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Conserved domains on  [gi|1829519332|ref|NP_001366481|]
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KN motif and ankyrin repeat domain-containing protein 2 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
658-833 1.57e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.70  E-value: 1.57e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 658 AMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLFRLG 737
Cdd:COG0666    70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAG 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 738 -NINAKASQaGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPScDISLTDRDGST 816
Cdd:COG0666   144 aDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKT 221

                         170
                  ....*....|....*..
gi 1829519332 817 ALMVALDAGQSEIASML 833
Cdd:COG0666   222 ALDLAAENGNLEIVKLL 238
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-69 2.69e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


:

Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 2.69e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1829519332  31 PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPR 69
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
LGT super family cl00478
Prolipoprotein diacylglyceryl transferase;
450-593 3.84e-03

Prolipoprotein diacylglyceryl transferase;


The actual alignment was detected with superfamily member PRK13108:

Pssm-ID: 469786 [Multi-domain]  Cd Length: 460  Bit Score: 40.73  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 450 QEPTHREPTRQAASQESEEAGGTAPPLSSPPGGPPAGVRSImkrKEEVADPTAHrrslqfVGVNGGYESSSEDSSTAENI 529
Cdd:PRK13108  293 DEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAV---KAEVAEVTDE------VAAESVVQVADRDGESTPAV 363

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829519332 530 SDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIP----TAEGASGSNTEEE 593
Cdd:PRK13108  364 EETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPevpeKAAPIPDPAKPDE 431
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
658-833 1.57e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.70  E-value: 1.57e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 658 AMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLFRLG 737
Cdd:COG0666    70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAG 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 738 -NINAKASQaGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPScDISLTDRDGST 816
Cdd:COG0666   144 aDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKT 221

                         170
                  ....*....|....*..
gi 1829519332 817 ALMVALDAGQSEIASML 833
Cdd:COG0666   222 ALDLAAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
751-836 1.30e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.09  E-value: 1.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 751 LMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLtdrDGSTALMVALDAGQSEIA 830
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIV 77


                  ....*.
gi 1829519332 831 SMLYSR 836
Cdd:pfam12796  78 KLLLEK 83
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-69 2.69e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 2.69e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1829519332  31 PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPR 69
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 663-800 4.83e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.76  E-value: 4.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 663 LLDYV--VNIADSNGNTALHYSVS--HANFPVVQQLLDSGVcKVDKQNRAGYspimltalatlktqddietvlqLFRLG- 737
Cdd:PHA03100  127 LLDNGanVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV-DINAKNRVNY----------------------LLSYGv 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829519332 738 NINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL 800
Cdd:PHA03100  184 PINIK-DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 747-775 1.09e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.88  E-value: 1.09e-04
                           10        20
                   ....*....|....*....|....*....
gi 1829519332  747 GQTALMLAVSHGRVDVVKALLACEADVNV 775
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 450-593 3.84e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 40.73  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 450 QEPTHREPTRQAASQESEEAGGTAPPLSSPPGGPPAGVRSImkrKEEVADPTAHrrslqfVGVNGGYESSSEDSSTAENI 529
Cdd:PRK13108  293 DEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAV---KAEVAEVTDE------VAAESVVQVADRDGESTPAV 363

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829519332 530 SDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIP----TAEGASGSNTEEE 593
Cdd:PRK13108  364 EETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPevpeKAAPIPDPAKPDE 431
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
658-833 1.57e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.70  E-value: 1.57e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 658 AMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLFRLG 737
Cdd:COG0666    70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAG 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 738 -NINAKASQaGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPScDISLTDRDGST 816
Cdd:COG0666   144 aDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKT 221

                         170
                  ....*....|....*..
gi 1829519332 817 ALMVALDAGQSEIASML 833
Cdd:COG0666   222 ALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
636-830 6.09e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.53  E-value: 6.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 636 LRLACRSDaHPELVRRhlvtframsarLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPI 713
Cdd:COG0666    91 LHAAARNG-DLEIVKL-----------LLEAgaDVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPL 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 714 MLTALatlktQDDIETVLQLFRLG-NINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGH 792
Cdd:COG0666   158 HLAAA-----NGNLEIVKLLLEAGaDVNAR-DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1829519332 793 KEIAGLLLAVPScDISLTDRDGSTALMVALDAGQSEIA 830
Cdd:COG0666   232 LEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIV 268
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
636-833 1.18e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.37  E-value: 1.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 636 LRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIML 715
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-DINAKDDGGNTLLHA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 716 TAlatlkTQDDIETVLQLFRLG-NINAKASQaGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKE 794
Cdd:COG0666    94 AA-----RNGDLEIVKLLLEAGaDVNARDKD-GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLE 167

