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Conserved domains on  [gi|1829519622|ref|NP_001366491|]
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KN motif and ankyrin repeat domain-containing protein 2 isoform 2 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13778391)

ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions; ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions; similar to Homo sapiens ankyrin repeat and SOCS box protein 7 isoform 1; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  15152081|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
650-825 1.54e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.70  E-value: 1.54e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 650 AMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLFRLG 729
Cdd:COG0666    70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAG 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 730 -NINAKASQaGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPScDISLTDRDGST 808
Cdd:COG0666   144 aDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKT 221

                         170
                  ....*....|....*..
gi 1829519622 809 ALMVALDAGQSEIASML 825
Cdd:COG0666   222 ALDLAAENGNLEIVKLL 238
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-69 3.40e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


:

Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 3.40e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1829519622  31 PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPR 69
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
650-825 1.54e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.70  E-value: 1.54e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 650 AMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLFRLG 729
Cdd:COG0666    70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAG 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 730 -NINAKASQaGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPScDISLTDRDGST 808
Cdd:COG0666   144 aDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKT 221

                         170
                  ....*....|....*..
gi 1829519622 809 ALMVALDAGQSEIASML 825
Cdd:COG0666   222 ALDLAAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
743-828 1.28e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.09  E-value: 1.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 743 LMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLtdrDGSTALMVALDAGQSEIA 822
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIV 77


                  ....*.
gi 1829519622 823 SMLYSR 828
Cdd:pfam12796  78 KLLLEK 83
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-69 3.40e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 3.40e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1829519622  31 PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPR 69
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 655-792 4.77e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.76  E-value: 4.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 655 LLDYV--VNIADSNGNTALHYSVS--HANFPVVQQLLDSGVcKVDKQNRAGYspimltalatlktqddietvlqLFRLG- 729
Cdd:PHA03100  127 LLDNGanVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV-DINAKNRVNY----------------------LLSYGv 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829519622 730 NINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL 792
Cdd:PHA03100  184 PINIK-DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 739-767 1.08e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.88  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|....*....
gi 1829519622  739 GQTALMLAVSHGRVDVVKALLACEADVNV 767
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
650-825 1.54e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.70  E-value: 1.54e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 650 AMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLFRLG 729
Cdd:COG0666    70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAG 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 730 -NINAKASQaGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPScDISLTDRDGST 808
Cdd:COG0666   144 aDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKT 221

                         170
                  ....*....|....*..
gi 1829519622 809 ALMVALDAGQSEIASML 825
Cdd:COG0666   222 ALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
628-822 6.02e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.53  E-value: 6.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 628 LRLACRSDaHPELVRRhlvtframsarLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPI 705
Cdd:COG0666    91 LHAAARNG-DLEIVKL-----------LLEAgaDVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPL 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 706 MLTALatlktQDDIETVLQLFRLG-NINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGH 784
Cdd:COG0666   158 HLAAA-----NGNLEIVKLLLEAGaDVNAR-DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1829519622 785 KEIAGLLLAVPScDISLTDRDGSTALMVALDAGQSEIA 822
Cdd:COG0666   232 LEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIV 268
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
628-825 1.16e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.37  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 628 LRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIML 707
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-DINAKDDGGNTLLHA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 708 TAlatlkTQDDIETVLQLFRLG-NINAKASQaGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKE 786
Cdd:COG0666    94 AA-----RNGDLEIVKLLLEAGaDVNARDKD-GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLE 167

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1829519622 787 IAGLLLAVPsCDISLTDRDGSTALMVALDAGQSEIASML 825
Cdd:COG0666   168 IVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
653-825 2.68e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.18  E-value: 2.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 653 ARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNIN 732
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 733 AKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL---AvpscDISLTDRDGSTA 809
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLeagA----DVNAQDNDGNTP 156

