|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
28-717 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 781.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 28 QPQWSPPA--GTQPCRLHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYFKFDVFYC 105
Cdd:PTZ00399 24 LPEWKKPSkeGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYFGYDVFYV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 106 MNITDIDDKIIKRARQNHLfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqs 185
Cdd:PTZ00399 104 MNITDIDDKIIKRAREEKL------------------------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 186 rltgeevnscvevlleeakdllsdwldstlgcdvtdnSIFSKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFV 265
Cdd:PTZ00399 123 -------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFI 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 266 QKIVDNGYGYVSNGSVYFDTAKFASSeKHSYGKLVPEAVGDQKALQEGEGDLSISAdrlSEKRSPNDFALWKASKPGEPS 345
Cdd:PTZ00399 166 QKIIDNGFAYESNGSVYFDVEAFRKA-GHVYPKLEPESVADEDRIAEGEGALGKVS---GEKRSPNDFALWKASKPGEPS 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 346 WPCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMSKSLK 425
Cdd:PTZ00399 242 WDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHLHIKGLKMSKSLK 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 426 NFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPVdiTGQFEKWGEEEAELNK 505
Cdd:PTZ00399 322 NFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESE--LTSPQKWTQHDFELNE 399
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 506 NFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAArkavRKRPNQALLENIALYLTHMLKIFGAVEEDSSLGFPVG 585
Cdd:PTZ00399 400 LFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNS----GEQPSAPLLRSVAQYVTKILSIFGLVEGSDGLGSQGQ 475
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 586 GpgtslSLEATVMPYLQVLSEFREGVRKIAR--------EQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDR 657
Cdd:PTZ00399 476 N-----STSENFKPLLEALLRFRDEVRDAAKaemklislDKKKKQLLQLCDKLRDEWLPNLGIRIEDKPDGPSVWKLDDK 550
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 658 NTLLKEREEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDEN 717
Cdd:PTZ00399 551 EELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEDKYSAFDET 610
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
42-645 |
3.88e-161 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 473.82 E-value: 3.88e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 42 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 121
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 122 NhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNscvevlle 201
Cdd:COG0215 81 E------------------------------------------------------------------GESIW-------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 202 eakdllsdwldstlgcDVTDnsifsklpkFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 281
Cdd:COG0215 87 ----------------ELAE---------RYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEADGDV 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 282 YFDTAKFassekHSYGKL---VPEAvgdqkaLQEGEgdlsiSADRLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWH 358
Cdd:COG0215 142 YFDVRSF-----PDYGKLsgrNLDD------LRAGA-----RVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWH 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 359 IECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHS 438
Cdd:COG0215 206 IECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLLKKYD 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 439 ARQLRLAFLMHSWKDTLDYSSNTMESALQ-YEKfLNEFFLNVKDILRAPVDITGQFEKWgeeeaelnknfydkKTAIHKA 517
Cdd:COG0215 285 PEVLRFFLLSAHYRSPLDFSEEALEEAEKaLER-LYNALRRLEEALGAADSSAEEIEEL--------------REEFIAA 349
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 518 LCDNVDTRTVMEEMRALVSQCNlymaarKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSSLgfpVGGPGTSLSLEATV 597
Cdd:COG0215 350 MDDDFNTPEALAVLFELVREIN------KALDEGEDKAALAALAALLRALGGVLGLLLLEPEA---WQGAAEDELLDALI 420
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 1802776437 598 MPYLQvlsefregVRKIAREQKvpeILQLSDALRDNILpELGVRFEDH 645
Cdd:COG0215 421 EALIE--------ERAEARKAK---DFARADRIRDELA-ALGIVLEDT 456
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
42-644 |