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1829519332 795 IAGLLLAVPsCDISLTDRDGSTALMVALDAGQSEIASML 833
Cdd:COG0666   168 IVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
661-833 2.72e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.18  E-value: 2.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 661 ARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNIN 740
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 741 AKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL---AvpscDISLTDRDGSTA 817
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLeagA----DVNAQDNDGNTP 156

                         170
                  ....*....|....*.
gi 1829519332 818 LMVALDAGQSEIASML 833
Cdd:COG0666   157 LHLAAANGNLEIVKLL 172
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
636-801 1.03e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.48  E-value: 1.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 636 LRLACRSDaHPELVRRhlvtframsarLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPI 713
Cdd:COG0666   124 LHLAAYNG-NLEIVKL-----------LLEAgaDVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 714 MLTALatlktQDDIETVLQLFRLG-NINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGH 792
Cdd:COG0666   191 HLAAE-----NGHLEIVKLLLEAGaDVNAK-DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264


                  ....*....
gi 1829519332 793 KEIAGLLLA 801
Cdd:COG0666   265 ALIVKLLLL 273
Ank_2 pfam12796
Ankyrin repeats (3 copies);
751-836 1.30e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.09  E-value: 1.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 751 LMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLtdrDGSTALMVALDAGQSEIA 830
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIV 77


                  ....*.
gi 1829519332 831 SMLYSR 836
Cdd:pfam12796  78 KLLLEK 83
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-69 2.69e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 2.69e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1829519332  31 PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPR 69
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
679-777 3.21e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 3.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 679 LHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLfrLGNINAKASQAGQTALMLAVSHG 758
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKN-----GHLEIVKLL--LEHADVNLKDNGRTALHYAARSG 72

                          90
                  ....*....|....*....
gi 1829519332 759 RVDVVKALLACEADVNVQD 777
Cdd:pfam12796  73 HLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
749-800 1.38e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 57.28  E-value: 1.38e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1829519332 749 TALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL 800
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 663-800 4.83e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.76  E-value: 4.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 663 LLDYV--VNIADSNGNTALHYSVS--HANFPVVQQLLDSGVcKVDKQNRAGYspimltalatlktqddietvlqLFRLG- 737
Cdd:PHA03100  127 LLDNGanVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV-DINAKNRVNY----------------------LLSYGv 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829519332 738 NINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL 800
Cdd:PHA03100  184 PINIK-DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 668-822 1.69e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.58  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 668 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTAlatlkTQDDIETVLQLFRLGNINAKASQAG 747
Cdd:PHA02874  150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA-YANVKDNNGESPLHNAA-----EYGDYACIKLLIDHGNHIMNKCKNG 223

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829519332 748 QTALMLAVSHGRVDVvkALLACEADVNVQDDDGSTALMCACEHG-HKEIAGLLLaVPSCDISLTDRDGSTALMVAL 822
Cdd:PHA02874  224 FTPLHNAIIHNRSAI--ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILL-YHKADISIKDNKGENPIDTAF 296
Ank_5 pfam13857
Ankyrin repeats (many copies);
731-784 2.10e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.50  E-value: 2.10e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829519332 731 LQLFRLGNINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 784
Cdd:pfam13857   1 LLEHGPIDLNRL-DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 668-787 3.37e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.73  E-value: 3.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 668 VNIADSNGNTALHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPIMLtALATLKTQDDIETVLQlfRLGNINAKASQAG 747
Cdd:PHA02878  194 VNIPDKTNNSPLHHAVKHYNKPIVHILLENG-ASTDARDKCGNTPLHI-SVGYCKDYDILKLLLE--HGVDVNAKSYILG 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1829519332 748 QTALMLAVSHGRvdVVKALLACEADVNVQDDDGSTALMCA 787
Cdd:PHA02878  270 LTALHSSIKSER--KLKLLLEYGADINSLNSYKLTPLSSA 307
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 763-835 5.00e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.36  E-value: 5.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829519332 763 VKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVpSCDISLTDRDGSTALMVALDAGQSEIASMLYS 835
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEF-GADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
Ank_2 pfam12796
Ankyrin repeats (3 copies);
784-841 1.08e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1829519332 784 LMCACEHGHKEIAGLLLAVPsCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKC 841
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL 57
PHA03095 PHA03095
ankyrin-like protein; Provisional
 652-768 1.18e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 652 HLVTFRAMSA---RLLDYVVNIA--DSNGNTALHYSVSHANF--PVVQQLLDSGVcKVDKQNRAGYSPIMLTAlatlkTQ 724
Cdd:PHA03095  194 HLQSFKPRARivrELIRAGCDPAatDMLGNTPLHSMATGSSCkrSLVLPLLIAGI-SINARNRYGQTPLHYAA-----VF 267

