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Conserved domains on  [gi|1770726406|ref|NP_001362406|]
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probable E3 ubiquitin-protein ligase HERC3 isoform 4 [Homo sapiens]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18806229)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 576-922 5.97e-140

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 420.82  E-value: 5.97e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 576 LVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS-NLLWFSDT 654
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 655 CFV---EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEdvEETFCLNF 731
Cdd:cd00078    81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 732 TICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVG 810
Cdd:cd00078   159 TIELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 811 NSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPV 888
Cdd:cd00078   239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNpkFTIRRVGSPDDRLPT 318

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1770726406 889 AHTCYNLLDLPKYSSKEILSARLTQALDNYEGFS 922
Cdd:cd00078   319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 2-225 7.05e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 179.79  E-value: 7.05e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406   2 TTEDSvAVPRLIQKLnqQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGG 81
Cdd:COG5184    34 TTTDR-STPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDG-TTTDRTTPVKVPGLTGV--VAVAAGY 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  82 AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVkLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSM 161
Cdd:COG5184   108 YHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTT 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1770726406 162 NDEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 225
Cdd:COG5184   187 TDRPTPVQVGGL--SGVVAVAAGGDHSCA-LKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG 247
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
195-259 1.25e-07

Regulator of chromosome condensation (RCC1) repeat;


:

Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 48.67  E-value: 1.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1770726406 195 SGLIYAFGCGARGQLGTGHTCNVKCPSPVKGywaahsgqlsaradrFKYHIVKQIFSGGDQTFVL 259
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG---------------LSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 576-922 5.97e-140

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 420.82  E-value: 5.97e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 576 LVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS-NLLWFSDT 654
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 655 CFV---EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEdvEETFCLNF 731
Cdd:cd00078    81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 732 TICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVG 810
Cdd:cd00078   159 TIELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 811 NSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPV 888
Cdd:cd00078   239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNpkFTIRRVGSPDDRLPT 318

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1770726406 889 AHTCYNLLDLPKYSSKEILSARLTQALDNYEGFS 922
Cdd:cd00078   319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 600-921 1.45e-128

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 390.44  E-value: 1.45e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  600 DLKKP-LKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH----NWFHLIGITCGLAIY 674
Cdd:smart00119   1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  675 NSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL-LDYPGEDVEEtfcLNFTICRES-YGVIEQKKLIPGGDN 752
Cdd:smart00119  81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  753 VTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSAT 832
Cdd:smart00119 158 IPVTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSAN 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  833 HPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSAR 910
Cdd:smart00119 238 SQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSpkFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317

                          330
                   ....*....|.
gi 1770726406  911 LTQALDNYEGF 921
Cdd:smart00119 318 LLLAINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 634-924 3.87e-98

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 309.93  E-value: 3.87e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 634 NPIYGMFTY-YQDSNLLWFSDTCFVEH-----NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPT 707
Cdd:pfam00632   9 DPNYGLFEYeTEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 708 EGRSLQELLDYPgEDVEETFCLNFTIcrESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGF 787
Cdd:pfam00632  89 LYKSLKSLLNMD-NDDDEDLGLTFTI--PVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGF 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 788 LKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIY 867
Cdd:pfam00632 166 YSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVG 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1770726406 868 GMASLQ-IVIQS-TASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 924
Cdd:pfam00632 246 GFKSLPkFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
274-924 8.64e-83

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 285.51  E-value: 8.64e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 274 TMNQAHYTSLINDETIAVWRQKLSEHNN------ANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKI---PGIDLNS 344
Cdd:COG5021   198 AVSNVEKSEPDNVLFGLPYRSALTMRTNflkldtGNLSGEVQALLARYISIKLVIKKLYLGPGPDASSRIstlIIRLSNT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 345 TRVlfEKLMN-SQHSMILEQILnsfescLIPQLSSSPPDVEAMRIYLILPEFpLLQDSKYyiTLTIPLAMAILRLDTNPS 423
Cdd:COG5021   278 NLN--RRLSYiLSHSSFEDSLL------RLNSLFSTRADSFGRTYYLDHDRI-LTQYSRP--LLEETLGESTSFLVVNND 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 424 KVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFL----IPVLFNNYITAALKLLE-------KLYKVNLKVKHVEYD 492
Cdd:COG5021   347 DSSSIKDLPHQVGSNPFLEAHPEFSELLKNQSRGTTRdfrnKPTGWSSSIEDLGQFLFsdfltssSTYEDLRREQLGRES 426

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 493 TFYIPEISNlVDIQEDYLMWFLHqAGMDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLAR 572
Cdd:COG5021   427 DESFYVASN-VQQQRASREGPLL-SGWKTRLNNLYRFYFVEHRKKTLTKNDSRLGSFISLNKLDIRRIKEDKRRKLFYSL 504