2.23e-140 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 420.64 E-value: 2.23e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 42 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 121
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 122 NhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNSCVEVLLE 201
Cdd:TIGR00435 80 N------------------------------------------------------------------GESVYEVSERFIE 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 202 EakdllsdwldstlgcdvtdnsifsklpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVS-NGS 280
Cdd:TIGR00435 94 A---------------------------------YFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSdNGD 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 281 VYFDTAKFassekHSYGKLvpeAVGDQKALQEGEGDLSISAdrlseKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIE 360
Cdd:TIGR00435 141 VYFDVSKF-----KDYGKL---SKQDLDQLEAGARVDVDEA-----KRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIE 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 361 CSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSAR 440
Cdd:TIGR00435 208 CSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF-GKQLAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVLKNYDPE 286
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 441 QLRLAFLMHSWKDTLDYSsntmESALQYEKFLNEFFLNVKDILRApvDITGQFEkWGEEEAELNKNFYDkktAIHKALCD 520
Cdd:TIGR00435 287 ILRYFLLSVHYRSPLDFS----EELLEAAKNALERLYKALRVLDT--SLAYSGN-QSLNKFPDEKEFEA---RFVEAMDD 356
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 521 NVDTR---TVMEEMralVSQCNLYMAarkavrkrpNQALLENIALYLTHMLKIFGAVEEDSSLGFPVGGPGTSLSLEATV 597
Cdd:TIGR00435 357 DLNTAnalAVLFEL---AKSINLTFV---------SKADAALLIEHLIFLESRLGLLLGLPSKPVQAGSNDDLGEIEALI 424
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 1802776437 598 MPylqvlsefregvRKIAREQKVpeiLQLSDALRDNiLPELGVRFED 644
Cdd:TIGR00435 425 EE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLED 455
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
55-470 |
2.39e-139 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 411.76 E-value: 2.39e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 55 FIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQNHLFEQyrekrpe 134
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQEGESFR------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 135 aaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevlleeakdllsdwldst 214
Cdd:pfam01406 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 215 lgcdvtdnsifsKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVS-NGSVYFDTAKFassek 293
Cdd:pfam01406 74 ------------QLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSdNGDVYFDVSSF----- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 294 HSYGKLVPEAVGDQKALQEGEGDlsisadrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLGASM 373
Cdd:pfam01406 137 PDYGKLSGQNLEQLEAGARGEVS--------EGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQI 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 374 DIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKD 453
Cdd:pfam01406 209 DIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRS 287
|
410
....*....|....*..
gi 1802776437 454 TLDYSsntmESALQYEK 470
Cdd:pfam01406 288 PLDFS----EELLEQAK 300
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
43-458 |
7.13e-110 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 332.24 E-value: 7.13e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 43 HLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYFkFDVFYCMNITDIDDKIIKRARQN 122
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDLG-YKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 123 HLFeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevllee 202
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 203 akdllsdwldstlgcdvtdnsiFSKLPKFWEGDFHRDMEALNVLPPDVLTRVseyvpeivnfvqkivdngygyvsngsvy 282
Cdd:cd00672 83 ----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 283 fdtakfassekhsygklvpeavgdqkalqegegdlsisadrlsekrspndfalwkaskpgepswpcpwgkgrpgWHIECS 362
Cdd:cd00672 113 --------------------------------------------------------------------------WHIECS 118
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 363 AMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQL 442
Cdd:cd00672 119 AMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAAT-GKPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVL 197
|
410
....*....|....*.