                         170
                  ....*....|....*.
gi 1829519622 810 LMVALDAGQSEIASML 825
Cdd:COG0666   157 LHLAAANGNLEIVKLL 172
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
628-793 1.02e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.48  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 628 LRLACRSDaHPELVRRhlvtframsarLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPI 705
Cdd:COG0666   124 LHLAAYNG-NLEIVKL-----------LLEAgaDVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 706 MLTALatlktQDDIETVLQLFRLG-NINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGH 784
Cdd:COG0666   191 HLAAE-----NGHLEIVKLLLEAGaDVNAK-DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264


                  ....*....
gi 1829519622 785 KEIAGLLLA 793
Cdd:COG0666   265 ALIVKLLLL 273
Ank_2 pfam12796
Ankyrin repeats (3 copies);
743-828 1.28e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.09  E-value: 1.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 743 LMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLtdrDGSTALMVALDAGQSEIA 822
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIV 77


                  ....*.
gi 1829519622 823 SMLYSR 828
Cdd:pfam12796  78 KLLLEK 83
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-69 3.40e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 3.40e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1829519622  31 PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPR 69
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
671-769 3.18e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 3.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 671 LHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLfrLGNINAKASQAGQTALMLAVSHG 750
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKN-----GHLEIVKLL--LEHADVNLKDNGRTALHYAARSG 72

                          90
                  ....*....|....*....
gi 1829519622 751 RVDVVKALLACEADVNVQD 769
Cdd:pfam12796  73 HLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
741-792 1.37e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 57.28  E-value: 1.37e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1829519622 741 TALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL 792
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 655-792 4.77e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.76  E-value: 4.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 655 LLDYV--VNIADSNGNTALHYSVS--HANFPVVQQLLDSGVcKVDKQNRAGYspimltalatlktqddietvlqLFRLG- 729
Cdd:PHA03100  127 LLDNGanVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV-DINAKNRVNY----------------------LLSYGv 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829519622 730 NINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL 792
Cdd:PHA03100  184 PINIK-DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 660-814 1.67e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.58  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTAlatlkTQDDIETVLQLFRLGNINAKASQAG 739
Cdd:PHA02874  150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA-YANVKDNNGESPLHNAA-----EYGDYACIKLLIDHGNHIMNKCKNG 223

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829519622 740 QTALMLAVSHGRVDVvkALLACEADVNVQDDDGSTALMCACEHG-HKEIAGLLLaVPSCDISLTDRDGSTALMVAL 814
Cdd:PHA02874  224 FTPLHNAIIHNRSAI--ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILL-YHKADISIKDNKGENPIDTAF 296
Ank_5 pfam13857
Ankyrin repeats (many copies);
723-776 2.08e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.50  E-value: 2.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829519622 723 LQLFRLGNINAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 776
Cdd:pfam13857   1 LLEHGPIDLNRL-DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 660-779 3.33e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.73  E-value: 3.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPIMLtALATLKTQDDIETVLQlfRLGNINAKASQAG 739
Cdd:PHA02878  194 VNIPDKTNNSPLHHAVKHYNKPIVHILLENG-ASTDARDKCGNTPLHI-SVGYCKDYDILKLLLE--HGVDVNAKSYILG 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1829519622 740 QTALMLAVSHGRvdVVKALLACEADVNVQDDDGSTALMCA 779
Cdd:PHA02878  270 LTALHSSIKSER--KLKLLLEYGADINSLNSYKLTPLSSA 307
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 755-827 4.98e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.36  E-value: 4.98e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829519622 755 VKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVpSCDISLTDRDGSTALMVALDAGQSEIASMLYS 827
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEF-GADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
Ank_2 pfam12796
Ankyrin repeats (3 copies);
776-833 1.06e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.06e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1829519622 776 LMCACEHGHKEIAGLLLAVPsCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKC 833
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL 57
PHA03095 PHA03095
ankyrin-like protein; Provisional
 644-760 1.17e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 644 HLVTFRAMSA---RLLDYVVNIA--DSNGNTALHYSVSHANF--PVVQQLLDSGVcKVDKQNRAGYSPIMLTAlatlkTQ 716
Cdd:PHA03095  194 HLQSFKPRARivrELIRAGCDPAatDMLGNTPLHSMATGSSCkrSLVLPLLIAGI-SINARNRYGQTPLHYAA-----VF 267

