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Conserved domains on  [gi|1802564000|ref|NP_001365034|]
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WD repeat-containing protein 17 isoform 6 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
333-604 1.87e-49

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 181.26  E-value: 1.87e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  333 AFSLPPGHAVCCFLDGGVGLYDMGAKKWdFLRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNE 412
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  413 GVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfcIIRTID---GK 489
Cdd:COG2319    163 GAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADG--TVRLWDlatGK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  490 VLHKYK-HPAAVFGCDWSQN---------NNTVRIWDYTQDACINILNGHTAPVRGLMWNteiP--YLLISGSWDYTIKV 557
Cdd:COG2319    238 LLRTLTgHSGSVRSVAFSPDgrllasgsaDGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PdgKLLASGSDDGTVRL 314

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1802564000  558 WDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSLT 604
Cdd:COG2319    315 WDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
50-401 2.29e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 2.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   50 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEdVVAFVSHRGPL 127
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTV 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  128 FIW---------TISGPDSGVivhkdaHS--FLSDicmfrwhthqkGK-VVFGHIDGSLSIFHPGNKNQKHVLrpesleg 195
Cdd:COG2319    187 RLWdlatgkllrTLTGHTGAV------RSvaFSPD-----------GKlLASGSADGTVRLWDLATGKLLRTL------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  196 TDEEDPVTALEWDPLSTdYLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSapG-MFITGdSQVGVLRIWN 274
Cdd:COG2319    243 TGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPD--GkLLASG-SDDGTVRLWD 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  275 VSrttpidnlklkkTGfHCLHVLNSPPRKKFSVqsptknhytsstseavppptltqnqAFSlPPG-HAVCCFLDGGVGLY 353
Cdd:COG2319    317 LA------------TG-KLLRTLTGHTGAVRSV-------------------------AFS-PDGkTLASGSDDGTVRLW 357

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1802564000  354 DMGAKKWdfLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINT 401
Cdd:COG2319    358 DLATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
333-604 1.87e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 181.26  E-value: 1.87e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  333 AFSLPPGHAVCCFLDGGVGLYDMGAKKWdFLRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNE 412
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  413 GVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfcIIRTID---GK 489
Cdd:COG2319    163 GAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADG--TVRLWDlatGK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  490 VLHKYK-HPAAVFGCDWSQN---------NNTVRIWDYTQDACINILNGHTAPVRGLMWNteiP--YLLISGSWDYTIKV 557
Cdd:COG2319    238 LLRTLTgHSGSVRSVAFSPDgrllasgsaDGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PdgKLLASGSDDGTVRL 314

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1802564000  558 WDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSLT 604
Cdd:COG2319    315 WDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 339-602 2.27e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.89  E-value: 2.27e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  339 GHA----VCCFLDGG----VGLYDMGAKKWDF------LRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTA 404
Cdd:cd00200      7 GHTggvtCVAFSPDGkllaTGSGDGTIKVWDLetgellRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  405 VYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFciIR 484
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGT--IK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  485 TID---GKVLHKYK-HPAAVFGCDWSQNN---------NTVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISGSW 551
Cdd:cd00200    161 LWDlrtGKCVATLTgHTGEVNSVAFSPDGekllssssdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSE 239

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1802564000  552 DYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 602
Cdd:cd00200    240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
50-401 2.29e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 2.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   50 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEdVVAFVSHRGPL 127
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTV 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  128 FIW---------TISGPDSGVivhkdaHS--FLSDicmfrwhthqkGK-VVFGHIDGSLSIFHPGNKNQKHVLrpesleg 195
Cdd:COG2319    187 RLWdlatgkllrTLTGHTGAV------RSvaFSPD-----------GKlLASGSADGTVRLWDLATGKLLRTL------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  196 TDEEDPVTALEWDPLSTdYLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSapG-MFITGdSQVGVLRIWN 274
Cdd:COG2319    243 TGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPD--GkLLASG-SDDGTVRLWD 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  275 VSrttpidnlklkkTGfHCLHVLNSPPRKKFSVqsptknhytsstseavppptltqnqAFSlPPG-HAVCCFLDGGVGLY 353
Cdd:COG2319    317 LA------------TG-KLLRTLTGHTGAVRSV-------------------------AFS-PDGkTLASGSDDGTVRLW 357

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1802564000  354 DMGAKKWdfLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINT 401
Cdd:COG2319    358 DLATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-274 1.35e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 1.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   14 CQPWNKDVCAASGDRfaycaTLAIYIYQLDHRYNEFKlhaimsEHKKTITAISWCPHNPdLFASGSTDNLVIIWNVAEQK 93
Cdd:cd00200     59 ASADGTYLASGSSDK-----TIRLWDLETGECVRTLT------GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   94 VIAKLDSTKGIPASLSWCWNaEDVVAFVSHRGPLFIWTISgpdSGVIVHK-DAHSflSDICMFRWHtHQKGKVVFGHIDG 172
Cdd:cd00200    127 CLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLR---TGKCVATlTGHT--GEVNSVAFS-PDGEKLLSSSSDG 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  173 SLSIFHPGNKNQKHVLRPEslegtdeEDPVTALEWDPlsTDYLLVVNLHYG-IRLVDSESLSCITTfnLPSAAASVQCLA 251
Cdd:cd00200    200 TIKLWDLSTGKCLGTLRGH-------ENGVNSVAFSP--DGYLLASGSEDGtIRVWDLRTGECVQT--LSGHTNSVTSLA 268

                          250       260
                   ....*....|....*....|...
gi 1802564000  252 WVPSAPgMFITGdSQVGVLRIWN 274
Cdd:cd00200    269 WSPDGK-RLASG-SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 522-559 3.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.75e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1802564000   522 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 559
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
522-559 2.74e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.74e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1802564000  522 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 559
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 526-626 3.71e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 3.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  526 LNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-EGTCVDTVYD-------HGADVYGLTCHPSRPFTMASCSRDST 597
Cdd:PTZ00420    70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDWNPMNYYIMCSSGFDSF 149

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1802564000  598 VRLWSLTALVTPVQINI---LADRSWeEIIGN 626
Cdd:PTZ00420   150 VNIWDIENEKRAFQINMpkkLSSLKW-NIKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-88 3.77e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.77e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1802564000    49 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 88
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
49-88 1.04e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.04e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1802564000   49 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 88
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 35-110 2.46e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   35 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIpASLSW 110
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKKL-SSLKW 175
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
333-604 1.87e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 181.26  E-value: 1.87e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  333 AFSLPPGHAVCCFLDGGVGLYDMGAKKWdFLRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNE 412
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  413 GVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfcIIRTID---GK 489
Cdd:COG2319    163 GAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADG--TVRLWDlatGK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  490 VLHKYK-HPAAVFGCDWSQN---------NNTVRIWDYTQDACINILNGHTAPVRGLMWNteiP--YLLISGSWDYTIKV 557
Cdd:COG2319    238 LLRTLTgHSGSVRSVAFSPDgrllasgsaDGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PdgKLLASGSDDGTVRL 314

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1802564000  558 WDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSLT 604
Cdd:COG2319    315 WDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
347-604 4.29e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.33  E-value: 4.29e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  347 DGGVGLYDMGAKKwdFLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGl 425
Cdd:COG2319    141 DGTVRLWDLATGK--LLRTLtGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG- 216

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  426 NCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDG-FCIIRTIDGKVLHKYK-HPAAVFGC 503
Cdd:COG2319    217 KLLASGSADGTVRLWDLATGKLLRTLTGH-SGSVRSVAFSP-DGRLLASGSADGtVRLWDLATGELLRTLTgHSGGVNSV 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  504 DWSQN---------NNTVRIWDYTQDACINILNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTREGTCVDTVYDH 572
Cdd:COG2319    295 AFSPDgkllasgsdDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGH 371

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1802564000  573 GADVYGLTCHPSRPfTMASCSRDSTVRLWSLT 604
Cdd:COG2319    372 TGAVTSVAFSPDGR-TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 339-602 2.27e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.89  E-value: 2.27e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  339 GHA----VCCFLDGG----VGLYDMGAKKWDF------LRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTA 404
Cdd:cd00200      7 GHTggvtCVAFSPDGkllaTGSGDGTIKVWDLetgellRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  405 VYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFciIR 484
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGT--IK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  485 TID---GKVLHKYK-HPAAVFGCDWSQNN---------NTVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISGSW 551
Cdd:cd00200    161 LWDlrtGKCVATLTgHTGEVNSVAFSPDGekllssssdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSE 239

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1802564000  552 DYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 602
Cdd:cd00200    240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 367-603 5.24e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 150.18  E-value: 5.24e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  367 GHVETIFDCKFKPDdPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGK 446
Cdd:cd00200      7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  447 IIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFCII-RTIDGKVLHKYK-HPAAVFGCDWSQNN---------NTVRIW 515
Cdd:cd00200     85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGtfvasssqdGTIKLW 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  516 DYTQDACINILNGHTAPVRGLMWnTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFtMASCSRD 595
Cdd:cd00200    163 DLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-LASGSED 240


                   ....*...
gi 1802564000  596 STVRLWSL 603
Cdd:cd00200    241 GTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
363-604 2.96e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 2.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  363 LRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNV 442
Cdd:COG2319     30 LLLLGLAAAVASLAASPDG-ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG-RLLASASADGTVRLWDL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  443 QKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGF-CIIRTIDGKVLHKYK-HPAAVFGCDWSQN---------NNT 511
Cdd:COG2319    108 ATGLLLRTLTGH-TGAVRSVAFSP-DGKTLASGSADGTvRLWDLATGKLLRTLTgHSGAVTSVAFSPDgkllasgsdDGT 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  512 VRIWDYTQDACINILNGHTAPVRGLMWNteiP--YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTM 589
Cdd:COG2319    186 VRLWDLATGKLLRTLTGHTGAVRSVAFS---PdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LL 261

                          250
                   ....*....|....*
gi 1802564000  590 ASCSRDSTVRLWSLT 604
Cdd:COG2319    262 ASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 199-559 2.81e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 2.81e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  199 EDPVTALEWDPLStDYLLVvnlhyG-----IRLVDSESLSCITTfnLPSAAASVQCLAWVPSAPGMFITG-DSQVgvlRI 272
Cdd:cd00200      9 TGGVTCVAFSPDG-KLLAT-----GsgdgtIKVWDLETGELLRT--LKGHTGPVRDVAASADGTYLASGSsDKTI---RL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  273 WNVSRTTPIDNLklkkTGfHCLHVlnspprkkFSVQSPTKNHYtsstseavppptltqnqafslppghAVCCFLDGGVGL 352
Cdd:cd00200     78 WDLETGECVRTL----TG-HTSYV--------SSVAFSPDGRI-------------------------LSSSSRDKTIKV 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  353 YDMGAKKwdFLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGG 431
Cdd:cd00200    120 WDVETGK--CLTTLrGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  432 TSRNgAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfciirtidgkvlhkykhpaavfgcdwsqnnnT 511
Cdd:cd00200    197 SDGT-IKLWDLSTGKCLGTLRGH-ENGVNSVAFSP-DGYLLASGSEDG-------------------------------T 242

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1802564000  512 VRIWDYTQDACINILNGHTAPVRGLMWNTEIPYlLISGSWDYTIKVWD 559
Cdd:cd00200    243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 448-606 2.52e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 2.52e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  448 IQRFNEHgTNGIFCIAWsHKDSKRIATCSSDGFCII-RTIDGKVLHKYK-HPAAVFGCDWSQN---------NNTVRIWD 516
Cdd:cd00200      2 RRTLKGH-TGGVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADgtylasgssDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  517 YTQDACINILNGHTAPVRGLMWNTEIPYLLiSGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTmASCSRDS 596
Cdd:cd00200     80 LETGECVRTLTGHTSYVSSVAFSPDGRILS-SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDG 157

