MSF1) and its orthologs from other eukaryotic species. [Protein synthesis, tRNA aminoacylation] Pssm-ID: 129561 [Multi-domain] Cd Length: 460 Bit Score: 271.56 E-value: 9.55e-90
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PheRS_alpha_core | cd00496 | Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class ... |
1-106 | 9.19e-48 | ||||
Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. Pssm-ID: 238277 [Multi-domain] Cd Length: 218 Bit Score: 156.17 E-value: 9.19e-48
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PheS | COG0016 | Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; ... |
10-111 | 6.53e-33 | ||||
Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase alpha subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases Pssm-ID: 439787 [Multi-domain] Cd Length: 339 Bit Score: 120.93 E-value: 6.53e-33
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FDX-ACB | smart00896 | Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ... |
126-218 | 1.01e-32 | ||||
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold, consisting of an alpha+beta sandwich with anti-parallel beta-sheets (beta-alpha-beta x2). Pssm-ID: 214893 [Multi-domain] Cd Length: 93 Bit Score: 113.67 E-value: 1.01e-32
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tRNA-synt_2d | pfam01409 | tRNA synthetases class II core domain (F); Other tRNA synthetase sub-families are too ... |
10-111 | 3.44e-31 | ||||
tRNA synthetases class II core domain (F); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain. Pssm-ID: 396130 [Multi-domain] Cd Length: 245 Bit Score: 114.21 E-value: 3.44e-31
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pheS | TIGR00468 | phenylalanyl-tRNA synthetase, alpha subunit; Most phenylalanyl-tRNA synthetases are ... |
10-111 | 1.06e-26 | ||||
phenylalanyl-tRNA synthetase, alpha subunit; Most phenylalanyl-tRNA synthetases are heterodimeric, with 2 alpha (pheS) and 2 beta (pheT) subunits. This model describes the alpha subunit, which shows some similarity to class II aminoacyl-tRNA ligases. Mitochondrial phenylalanyl-tRNA synthetase is a single polypeptide chain, active as a monomer, and similar to this chain rather than to the beta chain, but excluded from this model. An interesting feature of the alignment of all sequences captured by this model is a deep split between non-spirochete bacterial examples and all other examples; supporting this split is a relative deletion of about 50 residues in the former set between two motifs well conserved throughout the alignment. [Protein synthesis, tRNA aminoacylation] Pssm-ID: 273095 [Multi-domain] Cd Length: 293 Bit Score: 103.55 E-value: 1.06e-26
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FDX-ACB | pfam03147 | Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ... |
126-218 | 8.16e-23 | ||||
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold. Pssm-ID: 460826 [Multi-domain] Cd Length: 94 Bit Score: 88.31 E-value: 8.16e-23
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pheT_bact | TIGR00472 | phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ... |
9-218 | 1.77e-16 | ||||
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation] Pssm-ID: 273097 [Multi-domain] Cd Length: 797 Bit Score: 77.33 E-value: 1.77e-16
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pheT | PRK00629 | phenylalanyl-tRNA synthetase subunit beta; Reviewed |
119-216 | 6.38e-16 | ||||
phenylalanyl-tRNA synthetase subunit beta; Reviewed Pssm-ID: 234804 [Multi-domain] Cd Length: 791 Bit Score: 75.98 E-value: 6.38e-16
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pheS | PRK04172 | phenylalanine--tRNA ligase subunit alpha; |
10-109 | 1.12e-15 | ||||
phenylalanine--tRNA ligase subunit alpha; Pssm-ID: 235239 [Multi-domain] Cd Length: 489 Bit Score: 74.87 E-value: 1.12e-15
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PheT | COG0072 | Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ... |
113-216 | 1.99e-15 | ||||
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases Pssm-ID: 439842 [Multi-domain] Cd Length: 793 Bit Score: 74.43 E-value: 1.99e-15
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syfB | CHL00192 | phenylalanyl-tRNA synthetase beta chain; Provisional |
122-218 | 1.21e-07 | ||||
phenylalanyl-tRNA synthetase beta chain; Provisional Pssm-ID: 214391 [Multi-domain] Cd Length: 704 Bit Score: 51.63 E-value: 1.21e-07
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PTZ00326 | PTZ00326 | phenylalanyl-tRNA synthetase alpha chain; Provisional |
35-100 | 2.41e-06 | ||||
phenylalanyl-tRNA synthetase alpha chain; Provisional Pssm-ID: 240361 [Multi-domain] Cd Length: 494 Bit Score: 47.27 E-value: 2.41e-06
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PLN02853 | PLN02853 | Probable phenylalanyl-tRNA synthetase alpha chain |
28-100 | 3.25e-06 | ||||
Probable phenylalanyl-tRNA synthetase alpha chain Pssm-ID: 215458 [Multi-domain] Cd Length: 492 Bit Score: 46.98 E-value: 3.25e-06
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Blast search parameters | ||||
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