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Conserved domains on  [gi|1776945221|ref|NP_001363743|]
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NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 7 [Homo sapiens]

Protein Classification

SIR2 family protein( domain architecture ID 1222)

SIR2 family protein similar to NAD-dependent deacetylase that catalyzes NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose

PubMed:  7498786

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIR2 super family cl00195
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 51-158 9.74e-62

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


The actual alignment was detected with superfamily member cd01412:

Pssm-ID: 444738  Cd Length: 224  Bit Score: 191.26  E-value: 9.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  51 KHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGk 130
Cdd:cd01412     1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRAQPNPAHLALAELERRLP- 79

                          90       100
                  ....*....|....*....|....*...
gi 1776945221 131 qgrRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:cd01412    80 ---NVLLITQNVDGLHERAGSRNVIELH 104
 
Name Accession Description Interval E-value
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
 51-158 9.74e-62

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 191.26  E-value: 9.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  51 KHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGk 130
Cdd:cd01412     1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRAQPNPAHLALAELERRLP- 79

                          90       100
                  ....*....|....*....|....*...
gi 1776945221 131 qgrRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:cd01412    80 ---NVLLITQNVDGLHERAGSRNVIELH 104
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 38-158 4.29e-55

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 174.96  E-value: 4.29e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  38 SSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAG 117
Cdd:COG0846     2 TKIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLRDAEPNAA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1776945221 118 HRAIAEcetrLGKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:COG0846    82 HRALAE----LEKAGKLVFVITQNVDGLHQRAGSKNVIELH 118
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
 40-158 1.01e-53

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 171.52  E-value: 1.01e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  40 MADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHR 119
Cdd:PRK00481    3 IEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLLDAKPNAAHR 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1776945221 120 AIAEcetrLGKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:PRK00481   83 ALAE----LEKLGKLVTVITQNIDGLHERAGSKNVIELH 117
prot_deacyl_CobB NF040867
NAD-dependent protein deacetylase;
45-158 2.74e-44

NAD-dependent protein deacetylase;


Pssm-ID: 468804  Cd Length: 242  Bit Score: 147.34  E-value: 2.74e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  45 KFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAEC 124
Cdd:NF040867    5 ELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRRYDPEELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYALAEL 84

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1776945221 125 EtrlgKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:NF040867   85 E----RMGILKAVITQNVDGLHQRAGSRNVIELH 114
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
 58-158 1.43e-33

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 118.12  E-value: 1.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  58 GAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWE---FYHYRREVM-GSKEPNAGHRAIAECEtrlgKQGR 133
Cdd:pfam02146   1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWDpepFYNIARELLpGEAQPNPAHYFIAKLE----DKGK 76

                          90       100
                  ....*....|....*....|....*
gi 1776945221 134 RVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:pfam02146  77 LLRLITQNIDGLHERAGSKKVVELH 101
 
Name Accession Description Interval E-value
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
 51-158 9.74e-62

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 191.26  E-value: 9.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  51 KHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGk 130
Cdd:cd01412     1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRAQPNPAHLALAELERRLP- 79

                          90       100
                  ....*....|....*....|....*...
gi 1776945221 131 qgrRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:cd01412    80 ---NVLLITQNVDGLHERAGSRNVIELH 104
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 38-158 4.29e-55

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 174.96  E-value: 4.29e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  38 SSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAG 117
Cdd:COG0846     2 TKIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLRDAEPNAA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1776945221 118 HRAIAEcetrLGKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:COG0846    82 HRALAE----LEKAGKLVFVITQNVDGLHQRAGSKNVIELH 118
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
 40-158 1.01e-53

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 171.52  E-value: 1.01e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  40 MADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHR 119
Cdd:PRK00481    3 IEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLLDAKPNAAHR 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1776945221 120 AIAEcetrLGKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:PRK00481   83 ALAE----LEKLGKLVTVITQNIDGLHERAGSKNVIELH 117
SIR2-fam cd01407
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ...
 51-158 5.06e-49

SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.