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1829519332 725 DDIETVLQLFRLG-NINAkASQAGQTALMLAVSHGRVDVVKALLA 768
Cdd:PHA03095  268 NNPRACRRLIALGaDINA-VSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA03095 PHA03095
ankyrin-like protein; Provisional
 668-786 3.03e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.79  E-value: 3.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 668 VNIADSNGNTALHYSVSHANFP---VVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLF-RLG-NINAK 742
Cdd:PHA03095   40 VNFRGEYGKTPLHLYLHYSSEKvkdIVRLLLEAGA-DVNAPERCGFTPLHLYLYN-----ATTLDVIKLLiKAGaDVNAK 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1829519332 743 aSQAGQTAL--MLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 786
Cdd:PHA03095  114 -DKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAV 158
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 747-778 3.18e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.20  E-value: 3.18e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1829519332 747 GQTALMLAVSH-GRVDVVKALLACEADVNVQDD 778
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 679-840 6.97e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 6.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 679 LHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLG--------------------- 737
Cdd:PHA03100   39 LYLAKEARNIDVVKILLDNG-ADINSSTKNNSTPLHYLSNIKYNLTDVKEIVKLLLEYGanvnapdnngitpllyaiskk 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 738 ---------------NINAKASQaGQTALMLAVSHGRVDV------------------VKALLACEADVNVQDDDGSTAL 784
Cdd:PHA03100  118 snsysiveylldngaNVNIKNSD-GENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPL 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1829519332 785 MCACEHGHKEIAGLLLAVpSCDISLTDRDGSTALMVALDAGQSEIASM-LYSRMNIK 840
Cdd:PHA03100  197 HYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLlLNNGPSIK 252
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 747-775 9.64e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 43.01  E-value: 9.64e-06
                          10        20
                  ....*....|....*....|....*....
gi 1829519332 747 GQTALMLAVSHGRVDVVKALLACEADVNV 775
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 669-800 1.00e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 669 NIADSNGNTALHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPiMLTALATlkTQDDIETVLQLFrlgninAKAS--QA 746
Cdd:PLN03192  552 DIGDSKGRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTA-LWNAISA--KHHKIFRILYHF------ASISdpHA 621

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829519332 747 GQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL 800
Cdd:PLN03192  622 AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
Ank_5 pfam13857
Ankyrin repeats (many copies);
766-821 1.56e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 1.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1829519332 766 LLACE-ADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPsCDISLTDRDGSTALMVA 821
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 747-853 1.70e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 747 GQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEI---------------AGLLLAVPS------- 804
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIfrilyhfasisdphaAGDLLCTAAkrndlta 637

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1829519332 805 --------CDISLTDRDGSTALMVALDAGQSEIASMLYsrMN-IKCSFAPMSDDESPT 853
Cdd:PLN03192  638 mkellkqgLNVDSEDHQGATALQVAMAEDHVDMVRLLI--MNgADVDKANTDDDFSPT 693
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 679-836 1.78e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.06  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 679 LHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLFRLGNINAKASQAGQTALMLAVSHG 758
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATIL-----KKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1829519332 759 RVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAvPSCDISLTDRDGSTALM-VALDAGQSEIASMLYSR 836
Cdd:PHA02875  147 DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKR 224
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 747-809 3.20e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 3.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829519332 747 GQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISL 809
Cdd:PTZ00322  115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
Ank_4 pfam13637
Ankyrin repeats (many copies);
780-833 3.62e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 3.62e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829519332 780 GSTALMCACEHGHKEIAGLLLAvPSCDISLTDRDGSTALMVALDAGQSEIASML 833
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLL 53
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 751-848 5.09e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.17  E-value: 5.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 751 LMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAvPSCDISLTDRDGSTALMVALDAGQSEIA 830
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLK-HACNVHIRDANGNTALWNAISAKHHKIF 607

                          90
                  ....*....|....*...
gi 1829519332 831 SMLYsrmnikcSFAPMSD 848
Cdd:PLN03192  608 RILY-------HFASISD 618
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 747-775 1.09e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.88  E-value: 1.09e-04
                           10        20
                   ....*....|....*....|....*....
gi 1829519332  747 GQTALMLAVSHGRVDVVKALLACEADVNV 775
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 668-839 1.61e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 668 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALATlkTQDDIETVLQLFRLGNINakaSQAG 747
Cdd:PHA02874  117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIKHN--FFDIIKLLLEKGAYANVK---DNNG 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 748 QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAgllLAVPSCDISLTDRDGSTALMVALDAGQS 827
Cdd:PHA02874  191 ESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIE---LLINNASINDQDIDGSTPLHHAINPPCD 267