gi 1802776437 443 RLAFLMHSWKDTLDYS 458
Cdd:cd00672 198 RLALLSSHYRSPLDFS 213
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
28-717 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 781.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 28 QPQWSPPA--GTQPCRLHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYFKFDVFYC 105
Cdd:PTZ00399 24 LPEWKKPSkeGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYFGYDVFYV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 106 MNITDIDDKIIKRARQNHLfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqs 185
Cdd:PTZ00399 104 MNITDIDDKIIKRAREEKL------------------------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 186 rltgeevnscvevlleeakdllsdwldstlgcdvtdnSIFSKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFV 265
Cdd:PTZ00399 123 -------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFI 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 266 QKIVDNGYGYVSNGSVYFDTAKFASSeKHSYGKLVPEAVGDQKALQEGEGDLSISAdrlSEKRSPNDFALWKASKPGEPS 345
Cdd:PTZ00399 166 QKIIDNGFAYESNGSVYFDVEAFRKA-GHVYPKLEPESVADEDRIAEGEGALGKVS---GEKRSPNDFALWKASKPGEPS 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 346 WPCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMSKSLK 425
Cdd:PTZ00399 242 WDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHLHIKGLKMSKSLK 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 426 NFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPVdiTGQFEKWGEEEAELNK 505
Cdd:PTZ00399 322 NFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESE--LTSPQKWTQHDFELNE 399
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 506 NFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAArkavRKRPNQALLENIALYLTHMLKIFGAVEEDSSLGFPVG 585
Cdd:PTZ00399 400 LFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNS----GEQPSAPLLRSVAQYVTKILSIFGLVEGSDGLGSQGQ 475
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 586 GpgtslSLEATVMPYLQVLSEFREGVRKIAR--------EQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDR 657
Cdd:PTZ00399 476 N-----STSENFKPLLEALLRFRDEVRDAAKaemklislDKKKKQLLQLCDKLRDEWLPNLGIRIEDKPDGPSVWKLDDK 550
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 658 NTLLKEREEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDEN 717
Cdd:PTZ00399 551 EELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEDKYSAFDET 610
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
42-645 |
3.88e-161 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 473.82 E-value: 3.88e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 42 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 121
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 122 NhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNscvevlle 201
Cdd:COG0215 81 E------------------------------------------------------------------GESIW-------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 202 eakdllsdwldstlgcDVTDnsifsklpkFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 281
Cdd:COG0215 87 ----------------ELAE---------RYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEADGDV 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 282 YFDTAKFassekHSYGKL---VPEAvgdqkaLQEGEgdlsiSADRLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWH 358
Cdd:COG0215 142 YFDVRSF-----PDYGKLsgrNLDD------LRAGA-----RVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWH 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 359 IECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHS 438
Cdd:COG0215 206 IECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLLKKYD 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 439 ARQLRLAFLMHSWKDTLDYSSNTMESALQ-YEKfLNEFFLNVKDILRAPVDITGQFEKWgeeeaelnknfydkKTAIHKA 517
Cdd:COG0215 285 PEVLRFFLLSAHYRSPLDFSEEALEEAEKaLER-LYNALRRLEEALGAADSSAEEIEEL--------------REEFIAA 349
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 518 LCDNVDTRTVMEEMRALVSQCNlymaarKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSSLgfpVGGPGTSLSLEATV 597
Cdd:COG0215 350 MDDDFNTPEALAVLFELVREIN------KALDEGEDKAALAALAALLRALGGVLGLLLLEPEA---WQGAAEDELLDALI 420
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 1802776437 598 MPYLQvlsefregVRKIAREQKvpeILQLSDALRDNILpELGVRFEDH 645
Cdd:COG0215 421 EALIE--------ERAEARKAK---DFARADRIRDELA-ALGIVLEDT 456
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
42-644 |
2.23e-140 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 420.64 E-value: 2.23e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 42 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 121
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 122 NhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNSCVEVLLE 201
Cdd:TIGR00435 80 N------------------------------------------------------------------GESVYEVSERFIE 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 202 EakdllsdwldstlgcdvtdnsifsklpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVS-NGS 280
Cdd:TIGR00435 94 A---------------------------------YFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSdNGD 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 281 VYFDTAKFassekHSYGKLvpeAVGDQKALQEGEGDLSISAdrlseKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIE 360
