NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1775985210|ref|NP_001363498|]
View 

mitochondrial pyruvate carrier 1 isoform 3 [Homo sapiens]

Protein Classification

mitochondrial pyruvate carrier family protein( domain architecture ID 2488)

mitochondrial pyruvate carrier (MPC) family protein mediates the uptake of pyruvate into mitochondria

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MPC super family cl04196
Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, ...
 24-58 1.70e-17

Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, such as Mpc 1/2 and their homologs. They mediate the uptake of pyruvate into mitochondria. In humans, Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane. MPC1 contains two predicted transmembrane regions. MPC2 contains three predicted transmembrane regions. Several studies have demonstrated MPC involvement in the control of cell fate in cancer and gluconeogenesis in models of type 2 diabetes.


The actual alignment was detected with superfamily member pfam03650:

Pssm-ID: 427425  Cd Length: 110  Bit Score: 69.96  E-value: 1.70e-17
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1775985210  24 STHFWGPVANWGLPIAAINDMKKSPEIISGRMTFA 58
Cdd:pfam03650  14 TVHFWAPVMKWGLVIAGISDLKRPPEKISGPQNLA 48
 
Name Accession Description Interval E-value
MPC pfam03650
Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, ...
 24-58 1.70e-17

Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, such as Mpc 1/2 and their homologs. They mediate the uptake of pyruvate into mitochondria. In humans, Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane. MPC1 contains two predicted transmembrane regions. MPC2 contains three predicted transmembrane regions. Several studies have demonstrated MPC involvement in the control of cell fate in cancer and gluconeogenesis in models of type 2 diabetes.


Pssm-ID: 427425  Cd Length: 110  Bit Score: 69.96  E-value: 1.70e-17
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1775985210  24 STHFWGPVANWGLPIAAINDMKKSPEIISGRMTFA 58
Cdd:pfam03650  14 TVHFWAPVMKWGLVIAGISDLKRPPEKISGPQNLA 48
 
Name Accession Description Interval E-value
MPC pfam03650
Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, ...
 24-58 1.70e-17

Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, such as Mpc 1/2 and their homologs. They mediate the uptake of pyruvate into mitochondria. In humans, Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane. MPC1 contains two predicted transmembrane regions. MPC2 contains three predicted transmembrane regions. Several studies have demonstrated MPC involvement in the control of cell fate in cancer and gluconeogenesis in models of type 2 diabetes.


Pssm-ID: 427425  Cd Length: 110  Bit Score: 69.96  E-value: 1.70e-17
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1775985210  24 STHFWGPVANWGLPIAAINDMKKSPEIISGRMTFA 58
Cdd:pfam03650  14 TVHFWAPVMKWGLVIAGISDLKRPPEKISGPQNLA 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH