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Conserved domains on  [gi|1820250827|ref|NP_001365718|]
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ceramide synthase 3 isoform 2 [Homo sapiens]

Protein Classification

ceramide synthase( domain architecture ID 10053302)

ceramide synthase catalyzes formation of ceramide from sphinganine and acyl-CoA substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TRAM_LAG1_CLN8 pfam03798
TLC domain;
131-324 3.17e-37

TLC domain;


:

Pssm-ID: 461055  Cd Length: 200  Bit Score: 133.56  E-value: 3.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 131 KFQEACWRFAFYLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPL---LPSQYWYYILEMSFY-WSLLFRLGFDVKRKDFL 206
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLgytSWLVKFYYLIQLGYFiWDLLVLLFYEKRRKDFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 207 AHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYC 286
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLFVLFLVSFFVTRLVLGPFWILLS 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1820250827 287 TLILPMYHL--EPFFSYIFLNLQLMILQVLHLYWGYYILK 324
Cdd:pfam03798 161 ILDYAGLDVptGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
82-128 2.72e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 47.24  E-value: 2.72e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1820250827  82 VLENFFKHsTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQERPSR 128
Cdd:cd00086    14 ELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
 
Name Accession Description Interval E-value
TRAM_LAG1_CLN8 pfam03798
TLC domain;
131-324 3.17e-37

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 133.56  E-value: 3.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 131 KFQEACWRFAFYLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPL---LPSQYWYYILEMSFY-WSLLFRLGFDVKRKDFL 206
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLgytSWLVKFYYLIQLGYFiWDLLVLLFYEKRRKDFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 207 AHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYC 286
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLFVLFLVSFFVTRLVLGPFWILLS 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1820250827 287 TLILPMYHL--EPFFSYIFLNLQLMILQVLHLYWGYYILK 324
Cdd:pfam03798 161 ILDYAGLDVptGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
130-330 5.60e-37

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 132.80  E-value: 5.60e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827  130 KKFQEACWRFAFYLMITVAGIAFLYDKPWLYDlweVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRL--GFDVKRKDFLA 207
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSD---PKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALllFQDLKRKDFKE 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827  208 HIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADIWLESAKMFSYAGW--TQTCNTLFFIFSTIFFISRLIVFPFWILY 285
Cdd:smart00724  78 MLVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRkkSLLYDVNFVLFAVVFFVFRLILFPFLILT 157
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1820250827  286 CTLILPMYHL--EPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCI 330
Cdd:smart00724 158 VTVHYAQAESglFPPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLL 204
LAG1 COG5058
Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, ...
113-340 7.69e-17

Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion];


Pssm-ID: 227391 [Multi-domain]  Cd Length: 395  Bit Score: 81.42  E-value: 7.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 113 VERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFLYDKP-WLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYW- 190
Cdd:COG5058   138 VIRPFGLELNVRSEKKIKRFCEQMYAIFYYGVSGPFGLYVMRSSPlWFFNTKALYETYPVFYNPFLFKAFYLIQAAFWAq 217
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 191 -SLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADIWLESAKMFSYAGwTQTCNTLFFIFST 269
Cdd:COG5058   218 qACILVLQLEKPRKDFKELVFHHIVTLLLIWLSYVFHFTRMGLAIYITMDVSDFFLSLSKTLNYLN-SVLATFIFGIFVF 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 270 IFFISRLIVFP--FWILYCT--------LILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMKSIQDVR 339
Cdd:COG5058   297 IWIYSRHYLNLkiLWSVLTAfrtignfvLDVATQQYKCWISLPIVFILLQALQLVNIYWLFLIVRVAYRVIWEGELKDER 376

                  .
gi 1820250827 340 S 340
Cdd:COG5058   377 S 377
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
82-128 2.72e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 47.24  E-value: 2.72e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1820250827  82 VLENFFKHsTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQERPSR 128
Cdd:cd00086    14 ELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
82-125 5.15e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 40.56  E-value: 5.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1820250827  82 VLENFFkHSTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQER 125
Cdd:pfam00046  14 ELEKEF-QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
82-125 1.34e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 39.54  E-value: 1.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1820250827   82 VLENFFkHSTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQER 125
Cdd:smart00389  15 ELEKEF-QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Name Accession Description Interval E-value
TRAM_LAG1_CLN8 pfam03798
TLC domain;
131-324 3.17e-37

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 133.56  E-value: 3.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 131 KFQEACWRFAFYLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPL---LPSQYWYYILEMSFY-WSLLFRLGFDVKRKDFL 206
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLgytSWLVKFYYLIQLGYFiWDLLVLLFYEKRRKDFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 207 AHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYC 286
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLFVLFLVSFFVTRLVLGPFWILLS 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1820250827 287 TLILPMYHL--EPFFSYIFLNLQLMILQVLHLYWGYYILK 324
Cdd:pfam03798 161 ILDYAGLDVptGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
130-330 5.60e-37

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 132.80  E-value: 5.60e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827  130 KKFQEACWRFAFYLMITVAGIAFLYDKPWLYDlweVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRL--GFDVKRKDFLA 207
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSD---PKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALllFQDLKRKDFKE 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827  208 HIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADIWLESAKMFSYAGW--TQTCNTLFFIFSTIFFISRLIVFPFWILY 285
Cdd:smart00724  78 MLVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRkkSLLYDVNFVLFAVVFFVFRLILFPFLILT 157
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1820250827  286 CTLILPMYHL--EPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCI 330
Cdd:smart00724 158 VTVHYAQAESglFPPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLL 204
LAG1 COG5058
Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, ...
113-340 7.69e-17

Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion];


Pssm-ID: 227391 [Multi-domain]  Cd Length: 395  Bit Score: 81.42  E-value: 7.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 113 VERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFLYDKP-WLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYW- 190
Cdd:COG5058   138 VIRPFGLELNVRSEKKIKRFCEQMYAIFYYGVSGPFGLYVMRSSPlWFFNTKALYETYPVFYNPFLFKAFYLIQAAFWAq 217
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 191 -SLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADIWLESAKMFSYAGwTQTCNTLFFIFST 269
Cdd:COG5058   218 qACILVLQLEKPRKDFKELVFHHIVTLLLIWLSYVFHFTRMGLAIYITMDVSDFFLSLSKTLNYLN-SVLATFIFGIFVF 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820250827 270 IFFISRLIVFP--FWILYCT--------LILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMKSIQDVR 339
Cdd:COG5058   297 IWIYSRHYLNLkiLWSVLTAfrtignfvLDVATQQYKCWISLPIVFILLQALQLVNIYWLFLIVRVAYRVIWEGELKDER 376

                  .
gi 1820250827 340 S 340
Cdd:COG5058   377 S 377
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
82-128 2.72e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 47.24  E-value: 2.72e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1820250827  82 VLENFFKHsTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQERPSR 128
Cdd:cd00086    14 ELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
82-125 5.15e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 40.56  E-value: 5.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1820250827  82 VLENFFkHSTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQER 125
Cdd:pfam00046  14 ELEKEF-QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
82-125 1.34e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 39.54  E-value: 1.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1820250827   82 VLENFFkHSTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQER 125
Cdd:smart00389  15 ELEKEF-QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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