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Conserved domains on  [gi|1777375936|ref|NP_001363797|]
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plexin-B2 isoform 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
1271-1837 0e+00

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


:

Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 817.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF 1350
Cdd:cd12792      1 RIPFLDYKTYTDRVFFLPSKDGANDVMITGKLDIPEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430
Cdd:cd12792     81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVHSKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1431 QVEKGPVDAVQKKakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510
Cdd:cd12792    161 QVEKGPVDAVQKK------------------------------------------------------------------- 173
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1511 dsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvwh 1590
Cdd:cd12792        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1591 lvrptdevdegkskrgsvkeKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNI 1670
Cdd:cd12792    174 --------------------KERTKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCSGAVVPPAVKYFFDFLDEQAEKHDI 233
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1671 QDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKK 1750
Cdd:cd12792    234 VDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNKLLYAKEISTYKK 313
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1751 MVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAA 1830
Cdd:cd12792    314 MVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINSLEEDPAAQSKQLTLRLQQIAAA 393

                   ....*..
gi 1777375936 1831 LENKVTD 1837
Cdd:cd12792    394 LENKVTD 400
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
27-467 0e+00

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 771.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   27 FFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPR 106
Cdd:cd11276      1 FFQSATELNHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSAN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  107 KRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTR 186
Cdd:cd11276     81 KTLVVCGSLFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSLKPGNDRVFFVGKGNGSNDNGKIISTR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  187 LLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQC 266
Cdd:cd11276    161 LLQNYDDREVFENYIDAATVKSAYVSRYTQQFRYAFEDNNYVYFLFNQQLGHPDKNRTLIARLCENDHHYYSYTEMDLNC 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  267 RDPDihaAAFGTCLAASVAAPG------------SGRVLYAVFSRDSRSSGgpGAGLCLFPLDKVHAKMEANRNACYTGT 334
Cdd:cd11276    241 RDGA---NAYNKCQAAYVSTPGkelaqnygnsilSDKVLFAVFSRDEKDSG--ESALCMFPLKSINAKMEANREACYTGT 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  335 REARDIFYKPFH--GDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTA-VLQRGGLNLTAVTVAAENNHTVAFLGTS 411
Cdd:cd11276    316 IDDRDVFYKPFHsqKDIICGSHQQKNSKSFPCGSEHLPYPLGSRDELALTApVLQRGGLNLTAVTVAVENGHTVAFLGTS 395
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1777375936  412 DGRILKVYLTPDgtSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQ 467
Cdd:cd11276    396 DGRILKVHLSPD--PEEYNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPVQ 449
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
1448-1558 9.46e-47

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


:

Pssm-ID: 466321  Cd Length: 113  Bit Score: 163.52  E-value: 9.46e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1448 LNDTGLLGDDVEYAPLTVSVIVQDEGVDA-IPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQ-I 1525
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEGEVSEsVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHGRGGRlI 80
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1777375936 1526 LSDLDLTSQREGRWKRVNTLMHYNVRDGATLIL 1558
Cdd:pfam20170   81 LQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
803-894 4.44e-34

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 126.66  E-value: 4.44e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIQ-RISVAGRNCSFQPERYSVSTRIVCVIEAAETP-FTGGVEVDVFGK 880
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRhGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPvFNGPVEVTVGHG 80
                           90
                   ....*....|....
gi 1777375936  881 LGRSPPNVQFTFQQ 894
Cdd:cd01180     81 SFRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
895-981 1.22e-29

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 113.47  E-value: 1.22e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQedVRVTLNGVPCKVTKFGA-QLQCVTGPQATRGQMLLEVSYGGSPVpNP 973
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSS--VRVTVGGQPCKILSVSSsQIVCLTPPSASPGEAPVKVLIDGARR-LA 77

                   ....*...
gi 1777375936  974 GIFFTYRE 981
Cdd:cd01179     78 PLVFTYTE 85
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
525-613 1.62e-19

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 84.63  E-value: 1.62e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  525 QPQNMSRRAQGEVQLTVSPLPALSEEdeLLCLFGESPPHPARVEGEAVICNSPSS--IPVTPPGQDHVAVTIQLLLRRGN 602
Cdd:pfam17960    1 TPDNISRTTATQLTLTVPNLPALSEG--YSCVFGDLTESPATVHDNGVKCATPPPsqLPPIPTGQDHVTVKLSLRSSETG 78
                           90
                   ....*....|.
gi 1777375936  603 IFLTSYQYPFY 613
Cdd:pfam17960   79 VDFASTNFTFY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
469-517 1.86e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 66.19  E-value: 1.86e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1777375936  469 CLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECpRAEEASHWLWSRSKS 517
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSAC-GAPEGNCEEWEQASS 49
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
759-799 4.01e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 48.47  E-value: 4.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1777375936  759 NCSfGRSDCSLCRAAnPDYRCAWCGGQSRCVYEALCNTTSE 799
Cdd:pfam01437    1 RCS-QYTSCSSCLAA-RDPYCGWCSSEGRCVRRSACGAPEG 39
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
983-1093 6.01e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01181:

Pssm-ID: 472823  Cd Length: 99  Bit Score: 43.56  E-value: 6.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  983 PVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVViaeplqswqppreaeslqpmTVVG---TDYVFHNDTKVVFLSPA 1059
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRV--------------------KYGGvekTSCKVRNSTLMTCPAPS 60
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1777375936 1060 VPEEPEAYNLT-----VLIEMDGHRALLRTEAGAFEYVP 1093
Cdd:cd01181     61 LALLNRSPEPGerpveFGLDGDNVQSLLILNRTSFSYYP 99
 
Name Accession Description Interval E-value
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
1271-1837 0e+00

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 817.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF 1350
Cdd:cd12792      1 RIPFLDYKTYTDRVFFLPSKDGANDVMITGKLDIPEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430
Cdd:cd12792     81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVHSKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1431 QVEKGPVDAVQKKakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510
Cdd:cd12792    161 QVEKGPVDAVQKK------------------------------------------------------------------- 173
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1511 dsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvwh 1590
Cdd:cd12792        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1591 lvrptdevdegkskrgsvkeKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNI 1670
Cdd:cd12792    174 --------------------KERTKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCSGAVVPPAVKYFFDFLDEQAEKHDI 233
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1671 QDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKK 1750
Cdd:cd12792    234 VDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNKLLYAKEISTYKK 313
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1751 MVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAA 1830
Cdd:cd12792    314 MVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINSLEEDPAAQSKQLTLRLQQIAAA 393

                   ....*..
gi 1777375936 1831 LENKVTD 1837
Cdd:cd12792    394 LENKVTD 400
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
1271-1800 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 798.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFlPskdGDKDVMITGKLDIPEP---RRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAK 1347
Cdd:pfam08337    1 GIPFLDYRTYAMRVLF-P---GVEDHPLLVLLDVPVTndgRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDR 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1348 VYFASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKA 1427
Cdd:pfam08337   77 CNVASLLMVALHGKLEYATEILKTLLRDLIDKSVESKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKA 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1428 IKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDA-IPVKVLNCDTISQVKEKIIDQVYRGQPCSC 1506
Cdd:pfam08337  157 IKQQVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSEsVPVKVLDCDTITQVKEKILDAIYKNTPYSQ 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1507 WPRPDSVVLEWRPGSTAQ-ILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILSKvgvsqqpedsqqdlpgerhalleee 1585
Cdd:pfam08337  237 RPSIDEVDLEWRHGRGGRlTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP------------------------- 291
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1586 nRVWHLVRPTDEVDEGKSKRgsvkekERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVL-APGHAVPPAVKYFFDFLDEQ 1664
Cdd:pfam08337  292 -KYWHLVKPSDEGDQRKKSE------RRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILsVPNSALPLAVKYLFDFLDEQ 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1665 AEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKE 1744
Cdd:pfam08337  365 AEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNKLLYAKD 444
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1777375936 1745 ISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQK 1800
Cdd:pfam08337  445 IPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
27-467 0e+00

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 771.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   27 FFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPR 106
Cdd:cd11276      1 FFQSATELNHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSAN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  107 KRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTR 186
Cdd:cd11276     81 KTLVVCGSLFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSLKPGNDRVFFVGKGNGSNDNGKIISTR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  187 LLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQC 266
Cdd:cd11276    161 LLQNYDDREVFENYIDAATVKSAYVSRYTQQFRYAFEDNNYVYFLFNQQLGHPDKNRTLIARLCENDHHYYSYTEMDLNC 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  267 RDPDihaAAFGTCLAASVAAPG------------SGRVLYAVFSRDSRSSGgpGAGLCLFPLDKVHAKMEANRNACYTGT 334
Cdd:cd11276    241 RDGA---NAYNKCQAAYVSTPGkelaqnygnsilSDKVLFAVFSRDEKDSG--ESALCMFPLKSINAKMEANREACYTGT 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  335 REARDIFYKPFH--GDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTA-VLQRGGLNLTAVTVAAENNHTVAFLGTS 411
Cdd:cd11276    316 IDDRDVFYKPFHsqKDIICGSHQQKNSKSFPCGSEHLPYPLGSRDELALTApVLQRGGLNLTAVTVAVENGHTVAFLGTS 395
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1777375936  412 DGRILKVYLTPDgtSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQ 467
Cdd:cd11276    396 DGRILKVHLSPD--PEEYNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPVQ 449
Sema smart00630
semaphorin domain;
34-436 3.69e-78

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 264.62  E-value: 3.69e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936    34 LNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQcheAEMTDNVNQL-LLLDPPRKRLVEC 112
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSKGK---DPPTDCVNYIrLLLDYNEDRLLVC 77
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   113 GS-LFKGICALRALSNislrlFYedgsgeksfvasndegVATVglvsSTGPGGDRVLFvgkgngphdngIIVSTRLLDRT 191
Cdd:smart00630   78 GTnAFQPVCRLRNLGE-----LY----------------VGTV----ADFSGSDPAIP-----------RSLSVRRLKGT 121
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   192 dsreafeAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKH----PARNRTLLARMCRED--------PNYYSY 259
Cdd:smart00630  122 -------SGVSLRTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEddncGKAVHSRVARVCKNDvggprsldKKWTSF 194
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   260 LEMDLQCRDPDIHAAAFGTCLAASVAAPGSGR--VLYAVFSRDSrsSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREA 337
Cdd:smart00630  195 LKARLECSVPGEDPFYFNELQAAFLLPPGSESddVLYGVFSTSS--NPIPGSAVCAFSLSDINAVFNGPFKECETSTSQW 272
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   338 RDIF--YKPFHGDIQCGgHAPGSSKSFPC----GSEHLPYPLGSRDGLRGTAVLQRGGLN--LTAVTV---AAENNHTVA 406
Cdd:smart00630  273 LPYSrgKVPYPRPGTCP-NKPPSSKDLPDetlnFIKSHPLMDEVVQPLTGRPLFVKTDSNylLTSIAVdrvATDGNYTVL 351
                           410       420       430
                    ....*....|....*....|....*....|
gi 1777375936   407 FLGTSDGRILKVYLTPDGTSSEyDSILVEI 436
Cdd:smart00630  352 FLGTSDGRILKVVLSESSSSSE-SVVLEEI 380
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
1448-1558 9.46e-47

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 163.52  E-value: 9.46e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1448 LNDTGLLGDDVEYAPLTVSVIVQDEGVDA-IPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQ-I 1525
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEGEVSEsVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHGRGGRlI 80
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1777375936 1526 LSDLDLTSQREGRWKRVNTLMHYNVRDGATLIL 1558
Cdd:pfam20170   81 LQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
803-894 4.44e-34

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 126.66  E-value: 4.44e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIQ-RISVAGRNCSFQPERYSVSTRIVCVIEAAETP-FTGGVEVDVFGK 880
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRhGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPvFNGPVEVTVGHG 80
                           90
                   ....*....|....
gi 1777375936  881 LGRSPPNVQFTFQQ 894
Cdd:cd01180     81 SFRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
895-981 1.22e-29

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 113.47  E-value: 1.22e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQedVRVTLNGVPCKVTKFGA-QLQCVTGPQATRGQMLLEVSYGGSPVpNP 973
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSS--VRVTVGGQPCKILSVSSsQIVCLTPPSASPGEAPVKVLIDGARR-LA 77

                   ....*...
gi 1777375936  974 GIFFTYRE 981
Cdd:cd01179     78 PLVFTYTE 85
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
281-447 3.60e-25

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 104.27  E-value: 3.60e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  281 AASVAAPGSGR----VLYAVFSRdSRSSGGPGAGLCLFPLDKVHAKMEaNRNACYTG--TREARDIFYKPFHGDIQCGGH 354
Cdd:pfam01403    3 DVFVLKPGAGDaldtVLYGVFTT-QWSNSIGGSAVCAFSLSDINAVFE-GPFKEQEKsdSKWLPYTGKVPYPRPGTCIND 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  355 APGSS--KSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTV----AAENNHTVAFLGTSDGRILKVYLTPDGTSSE 428
Cdd:pfam01403   81 PLRLDlpDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVdrvqALDGNYTVLFLGTDDGRLHKVVLVGSEESHI 160
                          170       180
                   ....*....|....*....|
gi 1777375936  429 YDSI-LVEINKRVKRDLVLS 447
Cdd:pfam01403  161 IEEIqVFPEPQPVLNLLLSS 180
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
525-613 1.62e-19

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 84.63  E-value: 1.62e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  525 QPQNMSRRAQGEVQLTVSPLPALSEEdeLLCLFGESPPHPARVEGEAVICNSPSS--IPVTPPGQDHVAVTIQLLLRRGN 602
Cdd:pfam17960    1 TPDNISRTTATQLTLTVPNLPALSEG--YSCVFGDLTESPATVHDNGVKCATPPPsqLPPIPTGQDHVTVKLSLRSSETG 78
                           90
                   ....*....|.
gi 1777375936  603 IFLTSYQYPFY 613
Cdd:pfam17960   79 VDFASTNFTFY 89
IPT smart00429
ig-like, plexins, transcription factors;
895-980 1.47e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 70.91  E-value: 1.47e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVT-KFGAQLQCVTGPQAT-RGQM-LLEVSYGGSPVP 971
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSpSSSTAIVCKTPPYHNiPGSVpVRTVGLRNGGVP 81

                    ....*....
gi 1777375936   972 NPGIFFTYR 980
Cdd:smart00429   82 SSPQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
802-892 5.16e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 69.37  E-value: 5.16e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   802 PPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERysvSTRIVCVI-EAAETPFTGGVEVDVFGK 880
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSS---STAIVCKTpPYHNIPGSVPVRTVGLRN 77
                            90
                    ....*....|..
gi 1777375936   881 LGRSPPNVQFTF 892
Cdd:smart00429   78 GGVPSSPQPFTY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
469-517 1.86e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 66.19  E-value: 1.86e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1777375936  469 CLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECpRAEEASHWLWSRSKS 517
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSAC-GAPEGNCEEWEQASS 49
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
895-979 2.05e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.39  E-value: 2.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSqEDVRVTLNGVPCKVTKFGA-QLQCVTgPQATRGQMLLEVSYGGSPVPNP 973
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS-SDLKVTIGGTPCTVISVSStTIVCTT-PPGTSGLVNVSVTVGGGGISSS 78

                   ....*.
gi 1777375936  974 GIFFTY 979
Cdd:pfam01833   79 PLTFTY 84
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
468-518 1.11e-11

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 61.02  E-value: 1.11e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1777375936   468 ECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEasHWLwsrSKSC 518
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQ--NWL---SGGC 46
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
803-892 2.56e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 2.56e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIqRISVAGRNCSFQperYSVSTRIVCVIEAAEtpfTGGVEVDVF-GKL 881
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL-KVTIGGTPCTVI---SVSSTTIVCTTPPGT---SGLVNVSVTvGGG 73
                           90
                   ....*....|.
gi 1777375936  882 GRSPPNVQFTF 892
Cdd:pfam01833   74 GISSSPLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
759-799 4.01e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 48.47  E-value: 4.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1777375936  759 NCSfGRSDCSLCRAAnPDYRCAWCGGQSRCVYEALCNTTSE 799
Cdd:pfam01437    1 RCS-QYTSCSSCLAA-RDPYCGWCSSEGRCVRRSACGAPEG 39
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
759-801 4.26e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.23  E-value: 4.26e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1777375936   759 NCSFGRSdCSLCRAANPDYrCAWCGGQSRCVYEALCNTTSE------CP 801
Cdd:smart00423    1 RCSKYTS-CSECLLARDPY-CAWCSSQGRCTSGERCDSRRQnwlsggCP 47
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
983-1093 6.01e-05

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 43.56  E-value: 6.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  983 PVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVViaeplqswqppreaeslqpmTVVG---TDYVFHNDTKVVFLSPA 1059
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRV--------------------KYGGvekTSCKVRNSTLMTCPAPS 60
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1777375936 1060 VPEEPEAYNLT-----VLIEMDGHRALLRTEAGAFEYVP 1093
Cdd:cd01181     61 LALLNRSPEPGerpveFGLDGDNVQSLLILNRTSFSYYP 99
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
983-1091 9.59e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.82  E-value: 9.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  983 PVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEplqswqppreaeslqpmtvVGTDYVFHNDTKVVFLSPAVPE 1062
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGG-------------------TPCTVISVSSTTIVCTTPPGTS 61
                           90       100
                   ....*....|....*....|....*....
gi 1777375936 1063 EPeaynLTVLIEMDGhrALLRTEAGAFEY 1091
Cdd:pfam01833   62 GL----VNVSVTVGG--GGISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
982-1092 3.98e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 38.17  E-value: 3.98e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   982 NPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVViaeplqswqppREAEslQPMTVVGTdyvfhNDTKVVFLSPAVP 1061
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEV-----------GVGE--APCTFSPS-----SSTAIVCKTPPYH 62
                            90       100       110
                    ....*....|....*....|....*....|..
gi 1777375936  1062 EEPEAYNL-TVLIEMDGhralLRTEAGAFEYV 1092
Cdd:smart00429   63 NIPGSVPVrTVGLRNGG----VPSSPQPFTYV 90
 
Name Accession Description Interval E-value
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
1271-1837 0e+00

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 817.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF 1350
Cdd:cd12792      1 RIPFLDYKTYTDRVFFLPSKDGANDVMITGKLDIPEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430
Cdd:cd12792     81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVHSKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1431 QVEKGPVDAVQKKakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510
Cdd:cd12792    161 QVEKGPVDAVQKK------------------------------------------------------------------- 173
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1511 dsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvwh 1590
Cdd:cd12792        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1591 lvrptdevdegkskrgsvkeKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNI 1670
Cdd:cd12792    174 --------------------KERTKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCSGAVVPPAVKYFFDFLDEQAEKHDI 233
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1671 QDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKK 1750
Cdd:cd12792    234 VDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNKLLYAKEISTYKK 313
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1751 MVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAA 1830
Cdd:cd12792    314 MVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINSLEEDPAAQSKQLTLRLQQIAAA 393

                   ....*..
gi 1777375936 1831 LENKVTD 1837
Cdd:cd12792    394 LENKVTD 400
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
1271-1800 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 798.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFlPskdGDKDVMITGKLDIPEP---RRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAK 1347
Cdd:pfam08337    1 GIPFLDYRTYAMRVLF-P---GVEDHPLLVLLDVPVTndgRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDR 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1348 VYFASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKA 1427
Cdd:pfam08337   77 CNVASLLMVALHGKLEYATEILKTLLRDLIDKSVESKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKA 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1428 IKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDA-IPVKVLNCDTISQVKEKIIDQVYRGQPCSC 1506
Cdd:pfam08337  157 IKQQVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSEsVPVKVLDCDTITQVKEKILDAIYKNTPYSQ 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1507 WPRPDSVVLEWRPGSTAQ-ILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILSKvgvsqqpedsqqdlpgerhalleee 1585
Cdd:pfam08337  237 RPSIDEVDLEWRHGRGGRlTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP------------------------- 291
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1586 nRVWHLVRPTDEVDEGKSKRgsvkekERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVL-APGHAVPPAVKYFFDFLDEQ 1664
Cdd:pfam08337  292 -KYWHLVKPSDEGDQRKKSE------RRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILsVPNSALPLAVKYLFDFLDEQ 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1665 AEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKE 1744
Cdd:pfam08337  365 AEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNKLLYAKD 444
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1777375936 1745 ISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQK 1800
Cdd:pfam08337  445 IPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
27-467 0e+00