Pssm-ID: 238698  Cd Length: 218  Bit Score: 158.89  E-value: 5.06e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  51 KHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLA-TPLAFAHNPSRVWEFYHYRREVMGSKePNAGHRAIAECEtrlg 129
Cdd:cd01407     1 KRIVVLTGAGISTESGIPDFRSPGGLWARLDPEELAfSPEAFRRDPELFWGFYRERRYPLNAQ-PNPAHRALAELE---- 75

                          90       100
                  ....*....|....*....|....*....
gi 1776945221 130 KQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:cd01407    76 RKGKLKRVITQNVDGLHQRAGSPKVIELH 104
prot_deacyl_CobB NF040867
NAD-dependent protein deacetylase;
45-158 2.74e-44

NAD-dependent protein deacetylase;


Pssm-ID: 468804  Cd Length: 242  Bit Score: 147.34  E-value: 2.74e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  45 KFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAEC 124
Cdd:NF040867    5 ELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRRYDPEELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYALAEL 84

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1776945221 125 EtrlgKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:NF040867   85 E----RMGILKAVITQNVDGLHQRAGSRNVIELH 114
SIR2 cd00296
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 51-158 3.82e-41

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


Pssm-ID: 238184 [Multi-domain]  Cd Length: 222  Bit Score: 138.63  E-value: 3.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  51 KHIVIISGAGVSAESGVPTFRGAG-GYWRKWQAQDLA-TPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECEtrl 128
Cdd:cd00296     1 KRVVVFTGAGISTESGIPDFRGLGtGLWTRLDPEELAfSPEAFRRDPELFWLFYKERRYTPLDAKPNPAHRALAELE--- 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1776945221 129 gKQGRRVVVITQNIDELHRKAGTK--NLLEIH 158
Cdd:cd00296    78 -RKGKLKRIITQNVDGLHERAGSRrnRVIELH 108
SIR2_Af2 cd01413
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ...
 48-158 2.61e-39

SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.


Pssm-ID: 238704  Cd Length: 222  Bit Score: 134.03  E-value: 2.61e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  48 AKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECEtr 127
Cdd:cd01413     2 TKSRKTVVLTGAGISTESGIPDFRSPDGLWKKYDPEEVASIDYFYRNPEEFWRFYKEIILGLLEAQPNKAHYFLAELE-- 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1776945221 128 lgKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:cd01413    80 --KQGIIKAIITQNIDGLHQRAGSKNVIELH 108
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
 58-158 1.43e-33

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 118.12  E-value: 1.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  58 GAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWE---FYHYRREVM-GSKEPNAGHRAIAECEtrlgKQGR 133
Cdd:pfam02146   1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWDpepFYNIARELLpGEAQPNPAHYFIAKLE----DKGK 76

                          90       100
                  ....*....|....*....|....*
gi 1776945221 134 RVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:pfam02146  77 LLRLITQNIDGLHERAGSKKVVELH 101
PTZ00408 PTZ00408
NAD-dependent deacetylase; Provisional
 49-158 3.91e-33

NAD-dependent deacetylase; Provisional


Pssm-ID: 240405  Cd Length: 242  Bit Score: 118.77  E-value: 3.91e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  49 KAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKE--PNAGHRAIAECET 126
Cdd:PTZ00408    3 ACRCITILTGAGISAESGISTFRDGNGLWENHRVEDVATPDAFLRNPALVQRFYNERRRALLSSSvkPNKAHFALAKLER 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1776945221 127 RLgkQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:PTZ00408   83 EY--RGGKVVVVTQNVDNLHERAGSTHVLHMH 112
SIR2H cd01411
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ...
 45-158 1.21e-25

SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238702  Cd Length: 225  Bit Score: 98.59  E-value: 1.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  45 KFFAKAKHIVIISGAGVSAESGVPTFRGAGGYW---RKWQAQDLATPLAFAHNPSrvwEFYHYRREVM---GSKePNAGH 118
Cdd:cd01411     3 HILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYneiYKYSPEYLLSHDFLEREPE---KFYQFVKENLyfpDAK-PNIIH 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1776945221 119 RAIAECEtrlgKQGRrVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:cd01411    79 QKMAELE----KMGL-KAVITQNIDGLHQKAGSKNVVEFH 113
SIRT4 cd01409
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ...
 43-158 1.58e-22

SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238700  Cd Length: 260  Bit Score: 91.20  E-value: 1.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  43 FRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKwqaqdLATPL---AFAHNPS---RVW--EFYHYRRevMGSKEP 114
Cdd:cd01409     1 LQDFVARSRRLLVLTGAGISTESGIPDYRSEGGLYSR-----TFRPMthqEFMRSPAarqRYWarSFVGWPR--FSAAQP 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1776945221 115 NAGHRAIAecetRLGKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:cd01409    74 NAAHRALA----ALEAAGRLHGLITQNVDGLHTKAGSRNVVELH 113
PTZ00409 PTZ00409
Sir2 (Silent Information Regulator) protein; Provisional
 37-194 1.24e-21