                          170
                   ....*....|
gi 1802564000  597 TVRLWSLTAL 606
Cdd:cd00200    158 TIKLWDLRTG 167
WD40 COG2319
WD40 repeat [General function prediction only];
50-561 1.98e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 1.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   50 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDstkgipaslswcwnaedvvafvshrgpl 127
Cdd:COG2319    153 KLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLATGKLLRTLT---------------------------- 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  128 fiwtisgpdsgvivhkdahsflsdicmfrwhthqkgkvvfGHidgslsifhpgnknqkhvlrpeslegtdeEDPVTALEW 207
Cdd:COG2319    202 ----------------------------------------GH-----------------------------TGAVRSVAF 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  208 DPlstdyllvvnlhygirlvDSESLscittfnlpsAAASvqclawvpsapgmfitGDsqvGVLRIWNVSRTTPIDNLKlk 287
Cdd:COG2319    213 SP------------------DGKLL----------ASGS----------------AD---GTVRLWDLATGKLLRTLT-- 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  288 ktgfhclhvlnspprkkfsvqsptknhytsstseavppptltqnqafslppghavccfldggvglydmgakkwdflrdlG 367
Cdd:COG2319    244 -------------------------------------------------------------------------------G 244

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  368 HVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKI 447
Cdd:COG2319    245 HSGSVRSVAFSPDG-RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLWDLATGKL 322

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  448 IQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfciirtidgkvlhkykhpaavfgcdwsqnnnTVRIWDYTQDACINILN 527
Cdd:COG2319    323 LRTLTGH-TGAVRSVAFSP-DGKTLASGSDDG-------------------------------TVRLWDLATGELLRTLT 369

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1802564000  528 GHTAPVRGLMWNTEIPYlLISGSWDYTIKVWDTR 561
Cdd:COG2319    370 GHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
50-401 2.29e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 2.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   50 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEdVVAFVSHRGPL 127
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTV 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  128 FIW---------TISGPDSGVivhkdaHS--FLSDicmfrwhthqkGK-VVFGHIDGSLSIFHPGNKNQKHVLrpesleg 195
Cdd:COG2319    187 RLWdlatgkllrTLTGHTGAV------RSvaFSPD-----------GKlLASGSADGTVRLWDLATGKLLRTL------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  196 TDEEDPVTALEWDPLSTdYLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSapG-MFITGdSQVGVLRIWN 274
Cdd:COG2319    243 TGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPD--GkLLASG-SDDGTVRLWD 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  275 VSrttpidnlklkkTGfHCLHVLNSPPRKKFSVqsptknhytsstseavppptltqnqAFSlPPG-HAVCCFLDGGVGLY 353
Cdd:COG2319    317 LA------------TG-KLLRTLTGHTGAVRSV-------------------------AFS-PDGkTLASGSDDGTVRLW 357

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1802564000  354 DMGAKKWdfLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINT 401
Cdd:COG2319    358 DLATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 522-603 3.57e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 3.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  522 CINILNGHTAPVRGLMWNTEIPYLLiSGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLW 601
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLW 78


                   ..
gi 1802564000  602 SL 603
Cdd:cd00200     79 DL 80
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-274 1.35e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 1.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   14 CQPWNKDVCAASGDRfaycaTLAIYIYQLDHRYNEFKlhaimsEHKKTITAISWCPHNPdLFASGSTDNLVIIWNVAEQK 93
Cdd:cd00200     59 ASADGTYLASGSSDK-----TIRLWDLETGECVRTLT------GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   94 VIAKLDSTKGIPASLSWCWNaEDVVAFVSHRGPLFIWTISgpdSGVIVHK-DAHSflSDICMFRWHtHQKGKVVFGHIDG 172
Cdd:cd00200    127 CLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLR---TGKCVATlTGHT--GEVNSVAFS-PDGEKLLSSSSDG 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  173 SLSIFHPGNKNQKHVLRPEslegtdeEDPVTALEWDPlsTDYLLVVNLHYG-IRLVDSESLSCITTfnLPSAAASVQCLA 251
Cdd:cd00200    200 TIKLWDLSTGKCLGTLRGH-------ENGVNSVAFSP--DGYLLASGSEDGtIRVWDLRTGECVQT--LSGHTNSVTSLA 268

