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Conserved domains on  [gi|1770718528|ref|NP_001362497|]
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focadhesin isoform 2 [Homo sapiens]

Protein Classification

DUF3730 and Focadhesin domain-containing protein( domain architecture ID 10576055)

DUF3730 and Focadhesin domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Focadhesin pfam11229
Focadhesin; Focadhesin (FOCAD) is focal adhesion protein with potential tumour suppressor ...
1178-1766 0e+00

Focadhesin; Focadhesin (FOCAD) is focal adhesion protein with potential tumour suppressor function in gliomas. The structure prediction indicates that it consists in repetitive alpha hairpins that adopt an armadillo-like fold.


:

Pssm-ID: 463242  Cd Length: 589  Bit Score: 1107.48  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1178 MNKLRLLVENSQQTSGFALALGNIVHGLSVCGHGKAEDLGSKLLPAWIRIVLTEGTPTMLCLAALHGMVALVGSEGDVMQ 1257
Cdd:pfam11229    1 MNKLRSLTEESQQTPGFALALGNIVHGLSVCGHGKAEDLHPRLLPAWIKILLAEGCPTMQRLAAVNGLVALVGSEGSLIQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1258 LKSEAIQTSHFQGRLNEVIRTLTQVISVSGVIGLQSNAVWLLGHLHLSTLSSSQSRASVPTDYSYLPESSFIGAAIGFFI 1337
Cdd:pfam11229   81 LKSETIQSSQQQSRLNEVIRTITQVITFSGAIGLQSNAACLLGHLHLSHLSSSQSRTSVPPDFSYLPEKSVIRAAVDFLI 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1338 TGGKKGPESVPPSLLKVVMKPIATVGESYQYPPVNWAALLSPLMRLNFGEEIQQLCLEIMVTQAQSSQNAAALLGLWVTP 1417
Cdd:pfam11229  161 EAGKKGPESVPPSLVKVALKPLASVGASFQYPPVNWAALLSPLMRLNFGEEVQHLCLELAVTQAQSSQSAAMFLGMWLSP 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1418 PLIHSLSLNTKRYLLISAPLWIKHISDEQILGFVENLMVAVFKAASPLGSPELCPSALHGLSQAMKLPSPAHHLWSLLSE 1497
Cdd:pfam11229  241 PLVHSLSLKTRAYLYESLSLWMKHVAEDKLQVFVEVLGVQQFEAKSRPQRPELCQSILQGLSQAMKLPNPAQHCWSVLCS 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1498 ATGKIFDLLPNKIRRKDLELYISIAKCLLEMTDDDANRIAQVTKSNIEKAAFVKLYLVSQGRFPLVNLTDMLSVAVQHRE 1577
Cdd:pfam11229  321 TTEKIFELLPNKIQRNEVELYVGIAKCLSEMSDTEIDRITRVTEANIEKTAFILAYLVSQGRVPLLGLNDVISTALRCWP 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1578 KEVLAWMILHSLYQARIVSHANTGVLKRMEWLLELMGYIRNVAYQSTSFHNTALDKALDFFLLIFATAVVAWADHTAPLL 1657
Cdd:pfam11229  401 KERVAWMLLQSFYQARIASHPNTGVLKRMEWLLELMGHIRNVAYGSTSVQNVDLKEATDFLLQVFAAAVVAWADHVAPLL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1658 LGLSASWLPWHQENGPAGPVPSFLGRSPMHRVTLQEVLTLLPNSMALLLQKEPWKEQTQKFIDWLFSIMESPKEALSAQS 1737
Cdd:pfam11229  481 LGLSASWLPWQQEAAPPGLSHSLLGNSSLDELALQECLTLLPYSLALLLSKEPWKEQTQKFIDWLFSITESPKEALSASS 560
                          570       580
                   ....*....|....*....|....*....
gi 1770718528 1738 RDLLKATLLSLRVLPEFKKKAVWTRAYGW 1766
Cdd:pfam11229  561 RDTLKAALLALRSLPEFKKKAVWTRAYGW 589
DUF3730 pfam12530
Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals ...
453-679 1.43e-69

Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.