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 771.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   27 FFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPR 106
Cdd:cd11276      1 FFQSATELNHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSAN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  107 KRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTR 186
Cdd:cd11276     81 KTLVVCGSLFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSLKPGNDRVFFVGKGNGSNDNGKIISTR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  187 LLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQC 266
Cdd:cd11276    161 LLQNYDDREVFENYIDAATVKSAYVSRYTQQFRYAFEDNNYVYFLFNQQLGHPDKNRTLIARLCENDHHYYSYTEMDLNC 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  267 RDPDihaAAFGTCLAASVAAPG------------SGRVLYAVFSRDSRSSGgpGAGLCLFPLDKVHAKMEANRNACYTGT 334
Cdd:cd11276    241 RDGA---NAYNKCQAAYVSTPGkelaqnygnsilSDKVLFAVFSRDEKDSG--ESALCMFPLKSINAKMEANREACYTGT 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  335 REARDIFYKPFH--GDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTA-VLQRGGLNLTAVTVAAENNHTVAFLGTS 411
Cdd:cd11276    316 IDDRDVFYKPFHsqKDIICGSHQQKNSKSFPCGSEHLPYPLGSRDELALTApVLQRGGLNLTAVTVAVENGHTVAFLGTS 395
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1777375936  412 DGRILKVYLTPDgtSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQ 467
Cdd:cd11276    396 DGRILKVHLSPD--PEEYNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPVQ 449
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
1271-1833 0e+00

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 739.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFLPSKDGDKDVMItgKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF 1350
Cdd:cd12787      1 GIPFLDYKTYAERVFFPGHKDGPLDVMI--KLDIPEPRRPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYV 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQYVVaKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430
Cdd:cd12787     79 ASLLTVALHGKLEYYTDIMRTLLLDLLAQYVV-KNPKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKH 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1431 QVEKGPVDAVQKKakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510
Cdd:cd12787    158 QVDKGPVDAVTGK------------------------------------------------------------------- 170
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1511 dsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvwh 1590
Cdd:cd12787        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1591 lvrptdevdegkskrgsvkekeRTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNI 1670
Cdd:cd12787    171 ----------------------RAKAIPEIYLTRLLSMKGTLQKFVDDFFQSILSPGRPVPPAVKYFFDLLDEQAEKHGI 228
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1671 QDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKK 1750
Cdd:cd12787    229 QDEDTIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHKLGRDSPSNKLLYAREIPRYKK 308
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1751 MVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAA 1830
Cdd:cd12787    309 MVERYYADIRQMVPASDQEMNSHLAELSRNYTDSLNTLVALHELYQYIQKYYDQIINALEEDPAAQKMQLAFRLQQIAAA 388

                   ...
gi 1777375936 1831 LEN 1833
Cdd:cd12787    389 VEN 391
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
1271-1837 0e+00

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 554.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFlpskDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF 1350
Cdd:cd12793      1 GIPFLDYRMYAERIFF----PGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQYVvAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430
Cdd:cd12793     77 ASLLTVALHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKH 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1431 QVEKGPVDAVqkkakytlndTGllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510
Cdd:cd12793    156 QVDKGPVDAV----------TG---------------------------------------------------------- 167
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1511 dsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvwh 1590
Cdd:cd12793        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1591 lvrptdevdegkskrgsvkeKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNI 1670
Cdd:cd12793    168 --------------------KERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDEQALQHGI 227
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1671 QDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKK 1750
Cdd:cd12793    228 SDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYARDIPRYKQ 307
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1751 MVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAA 1830
Cdd:cd12793    308 MVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQLGYRLQQIAAA 387

                   ....*..
gi 1777375936 1831 LENKVTD 1837
Cdd:cd12793    388 VENKVTD 394
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
1271-1837 2.41e-179

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 546.75  E-value: 2.41e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFlPSKdGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF 1350
Cdd:cd12791      1 GIPFLDYRTYAERVFF-PGH-GGCPLQPSLEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHV 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQYVvAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430
Cdd:cd12791     79 ASLLSLALHGKLEYLTDIMKTLLGDLAAHYV-HKNPKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKY 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1431 QVEKGPVDAVQKKakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510
Cdd:cd12791    158 QVDKGPVDAVTGK------------------------------------------------------------------- 170
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1511 dsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvwh 1590
Cdd:cd12791        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1591 lvrptdevdegkskrgsvkeKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNI 1670
Cdd:cd12791    171 --------------------RERAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPVPIAVKYLFDFLDELAEKHGI 230
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1671 QDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKK 1750
Cdd:cd12791    231 EDPETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVGRDSPVNKLLYAREIPRYKQ 310
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1751 MVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAA 1830
Cdd:cd12791    311 MVEKYYADIRQSSPASYQEMNSALTELSGNYTSAPHCLVALQELYNHIHRYYDQIISALEEDPVGQKMQLACRLQQIAAL 390

                   ....*..
gi 1777375936 1831 LENKVTD 1837
Cdd:cd12791    391 VENKVTD 397
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
1271-1829 9.56e-172

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 525.64  E-value: 9.56e-172
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFLPSKDGDkdvmITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF 1350
Cdd:cd12205      1 GIPFLDFREYIIRVLFPGVNDHP----VLLSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430
Cdd:cd12205     77 ASLLMVALQGKMEYATEILFDLLTDLIEKSVSKKHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQ 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1431 QVEKGPVDAVqkkakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510
Cdd:cd12205    157 QIEKGPVDAI---------------------------------------------------------------------- 166
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1511 dsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvwh 1590
Cdd:cd12205        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1591 lvrptdevdegkskrgsvkekertKAITEIYLTRLLSVKGTLQQFVDNFFQSVL-APGHAVPPAVKYFFDFLDEQAEKHN 1669
Cdd:cd12205    167 ------------------------KLIPEIFLTRLLSTKGTLQKFVDDLFESILsVPQRSLPPAIKYLFDFLDEQARKHG 222
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1670 IQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYK 1749
Cdd:cd12205    223 ISDPDVLHAWKTNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLGKDSPSNKLLFAKDIPRYR 302
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1750 KMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAA 1829
Cdd:cd12205    303 EMVANFYRDISNLPPVSDEEMNSYLAELSESHSGEFNTNVALSELYIYAVKYGDQLLEALEDDREARVQQLADKLSQVAR 382
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
1271-1827 2.30e-152

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 473.45  E-value: 2.30e-152
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFFlPSKDgdkDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF 1350
Cdd:cd12790      1 GIPFLDYRTYAMRVLF-PGIE---DHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKN-PKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIK 1429
Cdd:cd12790     77 ASLIMVVLQSKMEYATDILKQLLADLIEKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIK 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1430 HQVEKGPVDAVqkkakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwpr 1509
Cdd:cd12790    157 QQMEKGPIDAI--------------------------------------------------------------------- 167
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1510 pdsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvw 1589
Cdd:cd12790        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1590 hlvrptdevdegkskrgsvkekertKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAP---GHAVPPAVKYFFDFLDEQAE 1666
Cdd:cd12790    168 -------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTahrGSALPLAIKYMFDFLDEQAD 222
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1667 KHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEIS 1746
Cdd:cd12790    223 QHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIP 302
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1747 TYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQ 1826
Cdd:cd12790    303 NYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEEDEFARKQRLAYKLEQ 382

                   .
gi 1777375936 1827 I 1827
Cdd:cd12790    383 V 383
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
1271-1835 3.08e-132

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 419.78  E-value: 3.08e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1271 GIPVLDYKTYTDRVFF------------LPSKDGDKDVM--------ITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLI 1330
Cdd:cd12788      2 GIPFLEYKHFVTRTFFpkcsslyeeryvLPSQENNSQGPrqvpethpLLQEWKIPESCRPNMEEGITLFSTLLNNKHFLV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1331 NFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQyVVAKNPKLMLRRSETVVERMLSNWMSICLY 1410
Cdd:cd12788     82 TFVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDA-SASKNPKLMLRRTESVVEKMLTNWMSICMY 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1411 QYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKkakytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqv 1490
Cdd:cd12788    161 SYLRETVGEPFFLLLCAIKQQINKGSIDAIKK------------------------------------------------ 192
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1491 kekiidqvyrgqpcscwprpdsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpeds 1570
Cdd:cd12788        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1571 qqdlpgerhalleeenrvwhlVRPtdevdegkskrgsvkekertkaitEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAV 1650
Cdd:cd12788    193 ---------------------VLP------------------------EIYLTRLLSTKGTLQKFLDDLFQAILSIPEDR 227
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1651 PP-AVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHK 1729
Cdd:cd12788    228 PPlAVKYFFDFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHMDACLSVIAQAFIDACSISDLQ 307
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1730 LSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINAL 1809
Cdd:cd12788    308 LGKDSPTNKLLYAKEIPEYRKIVQRYYQQIQEMPPLSEQEMNAHLAEESRKYRNEFNTNVAMAEIYKYAKRYRAQIVSAL 387
                          570       580
                   ....*....|....*....|....*.
gi 1777375936 1810 EEDPAAQKMQLAFRLQQIAAALENKV 1835
Cdd:cd12788    388 ESNPTARRTQLQHKFEQVIALMEDNI 413
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
34-467 2.18e-114

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 370.42  E-value: 2.18e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   34 LNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECG 113
Cdd:cd11245      2 INHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQAKETDNFNKLLLVNSANGTLVVCG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  114 SLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDrVLFVGKGNGPHDNGII--VSTRLLDRT 191
Cdd:cd11245     82 SLFQGVCELRNLNSVNKPLYRPETPGDKQYVAANEPSVSTVGLISYFKDGLS-LLFVGRGYTSSLSGGIppITTRLLQEH 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  192 DSREAFEaYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARN-RTLLARMCREDPNYYSYLEMDLQCRDPd 270
Cdd:cd11245    161 GEMDAFS-NEVEAKLVVGSASRYHHDFVYAFADNGYIYFLFSRRPGTADSTkRTYISRLCENDHHYYSYVELPLNCTVN- 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  271 iHAAAFGTCLAASVAAPGS---GRVLYAVFSRDSRSSGGPG--AGLCLFPLDKVHAKMEANRNACYTGTREARD---IFY 342
Cdd:cd11245    239 -QENTYNLVQAAYLAKPGKvlnGKVLFGVFSADEASTAAPDgrSALCMYPLSSVDARFERTRESCYTGEGLEDDkpeTAY 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  343 KPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRgGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTP 422
Cdd:cd11245    318 IEYNVKSICKTLPDKNVKAYPCGAEHTPSPLASRYPLAAKPILTR-NDMLTAVAVAVENGHTIAFLGDSGGQLHKVYLDP 396
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 1777375936  423 dGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQ 467
Cdd:cd11245    397 -NHTDFYSTIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPVQ 440
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
1272-1834 8.83e-110