Sir2 (Silent Information Regulator) protein; Provisional


Pssm-ID: 173599 [Multi-domain]  Cd Length: 271  Bit Score: 89.21  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  37 SSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAG-GYWRKWQAQDLATPLAFAHNPSRVWEFYhyrREVMGSKE-- 113
Cdd:PTZ00409   15 SITLEDLADMIRKCKYVVALTGSGTSAESNIPSFRGPSsSIWSKYDPKIYGTIWGFWKYPEKIWEVI---RDISSDYEie 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221 114 PNAGHRAIaeceTRLGKQGRRVVVITQNIDELHRKAGTKNLLEIH--VLQ------NLELKMPASQLRNfpGGHFLCGVP 185
Cdd:PTZ00409   92 LNPGHVAL----STLESLGYLKFVVTQNVDGLHEESGNTKVIPLHgsVFEarcctcRKTIQLNKIMLQK--TSHFMHQLP 165


                  ....*....
gi 1776945221 186 SShvCPPGG 194
Cdd:PTZ00409  166 PE--CPCGG 172
PRK14138 PRK14138
NAD-dependent deacetylase; Provisional
 40-158 2.34e-21

NAD-dependent deacetylase; Provisional


Pssm-ID: 172627 [Multi-domain]  Cd Length: 244  Bit Score: 87.96  E-value: 2.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  40 MADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWqAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHR 119
Cdd:PRK14138    1 MKEFLELLNESRLTVTLTGAGISTPSGIPDFRGPQGIYKKY-PQNVFDIDFFYSHPEEFYRFAKEGIFPMLEAKPNLAHV 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1776945221 120 AIAECEtrlgKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:PRK14138   80 LLAKLE----EKGLIEAVITQNIDRLHQKAGSKKVIELH 114
PRK05333 PRK05333
NAD-dependent protein deacetylase;
33-158 2.09e-18

NAD-dependent protein deacetylase;


Pssm-ID: 235415  Cd Length: 285  Bit Score: 80.88  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  33 MARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSK 112
Cdd:PRK05333    2 PDADPAALDALQDFVERHPRLFVLTGAGISTDSGIPDYRDRNGQWKRSPPITYQAFMGSDAARRRYWARSMVGWPVFGRA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1776945221 113 EPNAGHRAIAecetRLGKQGRRVVVITQNIDELHRKAGTKNLLEIH 158
Cdd:PRK05333   82 QPNAAHHALA----RLGAAGRIERLVTQNVDGLHQRAGSRDVIELH 123
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
 51-158 3.00e-18

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 78.88  E-value: 3.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  51 KHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLAtplafahnPSRVWEFYhyrrevmgSKEPNAGHRAIAEcetrLGK 130
Cdd:cd01410     1 KHLVVFTGAGISTSAGIPDFRGPNGVWTLLPEDKGR--------RRFSWRFR--------RAEPTLTHMALVE----LER 60

                          90       100       110
                  ....*....|....*....|....*....|
gi 1776945221 131 QGRRVVVITQNIDELHRKAG--TKNLLEIH 158
Cdd:cd01410    61 AGLLKFVISQNVDGLHLRSGlpREKLSELH 90
PTZ00410 PTZ00410
NAD-dependent SIR2; Provisional
 53-158 8.81e-04

NAD-dependent SIR2; Provisional


Pssm-ID: 185600  Cd Length: 349  Bit Score: 39.08  E-value: 8.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776945221  53 IVIISGAGVSAESGVPTFRGA-GGYWRKWQAQDLATPL-AFA-----HNPSRvweFYHYRREV---MGSKEPNAGHRAIa 122
Cdd:PTZ00410   32 ILVMVGAGISVAAGIPDFRSPhTGIYAKLGKYNLNSPTdAFSltllrEKPEV---FYSIAREMdlwPGHFQPTAVHHFI- 107

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1776945221 123 eceTRLGKQGRRVVVITQNIDELHRKAGTKN--LLEIH 158
Cdd:PTZ00410  108 ---RLLADEGRLLRCCTQNIDGLERAAGVPPslLVEAH 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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