Cdd:TIGR00435 141 VYFDVSKF-----KDYGKL---SKQDLDQLEAGARVDVDEA-----KRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIE 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 361 CSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSAR 440
Cdd:TIGR00435 208 CSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF-GKQLAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVLKNYDPE 286
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 441 QLRLAFLMHSWKDTLDYSsntmESALQYEKFLNEFFLNVKDILRApvDITGQFEkWGEEEAELNKNFYDkktAIHKALCD 520
Cdd:TIGR00435 287 ILRYFLLSVHYRSPLDFS----EELLEAAKNALERLYKALRVLDT--SLAYSGN-QSLNKFPDEKEFEA---RFVEAMDD 356
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 521 NVDTR---TVMEEMralVSQCNLYMAarkavrkrpNQALLENIALYLTHMLKIFGAVEEDSSLGFPVGGPGTSLSLEATV 597
Cdd:TIGR00435 357 DLNTAnalAVLFEL---AKSINLTFV---------SKADAALLIEHLIFLESRLGLLLGLPSKPVQAGSNDDLGEIEALI 424
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 1802776437 598 MPylqvlsefregvRKIAREQKVpeiLQLSDALRDNiLPELGVRFED 644
Cdd:TIGR00435 425 EE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLED 455
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
55-470 |
2.39e-139 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 411.76 E-value: 2.39e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 55 FIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQNHLFEQyrekrpe 134
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQEGESFR------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 135 aaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevlleeakdllsdwldst 214
Cdd:pfam01406 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 215 lgcdvtdnsifsKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVS-NGSVYFDTAKFassek 293
Cdd:pfam01406 74 ------------QLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSdNGDVYFDVSSF----- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 294 HSYGKLVPEAVGDQKALQEGEGDlsisadrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLGASM 373
Cdd:pfam01406 137 PDYGKLSGQNLEQLEAGARGEVS--------EGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQI 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 374 DIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKD 453
Cdd:pfam01406 209 DIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRS 287
|
410
....*....|....*..
gi 1802776437 454 TLDYSsntmESALQYEK 470
Cdd:pfam01406 288 PLDFS----EELLEQAK 300
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
43-458 |
7.13e-110 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 332.24 E-value: 7.13e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 43 HLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYFkFDVFYCMNITDIDDKIIKRARQN 122
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDLG-YKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 123 HLFeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevllee 202
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 203 akdllsdwldstlgcdvtdnsiFSKLPKFWEGDFHRDMEALNVLPPDVLTRVseyvpeivnfvqkivdngygyvsngsvy 282
Cdd:cd00672 83 ----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 283 fdtakfassekhsygklvpeavgdqkalqegegdlsisadrlsekrspndfalwkaskpgepswpcpwgkgrpgWHIECS 362
Cdd:cd00672 113 --------------------------------------------------------------------------WHIECS 118
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 363 AMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQL 442
Cdd:cd00672 119 AMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAAT-GKPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVL 197
|
410
....*....|....*.
gi 1802776437 443 RLAFLMHSWKDTLDYS 458
Cdd:cd00672 198 RLALLSSHYRSPLDFS 213
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
42-465 |
1.03e-92 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 299.92 E-value: 1.03e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 42 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 121
Cdd:PLN02946 60 LHLYNTMSRKKELFKPKVEGKVGMYVCGVTAYDLSHIGHARVYVTFDVLYRYLK-HLGYEVRYVRNFTDVDDKIIARANE 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 122 nhlfeqyrekrpeaaqLLEDvqaalkPFSvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevlle 201
Cdd:PLN02946 139 ----------------LGED------PIS--------------------------------------------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 202 eakdllsdwldstlgcdvtdnsifskLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 281
Cdd:PLN02946 146 --------------------------LSRRYCEEFLSDMAYLHCLPPSVEPRVSDHIPQIIDMIKQILDNGCAYRVDGDV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 282 YFDTAKFASsekhsYGKLVPEAVGDQKAlqeGEgdlSISADrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIEC 361
Cdd:PLN02946 200 YFSVDKFPE-----YGKLSGRKLEDNRA---GE---RVAVD--SRKKNPADFALWKAAKEGEPFWDSPWGPGRPGWHIEC 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 362 SAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFEnDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQ 441
Cdd:PLN02946 267 SAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQSCAACC-DSNISYWIHNGFVTVDSEKMSKSLGNFFTIRQVIDLYHPLA 345
|
410 420
....*....|....*....|....
gi 1802776437 442 LRLAFLMHSWKDTLDYSSNTMESA 465
Cdd:PLN02946 346 LRLFLLGTHYRSPINYSDVQLESA 369
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
44-465 |
4.23e-66 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 232.30 E-value: 4.23e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 44 LYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDyFKFDVFYCMNITDIDDKIIKRARQNh 123
Cdd:PRK14535 230 IYNTLTRQKEPFAPIDPENVRMYVCGMTVYDYCHLGHARVMVVFDMIARWLRE-CGYPLTYVRNITDIDDKIIARAAEN- 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 124 lfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNSCVEVLLEEa 203
Cdd:PRK14535 308 -----------------------------------------------------------------GETIGELTARFIQA- 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 204 kdllsdwldstlgcdvtdnsifsklpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGY-VSNGSVY 282
Cdd:PRK14535 322 --------------------------------MHEDADALGVLRPDIEPKATENIPQMIAMIETLIQNGKAYpAANGDVY 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 283 FDTAKFASsekhsYGKLVPEAVGDQKALQEGEGDlsisadrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECS 362
Cdd:PRK14535 370 YAVREFAA-----YGQLSGKSLDDLRAGERVEVD--------GFKRDPLDFVLWKAAKAGEPAWESPWGNGRPGWHIECS 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 363 AMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDC---------------WVRYFLHTGHLTIAGCKMSKSLKNF 427
Cdd:PRK14535 437 AMSENLFGDTFDIHGGGADLQFPHHENEIAQSVGATGHTCghhhaqthhgqsiasHVKYWLHNGFIRVDGEKMSKSLGNF 516
|
410 420 430
....*....|....*....|....*....|....*...
gi 1802776437 428 ITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESA 465
Cdd:PRK14535 517 FTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHLDDA 554
|
|
| PRK12418 |
PRK12418 |
cysteinyl-tRNA synthetase; Provisional |
60-467 |
3.52e-61 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 183518 [Multi-domain] Cd Length: 384 Bit Score: 210.56 E-value: 3.52e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 60 GKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYfKFDVFYCMNITDIDDKIIKRARQnhlfeqyrekrpeaaqll 139
Cdd:PRK12418 7 GGTATMYVCGITPYDATHLGHAATYLAFDLVNRVWRDA-GHDVHYVQNVTDVDDPLLERAAR------------------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 140 edvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrlTGEevnscvevlleeakdllsDWLDstLGCDV 219
Cdd:PRK12418 68 ------------------------------------------------DGV------------------DWRD--LAERE 79
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 220 TDnsifskLpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYV----SNGSVYFDTAkfassekhs 295
Cdd:PRK12418 80 IA------L-------FREDMEALRVLPPRDYVGAVESIPEVVELVEKLLASGAAYVvddeEYPDVYFSVD--------- 137
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 296 ygklVPEAVGDQKALQEGEGdLSISADRLSE-----KRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLG 370
Cdd:PRK12418 138 ----ATPQFGYESGYDRATM-LELFAERGGDpdrpgKRDPLDALLWRAARPGEPSWPSPFGPGRPGWHIECSAIALNRLG 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 371 ASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKdALKK--HSARQLRLAFLM 448
Cdd:PRK12418 213 SGFDIQGGGSDLIFPHHEFSAAHAEAATGERRFARHYVHAGMIGLDGEKMSKSRGNLVFVS-RLRAagVDPAAIRLALLA 291
|
410
....*....|....*....
gi 1802776437 449 HSWKDTLDYSSNTMESALQ 467
Cdd:PRK12418 292 GHYRADREWTDAVLAEAEA 310
|
|
| mycothiol_MshC |
TIGR03447 |
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this ... |
31-467 |
4.32e-61 |
|
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]
Pssm-ID: 132488 [Multi-domain] Cd Length: 411 Bit Score: 211.12 E-value: 4.32e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 31 WSPPA-----GTQPcRLHLYNSLTRNKEVFIPqdGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYfKFDVFYC 105
Cdd:TIGR03447 3 WPAPAvpalpGTGP-PLRLFDTADGQVRPVEP--GPEAGMYVCGITPYDATHLGHAATYLTFDLVNRVWRDA-GHRVHYV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 106 MNITDIDDKIIKRArqnhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmlERiqhavqlateplekavqs 185
Cdd:TIGR03447 79 QNVTDVDDPLFERA----------------------------------------------ER------------------ 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 186 rlTGEevnscvevlleeakdllsDWLDstLGCDVTDNsifsklpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFV 265
Cdd:TIGR03447 95 --DGV------------------DWRE--LGTSQIDL-------------FREDMEALRVLPPRDYIGAVESIDEVVEMV 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 266 QKIVDNGYGYV----SNGSVYFDTAkfaSSEKHSYGKLVPEAVGDQKALQEGeGDlsisADRLSeKRSPNDFALWKASKP 341
Cdd:TIGR03447 140 EKLLASGAAYIvegpEYPDVYFSID---ATEQFGYESGYDRATMLELFAERG-GD----PDRPG-KRDPLDALLWRAARE 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 342 GEPSWPCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMS 421
Cdd:TIGR03447 211 GEPSWDSPFGRGRPGWHIECSAIALNRLGAGFDIQGGGSDLIFPHHEFSAAHAEAATGVRRMARHYVHAGMIGLDGEKMS 290
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1802776437 422 KSLKNFITIKDaLKK--HSARQLRLAFLMHSWKDTLDYSSNTMESALQ 467
Cdd:TIGR03447 291 KSLGNLVFVSK-LRAagVDPAAIRLGLLAGHYRQDRDWTDAVLAEAEA 337
|
|
| cysS |
PRK14536 |
cysteinyl-tRNA synthetase; Provisional |
42-579 |
9.51e-61 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 184731 [Multi-domain] Cd Length: 490 Bit Score: 212.47 E-value: 9.51e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 42 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIddkiikrarq 121
Cdd:PRK14536 3 LRLYNTLGRQQEEFQPIEHGHVRLYGCGPTVYNYAHIGNLRTYVFQDTLRRTLH-FLGYRVTHVMNITDV---------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 122 NHLfeqyrekrpeaaqlledvqaalkpfsvklneTTDPDKKQmleriqhavqlatEPLEKAVQSRltGEEVnscvevlLE 201
Cdd:PRK14536 72 GHL-------------------------------TDDADSGE-------------DKMVKSAQEH--GKSV-------LE 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 202 EAKdllsdwldstlgcdvtdnsifsklpkFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 281
Cdd:PRK14536 99 IAA--------------------------HYTAAFFRDTARLNIERPSIVCNATEHIQDMIALIKRLEARGHTYCAGGNV 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 282 YFDTAKFASsekhsYGKLVPEAVGDqkaLQEGEgdlSISADrlSEKRSPNDFALWKASKPGEP---SWPCPWGKGRPGWH 358
Cdd:PRK14536 153 YFDIRTFPS-----YGSLASAAVED---LQAGA---RIEHD--TNKRNPHDFVLWFTRSKFENhalTWDSPWGRGYPGWH 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 359 IECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAyFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKK-H 437
Cdd:PRK14536 220 IECSAMSMKYLGEQCDIHIGGVDHIRVHHTNEIAQCEA-ATGKPWVRYWLHHEFLLMNKGKMSKSAGQFLTLSSLQEKgF 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 438 SARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPVDITGQF------EKWGEEEAELNKNFYDKK 511
Cdd:PRK14536 299 QPLDYRFFLLGGHYRSQLAFSWEALKTAKAARRSLVRRVARVVDAARATTGSVRGTlaecaaERVAESRASESELLLTDF 378
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1802776437 512 TAihkALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSS 579
Cdd:PRK14536 379 RA---ALEDDFSTPKALSELQKLVKDTSVPPSLCLSVLQAMDTVLGLGLIQEATASLSAQVPAGPSEE 443
|
|
| cysS |
PRK14534 |
cysteinyl-tRNA synthetase; Provisional |
42-509 |
1.09e-41 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173000 [Multi-domain] Cd Length: 481 Bit Score: 158.86 E-value: 1.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 42 LHLYNslTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIddkiikrarq 121