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 355.71  E-value: 8.83e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1272 IPVLDYKTYTDRVFFlPSKDGDKDVMITgklDIPEPRRPV-VEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF 1350
Cdd:cd12789      4 VPFLDYKHFALRTFF-PESGGFTHIFTR---DDPHDRDQTdKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLF 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1351 ASLLTVALHGKLEYYTDIMHTLFLELLEQyVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKH 1430
Cdd:cd12789     80 ASFLTIALQTKLVYLTEILEVLTKDLMDQ-SSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQ 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1431 QVEKGPVDAVQKKAKytlndtgllgddveyapltvsvivqdegvdaipvkvlncdtisqvkekiidqvyrgqpcscwprp 1510
Cdd:cd12789    159 KINKGPVDVIKFKVK----------------------------------------------------------------- 173
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1511 dsvvlewrpgstaqilsdldltsqregrwkrvntlmhynvrdgatlilskvgvsqqpedsqqdlpgerhalleeenrvwh 1590
Cdd:cd12789        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1591 lvrptdevdegkskrgsvkekertkaitEIYLTRLLSVKGTLQQFVDNFFQSVLA-PGHAVPPAVKYFFDFLDEQAEKHN 1669
Cdd:cd12789    174 ----------------------------EMYLTKLLSTKVAIHSVVEKLFRSIWSlPNNKAPVAIKYFFDFLDAQAENKK 225
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1670 IQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYK 1749
Cdd:cd12789    226 ITDPDVLHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGKEAPTNKLLYAKDIPQYK 305
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1750 KMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLafRLQQIAA 1829
Cdd:cd12789    306 EEVKSYYKAIRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLERERGLEEVQK--QLLHVKA 383

                   ....*
gi 1777375936 1830 ALENK 1834
Cdd:cd12789    384 LFDEK 388
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
27-466 1.90e-96

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 319.98  E-value: 1.90e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   27 FFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPR 106
Cdd:cd11275      1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  107 KRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVsSTGPGGDRVLFVGKGNGPHD--NGI-IV 183
Cdd:cd11275     81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLV-AYSKDGVPLLFVGRGYTSRGvgGGIpPI 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  184 STRLL-----DRTDSREAFeAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQD-KHPARN-RTLLARMCREDPNY 256
Cdd:cd11275    160 TTRNLrahgdDATDSHSIF-SYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDlKSQSREyKTYISRICLDDSHY 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  257 YSYLEMDLQCRDPDihaAAFGTCLAASVAAPGS----------GRVLYAVFSRDSRSSGGPG--AGLCLFPLDKVHAKME 324
Cdd:cd11275    239 YSYVELPLLCQSKA---NTYSLLQAAYVTQPGErlaqgqldtdGEVLFAAFSAWQASSGKLSeeSALCAYPMDEVDRLTN 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  325 ANRNACYT---GTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAEN 401
Cdd:cd11275    316 WTRDVCYTrdgKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVNVED 395
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1777375936  402 NHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPV 466
Cdd:cd11275    396 GHTIAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPI 460
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
34-467 7.01e-92

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 304.64  E-value: 7.01e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   34 LNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECG 113
Cdd:cd11236      2 FNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPGCCSCDHPRSPTDNYNKILLIDYSSGRLITCG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  114 SLFKGICALRALSNISLRlfyEDGSGEKsfVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGII---VSTRLLDR 190
Cdd:cd11236     82 SLYQGVCQLRNLSNISVV---VERSSTP--VAANDPNASTVGFVGPGPYNNENVLYVGATYTNNGYRDYrpaVSSRSLPP 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  191 TDSREAFEAYTDHATY-KAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARN--RTLLARMCREDPNYYSYLEMDLQCR 267
Cdd:cd11236    157 DDDFNAGSLTGGSAISiDDEYRDRYSIKYVYGFSSGGFSYFVTVQRKSVDDESpyISRLVRVCQSDSNYYSYTEVPLQCT 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  268 DPD---------IHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAG--LCLFPLDKVhakmeanrnacytgtre 336
Cdd:cd11236    237 GGDgtnynllqaAYVGKAGSDLARSLGISTDDDVLFGVFSKSKGPSAEPSSKsaLCVFSMKDI----------------- 299
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  337 aRDIFYK--PFHGDIqcgghapgssksfpcgsehlpyPLGSRDGLRGTavlqrgglNLTAVTVAAENNHTVAFLGTSDGR 414
Cdd:cd11236    300 -EAAFNDncPLGGGV----------------------PITTSAVLSDS--------LLTSVAVTTTRNHTVAFLGTSDGQ 348
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1777375936  415 ILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQ 467
Cdd:cd11236    349 LKKVVLESSSSATQYETLLVDSGSPILPDMVFDPDGEHLYVMTPKKVTKVPVE 401
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
27-466 6.80e-89

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 297.11  E-value: 6.80e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   27 FFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPR 106
Cdd:cd11277      1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  107 KRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVssTGPGGDRVLFVGKG-NGPHDNGII-VS 184
Cdd:cd11277     81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLV--VEAPGRDLLLVGRGlTGKLSAGIPpLT 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  185 TRLLDRTdsreafEAYTDHATYK--AGYLSTNTQQFVAAFEDGPYVFFVFNQQD-KHPARNRTLLARMCREDPNYYSYLE 261
Cdd:cd11277    159 IRQLAGA------QAFSSEGLGKlvVGDFSDYNNSYVGAFAHNGYVYFLFRRRGaRAQAEYRTYVARVCLGDTNLYSYVE 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  262 MDLQCRDpdihaaafGTCLA-ASVAAPGsGRVLYAVFSRDSRSSGGP--GAGLCLFPLDKVHAKMEANRNACYT------ 332
Cdd:cd11277    233 VPLVCQG--------GYNLAqAAYLAPG-QGTLFVVFAAGQGSTPTPtdQTALCAYPLVELDSAMERARRLCYTaggggp 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  333 -GTREArdifYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGlNLTAVTVAAENNHTVAFLGTS 411
Cdd:cd11277    304 nGKEEA----TIEYGVTSRCVNLPKDSPESYPCGDEHTPSPIASRQPLEAEPLLTLTP-PLTAVAALQEDGHTIAFLGDT 378
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1777375936  412 DGRILKVYLTPDGtSSEYDSILVEINKR-VKRDLVLSGDLGSLYAMTQDKVFRLPV 466
Cdd:cd11277    379 QGQLHKVFLNGSA-GQVYSSQPVGPPGSaVNPDLLLDATGSHLYVLTARQVTKVPV 433
Sema smart00630
semaphorin domain;
34-436 3.69e-78

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 264.62  E-value: 3.69e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936    34 LNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQcheAEMTDNVNQL-LLLDPPRKRLVEC 112
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSKGK---DPPTDCVNYIrLLLDYNEDRLLVC 77
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   113 GS-LFKGICALRALSNislrlFYedgsgeksfvasndegVATVglvsSTGPGGDRVLFvgkgngphdngIIVSTRLLDRT 191
Cdd:smart00630   78 GTnAFQPVCRLRNLGE-----LY----------------VGTV----ADFSGSDPAIP-----------RSLSVRRLKGT 121
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   192 dsreafeAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKH----PARNRTLLARMCRED--------PNYYSY 259
Cdd:smart00630  122 -------SGVSLRTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEddncGKAVHSRVARVCKNDvggprsldKKWTSF 194
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   260 LEMDLQCRDPDIHAAAFGTCLAASVAAPGSGR--VLYAVFSRDSrsSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREA 337
Cdd:smart00630  195 LKARLECSVPGEDPFYFNELQAAFLLPPGSESddVLYGVFSTSS--NPIPGSAVCAFSLSDINAVFNGPFKECETSTSQW 272
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   338 RDIF--YKPFHGDIQCGgHAPGSSKSFPC----GSEHLPYPLGSRDGLRGTAVLQRGGLN--LTAVTV---AAENNHTVA 406
Cdd:smart00630  273 LPYSrgKVPYPRPGTCP-NKPPSSKDLPDetlnFIKSHPLMDEVVQPLTGRPLFVKTDSNylLTSIAVdrvATDGNYTVL 351
                           410       420       430
                    ....*....|....*....|....*....|
gi 1777375936   407 FLGTSDGRILKVYLTPDGTSSEyDSILVEI 436
Cdd:smart00630  352 FLGTSDGRILKVVLSESSSSSE-SVVLEEI 380
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
28-507 1.31e-68

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 241.37  E-value: 1.31e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   28 FRSEKE---LNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEA-EMTDNVNQLLLLD 103
Cdd:cd11272      4 FHSENRdwtFNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVlTLTNNVNKLLIID 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  104 PPRKRLVECGSLFKGICALRALSNisLRLFYEDGSGEKSFVASNDEGVATVGLVSSTgPGGDRVLFVGKG-NGPHDNGII 182
Cdd:cd11272     84 YSENRLLACGSLYQGVCKLLRLDD--LFILVEPSHKKEHYLSSVNKTGTMYGVIVRS-EGEDGKLFIGTAvDGKQDYFPT 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  183 VSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQ----------FVAAFEDGPYVFFVFNQQDK----HPARNRTL--- 245
Cdd:cd11272    161 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTlalvshfdifYIYGFASGNFVYFLTVQPETpegvSINSAGDLfyt 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  246 --LARMCREDPNYYSYLEMDLQCRDPDIH----AAAF----GTCLAASVAAPGSGRVLYAVFSRDSRSSGGP--GAGLCL 313
Cdd:cd11272    241 srIVRLCKDDPKFHSYVSLPFGCVRGGVEyrllQAAYlskpGEVLARSLNITAQEDVLFAIFSKGQKQYHHPpdDSALCA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  314 FPLDKVHAKMEANRNACYTGtrEARDIFYKPFHGDIQCGgHAPGSSKSFPCGSEhLPYPLGSRDGLRGTAVLQRGGLNLT 393
Cdd:cd11272    321 FPIRAINAQIKERLQSCYQG--EGNLELNWLLGKDVQCT-KAPVPIDDNFCGLD-INQPLGGSTPVEGVTLYTSSRDRLT 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  394 AVTVAAENNHTVAFLGTSDGRILKVYLT--PDGtSSEYDSILV-EINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECL 470
Cdd:cd11272    397 SVASYVYNGYSVVFVGTKSGKLKKIRADgpPHG-GVQYEMVSVfKDGSPILRDMAFSIDHKYLYVMSERQVSRVPVESCE 475
                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1777375936  471 SYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEA 507
Cdd:cd11272    476 QYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEP 512
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
27-469 4.03e-54