                         170
                  ....*....|....
gi 1829519332 828 E--IASMLYSRMNI 839
Cdd:PHA02874  268 IdiIDILLYHKADI 281
PHA03095 PHA03095
ankyrin-like protein; Provisional
 668-822 1.78e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 668 VNIADSNGNTALH-Y-SVSHANFPVVQQLLDSG--VCKVDKQnraGYSPI----------------MLTALATLKTQDDI 727
Cdd:PHA03095  110 VNAKDKVGRTPLHvYlSGFNINPKVIRLLLRKGadVNALDLY---GMTPLavllksrnanvellrlLIDAGADVYAVDDR 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 728 ETVL----------------QLFRLGNINAKASQAGQTAL--MLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACE 789
Cdd:PHA03095  187 FRSLlhhhlqsfkprarivrELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAV 266

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1829519332 790 HGHKEIAGLLLAVpSCDISLTDRDGSTALMVAL 822
Cdd:PHA03095  267 FNNPRACRRLIAL-GADINAVSSDGNTPLSLMV 298
PHA03095 PHA03095
ankyrin-like protein; Provisional
 653-801 2.03e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 653 LVTFRAMSARLLDYVVNI------ADSNGNTALHYsvsHANFP-----VVQQLLDSGvCKVDKQNRAGYSPimLTALATL 721
Cdd:PHA03095  159 LLKSRNANVELLRLLIDAgadvyaVDDRFRSLLHH---HLQSFkprarIVRELIRAG-CDPAATDMLGNTP--LHSMATG 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 722 KTQDDIetVLQLFRLGN--INAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLL 799
Cdd:PHA03095  233 SSCKRS--LVLPLLIAGisINAR-NRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAA 309


                  ..
gi 1829519332 800 LA 801
Cdd:PHA03095  310 LA 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
636-706 3.10e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 3.10e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1829519332 636 LRLACRSDaHPELVRRhlvtframsarLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGvCKVDKQN 706
Cdd:pfam12796  34 LHLAAKNG-HLEIVKL-----------LLEHADVNLKDNGRTALHYAARSGHLEIVKLLLEKG-ADINVKD 91
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 668-784 4.43e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 668 VNIADSNGNTALHYSVS---HANFPVVQQLldsgvCKVDKQNRAGyspimlTALATLKTQDDIETVLQLFRLG-NINAKA 743
Cdd:PLN03192  584 VHIRDANGNTALWNAISakhHKIFRILYHF-----ASISDPHAAG------DLLCTAAKRNDLTAMKELLKQGlNVDSED 652

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1829519332 744 SQaGQTALMLAVSHGRVDVVKALLACEADV---NVQDDDGSTAL 784
Cdd:PLN03192  653 HQ-GATALQVAMAEDHVDMVRLLIMNGADVdkaNTDDDFSPTEL 695
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 724-846 2.74e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 724 QDDIETVLQLFRLGNINAKASQagqTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAvP 803
Cdd:PHA02874  104 KDMIKTILDCGIDVNIKDAELK---TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE-K 179

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1829519332 804 SCDISLTDRDGSTALMVALDAGQSEIASMLY---SRMNIKCS--FAPM 846
Cdd:PHA02874  180 GAYANVKDNNGESPLHNAAEYGDYACIKLLIdhgNHIMNKCKngFTPL 227
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 450-593 3.84e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 40.73  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 450 QEPTHREPTRQAASQESEEAGGTAPPLSSPPGGPPAGVRSImkrKEEVADPTAHrrslqfVGVNGGYESSSEDSSTAENI 529
Cdd:PRK13108  293 DEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAV---KAEVAEVTDE------VAAESVVQVADRDGESTPAV 363

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829519332 530 SDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIP----TAEGASGSNTEEE 593
Cdd:PRK13108  364 EETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPevpeKAAPIPDPAKPDE 431
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 666-822 5.94e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 5.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 666 YVVNIADSNGNTALHYSVSHANFP-VVQQLLDSGVcKVDKQNRAGYSPIMLTAlatlKTQDDIETVLQLFRLG-NINAkA 743
Cdd:PHA02876  264 FSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGA-DVNAKNIKGETPLYLMA----KNGYDTENIRTLIMLGaDVNA-A 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519332 744 SQAGQTALMLAVSHGRV-DVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVpSCDISLTDRDGSTALMVAL 822
Cdd:PHA02876  338 DRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDY-GADIEALSQKIGTALHFAL 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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