Cdd:PRK14534 3 LKLYN--TKTKDLSELKNFSDVKVYACGPTVYNYAHIGNFRTYIFEDLLIKSLR-LLKYNVNYAMNITDI---------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 122 NHLfeqyrekrpeaaqlledvqaalkpfsvklneTTDPDKKQmleriqhavqlatEPLEKAVQSR-LTGEEVNscvevll 200
Cdd:PRK14534 70 GHL-------------------------------TGDFDDGE-------------DKVVKAARERgLTVYEIS------- 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 201 eeakdllsdwldstlgcdvtdnsifsklpKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGS 280
Cdd:PRK14534 99 -----------------------------RFFTEAFFDDCKKLNIVYPDKVLVASEYIPIMIEVVKVLEENGFTYFVNGN 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 281 VYFDTAKFassekHSYGKLVPEAVGDQKALQEGEGDLSISadrlseKRSPNDFALWKAS---KPGEPSWPCPWGKGRPGW 357
Cdd:PRK14534 150 VYFDTSCF-----KSYGQMAGINLNDFKDMSVSRVEIDKS------KRNKSDFVLWFTNskfKDQEMKWDSPWGFGYPSW 218
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 358 HIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKH 437
Cdd:PRK14534 219 HLECAAMNLEYFKSTLDIHLGGVDHIGVHHINEIAIAECYL-NKKWCDMFVHGEFLIMEYEKMSKSNNNFITIKDLEDQG 297
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1802776437 438 -SARQLRLAFLMHSWKDTLDYSSNTME-SALQYEKFLNE--FFLNVKDilraPVDITGQFEKWGEEEAELNKNFYD 509
Cdd:PRK14534 298 fSPLDFRYFCLTAHYRTQLKFTFNNLKaCKIARENMLNKltYFYSSLD----QFDLNLLNKDLENIEFSLEKEYYD 369
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
396-531 |
7.07e-08 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 56.03 E-value: 7.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 396 AYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLaFLMHS---WKDtLDYSSNTMESAL-QYEKF 471
Cdd:PRK12300 554 AIFPEEKWPRGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRL-YLTSSaelLQD-ADWREKEVESVRrQLERF 631
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 472 LnEFFLNVKDIlrAPVDITGQFEKWgeEEAELNKNFydKKTaiHKALcDNVDTRTVMEEM 531
Cdd:PRK12300 632 Y-ELAKELIEI--GGEEELRFIDKW--LLSRLNRII--KET--TEAM-ESFQTRDAVQEA 681
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
380-466 |
9.26e-06 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 49.30 E-value: 9.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 380 FDLRFPHHD---NELAQS----EAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRlaFLMHSWK 452
Cdd:PLN02959 672 FDLRVSGKDliqNHLTFAiynhTAIWAEEHWPRGFRCNGHLMLNSEKMSKSTGNFLTLRQAIEEFSADATR--FALADAG 749
|
90
....*....|....*..
gi 1802776437 453 DTLD---YSSNTMESAL 466
Cdd:PLN02959 750 DGVDdanFVFETANAAI 766
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
68-130 |
1.09e-05 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 45.93 E-value: 1.09e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1802776437 68 CGPTVYDASHMGHARSYISFDILRRVLKDyFKFDVFYCMNITDIDDKIIKRARQNHL-FEQYRE 130
Cdd:cd00802 4 SGITPNGYLHIGHLRTIVTFDFLAQAYRK-LGYKVRCIALIDDAGGLIGDPANKKGEnAKAFVE 66
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
404-450 |
2.08e-04 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 44.06 E-value: 2.08e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1802776437 404 VRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHS 450
Cdd:cd00814 265 PTRIVAHGYLTVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRER 311
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
410-450 |
7.02e-04 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 42.66 E-value: 7.02e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1802776437 410 TGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHS 450
Cdd:pfam09334 315 HGYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNR 355
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
356-424 |
1.22e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 39.77 E-value: 1.22e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776437 356 GWHIECSAMAGTLLGASMDIHGGGFDLRFpHHDNELAQSEAYfeNDCWVRYFLHTGHLTIA-GCKMSKSL 424
Cdd:cd00802 77 EYMFLQAADFLLLYETECDIHLGGSDQLG-HIELGLELLKKA--GGPARPFGLTFGRVMGAdGTKMSKSK 143
|
|
| |
