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Conserved domains on  [gi|1811242829|ref|NP_001365461|]
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V-type proton ATPase 116 kDa subunit a 1 isoform 8 [Homo sapiens]

Protein Classification

V-type ATPase subunit a family protein( domain architecture ID 11119844)

V-type ATPase 116kDa subunit a family protein such as vertebrate V-type proton ATPase 116 kDa subunit a and plant/yeast V-type proton ATPase subunit a, an essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes

Gene Ontology:  GO:0042625|GO:0033176|GO:1902600
PubMed:  9210392|10224039
SCOP:  4001703

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-869 0e+00

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


:

Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 1270.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829  27 SELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIM---DTGENPEVPFPRDMIDLEANFEK 103
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLDIIPIkdtLDLETPEAPSPREIDELEEKLEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 104 IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQMADPDLLEESSSLLEPSEMgrgtplRLGFVAGVIN 183
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDRASGEQEEIRAASSDQEEDNALLLDDV------ELGFVAGVIP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 184 RERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTveshsvvqarvqwrdlgspqpplpgfkrfsclslpsswglqGDYV 263
Cdd:pfam01496 155 REKVPAFERILWRATRGNLFLRQAEIEEPLEDPVT-----------------------------------------GEEV 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 264 HKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFI 343
Cdd:pfam01496 194 EKNVFIIFFHGEQLLQKIKKICESFGATLYPCPEDAEERREMLQEVNTRIEDLKTVLDQTEDHRRRELQAIASNLEEWKI 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 344 KVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQ 423
Cdd:pfam01496 274 FVRKEKAIYHTLNLFNYDVTRKCLIAEGWCPTSDLEEIQQALRRATEESGSSVPSILNVIQTNKTPPTYFRTNKFTEGFQ 353
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 424 NIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNeNEMFSTVFSGRYIILLMGV 503
Cdd:pfam01496 354 NIVDAYGIARYREVNPGLFTIITFPFLFAVMFGDIGHGLILFLFALYLILNEKKLKKKKL-NEIFDMFFGGRYIILLMGL 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 504 FSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETlrgNPVLQLnpalpgvFGGPYPFGIDPIWNIATNKLTFLNSF 583
Cdd:pfam01496 433 FSIYTGFIYNDFFSKSLNLFGSGWKWPEMKEGESIAKK---NGYLTL-------FGCPYPFGLDPAWHGAENELLFLNSY 502
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 584 KMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSeNAPSLLIHFINM 663
Cdd:pfam01496 503 KMKLSIILGVIHMTFGICLSLFNHIYFKSKLDIFFEFIPQLLFLQSIFGYLVFLIIYKWCTDWADGS-PAPSLLNMLINM 581
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 664 FLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLvlrrqYLRRKHlgtlnfggirvgngpteedaeiiqhdql 743
Cdd:pfam01496 582 FLSPGTVPPEEPLYPGQATVQVILLLIALICVPWMLLPKPL-----YLKRQH---------------------------- 628
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 744 sthsedaDEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHI-GLSVKSLAGGLVLFFFFT 822
Cdd:pfam01496 629 -------KKFDFGEIFIHQVIHTIEFVLGCISNTASYLRLWALSLAHAQLSEVLWEMTLRNaGLGMGGILGVIMLFIGFA 701
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*..
gi 1811242829 823 AFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSF 869
Cdd:pfam01496 702 VWAVLTVAILLVMEGLSAFLHALRLHWVEFQSKFYKGDGYKFEPFSF 748
 
Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-869 0e+00

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 1270.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829  27 SELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIM---DTGENPEVPFPRDMIDLEANFEK 103
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLDIIPIkdtLDLETPEAPSPREIDELEEKLEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 104 IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQMADPDLLEESSSLLEPSEMgrgtplRLGFVAGVIN 183
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDRASGEQEEIRAASSDQEEDNALLLDDV------ELGFVAGVIP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 184 RERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTveshsvvqarvqwrdlgspqpplpgfkrfsclslpsswglqGDYV 263
Cdd:pfam01496 155 REKVPAFERILWRATRGNLFLRQAEIEEPLEDPVT-----------------------------------------GEEV 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 264 HKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFI 343
Cdd:pfam01496 194 EKNVFIIFFHGEQLLQKIKKICESFGATLYPCPEDAEERREMLQEVNTRIEDLKTVLDQTEDHRRRELQAIASNLEEWKI 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 344 KVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQ 423
Cdd:pfam01496 274 FVRKEKAIYHTLNLFNYDVTRKCLIAEGWCPTSDLEEIQQALRRATEESGSSVPSILNVIQTNKTPPTYFRTNKFTEGFQ 353
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 424 NIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNeNEMFSTVFSGRYIILLMGV 503
Cdd:pfam01496 354 NIVDAYGIARYREVNPGLFTIITFPFLFAVMFGDIGHGLILFLFALYLILNEKKLKKKKL-NEIFDMFFGGRYIILLMGL 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 504 FSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETlrgNPVLQLnpalpgvFGGPYPFGIDPIWNIATNKLTFLNSF 583
Cdd:pfam01496 433 FSIYTGFIYNDFFSKSLNLFGSGWKWPEMKEGESIAKK---NGYLTL-------FGCPYPFGLDPAWHGAENELLFLNSY 502
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 584 KMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSeNAPSLLIHFINM 663
Cdd:pfam01496 503 KMKLSIILGVIHMTFGICLSLFNHIYFKSKLDIFFEFIPQLLFLQSIFGYLVFLIIYKWCTDWADGS-PAPSLLNMLINM 581
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 664 FLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLvlrrqYLRRKHlgtlnfggirvgngpteedaeiiqhdql 743
Cdd:pfam01496 582 FLSPGTVPPEEPLYPGQATVQVILLLIALICVPWMLLPKPL-----YLKRQH---------------------------- 628
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 744 sthsedaDEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHI-GLSVKSLAGGLVLFFFFT 822
Cdd:pfam01496 629 -------KKFDFGEIFIHQVIHTIEFVLGCISNTASYLRLWALSLAHAQLSEVLWEMTLRNaGLGMGGILGVIMLFIGFA 701
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*..
gi 1811242829 823 AFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSF 869
Cdd:pfam01496 702 VWAVLTVAILLVMEGLSAFLHALRLHWVEFQSKFYKGDGYKFEPFSF 748
NtpI COG1269
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
26-870 3.33e-44

Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 440880 [Multi-domain]  Cd Length: 645  Bit Score: 170.08  E-value: 3.33e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829  26 VSELGELGKVQFRDLNP---DVNVFQR-KFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANF 101
Cdd:COG1269    22 LEALQELGVVHIEDLDEeleEEEGLKPgEPDEELEELSELLSRLRSALSILGPYLEEKGGLKPKKEVTLEELEEELEEEL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 102 EKIENELKEINTNQEALKRNFLELTELKFILRKTQQF-FDEAELHHQQmadpdlleesssllepsemgrgtplRLGFVAG 180
Cdd:COG1269   102 EEIEEEVNELEERLEELEEELEELEELIEALEPWGDLdIDLEELRGTK-------------------------YLSVRVG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 181 VINRERIPTFErmlwrvcrgnvflrqaeiENPLEDPVTVESHSVVQARvqwrdlgspqpplpgfkrfsclslpsswglqg 260
Cdd:COG1269   157 TVPKENLEKLK------------------KALEILADYVEVVSSDKED-------------------------------- 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 261 dyvhKSVFIIFFQGDQlKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRV 340
Cdd:COG1269   187 ----EVYVVVIVPKED-EEEVEEVLRSLGFERLEIPELEGTPSEALEELEEEIEELEKEIEELEKELEELAEKYREDLLA 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 341 WFIKVRKMKAIYHTLNlcNIDVTQKCLIAEVWCPVTDLDSIQFALRRgtEHSGSTVPSILNRMqTNQTPPTYNKTNKFTY 420
Cdd:COG1269   262 LYEYLEIEKEKAEAPL--KLATTENLFVLEGWVPEEEVEELEKALEK--ATGGRVYVEEEDPE-EDDEPPTLLKNPKFVK 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 421 GFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLresrilsqKNENEMFSTVFsgrYIILL 500
Cdd:COG1269   337 PFELLVEMYGLPKYGEIDPTPFFALFFPLFFGMMFGDAGYGLLLLLAGLLLLK--------KFLSKGLKKLG---KLLLY 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 501 MGVFSMYTGLIYNdcfskslnifgsswsvrpmftynwteetlrgnpvlqlnpalpGVFGGPYPFGIDPIWNIATnkLTFL 580
Cdd:COG1269   406 LGISTIIFGLLYG------------------------------------------SFFGFELLAGLLPALWLDP--LEDP 441
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 581 NSFkMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTaydahtsenaPSLLIHF 660
Cdd:COG1269   442 NTM-LVLSLAIGVIHLLLGLILGIYNLLKRGDYKDALLDQGGWLLLLLGLLLLVLGLVLGGPL----------PLTTIGL 510
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 661 InmflfsypesgysmlysgqkgiqCFLVVVALLCVPWMLLFKPlvlrrqylrrkhlgtlnfGGIRVGNGPTEedaeiiqh 740
Cdd:COG1269   511 V-----------------------LLIIGLVLLLLFGGRSGKN------------------IGGRLGEGLFG-------- 541
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 741 dqlsthsedadefdfgdtmvhqaihTIEYcLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLS-VKSLAGGLVlff 819
Cdd:COG1269   542 -------------------------LYEI-TGYLSDVLSYIRLFALGLASAGLAMVVNTLAGMVGGGpIVGIIGGIL--- 592
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1811242829 820 fftafatltVAIL-----LIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSFE 870
Cdd:COG1269   593 ---------ILILghllnIALEGLGAFVHSLRLQYVEFFGKFYEGGGKPFKPFKLK 639
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
260-867 1.35e-34

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 140.83  E-value: 1.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 260 GDYVHKSVFIIFFQGDQLKNRVKKICE-GFRASLYPCPETPQERkemASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNI 338
Cdd:PRK05771  173 STDKGYVYVVVVVLKELSDEVEEELKKlGFERLELEEEGTPSEL---IREIKEELEEIEKERESLLEELKELAKKYLEEL 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 339 RVWF----IKVRKMKAiyhtlnLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEhsGSTVPSILNRMQTNQTPPTYNK 414
Cdd:PRK05771  250 LALYeyleIELERAEA------LSKFLKTDKTFAIEGWVPEDRVKKLKELIDKATG--GSAYVEFVEPDEEEEEVPTKLK 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 415 TNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLResriLSQKNENemfSTVFSg 494
Cdd:PRK05771  322 NPKFIKPFESLTEMYSLPKYNEIDPTPFLAIFFPLFFGMMLGDAGYGLLLLLIGLLLSFK----LKKKSEG---LKRLL- 393
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 495 rYIILLMGVFSMYTGLIYNDCfskslniFGSSWSVRPMFtynwteetlrgnPVLQLNPALPGVFGGPYPFGIdpiwniat 574
Cdd:PRK05771  394 -KILIYLGISTIIWGLLTGSF-------FGFSLPIFLPG------------GYLELPEGYPSLSTENDVMTI-------- 445
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 575 nkltflnsfkMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIfykwtaydahtsenaP 654
Cdd:PRK05771  446 ----------LIISLLIGVIHLFLGLLLGFINNVRKGDYKDAFLAQLGWLLILLGILLIVLGGF---------------G 500
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 655 SLLIHFINMFLfsypesGYSMLYSGqkgiqcfLVVVALLCVPwmllfkplvlrrqylrrkhlgtlnFGGIRVGNGPTEED 734
Cdd:PRK05771  501 LVVGLGPLGLI------GKYLIIGG-------VVLIILGEGI------------------------DGKSLGGALGGLGL 543
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 735 AEIIqhdqlsthsedadefdfgdtmvhqaihtieyclGCISNTASYLRLWALSLAHA-------QLSEVLWTMVIHIGLS 807
Cdd:PRK05771  544 YEIT---------------------------------GYLGDVLSYARLMALGLAGAgiamafnLMAGLLPPSIGVIGII 590
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1811242829 808 VkslagGLVlfffftafatltvaILLI-------MEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPF 867
Cdd:PRK05771  591 V-----GII--------------IFIFghllniaLSILGAFVHGLRLHYVEFFGKFYEGGGKKFNPF 638
 
Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-869 0e+00

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 1270.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829  27 SELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIM---DTGENPEVPFPRDMIDLEANFEK 103
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLDIIPIkdtLDLETPEAPSPREIDELEEKLEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 104 IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQMADPDLLEESSSLLEPSEMgrgtplRLGFVAGVIN 183
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDRASGEQEEIRAASSDQEEDNALLLDDV------ELGFVAGVIP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 184 RERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTveshsvvqarvqwrdlgspqpplpgfkrfsclslpsswglqGDYV 263
Cdd:pfam01496 155 REKVPAFERILWRATRGNLFLRQAEIEEPLEDPVT-----------------------------------------GEEV 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 264 HKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFI 343
Cdd:pfam01496 194 EKNVFIIFFHGEQLLQKIKKICESFGATLYPCPEDAEERREMLQEVNTRIEDLKTVLDQTEDHRRRELQAIASNLEEWKI 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 344 KVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQ 423
Cdd:pfam01496 274 FVRKEKAIYHTLNLFNYDVTRKCLIAEGWCPTSDLEEIQQALRRATEESGSSVPSILNVIQTNKTPPTYFRTNKFTEGFQ 353
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 424 NIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNeNEMFSTVFSGRYIILLMGV 503
Cdd:pfam01496 354 NIVDAYGIARYREVNPGLFTIITFPFLFAVMFGDIGHGLILFLFALYLILNEKKLKKKKL-NEIFDMFFGGRYIILLMGL 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 504 FSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETlrgNPVLQLnpalpgvFGGPYPFGIDPIWNIATNKLTFLNSF 583
Cdd:pfam01496 433 FSIYTGFIYNDFFSKSLNLFGSGWKWPEMKEGESIAKK---NGYLTL-------FGCPYPFGLDPAWHGAENELLFLNSY 502
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 584 KMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSeNAPSLLIHFINM 663
Cdd:pfam01496 503 KMKLSIILGVIHMTFGICLSLFNHIYFKSKLDIFFEFIPQLLFLQSIFGYLVFLIIYKWCTDWADGS-PAPSLLNMLINM 581
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 664 FLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLvlrrqYLRRKHlgtlnfggirvgngpteedaeiiqhdql 743
Cdd:pfam01496 582 FLSPGTVPPEEPLYPGQATVQVILLLIALICVPWMLLPKPL-----YLKRQH---------------------------- 628
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 744 sthsedaDEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHI-GLSVKSLAGGLVLFFFFT 822
Cdd:pfam01496 629 -------KKFDFGEIFIHQVIHTIEFVLGCISNTASYLRLWALSLAHAQLSEVLWEMTLRNaGLGMGGILGVIMLFIGFA 701
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*..
gi 1811242829 823 AFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSF 869
Cdd:pfam01496 702 VWAVLTVAILLVMEGLSAFLHALRLHWVEFQSKFYKGDGYKFEPFSF 748
NtpI COG1269
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
26-870 3.33e-44

Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 440880 [Multi-domain]  Cd Length: 645  Bit Score: 170.08  E-value: 3.33e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829  26 VSELGELGKVQFRDLNP---DVNVFQR-KFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANF 101
Cdd:COG1269    22 LEALQELGVVHIEDLDEeleEEEGLKPgEPDEELEELSELLSRLRSALSILGPYLEEKGGLKPKKEVTLEELEEELEEEL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 102 EKIENELKEINTNQEALKRNFLELTELKFILRKTQQF-FDEAELHHQQmadpdlleesssllepsemgrgtplRLGFVAG 180
Cdd:COG1269   102 EEIEEEVNELEERLEELEEELEELEELIEALEPWGDLdIDLEELRGTK-------------------------YLSVRVG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 181 VINRERIPTFErmlwrvcrgnvflrqaeiENPLEDPVTVESHSVVQARvqwrdlgspqpplpgfkrfsclslpsswglqg 260
Cdd:COG1269   157 TVPKENLEKLK------------------KALEILADYVEVVSSDKED-------------------------------- 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 261 dyvhKSVFIIFFQGDQlKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRV 340
Cdd:COG1269   187 ----EVYVVVIVPKED-EEEVEEVLRSLGFERLEIPELEGTPSEALEELEEEIEELEKEIEELEKELEELAEKYREDLLA 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 341 WFIKVRKMKAIYHTLNlcNIDVTQKCLIAEVWCPVTDLDSIQFALRRgtEHSGSTVPSILNRMqTNQTPPTYNKTNKFTY 420
Cdd:COG1269   262 LYEYLEIEKEKAEAPL--KLATTENLFVLEGWVPEEEVEELEKALEK--ATGGRVYVEEEDPE-EDDEPPTLLKNPKFVK 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 421 GFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLresrilsqKNENEMFSTVFsgrYIILL 500
Cdd:COG1269   337 PFELLVEMYGLPKYGEIDPTPFFALFFPLFFGMMFGDAGYGLLLLLAGLLLLK--------KFLSKGLKKLG---KLLLY 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 501 MGVFSMYTGLIYNdcfskslnifgsswsvrpmftynwteetlrgnpvlqlnpalpGVFGGPYPFGIDPIWNIATnkLTFL 580
Cdd:COG1269   406 LGISTIIFGLLYG------------------------------------------SFFGFELLAGLLPALWLDP--LEDP 441
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 581 NSFkMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTaydahtsenaPSLLIHF 660
Cdd:COG1269   442 NTM-LVLSLAIGVIHLLLGLILGIYNLLKRGDYKDALLDQGGWLLLLLGLLLLVLGLVLGGPL----------PLTTIGL 510
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 661 InmflfsypesgysmlysgqkgiqCFLVVVALLCVPWMLLFKPlvlrrqylrrkhlgtlnfGGIRVGNGPTEedaeiiqh 740
Cdd:COG1269   511 V-----------------------LLIIGLVLLLLFGGRSGKN------------------IGGRLGEGLFG-------- 541
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 741 dqlsthsedadefdfgdtmvhqaihTIEYcLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLS-VKSLAGGLVlff 819
Cdd:COG1269   542 -------------------------LYEI-TGYLSDVLSYIRLFALGLASAGLAMVVNTLAGMVGGGpIVGIIGGIL--- 592
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1811242829 820 fftafatltVAIL-----LIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSFE 870
Cdd:COG1269   593 ---------ILILghllnIALEGLGAFVHSLRLQYVEFFGKFYEGGGKPFKPFKLK 639
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
260-867 1.35e-34

