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Conserved domains on  [gi|1820433317|ref|NP_001365738|]
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high affinity immunoglobulin gamma Fc receptor I isoform 7 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 19-100 6.65e-43

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


:

Pssm-ID: 409411  Cd Length: 83  Bit Score: 141.67  E-value: 6.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317  19 WLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSG-MGKHRYTSAGIS 97
Cdd:cd05753     1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSYENSNFSIPQATLSDSGSYHCSGtVRIKRRSSESVN 80


                  ...
gi 1820433317  98 VTV 100
Cdd:cd05753    81 ITV 83
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 111-189 7.27e-09

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


:

Pssm-ID: 395002  Cd Length: 86  Bit Score: 51.81  E-value: 7.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317 111 ASVTSPLLEGNLVTLSCETKLllQRPGLQLYFSFYMGSKTL-------RGRNTSSEYQILTARREDSGLYWCEAATEDGN 183
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAST--GSPGPDVTWSKEGGTLIEslkvkhdNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGS 79


                  ....*.
gi 1820433317 184 VLKRSP 189
Cdd:pfam00047  80 ATLSTS 85
 
Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 19-100 6.65e-43

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 141.67  E-value: 6.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317  19 WLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSG-MGKHRYTSAGIS 97
Cdd:cd05753     1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSYENSNFSIPQATLSDSGSYHCSGtVRIKRRSSESVN 80


                  ...
gi 1820433317  98 VTV 100
Cdd:cd05753    81 ITV 83
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 19-100 1.09e-11

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 59.72  E-value: 1.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317  19 WLLLQVSSRVFTEGEPLALRCHAWKDKLVyNVLYYRNGKAFKffhWNSNLTILKTNISHNGTYHCS-GMGKHRYTSAGIS 97
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPP-SYTWYKDGSAIS---SSPNFFTLSVSAEDSGTYTCVaRNGRGGKVSNPVE 76


                  ...
gi 1820433317  98 VTV 100
Cdd:pfam13895  77 LTV 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 111-189 7.27e-09

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 51.81  E-value: 7.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317 111 ASVTSPLLEGNLVTLSCETKLllQRPGLQLYFSFYMGSKTL-------RGRNTSSEYQILTARREDSGLYWCEAATEDGN 183
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAST--GSPGPDVTWSKEGGTLIEslkvkhdNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGS 79


                  ....*.
gi 1820433317 184 VLKRSP 189
Cdd:pfam00047  80 ATLSTS 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-100 5.59e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 5.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317   25 SSRVFTEGEPLALRCHAWkDKLVYNVLYYRNGKAFKFF---------HWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG 95
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAEsgrfsvsrsGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80


                   ....*
gi 1820433317   96 ISVTV 100
Cdd:smart00410  81 TTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 119-184 1.83e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.41  E-value: 1.83e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820433317  119 EGNLVTLSCETK------LLLQRPGLQLyfSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNV 184
Cdd:smart00410   8 EGESVTLSCEASgspppeVTWYKQGGKL--LAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSA 77
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 117-175 7.09e-03

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 34.64  E-value: 7.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1820433317 117 LLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTlrgrntSSEYQILTARREDSGLYWC 175
Cdd:cd05752    12 VFQGEKVTLTCQGFYSPEQNSTQWYHNGTLISST------SSSYRIVAATVNDSGEYRC 64
 
Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 19-100 6.65e-43

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 141.67  E-value: 6.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317  19 WLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSG-MGKHRYTSAGIS 97
Cdd:cd05753     1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSYENSNFSIPQATLSDSGSYHCSGtVRIKRRSSESVN 80


                  ...
gi 1820433317  98 VTV 100
Cdd:cd05753    81 ITV 83
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 19-100 1.09e-11

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 59.72  E-value: 1.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317  19 WLLLQVSSRVFTEGEPLALRCHAWKDKLVyNVLYYRNGKAFKffhWNSNLTILKTNISHNGTYHCS-GMGKHRYTSAGIS 97
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPP-SYTWYKDGSAIS---SSPNFFTLSVSAEDSGTYTCVaRNGRGGKVSNPVE 76


                  ...
gi 1820433317  98 VTV 100
Cdd:pfam13895  77 LTV 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 111-189 7.27e-09

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 51.81  E-value: 7.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317 111 ASVTSPLLEGNLVTLSCETKLllQRPGLQLYFSFYMGSKTL-------RGRNTSSEYQILTARREDSGLYWCEAATEDGN 183
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAST--GSPGPDVTWSKEGGTLIEslkvkhdNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGS 79


                  ....*.
gi 1820433317 184 VLKRSP 189
Cdd:pfam00047  80 ATLSTS 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 106-195 3.29e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 41.61  E-value: 3.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317 106 APVLNASVTsPLLEGNLVTLSCetklllQRPGLQLY-FSFYMGSKTLrgrNTSSEYQILTARREDSGLYWCEAatEDGNV 184
Cdd:pfam13895   1 KPVLTPSPT-VVTEGEPVTLTC------SAPGNPPPsYTWYKDGSAI---SSSPNFFTLSVSAEDSGTYTCVA--RNGRG 68

                          90
                  ....*....|.
gi 1820433317 185 LKRSPELELQV 195
Cdd:pfam13895  69 GKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-100 5.59e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 5.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820433317   25 SSRVFTEGEPLALRCHAWkDKLVYNVLYYRNGKAFKFF---------HWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG 95
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAEsgrfsvsrsGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80


                   ....*
gi 1820433317   96 ISVTV 100
Cdd:smart00410  81 TTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 119-184 1.83e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.41  E-value: 1.83e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820433317  119 EGNLVTLSCETK------LLLQRPGLQLyfSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNV 184
Cdd:smart00410   8 EGESVTLSCEASgspppeVTWYKQGGKL--LAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSA 77
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 117-175 7.09e-03

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 34.64  E-value: 7.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1820433317 117 LLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTlrgrntSSEYQILTARREDSGLYWC 175
Cdd:cd05752    12 VFQGEKVTLTCQGFYSPEQNSTQWYHNGTLISST------SSSYRIVAATVNDSGEYRC 64
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 107-177 7.12e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 34.85  E-value: 7.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820433317 107 PVLNASVTSP-LLEGNLVTLSCET------KLLLQRPGLQLYFSFYMGSKTlrgRNTSSEYQILTARREDSGLYWCEA 177
Cdd:pfam13927   2 PVITVSPSSVtVREGETVTLTCEAtgspppTITWYKNGEPISSGSTRSRSL---SGSNSTLTISNVTRSDAGTYTCVA 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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