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 197.48  E-value: 4.03e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   27 FFRSEKE--LNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEA-EMTDNVNQLLLLD 103
Cdd:cd11274      4 FTGDQTEwtFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPlTLTNNINKMLLID 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  104 PPRKRLVECGSLFKGICALRALSNisLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIV 183
Cdd:cd11274     84 YKENRLIACGSLYQGICKLLRLDD--LFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTI 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  184 STRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQF----------VAAFEDGPYVFFVFNQQDK-HPARNRTL------- 245
Cdd:cd11274    162 SSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFtiipdfdiyyIYGFSSGNFVYFLTLQPEMiSPPGSTTKeqvytsk 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  246 LARMCREDPNYYSYLEMDLQCRDPDIH----AAAF----GTCLAASVAAPGSGRVLYAVFSRDS--RSSGGPGAGLCLFP 315
Cdd:cd11274    242 LVRLCKEDTAFNSYVEVPIGCEKNGVEyrllQAAYlskaGAILARSLGVGPDDDILFTVFSKGQkrKMKSLDESALCIFV 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  316 LDKVHAKMEANRNACYTGTREARDIFYKPfhGDIQCGGHAPGSSKSFpCGSEhLPYPLGSRDGLRGTAVLQRGGLNLTAV 395
Cdd:cd11274    322 LKEINDRIKDRLQSCYRGEGTLDLAWLKV--KDIPCSSALLTIDDNF-CGLD-MNAPLGVSEMVRGLPVFTEDRDRMTSV 397
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1777375936  396 TVAAENNHTVAFLGTSDGRILKVYLtpDGTSS---EYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQEC 469
Cdd:cd11274    398 IAYVYKNHSLAFVGTKSGKLKKIRV--DGTTKnalQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESC 472
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
28-467 1.67e-52

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 192.73  E-value: 1.67e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   28 FRSEKE---LNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEA-EMTDNVNQLLLLD 103
Cdd:cd11244      4 FRGEPRdwsFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPlTTTNNVNKLLLID 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  104 PPRKRLVECGSLFKGICALRALSNisLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRvLFVGKG-NGPHDNGII 182
Cdd:cd11244     84 YSENRLIACGSLYQGVCKLLRLED--LFKLGEPHHKKEHYLSGVNESGTMFGVIVSYSNGDDK-LFIGTAvDGKSEYFPT 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  183 VSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQF----------VAAFEDGPYVFFVFNQQDKH-PARNRT------- 244
Cdd:cd11244    161 LSSRKLTADEESDGMFAYVYHDEFVSSQIKIPSDTLsiipdfdiyyVYGFSSGNFVYFLTLQPETQlTPGDSTgeqfyts 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  245 LLARMCREDPNYYSYLEMDLQCRDPDIH----AAAF----GTCLAASVAAPGSGRVLYAVFSRDSRSSGGP--GAGLCLF 314
Cdd:cd11244    241 KIVRLCKDDTKFYSYVEFPIGCTRDGVEyrllQAAYlskpGKALAQALGISEDEDVLFTIFSKGQKNRMKPpdESALCLF 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  315 PLDKVHAKMEANRNACYTGtrEARDIFYKPFHGDIQCgGHAPGSSKSFPCGSEhLPYPLGSRDGLRGTAVLQRGGLNLTA 394
Cdd:cd11244    321 TLKQINLRIKERLQSCYRG--EGKLSLPWLLNKDLPC-INAPLQIDDNFCGLD-MNQPLGGSDMVEGIPLFTDDRDRMTS 396
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1777375936  395 VTVAAENNHTVAFLGTSDGRILKVYLT-PDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQ 467
Cdd:cd11244    397 VAAYVYKGHSVVFVGTKSGKLKKIRVDgPPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIMSERQVTRVPVE 470
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
28-466 2.31e-51

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 189.67  E-value: 2.31e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   28 FRSEKELNHLAVDEASGVVYLGAVNALYQLDA-KLQLEQQVATGPALDNKKCTPP--IEASQCHEAEMTDNVNQLLLLDP 104
Cdd:cd11247      5 FRSPTRTNNFALDGGRGRLYLAAVNRLYQLSGlVLALEAEAAVGPVLDSPLCHAPqlPQATCEHPRTLTDNYNKILQPDP 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  105 PRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSF-----VASNDEGVATVGLV-SSTGPGGDRVLFVGKG----- 173
Cdd:cd11247     85 EQGVLVVCGSIYQGLCQLRRLYNISAVAVRFPVDGDTVFpsmlnVAANHPNASTVGLVlWPRGGGGGLRLLVGATytgyg 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  174 ----NGPH-------DNGIIVSTRLLDRTDSREAFEAYTDHAT------YKAGYLSTNTQQFVAAFEDG---PYVFFVFN 233
Cdd:cd11247    165 sgffPRNRsledhrfENTPEIAIRALNTRGDLAKLFTFDINPSddnifkIKQGAKARHKLSFVRAFLQHflqPYAYLAMN 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  234 QQ----DKHPARNrTLLARMCREDPN----------YYSYLEMDLQCRDPdihaaafGTCLAASVAAPGSGRVLYAVFSR 299
Cdd:cd11247    245 GEanaaGKESQPP-SLLARICLPGRAppppgeakklTESYIQLGLRCEGA-------YTRLVSVFPARVEEEQLFAVFER 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  300 dsrsSGGPGAGLCLFPLDKVHAKMEANRNACytgtreardiFYKPFHGDIQC-----GGHAPGSSK---------SFPCG 365
Cdd:cd11247    317 ----AGGAPAALCAFRFAEVEEPIRAARTAC----------FVSPAAGVVTVldsvvQGTGPACERklniqlqpeQLDCG 382
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  366 SEHLPYPLGSRDGLRGTAVLQRGGlnLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLV 445
Cdd:cd11247    383 AAHLQHPLAILQPLKATPVFRAPG--LTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGEPVHHVMQ 460
                          490       500
                   ....*....|....*....|..
gi 1777375936  446 LS-GDLGSLYAMTQDKVFRLPV 466
Cdd:cd11247    461 FDpSDSTYLYLMTSHQMTRVKV 482
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
27-467 1.01e-47

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 179.01  E-value: 1.01e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   27 FFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQC-HEAEMTDNVNQLLLLDPP 105
Cdd:cd11271      7 FTASDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCpHGLGTTNNVNKLLLVDYA 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  106 RKRLVECGSLFKGICALRALSNisLRLFYEDGSGEKSFVASNDEGVATVGLVSStGPGGDRVLFVGKgngPHDNG----- 180
Cdd:cd11271     87 ANRLIACGSASQGICQFLRLDD--LFKLGEPHHRKEHYLSSVNESGTMSGVIIE-VGNGQNKLFVGT---PIDGKseyfp 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  181 IIVSTRLLDRTDSREAFE-AYTDHATYKAGYLSTNTQQ--------FVAAFEDGPYVFFVFNQQDKH---PARN-----R 243
Cdd:cd11271    161 TLSSRKLMANEENAEMFGfVYQDEFVSSQLKIPSDTLSkfptfdiyYVYSFSSEQFVYYLTLQLDTQltsPDSTgeqffT 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  244 TLLARMCREDPNYYSYLEMDLQCRD--------PDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGP--GAGLCL 313
Cdd:cd11271    241 SKIVRLCVDDPKFYSYVEFPIGCEQdgveyrliQDAYLSKPGKALAKQLGISEREDILFTVFSQGQKNRVKPpkESVLCL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  314 FPLDKVHAKMEANRNACYTGtrEARDIFYKPFHGDIQCGGHAPGSSKSFpCGSEhLPYPLGSRDGLRGTAVLQRGGLNLT 393
Cdd:cd11271    321 FTLKKIKDKIKERIQSCYRG--EGKLSLPWLLNKELGCINSPLQIDDNF-CGQD-FNQPLGGTVTIEGTPLFVDKEDGMT 396
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777375936  394 AVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSS----EYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQ 467
Cdd:cd11271    397 SVAAYDYRGRTVVFAGTRSGRIKKILVDLSAPSSrpalQYENVVAHEGSPILRDLVLSPDRQYIYAMTEKQVTRVPVE 474
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
27-467 1.32e-47

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 178.20  E-value: 1.32e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   27 FFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQC-HEAEMTDNVNQLLLLDPP 105
Cdd:cd11273      6 FVVTDTTLTHLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCaHRLAPVDNVNKLLLVDYA 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  106 RKRLVECGSLFKGICALRALSNisLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRvLFVGKGNGPHDN--GIIV 183
Cdd:cd11273     86 GNRLVACGSIWQGVCQFLRLED--LFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGKGPSK-LFVGTAIDGKSEyfPTLS 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  184 STRLLDRTDSREAFE-AYTDHATYKAGYLSTNTQQ--------FVAAFEDGPYVFFVFNQQDKHPARNRTL--------L 246
Cdd:cd11273    163 SRKLISDEDSADMFSlVYQDEFVSSQIKIPSDTLSlypafdiyYVYGFVSASFVYFLTLQLDTQQTLLDTAgekfftskI 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  247 ARMCREDPNYYSYLEMDLQCRDPDI--------HAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGP--GAGLCLFPL 316
Cdd:cd11273    243 VRMCANDTEFYSYVEFPLGCSKDGVeyrlvqaaHLAKPGLLLAQALGVPEDEDVLFTIFSQGQKNRASPprETILCLFTL 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  317 DKVHAKMEANRNACYTGtrEARDIFYKPFHGDIQCGGHAPGSSKSFpCGSEhLPYPLGSRDGLRGTAVLQRGGLNLTAVT 396
Cdd:cd11273    323 SNINAHIRERIQSCYRG--EGTLSLPWLLNKELPCINTPMQINGNF-CGLV-LNQPLGGLHVIEGLPLLADSTDGMASVA 398
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1777375936  397 VAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQ 467
Cdd:cd11273    399 AYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDMVFSPDHRYIYLLSEKQVSQLPVE 469
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
1448-1558 9.46e-47

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 163.52  E-value: 9.46e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1448 LNDTGLLGDDVEYAPLTVSVIVQDEGVDA-IPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQ-I 1525
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEGEVSEsVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHGRGGRlI 80
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1777375936 1526 LSDLDLTSQREGRWKRVNTLMHYNVRDGATLIL 1558
Cdd:pfam20170   81 LQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
25-467 1.88e-38