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 573 S-------PFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQD 645
Cdd:COG5021   505 KqkakifdPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITE 584

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 646 SNL-LWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGE 721
Cdd:COG5021   585 DLYtLPINPLSSInpEHlSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDID 664

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 722 dvEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQP 801
Cdd:COG5021   665 --ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDE 742

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 802 SELRAMMVG-NSNYNWEELEETAIYKGdYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ------- 873
Cdd:COG5021   743 SELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQgsdgvrk 821

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1770726406 874 IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 924
Cdd:COG5021   822 FTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 2-225 7.05e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 179.79  E-value: 7.05e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406   2 TTEDSvAVPRLIQKLnqQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGG 81
Cdd:COG5184    34 TTTDR-STPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDG-TTTDRTTPVKVPGLTGV--VAVAAGY 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  82 AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVkLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSM 161
Cdd:COG5184   108 YHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTT 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1770726406 162 NDEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 225
Cdd:COG5184   187 TDRPTPVQVGGL--SGVVAVAAGGDHSCA-LKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG 247
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
90-139 2.59e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 70.62  E-value: 2.59e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1770726406  90 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVL 139
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
195-259 1.25e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 48.67  E-value: 1.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1770726406 195 SGLIYAFGCGARGQLGTGHTCNVKCPSPVKGywaahsgqlsaradrFKYHIVKQIFSGGDQTFVL 259
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG---------------LSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 576-922 5.97e-140

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 420.82  E-value: 5.97e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 576 LVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS-NLLWFSDT 654
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 655 CFV---EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEdvEETFCLNF 731
Cdd:cd00078    81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 732 TICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVG 810
Cdd:cd00078   159 TIELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 811 NSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPV 888
Cdd:cd00078   239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNpkFTIRRVGSPDDRLPT 318

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1770726406 889 AHTCYNLLDLPKYSSKEILSARLTQALDNYEGFS 922
Cdd:cd00078   319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 600-921 1.45e-128

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 390.44  E-value: 1.45e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  600 DLKKP-LKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH----NWFHLIGITCGLAIY 674
Cdd:smart00119   1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  675 NSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL-LDYPGEDVEEtfcLNFTICRES-YGVIEQKKLIPGGDN 752
Cdd:smart00119  81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  753 VTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSAT 832
Cdd:smart00119 158 IPVTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSAN 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  833 HPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSAR 910
Cdd:smart00119 238 SQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSpkFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317

                          330
                   ....*....|.
gi 1770726406  911 LTQALDNYEGF 921
Cdd:smart00119 318 LLLAINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 634-924 3.87e-98

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 309.93  E-value: 3.87e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 634 NPIYGMFTY-YQDSNLLWFSDTCFVEH-----NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPT 707
Cdd:pfam00632   9 DPNYGLFEYeTEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 708 EGRSLQELLDYPgEDVEETFCLNFTIcrESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGF 787
Cdd:pfam00632  89 LYKSLKSLLNMD-NDDDEDLGLTFTI--PVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGF 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 788 LKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIY 867
Cdd:pfam00632 166 YSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVG 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1770726406 868 GMASLQ-IVIQS-TASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 924
Cdd:pfam00632 246 GFKSLPkFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
274-924 8.64e-83

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 285.51  E-value: 8.64e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 274 TMNQAHYTSLINDETIAVWRQKLSEHNN------ANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKI---PGIDLNS 344
Cdd:COG5021   198 AVSNVEKSEPDNVLFGLPYRSALTMRTNflkldtGNLSGEVQALLARYISIKLVIKKLYLGPGPDASSRIstlIIRLSNT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 345 TRVlfEKLMN-SQHSMILEQILnsfescLIPQLSSSPPDVEAMRIYLILPEFpLLQDSKYyiTLTIPLAMAILRLDTNPS 423
Cdd:COG5021   278 NLN--RRLSYiLSHSSFEDSLL------RLNSLFSTRADSFGRTYYLDHDRI-LTQYSRP--LLEETLGESTSFLVVNND 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 424 KVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFL----IPVLFNNYITAALKLLE-------KLYKVNLKVKHVEYD 492
Cdd:COG5021   347 DSSSIKDLPHQVGSNPFLEAHPEFSELLKNQSRGTTRdfrnKPTGWSSSIEDLGQFLFsdfltssSTYEDLRREQLGRES 426

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 493 TFYIPEISNlVDIQEDYLMWFLHqAGMDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLAR 572
Cdd:COG5021   427 DESFYVASN-VQQQRASREGPLL-SGWKTRLNNLYRFYFVEHRKKTLTKNDSRLGSFISLNKLDIRRIKEDKRRKLFYSL 504

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 573 S-------PFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQD 645
Cdd:COG5021   505 KqkakifdPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITE 584

