NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1768365533|ref|NP_001362215|]
View 

alpha-synuclein isoform NACP140 [Homo sapiens]

Protein Classification

Synuclein domain-containing protein( domain architecture ID 10475760)

Synuclein domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Synuclein pfam01387
Synuclein; There are three types of synucleins in humans, these are called alpha, beta and ...
 1-131 9.34e-52

Synuclein; There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.


:

Pssm-ID: 460186 [Multi-domain]  Cd Length: 134  Bit Score: 160.48  E-value: 9.34e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768365533   1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQK 80
Cdd:pfam01387   1 MDVFMKGFSKAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVGSKTKEGVVQSVTTVAEKTKEQASHVGGAVVTSVTAVAQK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1768365533  81 TVEGAGSIAAATGFVKKDQLG---KNEEGAPQEGILEDMPVDPDNEAYEMPSEE 131
Cdd:pfam01387  81 TVEGAGNIAAATGLVKKEDLVppaPEEEGAEASEPMDEPESPPEGEPAEATEEE 134
 
Name Accession Description Interval E-value
Synuclein pfam01387
Synuclein; There are three types of synucleins in humans, these are called alpha, beta and ...
 1-131 9.34e-52

Synuclein; There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.


Pssm-ID: 460186 [Multi-domain]  Cd Length: 134  Bit Score: 160.48  E-value: 9.34e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768365533   1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQK 80
Cdd:pfam01387   1 MDVFMKGFSKAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVGSKTKEGVVQSVTTVAEKTKEQASHVGGAVVTSVTAVAQK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1768365533  81 TVEGAGSIAAATGFVKKDQLG---KNEEGAPQEGILEDMPVDPDNEAYEMPSEE 131
Cdd:pfam01387  81 TVEGAGNIAAATGLVKKEDLVppaPEEEGAEASEPMDEPESPPEGEPAEATEEE 134
 
Name Accession Description Interval E-value
Synuclein pfam01387
Synuclein; There are three types of synucleins in humans, these are called alpha, beta and ...
 1-131 9.34e-52

Synuclein; There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.


Pssm-ID: 460186 [Multi-domain]  Cd Length: 134  Bit Score: 160.48  E-value: 9.34e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768365533   1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQK 80
Cdd:pfam01387   1 MDVFMKGFSKAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVGSKTKEGVVQSVTTVAEKTKEQASHVGGAVVTSVTAVAQK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1768365533  81 TVEGAGSIAAATGFVKKDQLG---KNEEGAPQEGILEDMPVDPDNEAYEMPSEE 131
Cdd:pfam01387  81 TVEGAGNIAAATGLVKKEDLVppaPEEEGAEASEPMDEPESPPEGEPAEATEEE 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH