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Conserved domains on  [gi|1777375950|ref|NP_001363780|]
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muscleblind-like protein 1 isoform 21 [Homo sapiens]

Protein Classification

zinc finger CCCH domain-containing protein( domain architecture ID 10646956)

zinc finger CCCH domain-containing protein similar to Homo sapiens Muscleblind-like proteins

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|27990022
SCOP:  3001741

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_C3H1 smart00356
zinc finger;
89-113 1.24e-05

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.08  E-value: 1.24e-05
                           10        20
                   ....*....|....*....|....*
gi 1777375950   89 RLEVCREYQRGNCNRGENdCRFAHP 113
Cdd:smart00356   3 KTELCKFFKRGYCPRGDR-CKFAHP 26
ZnF_C3H1 smart00356
zinc finger;
126-148 6.95e-03

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 33.37  E-value: 6.95e-03
                           10        20
                   ....*....|....*....|....
gi 1777375950  126 VTVCMDYIKGRCSR-EKCKYFHPP 148
Cdd:smart00356   4 TELCKFFKRGYCPRgDRCKFAHPL 27
 
Name Accession Description Interval E-value
ZnF_C3H1 smart00356
zinc finger;
89-113 1.24e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.08  E-value: 1.24e-05
                           10        20
                   ....*....|....*....|....*
gi 1777375950   89 RLEVCREYQRGNCNRGENdCRFAHP 113
Cdd:smart00356   3 KTELCKFFKRGYCPRGDR-CKFAHP 26
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 93-112 3.30e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 37.01  E-value: 3.30e-04
                          10        20
                  ....*....|....*....|
gi 1777375950  93 CREYQRGNCNRGENdCRFAH 112
Cdd:pfam18345   1 CKFFLKGRCRYGDK-CRFAH 19
ZnF_C3H1 smart00356
zinc finger;
126-148 6.95e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 33.37  E-value: 6.95e-03
                           10        20
                   ....*....|....*....|....
gi 1777375950  126 VTVCMDYIKGRCSR-EKCKYFHPP 148
Cdd:smart00356   4 TELCKFFKRGYCPRgDRCKFAHPL 27
 
Name Accession Description Interval E-value
ZnF_C3H1 smart00356
zinc finger;
89-113 1.24e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.08  E-value: 1.24e-05
                           10        20
                   ....*....|....*....|....*
gi 1777375950   89 RLEVCREYQRGNCNRGENdCRFAHP 113
Cdd:smart00356   3 KTELCKFFKRGYCPRGDR-CKFAHP 26
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 93-112 3.30e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 37.01  E-value: 3.30e-04
                          10        20
                  ....*....|....*....|
gi 1777375950  93 CREYQRGNCNRGENdCRFAH 112
Cdd:pfam18345   1 CKFFLKGRCRYGDK-CRFAH 19
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
91-113 1.07e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 35.63  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....
gi 1777375950  91 EVCREYQR-GNCNRGENdCRFAHP 113
Cdd:pfam00642   4 ELCRFFLRtGYCKYGDR-CKFAHG 26
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 92-113 2.13e-03

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 34.49  E-value: 2.13e-03
                          10        20
                  ....*....|....*....|..
gi 1777375950  92 VCREYQRGNCNRGENdCRFAHP 113
Cdd:pfam18044   2 LCRYFQKGGCRYGDN-CRFSHD 22
ZnF_C3H1 smart00356
zinc finger;
126-148 6.95e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 33.37  E-value: 6.95e-03
                           10        20
                   ....*....|....*....|....
gi 1777375950  126 VTVCMDYIKGRCSR-EKCKYFHPP 148
Cdd:smart00356   4 TELCKFFKRGYCPRgDRCKFAHPL 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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