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Conserved domains on  [gi|1770726335|ref|NP_001362470|]
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microtubule-associated protein 2 isoform 26 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAP2_projctn super family cl25763
MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which ...
 143-194 1.18e-21

MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.


The actual alignment was detected with superfamily member pfam08377:

Pssm-ID: 429957 [Multi-domain]  Cd Length: 1134  Bit Score: 99.35  E-value: 1.18e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1770726335  143 SEQTVTVEEAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 194
Cdd:pfam08377 1083 SRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 1134
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 381-410 5.90e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.73  E-value: 5.90e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726335 381 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 410
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 412-442 1.94e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 58.58  E-value: 1.94e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726335 412 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 442
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 350-379 2.40e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.64  E-value: 2.40e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726335 350 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 379
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 155-377 4.30e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726335 155 KKAELAKKT-EVQAHSPSRKFIL--KPAIKyTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLP 231
Cdd:PTZ00449  553 KEGEVGKKPgPAKEHKPSKIPTLskKPEFP-KDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPK 631

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726335 232 RPSSILPPRRGVSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRRAGKSGTSTPTTPGSTAITP 292
Cdd:PTZ00449  632 SPKRPPPPQRPSSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTTVVLDESFESILKETLPETP 711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726335 293 GTPPSYSSRTPgtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLINQPLPDL-------KNVKS 364
Cdd:PTZ00449  712 GTPFTTPRPLP--PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPADTPLPDIlaeefkeEDIHA 784

                         250
                  ....*....|...
gi 1770726335 365 KIGSTDNIKYQPK 377
Cdd:PTZ00449  785 ETGEPDEAMKRPD 797
 
Name Accession Description Interval E-value
MAP2_projctn pfam08377
MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which ...
 143-194 1.18e-21

MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.


Pssm-ID: 429957 [Multi-domain]  Cd Length: 1134  Bit Score: 99.35  E-value: 1.18e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1770726335  143 SEQTVTVEEAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 194
Cdd:pfam08377 1083 SRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 1134
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 381-410 5.90e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.73  E-value: 5.90e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726335 381 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 410
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 412-442 1.94e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 58.58  E-value: 1.94e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726335 412 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 442
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 350-379 2.40e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.64  E-value: 2.40e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726335 350 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 379
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 155-377 4.30e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726335 155 KKAELAKKT-EVQAHSPSRKFIL--KPAIKyTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLP 231
Cdd:PTZ00449  553 KEGEVGKKPgPAKEHKPSKIPTLskKPEFP-KDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPK 631

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726335 232 RPSSILPPRRGVSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRRAGKSGTSTPTTPGSTAITP 292
Cdd:PTZ00449  632 SPKRPPPPQRPSSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTTVVLDESFESILKETLPETP 711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726335 293 GTPPSYSSRTPgtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLINQPLPDL-------KNVKS 364
Cdd:PTZ00449  712 GTPFTTPRPLP--PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPADTPLPDIlaeefkeEDIHA 784

                         250
                  ....*....|...
gi 1770726335 365 KIGSTDNIKYQPK 377
Cdd:PTZ00449  785 ETGEPDEAMKRPD 797
 
Name Accession Description Interval E-value
MAP2_projctn pfam08377
MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which ...
 143-194 1.18e-21

MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.


Pssm-ID: 429957 [Multi-domain]  Cd Length: 1134  Bit Score: 99.35  E-value: 1.18e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1770726335  143 SEQTVTVEEAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 194
Cdd:pfam08377 1083 SRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 1134
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 381-410 5.90e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.73  E-value: 5.90e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726335 381 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 410
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 412-442 1.94e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 58.58  E-value: 1.94e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726335 412 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 442
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 350-379 2.40e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.64  E-value: 2.40e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726335 350 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 379
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 155-377 4.30e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726335 155 KKAELAKKT-EVQAHSPSRKFIL--KPAIKyTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLP 231
Cdd:PTZ00449  553 KEGEVGKKPgPAKEHKPSKIPTLskKPEFP-KDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPK 631

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726335 232 RPSSILPPRRGVSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRRAGKSGTSTPTTPGSTAITP 292
Cdd:PTZ00449  632 SPKRPPPPQRPSSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTTVVLDESFESILKETLPETP 711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726335 293 GTPPSYSSRTPgtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLINQPLPDL-------KNVKS 364
Cdd:PTZ00449  712 GTPFTTPRPLP--PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPADTPLPDIlaeefkeEDIHA 784

                         250
                  ....*....|...
gi 1770726335 365 KIGSTDNIKYQPK 377
Cdd:PTZ00449  785 ETGEPDEAMKRPD 797
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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