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Conserved domains on  [gi|1776842854|ref|NP_001363556|]
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MAP kinase-activating death domain protein isoform 45 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10264016)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.30.450.200|3.40.50.11500
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 105-334 3.71e-57

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 195.88  E-value: 3.71e-57
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   105 TLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSErllgkklgiprgvqrdtmwriftgslLVEEkssallhdlreieaWIY 184
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSN--------------------------LPLE--------------LLI 40

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   185 RLLRSPVPVSGQKRVDIEVLPQELQpalTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNAL 264
Cdd:smart00799   41 SLLLYPVPPPGGSLVLVSLGPGDLI---ELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTL 117

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   265 SMSVMAFVAMIYPLEYMFPVIPLLPTCMASaeqLLLAPTPYIIGVPASFFLYKLDFKMpDDVWLVDLDSN 334
Cdd:smart00799  118 SAVIEALLALLYPFVWQHIYIPILPASLLD---VLSAPTPFIIGVHSSYFEEVKELPD-EDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 418-486 6.61e-11

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 59.23  E-value: 6.61e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   418 DVATRVAMVRFFnsANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPR-QTPFAEKLARTQAVEYFGEW 486
Cdd:smart00801    1 NDEIREAFLRFF--VNLFGGYRNFLRELRKEPGPVITFDKESFLKSRPSsERPFLSKFLETQMFSQFIEE 68
uDENN super family cl04085
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 4-30 1.10e-03

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


The actual alignment was detected with superfamily member smart00800:

Pssm-ID: 470944  Cd Length: 89  Bit Score: 39.63  E-value: 1.10e-03
                            10        20
                    ....*....|....*....|....*..
gi 1776842854     4 RDDTSFVFTLTDKDtGVTRYGICVNFY 30
Cdd:smart00800   64 KDPQFFSFVLTDID-GSRRYGFCLRFY 89
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 105-334 3.71e-57

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 195.88  E-value: 3.71e-57
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   105 TLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSErllgkklgiprgvqrdtmwriftgslLVEEkssallhdlreieaWIY 184
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSN--------------------------LPLE--------------LLI 40

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   185 RLLRSPVPVSGQKRVDIEVLPQELQpalTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNAL 264
Cdd:smart00799   41 SLLLYPVPPPGGSLVLVSLGPGDLI---ELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTL 117

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   265 SMSVMAFVAMIYPLEYMFPVIPLLPTCMASaeqLLLAPTPYIIGVPASFFLYKLDFKMpDDVWLVDLDSN 334
Cdd:smart00799  118 SAVIEALLALLYPFVWQHIYIPILPASLLD---VLSAPTPFIIGVHSSYFEEVKELPD-EDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 107-334 3.30e-39

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 144.64  E-value: 3.30e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854  107 TSLCVLSHYPFFSTFRECLYTL-KRLVDCCSERLlgkklgiprgvqrdtmwriftgsllveekssallhdlreIEAWIYR 185
Cdd:pfam02141    4 KAYCIISRLPFFNLFKKFLDELyRRRTISPLPNP---------------------------------------IERFIAN 44

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854  186 LLRS-PVPVSGQKRVDIEVLPQELQpalTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNAL 264
Cdd:pfam02141   45 LLYEvPFPPPGRTQKLKPLGGTEPI---LLQRPEDSELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARL 121

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854  265 SMSVMAFVAMIYPLEYMFPVIPLLPTCMASAeqlLLAPTPYIIGVPASFFlyKLDFKMPDDVWLVDLDSN 334
Cdd:pfam02141  122 TLVAEAVVALLYPFVWQHIYIPVLPASLLDV---LSAPTPFIIGVHSRYF--DLLEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 418-486 6.61e-11

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 59.23  E-value: 6.61e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   418 DVATRVAMVRFFnsANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPR-QTPFAEKLARTQAVEYFGEW 486
Cdd:smart00801    1 NDEIREAFLRFF--VNLFGGYRNFLRELRKEPGPVITFDKESFLKSRPSsERPFLSKFLETQMFSQFIEE 68
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 4-30 1.10e-03

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 39.63  E-value: 1.10e-03
                            10        20
                    ....*....|....*....|....*..
gi 1776842854     4 RDDTSFVFTLTDKDtGVTRYGICVNFY 30
Cdd:smart00800   64 KDPQFFSFVLTDID-GSRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 1-28 2.95e-03

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 37.59  E-value: 2.95e-03
                           10        20
                   ....*....|....*....|....*...
gi 1776842854    1 MSLRDDTSFVFTLTDKDtGVTRYGICVN 28
Cdd:pfam03456   33 LSSREPTFFSFVLTDED-GSRLYGACLT 59
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 105-334 3.71e-57

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 195.88  E-value: 3.71e-57
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   105 TLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSErllgkklgiprgvqrdtmwriftgslLVEEkssallhdlreieaWIY 184
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSN--------------------------LPLE--------------LLI 40

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   185 RLLRSPVPVSGQKRVDIEVLPQELQpalTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNAL 264
Cdd:smart00799   41 SLLLYPVPPPGGSLVLVSLGPGDLI---ELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTL 117

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   265 SMSVMAFVAMIYPLEYMFPVIPLLPTCMASaeqLLLAPTPYIIGVPASFFLYKLDFKMpDDVWLVDLDSN 334
Cdd:smart00799  118 SAVIEALLALLYPFVWQHIYIPILPASLLD---VLSAPTPFIIGVHSSYFEEVKELPD-EDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 107-334 3.30e-39

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 144.64  E-value: 3.30e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854  107 TSLCVLSHYPFFSTFRECLYTL-KRLVDCCSERLlgkklgiprgvqrdtmwriftgsllveekssallhdlreIEAWIYR 185
Cdd:pfam02141    4 KAYCIISRLPFFNLFKKFLDELyRRRTISPLPNP---------------------------------------IERFIAN 44

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854  186 LLRS-PVPVSGQKRVDIEVLPQELQpalTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNAL 264
Cdd:pfam02141   45 LLYEvPFPPPGRTQKLKPLGGTEPI---LLQRPEDSELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARL 121

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854  265 SMSVMAFVAMIYPLEYMFPVIPLLPTCMASAeqlLLAPTPYIIGVPASFFlyKLDFKMPDDVWLVDLDSN 334
Cdd:pfam02141  122 TLVAEAVVALLYPFVWQHIYIPVLPASLLDV---LSAPTPFIIGVHSRYF--DLLEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 418-486 6.61e-11

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 59.23  E-value: 6.61e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842854   418 DVATRVAMVRFFnsANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPR-QTPFAEKLARTQAVEYFGEW 486
Cdd:smart00801    1 NDEIREAFLRFF--VNLFGGYRNFLRELRKEPGPVITFDKESFLKSRPSsERPFLSKFLETQMFSQFIEE 68
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 4-30 1.10e-03

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 39.63  E-value: 1.10e-03
                            10        20
                    ....*....|....*....|....*..
gi 1776842854     4 RDDTSFVFTLTDKDtGVTRYGICVNFY 30
Cdd:smart00800   64 KDPQFFSFVLTDID-GSRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 1-28 2.95e-03

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 37.59  E-value: 2.95e-03
                           10        20
                   ....*....|....*....|....*...
gi 1776842854    1 MSLRDDTSFVFTLTDKDtGVTRYGICVN 28
Cdd:pfam03456   33 LSSREPTFFSFVLTDED-GSRLYGACLT 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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