:

Pssm-ID: 463619  Cd Length: 227  Bit Score: 233.32  E-value: 1.43e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528  453 FLLLAHLLVEDKGQNLHQILKVTTELAqadSSQVCIGQILRIIQLLGT---TPRLRAVTLRLLTSLWEKQDRVYPELQRF 529
Cdd:pfam12530    2 PELLYALEKSSNPELVLLLLKGLPSLA---RHKVCVPLVLPFIQPLSSrdaSPLLQAVALRLLCKLWKGMDRVYPFLQPF 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528  530 MAVSDvPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQaTPAALVLQGLHALCQAEVVCI 609
Cdd:pfam12530   79 LLFSK-SSSSAFARSLIESLASLAASLRDICKHRPDQHGEDLVDAYSACLNECESEVP-EVQALGLELLDALCEAEVVDF 156
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1770718528  610 RSTWNALSPKLSCDTRPLILKTLSELFSLVPSLTVNTTEYENFKVQVLSFLWTHTQ-NKDPIVANAAYRSL 679
Cdd:pfam12530  157 SSAWDVIQKKLGLDYRPLVLKSLCSLFALLPQLEVDHEQYEELKLDIILILWKLENsNDDARVASAAFEAL 227
 
Name Accession Description Interval E-value
Focadhesin pfam11229
Focadhesin; Focadhesin (FOCAD) is focal adhesion protein with potential tumour suppressor ...
1178-1766 0e+00

Focadhesin; Focadhesin (FOCAD) is focal adhesion protein with potential tumour suppressor function in gliomas. The structure prediction indicates that it consists in repetitive alpha hairpins that adopt an armadillo-like fold.


Pssm-ID: 463242  Cd Length: 589  Bit Score: 1107.48  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1178 MNKLRLLVENSQQTSGFALALGNIVHGLSVCGHGKAEDLGSKLLPAWIRIVLTEGTPTMLCLAALHGMVALVGSEGDVMQ 1257
Cdd:pfam11229    1 MNKLRSLTEESQQTPGFALALGNIVHGLSVCGHGKAEDLHPRLLPAWIKILLAEGCPTMQRLAAVNGLVALVGSEGSLIQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1258 LKSEAIQTSHFQGRLNEVIRTLTQVISVSGVIGLQSNAVWLLGHLHLSTLSSSQSRASVPTDYSYLPESSFIGAAIGFFI 1337
Cdd:pfam11229   81 LKSETIQSSQQQSRLNEVIRTITQVITFSGAIGLQSNAACLLGHLHLSHLSSSQSRTSVPPDFSYLPEKSVIRAAVDFLI 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1338 TGGKKGPESVPPSLLKVVMKPIATVGESYQYPPVNWAALLSPLMRLNFGEEIQQLCLEIMVTQAQSSQNAAALLGLWVTP 1417
Cdd:pfam11229  161 EAGKKGPESVPPSLVKVALKPLASVGASFQYPPVNWAALLSPLMRLNFGEEVQHLCLELAVTQAQSSQSAAMFLGMWLSP 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1418 PLIHSLSLNTKRYLLISAPLWIKHISDEQILGFVENLMVAVFKAASPLGSPELCPSALHGLSQAMKLPSPAHHLWSLLSE 1497
Cdd:pfam11229  241 PLVHSLSLKTRAYLYESLSLWMKHVAEDKLQVFVEVLGVQQFEAKSRPQRPELCQSILQGLSQAMKLPNPAQHCWSVLCS 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1498 ATGKIFDLLPNKIRRKDLELYISIAKCLLEMTDDDANRIAQVTKSNIEKAAFVKLYLVSQGRFPLVNLTDMLSVAVQHRE 1577
Cdd:pfam11229  321 TTEKIFELLPNKIQRNEVELYVGIAKCLSEMSDTEIDRITRVTEANIEKTAFILAYLVSQGRVPLLGLNDVISTALRCWP 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1578 KEVLAWMILHSLYQARIVSHANTGVLKRMEWLLELMGYIRNVAYQSTSFHNTALDKALDFFLLIFATAVVAWADHTAPLL 1657
Cdd:pfam11229  401 KERVAWMLLQSFYQARIASHPNTGVLKRMEWLLELMGHIRNVAYGSTSVQNVDLKEATDFLLQVFAAAVVAWADHVAPLL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1658 LGLSASWLPWHQENGPAGPVPSFLGRSPMHRVTLQEVLTLLPNSMALLLQKEPWKEQTQKFIDWLFSIMESPKEALSAQS 1737
Cdd:pfam11229  481 LGLSASWLPWQQEAAPPGLSHSLLGNSSLDELALQECLTLLPYSLALLLSKEPWKEQTQKFIDWLFSITESPKEALSASS 560
                          570       580
                   ....*....|....*....|....*....
gi 1770718528 1738 RDLLKATLLSLRVLPEFKKKAVWTRAYGW 1766
Cdd:pfam11229  561 RDTLKAALLALRSLPEFKKKAVWTRAYGW 589
DUF3730 pfam12530
Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals ...
453-679 1.43e-69

Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.


Pssm-ID: 463619  Cd Length: 227  Bit Score: 233.32  E-value: 1.43e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528  453 FLLLAHLLVEDKGQNLHQILKVTTELAqadSSQVCIGQILRIIQLLGT---TPRLRAVTLRLLTSLWEKQDRVYPELQRF 529
Cdd:pfam12530    2 PELLYALEKSSNPELVLLLLKGLPSLA---RHKVCVPLVLPFIQPLSSrdaSPLLQAVALRLLCKLWKGMDRVYPFLQPF 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528  530 MAVSDvPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQaTPAALVLQGLHALCQAEVVCI 609
Cdd:pfam12530   79 LLFSK-SSSSAFARSLIESLASLAASLRDICKHRPDQHGEDLVDAYSACLNECESEVP-EVQALGLELLDALCEAEVVDF 156
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1770718528  610 RSTWNALSPKLSCDTRPLILKTLSELFSLVPSLTVNTTEYENFKVQVLSFLWTHTQ-NKDPIVANAAYRSL 679
Cdd:pfam12530  157 SSAWDVIQKKLGLDYRPLVLKSLCSLFALLPQLEVDHEQYEELKLDIILILWKLENsNDDARVASAAFEAL 227
 
Name Accession Description Interval E-value
Focadhesin pfam11229
Focadhesin; Focadhesin (FOCAD) is focal adhesion protein with potential tumour suppressor ...
1178-1766 0e+00

Focadhesin; Focadhesin (FOCAD) is focal adhesion protein with potential tumour suppressor function in gliomas. The structure prediction indicates that it consists in repetitive alpha hairpins that adopt an armadillo-like fold.