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 140.83  E-value: 1.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 260 GDYVHKSVFIIFFQGDQLKNRVKKICE-GFRASLYPCPETPQERkemASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNI 338
Cdd:PRK05771  173 STDKGYVYVVVVVLKELSDEVEEELKKlGFERLELEEEGTPSEL---IREIKEELEEIEKERESLLEELKELAKKYLEEL 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 339 RVWF----IKVRKMKAiyhtlnLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEhsGSTVPSILNRMQTNQTPPTYNK 414
Cdd:PRK05771  250 LALYeyleIELERAEA------LSKFLKTDKTFAIEGWVPEDRVKKLKELIDKATG--GSAYVEFVEPDEEEEEVPTKLK 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 415 TNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLResriLSQKNENemfSTVFSg 494
Cdd:PRK05771  322 NPKFIKPFESLTEMYSLPKYNEIDPTPFLAIFFPLFFGMMLGDAGYGLLLLLIGLLLSFK----LKKKSEG---LKRLL- 393
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 495 rYIILLMGVFSMYTGLIYNDCfskslniFGSSWSVRPMFtynwteetlrgnPVLQLNPALPGVFGGPYPFGIdpiwniat 574
Cdd:PRK05771  394 -KILIYLGISTIIWGLLTGSF-------FGFSLPIFLPG------------GYLELPEGYPSLSTENDVMTI-------- 445
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 575 nkltflnsfkMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIfykwtaydahtsenaP 654
Cdd:PRK05771  446 ----------LIISLLIGVIHLFLGLLLGFINNVRKGDYKDAFLAQLGWLLILLGILLIVLGGF---------------G 500
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 655 SLLIHFINMFLfsypesGYSMLYSGqkgiqcfLVVVALLCVPwmllfkplvlrrqylrrkhlgtlnFGGIRVGNGPTEED 734
Cdd:PRK05771  501 LVVGLGPLGLI------GKYLIIGG-------VVLIILGEGI------------------------DGKSLGGALGGLGL 543
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242829 735 AEIIqhdqlsthsedadefdfgdtmvhqaihtieyclGCISNTASYLRLWALSLAHA-------QLSEVLWTMVIHIGLS 807
Cdd:PRK05771  544 YEIT---------------------------------GYLGDVLSYARLMALGLAGAgiamafnLMAGLLPPSIGVIGII 590
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1811242829 808 VkslagGLVlfffftafatltvaILLI-------MEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPF 867
Cdd:PRK05771  591 V-----GII--------------IFIFghllniaLSILGAFVHGLRLHYVEFFGKFYEGGGKKFNPF 638
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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