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 646 SNL-LWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGE 721
Cdd:COG5021   585 DLYtLPINPLSSInpEHlSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDID 664

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 722 dvEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQP 801
Cdd:COG5021   665 --ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDE 742

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 802 SELRAMMVG-NSNYNWEELEETAIYKGdYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ------- 873
Cdd:COG5021   743 SELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQgsdgvrk 821

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1770726406 874 IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 924
Cdd:COG5021   822 FTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 2-225 7.05e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 179.79  E-value: 7.05e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406   2 TTEDSvAVPRLIQKLnqQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGG 81
Cdd:COG5184    34 TTTDR-STPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDG-TTTDRTTPVKVPGLTGV--VAVAAGY 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  82 AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVkLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSM 161
Cdd:COG5184   108 YHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTT 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1770726406 162 NDEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 225
Cdd:COG5184   187 TDRPTPVQVGGL--SGVVAVAAGGDHSCA-LKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG 247
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-223 3.72e-49

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 177.86  E-value: 3.72e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406   3 TEDSVAVPRLIQkLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGA 82
Cdd:COG5184   134 TTTNRLTPVQVD-AGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGD 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  83 HSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMN 162
Cdd:COG5184   210 HSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTT 287

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1770726406 163 DEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFGCGARGQLGTGHTCNVkcPSPV 223
Cdd:COG5184   288 DRSTPVKVPGL--SGVVAVAAGSSHTCA-LLTDGTVWCWGDNAYGQLGDGTTTDR--STPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 23-225 2.35e-46

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 169.77  E-value: 2.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  23 QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSqASPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAG 102
Cdd:COG5184     2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPGLSNV--VAVAAGGDHTCALKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 103 QLGLSDEKDRESPchVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVlELMGSEVTQIA 182
Cdd:COG5184    79 QLGDGTTTDRTTP--VKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVAIA 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1770726406 183 CGRQHTLAfVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 225
Cdd:COG5184   156 AGGYHTCA-LKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG 197
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-225 9.78e-46

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 167.85  E-value: 9.78e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406   3 TEDSVAVPRLIQKLNqqTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGkEFPSQASPQRVR-SLEGIplAQVAAGG 81
Cdd:COG5184    84 TTTDRTTPVKVPGLT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQVDaGLSGV--VAIAAGG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  82 AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSM 161
Cdd:COG5184   159 YHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTT 236

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1770726406 162 NDEVNPRRVLELMGseVTQIACGRQHTLAfVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 225
Cdd:COG5184   237 TDRATPVQVAGLTG--VVAIAAGGSHTCA-LKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPG 297
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 75-259 1.61e-32

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 129.33  E-value: 1.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406  75 AQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTqkVVYISCGEEHTAVLTKSGGVFTFGAGSCG 154
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726406 155 QLGHDSMNDEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVkgywaahSGQL 234
Cdd:COG5184    79 QLGDGTTTDRTTPVKVPGL--TGVVAVAAGYYHSCA-LKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-------DAGL 148

                         170       180
                  ....*....|....*....|....*
gi 1770726406 235 SAradrfkyhiVKQIFSGGDQTFVL 259
Cdd:COG5184   149 SG---------VVAIAAGGYHTCAL 164
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
90-139 2.59e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 70.62  E-value: 2.59e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1770726406  90 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVL 139
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
37-87 6.17e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.77  E-value: 6.17e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1770726406  37 DGQFFTWGKNSHGQLGLGKEFpSQASPQRVRSLEGIPLAQVAAGGAHSFAL 87
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
142-190 7.02e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 63.69  E-value: 7.02e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1770726406 142 SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLA 190
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
21-50 6.39e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.96  E-value: 6.39e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726406  21 ILQVSCGNWHCLALAADGQFFTWGKNSHGQ 50
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
195-259 1.25e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 48.67  E-value: 1.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1770726406 195 SGLIYAFGCGARGQLGTGHTCNVKCPSPVKGywaahsgqlsaradrFKYHIVKQIFSGGDQTFVL 259
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG---------------LSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
75-103 1.76e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.11  E-value: 1.76e-06
                          10        20
                  ....*....|....*....|....*....
gi 1770726406  75 AQVAAGGAHSFALSLSGAVFGWGMNNAGQ 103
Cdd:pfam13540   2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
126-155 4.35e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 4.35e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726406 126 VVYISCGEEHTAVLTKSGGVFTFGAGSCGQ 155
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
3-34 7.38e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.96  E-value: 7.38e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1770726406   3 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLAL 34
Cdd:pfam00415  19 TTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
178-208 5.76e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.79  E-value: 5.76e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726406 178 VTQIACGRQHTLAFVpSSGLIYAFGCGARGQ 208
Cdd:pfam13540   1 VVSVAAGDNHTLALT-SDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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