Pssm-ID: 463242  Cd Length: 589  Bit Score: 1107.48  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1178 MNKLRLLVENSQQTSGFALALGNIVHGLSVCGHGKAEDLGSKLLPAWIRIVLTEGTPTMLCLAALHGMVALVGSEGDVMQ 1257
Cdd:pfam11229    1 MNKLRSLTEESQQTPGFALALGNIVHGLSVCGHGKAEDLHPRLLPAWIKILLAEGCPTMQRLAAVNGLVALVGSEGSLIQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1258 LKSEAIQTSHFQGRLNEVIRTLTQVISVSGVIGLQSNAVWLLGHLHLSTLSSSQSRASVPTDYSYLPESSFIGAAIGFFI 1337
Cdd:pfam11229   81 LKSETIQSSQQQSRLNEVIRTITQVITFSGAIGLQSNAACLLGHLHLSHLSSSQSRTSVPPDFSYLPEKSVIRAAVDFLI 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1338 TGGKKGPESVPPSLLKVVMKPIATVGESYQYPPVNWAALLSPLMRLNFGEEIQQLCLEIMVTQAQSSQNAAALLGLWVTP 1417
Cdd:pfam11229  161 EAGKKGPESVPPSLVKVALKPLASVGASFQYPPVNWAALLSPLMRLNFGEEVQHLCLELAVTQAQSSQSAAMFLGMWLSP 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1418 PLIHSLSLNTKRYLLISAPLWIKHISDEQILGFVENLMVAVFKAASPLGSPELCPSALHGLSQAMKLPSPAHHLWSLLSE 1497
Cdd:pfam11229  241 PLVHSLSLKTRAYLYESLSLWMKHVAEDKLQVFVEVLGVQQFEAKSRPQRPELCQSILQGLSQAMKLPNPAQHCWSVLCS 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1498 ATGKIFDLLPNKIRRKDLELYISIAKCLLEMTDDDANRIAQVTKSNIEKAAFVKLYLVSQGRFPLVNLTDMLSVAVQHRE 1577
Cdd:pfam11229  321 TTEKIFELLPNKIQRNEVELYVGIAKCLSEMSDTEIDRITRVTEANIEKTAFILAYLVSQGRVPLLGLNDVISTALRCWP 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1578 KEVLAWMILHSLYQARIVSHANTGVLKRMEWLLELMGYIRNVAYQSTSFHNTALDKALDFFLLIFATAVVAWADHTAPLL 1657
Cdd:pfam11229  401 KERVAWMLLQSFYQARIASHPNTGVLKRMEWLLELMGHIRNVAYGSTSVQNVDLKEATDFLLQVFAAAVVAWADHVAPLL 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528 1658 LGLSASWLPWHQENGPAGPVPSFLGRSPMHRVTLQEVLTLLPNSMALLLQKEPWKEQTQKFIDWLFSIMESPKEALSAQS 1737
Cdd:pfam11229  481 LGLSASWLPWQQEAAPPGLSHSLLGNSSLDELALQECLTLLPYSLALLLSKEPWKEQTQKFIDWLFSITESPKEALSASS 560
                          570       580
                   ....*....|....*....|....*....
gi 1770718528 1738 RDLLKATLLSLRVLPEFKKKAVWTRAYGW 1766
Cdd:pfam11229  561 RDTLKAALLALRSLPEFKKKAVWTRAYGW 589
DUF3730 pfam12530
Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals ...
453-679 1.43e-69

Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.


Pssm-ID: 463619  Cd Length: 227  Bit Score: 233.32  E-value: 1.43e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528  453 FLLLAHLLVEDKGQNLHQILKVTTELAqadSSQVCIGQILRIIQLLGT---TPRLRAVTLRLLTSLWEKQDRVYPELQRF 529
Cdd:pfam12530    2 PELLYALEKSSNPELVLLLLKGLPSLA---RHKVCVPLVLPFIQPLSSrdaSPLLQAVALRLLCKLWKGMDRVYPFLQPF 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770718528  530 MAVSDvPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQaTPAALVLQGLHALCQAEVVCI 609
Cdd:pfam12530   79 LLFSK-SSSSAFARSLIESLASLAASLRDICKHRPDQHGEDLVDAYSACLNECESEVP-EVQALGLELLDALCEAEVVDF 156
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1770718528  610 RSTWNALSPKLSCDTRPLILKTLSELFSLVPSLTVNTTEYENFKVQVLSFLWTHTQ-NKDPIVANAAYRSL 679
Cdd:pfam12530  157 SSAWDVIQKKLGLDYRPLVLKSLCSLFALLPQLEVDHEQYEELKLDIILILWKLENsNDDARVASAAFEAL 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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