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 151.42  E-value: 1.88e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   25 LDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPAL--DNKKCTppIEASQCHEAEMTDNVNQLLLL 102
Cdd:cd11248      1 LPFFTADTPIQNIVLNEGSTEVYVAAQNVIYALNPDLQKVWEYKTGPVGspDCQTCQ--DCSSGADPGVPKDTDNMVLVL 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  103 DPP-RKRLVECGSLFKGICALRALsnislrlfyEDGSGEKS-----FVASNDEGVATVGLVSStgPGGDRVLFVGKG--- 173
Cdd:cd11248     79 ETYyDDYLYSCGSTQNGVCYRHVL---------EDGADIQSevhclFSKKNNSPSYCPDCVAS--PLGTKVTNVESGrti 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  174 ------------NGPHDNGIIVSTRLLDRTDSREAFEAYTDHA-TYKAGYlstnTQQFVAAFEDGPYVFFVFNQQ---DK 237
Cdd:cd11248    148 yffvansvnsslAGSFPPHSISVRRLKEDGFGFLSDQSYLDVLpSLRDSY----PIKYVYSFHSGPFVYFLTVQReslTK 223
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  238 HPARNRTLLARMCREDPNYYSYLEMDLQCRDPD---------------IHAAAFGTC---LAASVAAPGSGRVLYAVFSR 299
Cdd:cd11248    224 PSSAFHTRLVRLCSSDSEIWRYREMPLECIFTPkrrrrsteedvvynvLQAAHVSKVgadLADELGASEGDDILFGVFAR 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  300 DSRSSGGPGA--GLCLFPLDKVHAKMEANRNACYTGTREArdiFYKPFHGDIQCGgHAPGSSKSFPCGSEHLP----YPL 373
Cdd:cd11248    304 SKPDSGEPMPnsALCAFPIKYVNDAIEKGVEKCCTSGLEH---FSGSLCHFQPCP-TCPGESSSCEATCKEYRtevtKPY 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  374 GSRDGLRGtavlQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEinKRVKRDLVLSGDLGSL 453
Cdd:cd11248    380 QRVDLFNG----QMSNVLLTSILVTTIGNHTVAHLGTSDGRVLQVVLSRSGPIPHVNFSLDS--QPVSREVAVLSSNGSL 453
                          490
                   ....*....|....
gi 1777375936  454 YAMTQDKVFRLPVQ 467
Cdd:cd11248    454 LFVTGDKITKVPLI 467
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
803-894 4.44e-34

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 126.66  E-value: 4.44e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIQ-RISVAGRNCSFQPERYSVSTRIVCVIEAAETP-FTGGVEVDVFGK 880
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRhGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPvFNGPVEVTVGHG 80
                           90
                   ....*....|....
gi 1777375936  881 LGRSPPNVQFTFQQ 894
Cdd:cd01180     81 SFRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
895-981 1.22e-29

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 113.47  E-value: 1.22e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQedVRVTLNGVPCKVTKFGA-QLQCVTGPQATRGQMLLEVSYGGSPVpNP 973
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSS--VRVTVGGQPCKILSVSSsQIVCLTPPSASPGEAPVKVLIDGARR-LA 77

                   ....*...
gi 1777375936  974 GIFFTYRE 981
Cdd:cd01179     78 PLVFTYTE 85
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
28-467 1.72e-25

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 112.57  E-value: 1.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   28 FRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPAlDNKKCTppiEASQC----HEAEMTDNVNQLLLLD 103
Cdd:cd11279     23 FSAGSPIQNIVSYEDASAVFVATRNHLHVLNPELKLLQNLVTGPT-GSPGCQ---ICALCppgpPGPSPEDTDNKVLVLD 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  104 PPRKRLVECGSLFKGICALRAL--SNISLRLfyedGSGEKSFVASNDEGVATVGLVSStgPGGDRVLFVGKGNGPH---- 177
Cdd:cd11279     99 PEEPWLYSCGSSLHGRCFLHELesRGSAVHI----ASTACLFSANANKPSDCPDCVAS--PLGTRVTVVEQSHTSYfyva 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  178 ---DNGII-------VSTRLL--DRTDSREAFEAYTDHATYKAGYLStntqQFVAAFEDGPYVFFVFNQQDKHPARN-RT 244
Cdd:cd11279    173 stlNSSVAasysprsVSIRRLksDQDGFAPGFHSLTVLPKYLDSYPI----HYVHSFTSGDFVYFLTVQPESPDSSAyHT 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  245 LLARMCREDPNYYSYLEMDLQCR-------------DPDI-------HAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSS 304
Cdd:cd11279    249 RLVRLSAKEPELRDYRELVLDCRfepkrrrrrrpaeREVPynvlqaaHAAPVGSKLAVELGISEGQEVLFGVFAESQPGS 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  305 GGPG--AGLCLFPLDKVHAKMEANRNACYTGTREAR-----DIFYKPFHGDIQCGGHAPGSSKS---FPCgseHLPYPLG 374
Cdd:cd11279    329 PVPQknSAVCAFPISLLNEAIDEGMEKCCSSSNSDRlfrglDFFQPQSYCPHPPNLSAAVSNTScwnFPT---LVSTSSF 405
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  375 SRDGLRGtavlQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTpdgTSSEY----DSILVEINKRVKRDLVLSGDl 450
Cdd:cd11279    406 RVDLFNG----HLSGVLLTSIYVTVLDNVTVAHLGTSDGRILQVVLQ---RSLNYllyvSNFSLGDGQPVQRDVSRLGD- 477
                          490
                   ....*....|....*..
gi 1777375936  451 gSLYAMTQDKVFRLPVQ 467
Cdd:cd11279    478 -SLLFASGNQVFKVNIT 493
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
281-447 3.60e-25

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 104.27  E-value: 3.60e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  281 AASVAAPGSGR----VLYAVFSRdSRSSGGPGAGLCLFPLDKVHAKMEaNRNACYTG--TREARDIFYKPFHGDIQCGGH 354
Cdd:pfam01403    3 DVFVLKPGAGDaldtVLYGVFTT-QWSNSIGGSAVCAFSLSDINAVFE-GPFKEQEKsdSKWLPYTGKVPYPRPGTCIND 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  355 APGSS--KSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTV----AAENNHTVAFLGTSDGRILKVYLTPDGTSSE 428
Cdd:pfam01403   81 PLRLDlpDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVdrvqALDGNYTVLFLGTDDGRLHKVVLVGSEESHI 160
                          170       180
                   ....*....|....*....|
gi 1777375936  429 YDSI-LVEINKRVKRDLVLS 447
Cdd:pfam01403  161 IEEIqVFPEPQPVLNLLLSS 180
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
803-894 6.10e-21

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 89.05  E-value: 6.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIqRISVAGRNCSFQPerySVSTRIVCVIEAAETPFTGGVEVDVFGKLG 882
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRV-RVTVGGVPCKVLN---VSSTEIVCRTPAAATPGEGPVEVTVDGANV 76
                           90
                   ....*....|....
gi 1777375936  883 --RSPPNVQFTFQQ 894
Cdd:cd00603     77 saRVLSNTTFTYVE 90
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
525-613 1.62e-19

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 84.63  E-value: 1.62e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  525 QPQNMSRRAQGEVQLTVSPLPALSEEdeLLCLFGESPPHPARVEGEAVICNSPSS--IPVTPPGQDHVAVTIQLLLRRGN 602
Cdd:pfam17960    1 TPDNISRTTATQLTLTVPNLPALSEG--YSCVFGDLTESPATVHDNGVKCATPPPsqLPPIPTGQDHVTVKLSLRSSETG 78
                           90
                   ....*....|.
gi 1777375936  603 IFLTSYQYPFY 613
Cdd:pfam17960   79 VDFASTNFTFY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
895-981 1.32e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.12  E-value: 1.32e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSqEDVRVTLNGVPCKVTKFGA-QLQCVTGPQATRGQMLLEVSYGGSPVPNP 973
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGVPCKVLNVSStEIVCRTPAAATPGEGPVEVTVDGANVSAR 79
                           90
                   ....*....|.
gi 1777375936  974 G---IFFTYRE 981
Cdd:cd00603     80 VlsnTTFTYVE 90
Sema_MET cd11278
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ...
44-435 2.01e-16

The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.


Pssm-ID: 200539 [Multi-domain]  Cd Length: 492  Bit Score: 84.53  E-value: 2.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   44 GVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQ---CHEAEMTDNVNQLLLLDP-PRKRLVECGSLFKGI 119
Cdd:cd11278     36 HHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFPCQDCSDkanLSNGVWKDNVNMALFVETyYDDQLISCGSVNRGT 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  120 CALRAL---------SNISLrLFYEDGSGEKSfvASNDEGVATVG---LVSStgpgGDRVL--FVGK---GNGPHDNGI- 181
Cdd:cd11278    116 CQRHVFphdhpadiqSEVHC-IYSPQIEEEPD--QCPDCVVSTLGskvLVTV----KDRFVnfFVGNtinSSYFPDHPLh 188
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  182 IVSTRLLDRTdsREAFEAYTDHAtykagYLSTNTQ-------QFVAAFEDGPYVFFVFNQQDKHPARN-RTLLARMCRED 253
Cdd:cd11278    189 SISVRRLKET--QDGFEFLTDQS-----YIDVLPEfrdsypiKYVHAFESNNFVYFLTVQRESLDSQTfHTRIIRFCSID 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  254 PNYYSYLEMDLQC------RDPDIHAAAFGTCLAASVAAPGSG-----------RVLYAVFSRDSRSSGGPG--AGLCLF 314
Cdd:cd11278    262 SELRSYMEMPLECiftekrRKRSTKKEVFNILQAAYVSKPGAQlaremgaslndDILFGVFAQSKPDSAEPMnrSAVCAV 341
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  315 PLDKVHakmEANRNACYTGTREARDIFYKPFHGdiQCGGHAPGSSKSFpCGSEHLPYPlgsrdgLRGTAVLQRGGLN--- 391
Cdd:cd11278    342 SIKTIN---EFFNKIVDKQNVKCLQHFYGKNHE--HCFNRTFLRNASY-CEARRDEYR------VEVTTALQRVDLFmgq 409
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1777375936  392 -----LTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVE 435
Cdd:cd11278    410 fsnvlLTSISVFTKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLD 458
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
803-894 4.52e-15

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 72.11  E-value: 4.52e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  803 PVITRIQPETGPLGGGIRITILGSNLGVqaGDIQRISV-AGRNCSFQPerySVSTRIVCVIEAAETPFTGGVEVDVFGK- 880
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGS--GSNLRVTFgGGVPCSVLS---VSSTAIVCTTPPYANPGPGPVEVTVDRGn 75
                           90
                   ....*....|....
gi 1777375936  881 LGRSPPNVQFTFQQ 894
Cdd:cd00102     76 GGITSSPLTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
895-980 1.47e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 70.91  E-value: 1.47e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVT-KFGAQLQCVTGPQAT-RGQM-LLEVSYGGSPVP 971
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSpSSSTAIVCKTPPYHNiPGSVpVRTVGLRNGGVP 81