                          250       260
                   ....*....|....*....|...
gi 1802564000  252 WVPSAPgMFITGdSQVGVLRIWN 274
Cdd:cd00200    269 WSPDGK-RLASG-SADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-302 5.94e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 5.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   51 LHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWC-----------------WN 113
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadgtylasgssdktirlWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  114 AED---VVAFVSHRGPLFIWTISgPDSGVIVhkdAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSI-FHPGNK------N 183
Cdd:cd00200     80 LETgecVRTLTGHTSYVSSVAFS-PDGRILS---SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVaFSPDGTfvasssQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  184 QKHV----LRPESLEGT--DEEDPVTALEWDPLSTDyLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSap 257
Cdd:cd00200    156 DGTIklwdLRTGKCVATltGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPD-- 230

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1802564000  258 GMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSPPR 302
Cdd:cd00200    231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 522-559 3.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.75e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1802564000   522 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 559
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
522-559 2.74e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.74e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1802564000  522 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 559
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 526-626 3.71e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 3.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  526 LNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-EGTCVDTVYD-------HGADVYGLTCHPSRPFTMASCSRDST 597
Cdd:PTZ00420    70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDWNPMNYYIMCSSGFDSF 149

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1802564000  598 VRLWSLTALVTPVQINI---LADRSWeEIIGN 626
Cdd:PTZ00420   150 VNIWDIENEKRAFQINMpkkLSSLKW-NIKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-88 3.77e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.77e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1802564000    49 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 88
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 366-487 3.96e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 3.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINT--LTAVYTSP-----GNEGVIYSLSWAPGGLNCIAGGTSRNGAF 438
Cdd:PTZ00421    72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEegLTQNISDPivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVN 151

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1802564000  439 IWNVQKGKIIQRFNEHgTNGIFCIAWShKDSKRIATCSSDGfcIIRTID 487
Cdd:PTZ00421   152 VWDVERGKAVEVIKCH-SDQITSLEWN-LDGSLLCTTSKDK--KLNIID 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 367-398 6.66e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 6.66e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1802564000   367 GHVETIFDCKFKPDDpNLLATASFDGTIKVWD 398
Cdd:smart00320   10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
367-398 1.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.37e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1802564000  367 GHVETIFDCKFKPDDpNLLATASFDGTIKVWD 398
Cdd:pfam00400    9 GHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 535-608 1.85e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 1.85e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1802564000  535 GLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVT 608
Cdd:PLN00181   537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVS 610
WD40 pfam00400
WD domain, G-beta repeat;
563-602 1.93e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1802564000  563 GTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 602
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 563-602 2.02e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.02e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1802564000   563 GTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 602
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
49-88 1.04e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.04e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1802564000   49 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 88
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 444-483 1.35e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.35e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1802564000   444 KGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFCII 483
Cdd:smart00320    1 SGELLKTLKGH-TGPVTSVAFSP-DGKYLASGSDDGTIKL 38
WD40 COG2319
WD40 repeat [General function prediction only];
511-620 1.99e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000  511 TVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMA 590
Cdd:COG2319     17 ALALLAAALGALLLLLLGLAAAVASLAASPD-GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-LLA 94

                           90       100       110
                   ....*....|....*....|....*....|
gi 1802564000  591 SCSRDSTVRLWSLTALVTPVQINILADRSW 620
Cdd:COG2319     95 SASADGTVRLWDLATGLLLRTLTGHTGAVR 124
PTZ00420 PTZ00420
coronin; Provisional
 35-110 2.46e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   35 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIpASLSW 110
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKKL-SSLKW 175
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-150 4.15e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 4.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802564000   13 GCQPWNKDVCAASGDRFAYCATL--AIYIYQLdhryNEFKLHAIMSEHKKTITAISWCPhNPDLFASGSTDNLVIIWNVA 90
Cdd:cd00200    133 GHTDWVNSVAFSPDGTFVASSSQdgTIKLWDL----RTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLS 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1802564000   91 EQKVIAKLDSTKGIPASLSWCWNaEDVVAFVSHRGPLFIW---------TISGPDSGVI---VHKDAHSFLS 150
Cdd:cd00200    208 TGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWdlrtgecvqTLSGHTNSVTslaWSPDGKRLAS 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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