                    ....*....
gi 1777375936   972 NPGIFFTYR 980
Cdd:smart00429   82 SSPQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
802-892 5.16e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 69.37  E-value: 5.16e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   802 PPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERysvSTRIVCVI-EAAETPFTGGVEVDVFGK 880
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSS---STAIVCKTpPYHNIPGSVPVRTVGLRN 77
                            90
                    ....*....|..
gi 1777375936   881 LGRSPPNVQFTF 892
Cdd:smart00429   78 GGVPSSPQPFTY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
469-517 1.86e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 66.19  E-value: 1.86e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1777375936  469 CLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECpRAEEASHWLWSRSKS 517
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSAC-GAPEGNCEEWEQASS 49
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
895-981 6.38e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 65.95  E-value: 6.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTlNGVPCKVTKFGA-QLQCVTGPQATRGQMLLEVSYGGSPVP-- 971
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFG-GGVPCSVLSVSStAIVCTTPPYANPGPGPVEVTVDRGNGGit 79
                           90
                   ....*....|
gi 1777375936  972 NPGIFFTYRE 981
Cdd:cd00102     80 SSPLTFTYVP 89
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
1618-1761 2.00e-12

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 69.44  E-value: 2.00e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1618 TEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPH 1697
Cdd:cd04519    114 KLPVGEDLEENLENLLELVNKLVDRILSSLDRLPPELRYVFKILREFLAERFPEEPDEAYQAVSGFLFLRFICPAIVSPE 193
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777375936 1698 --FIFDVHVHEVVDASLSVIAQTFMDACTRTEH--KLSRDSPSNKLlyakeISTYKKMVEDYYKGIRQ 1761
Cdd:cd04519    194 lfGLVPDEPSEQARRNLTLISKVLQSLANGVEFgdKEPFMKPLNDF-----IKSNKPKLKQFLDELSS 256
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
895-979 2.05e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.39  E-value: 2.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSqEDVRVTLNGVPCKVTKFGA-QLQCVTgPQATRGQMLLEVSYGGSPVPNP 973
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS-SDLKVTIGGTPCTVISVSStTIVCTT-PPGTSGLVNVSVTVGGGGISSS 78

                   ....*.
gi 1777375936  974 GIFFTY 979
Cdd:pfam01833   79 PLTFTY 84
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
468-518 1.11e-11

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 61.02  E-value: 1.11e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1777375936   468 ECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEasHWLwsrSKSC 518
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQ--NWL---SGGC 46
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
803-892 2.56e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 2.56e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIqRISVAGRNCSFQperYSVSTRIVCVIEAAEtpfTGGVEVDVF-GKL 881
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL-KVTIGGTPCTVI---SVSSTTIVCTTPPGT---SGLVNVSVTvGGG 73
                           90
                   ....*....|.
gi 1777375936  882 GRSPPNVQFTF 892
Cdd:pfam01833   74 GISSSPLTFTY 84
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
218-466 5.81e-11

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 67.16  E-value: 5.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  218 FVAAFEDGPYVFFVFNQ-QDKHPARNRTL---LARMCRED---------PNYYSYLEMDLQCRDPDIHAAAFGTCLAASV 284
Cdd:cd11242    175 FVHAVEYGDYVYFFFREiAVEYNTLGKVVfsrVARVCKNDmggsprvleKQWTSFLKARLNCSVPGDSHFYFDVLQAVTD 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  285 AAPGSGR-VLYAVFSRDSRSSggPGAGLCLFPLDKVHA----KMEANRNACYTGTREARDIFYKPFHGdiQCGGHAPGSS 359
Cdd:cd11242    255 VIRINGRpVVLGVFTTQYNSI--PGSAVCAFDMDDIEKvfegRFKEQKSPDSAWTPVPEDRVPKPRPG--CCAGSGSAEK 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  360 ---------------KSFPCGSEHLPyPLGSRDGLRGTAVlqRGGLNLTAVTVAA--ENNHTVAFLGTSDGRILKVyLTP 422
Cdd:cd11242    331 yktsndfpddtlnfiKTHPLMDEAVP-SIINRPWFTRTMV--RYRLTQIAVDNAAgpYQNYTVVFLGSEAGTVLKF-LAR 406
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1777375936  423 DGTSSEYDSILVE---------INKRVKRD-----LVLSGDLGSLYAMTQDKVFRLPV 466
Cdd:cd11242    407 IGPSGSNGSVFLEeidvynpakCSYDGEEDrriigLELDRASHALFVAFSGCVIRVPL 464
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
218-428 2.52e-09

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 61.77  E-value: 2.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  218 FVAAFEDGPYVFFVF-------NQQDKHPArnrTLLARMCRED---------PNYYSYLEMDLQCRDPDIHAAAFGTCLA 281
Cdd:cd11267    175 FVHAVEWGSHVYFFFreiamefNYLEKVVV---SRVARVCKNDmggsqrvleKQWTSFLKARLNCSVPGDSHFYFNVLQA 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  282 ASVAAPGSGR-VLYAVFSRDSRSSggPGAGLCLFPLDKVHAKMEA------NRNACYTGTREarDIFYKPFHGDIQCGGH 354
Cdd:cd11267    252 VSDILNLGGRpVVLAVFSTPTNSI--PGSAVCAFDMTQVAAVFEGrfreqkSPESIWTPVPE--ELVPRPRPGCCAAPGM 327
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  355 APGSS-----------KSFPCGSEHLPYpLGSRDGLRGTavLQRGGLNLTAVTVAA--ENNHTVAFLGTSDGRILKVYLT 421
Cdd:cd11267    328 RYNSSstlpdevlnfvKTHPLMDEAVPS-LGHAPWIVRT--MTRYQLTHMVVDTEAgpHGNHTVVFLGSTRGTVLKFLII 404

                   ....*..
gi 1777375936  422 PDGTSSE 428
Cdd:cd11267    405 PNASSSE 411
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
204-435 5.93e-08

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 57.40  E-value: 5.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  204 ATYKAGYLstNTQQFVAAFEDGPYVFFVFNQQDKHPAR----NRTLLARMCRED---------PNYYSYLEMDLQCRDPD 270
Cdd:cd11268    162 AKYDSKWL--REPHFVQALEHGDHVYFFFREVSVEDARlgrvQFSRVARVCKRDmggspraldRHWTSFLKLRLNCSVPG 239
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  271 IHAAAFGTCLAASVAAPGSGR-VLYAVFSRDSRSSggPGAGLCLFPLDKV----HAKMEANRNACYTGTREARDIFYKPF 345
Cdd:cd11268    240 DSTFYFDVLQALTGPVNLHGRsALFGVFTTQTNSI--PGSAVCAFYLDEIergfEGKFKEQRSLDGAWTPVSEDRVPSPR 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  346 HGDIQ-CGGHAPGSS------------KSFPCGSEHLPyPLGSRDGLRGTAvlqRGGLNLTAVTVAA--ENNHTVAFLGT 410
Cdd:cd11268    318 PGSCAgVGGAALFSSsrdlpddvltfiKAHPLLDPAVP-PVTHQPLLTLTS---RALLTQVAVDGMAgpHSNITVMFLGS 393
                          250       260
                   ....*....|....*....|....*
gi 1777375936  411 SDGRILKVyLTPDGTSSEYDSILVE 435
Cdd:cd11268    394 NDGTVLKV-LPPGGRSGGPEPILLE 417
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
36-467 6.81e-08

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 57.03  E-value: 6.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   36 HLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTppieasqCHEA--EMTDNVNQLLLLDP-PRKRLVEC 112
Cdd:cd11235      5 TKLLHEDRSTLYVGARDRVYLVDLDSLYTEQKVAWPSSPDDVDT-------CYLKgkSKDDCRNFIKVLEKnSDDSLLVC 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  113 GS-LFKGICALRALSNISLRLFYEDGSGEksfvASNDEGVATVGLVSSTGpggdrvLFVGKGNGPHDNGIIVSTRLLDRT 191
Cdd:cd11235     78 GTnAFNPSCRNYNVETFELVGKEESGRGK----CPYDPDHNSTALFADGE------LYSGTSADFLGTDPVIYRTLGHNP 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  192 DSReafeaytdhaTYKAGYLSTNTQQFVAAFEDGPYVFFVF--NQQDKHPARNRTL--LARMCRED--------PNYYSY 259
Cdd:cd11235    148 PLR----------TEYHDSKWLNEPQFVGAFDIGDYVYFFFreIAVEYINCGKAVYsrVARVCKNDqggsrsleKKWTTF 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  260 LEMDLQCRDPDIHAAAFGTCLAASVAAPGSGR--VLYAVFSrdSRSSGGPGAGLCLFPLDKVHA----KMEANRNACYTG 333
Cdd:cd11235    218 LKARLNCSVPGEFPFYFNELQDVFDLPSPSNKekIFYAVFT--TPYNSIPGSAVCAYSLSDIEAvfngPFKEQHSSNSAW 295
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  334 TREARDIFYKPFHGdiQCgghaPGSSKSFPcgSEHL----PYPLGSRdglRGTAVLQR-------GGLNLTAV---TVAA 399
Cdd:cd11235    296 LPVPDERVPEPRPG--TC----VDDSSPLP--DDTLnfikSHPLMDE---AVTPILNRplfiktdVNYRFTKIavdRVQA 364
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1777375936  400 ENN--HTVAFLGTSDGRILKVYLTPDGTSSEydSILVEI------NKRVKrDLVLSGDLGSLYAMTQDKVFRLPVQ 467
Cdd:cd11235    365 KLGqtYDVLFVGTDRGIILKVVSLPEQGLQA--SNILEEmpvgppPEPIQ-TMQLSRKRRSLYVGSETGVLQVPLA 437
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
759-799 4.01e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 48.47  E-value: 4.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1777375936  759 NCSfGRSDCSLCRAAnPDYRCAWCGGQSRCVYEALCNTTSE 799
Cdd:pfam01437    1 RCS-QYTSCSSCLAA-RDPYCGWCSSEGRCVRRSACGAPEG 39
Sema_5C cd11265
The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, ...
40-467 1.30e-06

The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, Sema5C was identified as an early development gene, which is expressed in stage 2 embryos with a striped pattern emerging at later stages. Sema5c may play a role in odor-guided behavior and in tumorigenesis. Sema5C belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200526 [Multi-domain]  Cd Length: 433  Bit Score: 52.86  E-value: 1.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   40 DEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKK--CTPPIEASQ-CHeaemtdnvNQLLLLDPPRKRLVECGS-L 115
Cdd:cd11265     15 DVARNQVIVGARDNLYRLSLDGLELLERASWPAAESKValCQNKGQSEEdCH--------NYVKVLLSYGKQLFACGTnA 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  116 FKGICALRALSNISLrlfyedgsgeksfVASNDEGVA---------TVGLVSSTGPggdrvLFVGkgnGPHD-------- 178
Cdd:cd11265     87 FSPRCSWREMENLTS-------------VTEWDSGVAkcpysphanITALLSSSGQ-----LFVG---SPTDfsgsdsai 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  179 --NGIIVSTRLLdRTdsreafeaytdhATYKAGYLstNTQQFVAAFEDGPYVFFVFNQQD-KHPARNRTL---LARMCRE 252
Cdd:cd11265    146 yrTLGTSNKSFL-RT------------KQYNSKWL--NEPQFVGSFETGNFVYFLFRESAvEYMNCGKVIysrIARVCKN 210
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  253 DP---------NYYSYLEMDLQCRDP--------DIHAAAFgtclaasvaAPGSGrVLYAVFSrdSRSSGGPGAGLCLFP 315
Cdd:cd11265    211 DVgggtmllkdNWTTFLKARLNCSLPgeypfyfdEIQGMTY---------LPDEG-ILYATFT--TPENSIAGSAVCAFN 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  316 LDKVHA------KMEANRNACYtgtrEARDIFYKPFHGdiQCGGHAPGS---SKSF--------PCGSEHLPYplgsrdg 378
Cdd:cd11265    279 LSSINAafdgpfKHQESSGAAW----ERVNVNHRDHFN--QCSSSSSSHlleSSRYqlmdeavqPITLEPLHH------- 345
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  379 lrgtAVLQRggLNLTAVTVAAENNHT---VAFLGTSDGRILKVYLTPDGTsseyDSILVEINKRVKR------DLVLSGD 449
Cdd:cd11265    346 ----AKLER--FSHIAVDVIPTKIHQsvhVLYVATTGGLIKKISVLPRTQ----ETCLVEIWQPLPTpdspikTMQYLKV 415
                          490
                   ....*....|....*...
gi 1777375936  450 LGSLYAMTQDKVFRLPVQ 467
Cdd:cd11265    416 TDSLYVGTELALMRIPAQ 433
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
759-801 4.26e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.23  E-value: 4.26e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1777375936   759 NCSFGRSdCSLCRAANPDYrCAWCGGQSRCVYEALCNTTSE------CP 801
Cdd:smart00423    1 RCSKYTS-CSECLLARDPY-CAWCSSQGRCTSGERCDSRRQnwlsggCP 47
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
37-436 1.97e-05

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 49.35  E-value: 1.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   37 LAVDEASGVVYLGAVNALYQLDAklqleQQVATGPALDNKKCTP--PIEASQCH---EAEMTDNVNQLLLLDPP--RKRL 109
Cdd:cd11238      6 LLLDEKRNALYVGAMDRVFRLNL-----YNINDTGNNCARDELTlsPSDVSECVskgKDEEYECRNHVRVIQPMgdGQTL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  110 VECGSLfkgicA----LRALSNISLRLFYEDGSGE----KSFVASNDEGVATvgLVSSTGPGGDRVLFVGKGNG-PHDNG 180
Cdd:cd11238     81 YVCSTN-----AmnpkDRVLDANLLHLPEYVPGPGngigKCPYDPDDNSTAV--WVEWGNPGDLPALYSGTRTEfTKANT 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  181 IIVSTRLLDRTDSREAFEAYTDHatYKAGYLstNTQQFVAAFEDGPYVFFVF------NQQDKHPARNRtlLARMCRED- 253
Cdd:cd11238    154 VIYRPPLYNNTKGRHESFMRTLK--YDSKWL--DEPNFVGSFDIGDYVYFFFretaveYINCGKVVYSR--VARVCKKDt 227
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  254 -------PNYYSYLEMDLQCRDPDIHAAAFGTClaASV-AAPGSGRVL-YAVFSrdSRSSGGPGAGLCLFPLDKVHA--- 321
Cdd:cd11238    228 ggknvlrQNWTTFLKARLNCSISGEFPFYFNEI--QSVyKVPGRDDTLfYATFT--TSENGFTGSAVCVFTLSDINAafd 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  322 ----KMEANRNACYTGTREARdifyKPFHGDIQCgghaPGSSKSFPCGSEHL--PYPLGSRDGLRGTAVLQRGGLNLTAV 395
Cdd:cd11238    304 tgkfKEQASSSSAWLPVLSSE----VPEPRPGTC----VNDSATLSDTVLHFarTHPLMDDAVSHGPPLLYLRDVVFTHL 375
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 1777375936  396 TV---AAENNH-TVAFLGTSDGRILKVYLTPDGTSSEydSILVEI 436
Cdd:cd11238    376 VVdklRIDDQEyVVFYAGSNDGKVYKIVHWKDAGESK--SNLLDV 418
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
895-952 2.91e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 44.61  E-value: 2.91e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1777375936  895 PKPLSVEPQQGPQAGGTTLTIHGTHLdtGSQ-EDVR--VTLNGVPCKVTK----FGAQLQCVTGP 952
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNL--GLRkNDVRhgVRVGGVPCNPEPpeysSSEKIVCTTGP 63
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
983-1093 6.01e-05

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 43.56  E-value: 6.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  983 PVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVViaeplqswqppreaeslqpmTVVG---TDYVFHNDTKVVFLSPA 1059
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRV--------------------KYGGvekTSCKVRNSTLMTCPAPS 60
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1777375936 1060 VPEEPEAYNLT-----VLIEMDGHRALLRTEAGAFEYVP 1093
Cdd:cd01181     61 LALLNRSPEPGerpveFGLDGDNVQSLLILNRTSFSYYP 99
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
983-1091 9.59e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.82  E-value: 9.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  983 PVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEplqswqppreaeslqpmtvVGTDYVFHNDTKVVFLSPAVPE 1062
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGG-------------------TPCTVISVSSTTIVCTTPPGTS 61
                           90       100
                   ....*....|....*....|....*....
gi 1777375936 1063 EPeaynLTVLIEMDGhrALLRTEAGAFEY 1091
Cdd:pfam01833   62 GL----VNVSVTVGG--GGISSSPLTFTY 84
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
895-939 1.22e-04

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 42.79  E-value: 1.22e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1777375936  895 PKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGV---PCKV 939
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVektSCKV 48
Sema_4A cd11256
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed ...
27-465 5.12e-04

The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed in immune cells and is thus termed an "immune semaphorin". It plays critical roles in T cell-DC interactions in the immune response. It has been reported to enhance activation and differentiation of T cells in vitro and generation of antigen-specific T cells in vivo. The function of Sema4A in the immune response implicates its role in infectious and noninfectious diseases. Sema4A exerts its function through three receptors, namely Plexin B, Plexin D1, and Tim-2. Sema4A belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. TThe Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200517 [Multi-domain]  Cd Length: 447  Bit Score: 44.52  E-value: 5.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   27 FFRSE--KELNHLAVDEASGVVYLGAVNALYQLDAK----LQLEQQvATGPALDNKKctppieaSQC---HEAEMTDNVN 97
Cdd:cd11256      1 RFRQEnvHNYDQLLLSPDETTLYVGARDNILALGIRtpgpIRLKHQ-IPWPANDSKI-------SECafkKKSNETECFN 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   98 QLLLLDP-PRKRLVECGSL-FKGICALRALSNISL-----RLFYEDGSGEKSFVASNDEGVATVglvsstgpggDRVLFV 170
Cdd:cd11256     73 FIRVLVPvNGTHLYTCGTYaFSPACTYIELDHFSLpppngTIITMDGKGQSPFDPQHNYTAILV----------DGELYT 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  171 GKGNGPHDNGIIVSTRLLDRTDSR-EAFEAYTDH-ATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQdkHPARnrtlLAR 248
Cdd:cd11256    143 GTMNNFRGNEPIIFRNLGTKVSLKtDGFLRWLNAdAVFVASFNPQGDSKVYFFFEETAREFDFFEKL--TVAR----VAR 216
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  249 MCRED--------PNYYSYLEMDLQCRDPD------IHAAAFgtclaasVAAPGSGR-VLYAVFSRDSRSSGGPGAGLCL 313
Cdd:cd11256    217 VCKNDvggekllqKKWTTFLKAQLTCSQQGhfpfnvIHHVAL-------LNQPDPNNsVFYAVFTSQWQLGGRRSSAVCA 289
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  314 FPLDKVH-----AKMEANRNACYTGTREARDIFYKPFhgdiQCGGhAPGSSKSFPCGSEHLPYPlGSRDGLRGTAVLQRG 388
Cdd:cd11256    290 YKLNDIEkvfngKYKELNKESSRWTRYMGPVSDPRPG----SCSG-GKSSDKALNFMKDHFLMD-EVVLPGAGRPLLVKS 363
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  389 GLNLTAVTV-----AAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFR 463
Cdd:cd11256    364 NVQYTRIAVdsvqgVSGHNYTVMFLGTDKGFLHKAVLMGGSESHIIEEIELLTPPEPVENLLLAANEGVVYIGYSAGVWR 443

                   ..
gi 1777375936  464 LP 465
Cdd:cd11256    444 VP 445
Sema_3 cd11239
The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins ...
371-469 2.82e-03

The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200500 [Multi-domain]  Cd Length: 471  Bit Score: 42.35  E-value: 2.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936  371 YPLGSRDGLRGTAVlqrgGLNLTAVTV----AAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVL 446
Cdd:cd11239    369 YPLHGRPLLIRTNV----PYRLTQIAVdrveAEDGQYDVLFIGTDSGTVLKVVSLPKENWEMEEVILEELQVFKHPSPIT 444
                           90       100
                   ....*....|....*....|....*..
gi 1777375936  447 SGDLGS----LYAMTQDKVFRLPVQEC 469
Cdd:cd11239    445 SMEISSkrqqLYVGSAEGVVQLPLHRC 471
IPT smart00429
ig-like, plexins, transcription factors;
982-1092 3.98e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 38.17  E-value: 3.98e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936   982 NPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVViaeplqswqppREAEslQPMTVVGTdyvfhNDTKVVFLSPAVP 1061
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEV-----------GVGE--APCTFSPS-----SSTAIVCKTPPYH 62
                            90       100       110
                    ....*....|....*....|....*....|..
gi 1777375936  1062 EEPEAYNL-TVLIEMDGhralLRTEAGAFEYV 1092
Cdd:smart00429   63 NIPGSVPVrTVGLRNGG----VPSSPQPFTYV 90
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
1319-1445 6.53e-03

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 40.55  E-value: 6.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777375936 1319 FSNLLNSKSFLINFihTLENQreFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEqyvvAKNPKLMLRRSeTVVE 1398
Cdd:cd04519      6 LSLLLTESPLALLR--ELSQV--LPVKDKEEVATALLRIFESRGLALEFLRYLVRSEVKN----TKNPNTLFRGN-SLAT 76
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1777375936 1399 RMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKKAK 1445
Cdd:cd04519     77 KLLDQYMKLVGQEYLKETLSPLIREILESKESCEIDTKLPVGEDLEE 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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