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1829519622 717 DDIETVLQLFRLG-NINAkASQAGQTALMLAVSHGRVDVVKALLA 760
Cdd:PHA03095  268 NNPRACRRLIALGaDINA-VSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA03095 PHA03095
ankyrin-like protein; Provisional
 660-778 3.00e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.79  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 660 VNIADSNGNTALHYSVSHANFP---VVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLF-RLG-NINAK 734
Cdd:PHA03095   40 VNFRGEYGKTPLHLYLHYSSEKvkdIVRLLLEAGA-DVNAPERCGFTPLHLYLYN-----ATTLDVIKLLiKAGaDVNAK 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1829519622 735 aSQAGQTAL--MLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
Cdd:PHA03095  114 -DKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAV 158
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 739-770 3.15e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.20  E-value: 3.15e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1829519622 739 GQTALMLAVSH-GRVDVVKALLACEADVNVQDD 770
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 671-832 6.89e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 6.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 671 LHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLG--------------------- 729
Cdd:PHA03100   39 LYLAKEARNIDVVKILLDNG-ADINSSTKNNSTPLHYLSNIKYNLTDVKEIVKLLLEYGanvnapdnngitpllyaiskk 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 730 ---------------NINAKASQaGQTALMLAVSHGRVDV------------------VKALLACEADVNVQDDDGSTAL 776
Cdd:PHA03100  118 snsysiveylldngaNVNIKNSD-GENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPL 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1829519622 777 MCACEHGHKEIAGLLLAVpSCDISLTDRDGSTALMVALDAGQSEIASM-LYSRMNIK 832
Cdd:PHA03100  197 HYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLlLNNGPSIK 252
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 739-767 9.55e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 43.01  E-value: 9.55e-06
                          10        20
                  ....*....|....*....|....*....
gi 1829519622 739 GQTALMLAVSHGRVDVVKALLACEADVNV 767
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 661-792 9.89e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 9.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPiMLTALATlkTQDDIETVLQLFrlgninAKAS--QA 738
Cdd:PLN03192  552 DIGDSKGRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTA-LWNAISA--KHHKIFRILYHF------ASISdpHA 621

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829519622 739 GQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL 792
Cdd:PLN03192  622 AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
Ank_5 pfam13857
Ankyrin repeats (many copies);
758-813 1.54e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 1.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1829519622 758 LLACE-ADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPsCDISLTDRDGSTALMVA 813
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 739-845 1.68e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 739 GQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEI---------------AGLLLAVPS------- 796
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIfrilyhfasisdphaAGDLLCTAAkrndlta 637

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1829519622 797 --------CDISLTDRDGSTALMVALDAGQSEIASMLYsrMN-IKCSFAPMSDDESPT 845
Cdd:PLN03192  638 mkellkqgLNVDSEDHQGATALQVAMAEDHVDMVRLLI--MNgADVDKANTDDDFSPT 693
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 671-828 1.76e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.06  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 671 LHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLFRLGNINAKASQAGQTALMLAVSHG 750
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATIL-----KKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1829519622 751 RVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAvPSCDISLTDRDGSTALM-VALDAGQSEIASMLYSR 828
Cdd:PHA02875  147 DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKR 224
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 739-801 3.21e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 3.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829519622 739 GQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISL 801
Cdd:PTZ00322  115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
Ank_4 pfam13637
Ankyrin repeats (many copies);
772-825 3.59e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 3.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829519622 772 GSTALMCACEHGHKEIAGLLLAvPSCDISLTDRDGSTALMVALDAGQSEIASML 825
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLL 53
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 743-840 5.03e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.17  E-value: 5.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 743 LMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAvPSCDISLTDRDGSTALMVALDAGQSEIA 822
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLK-HACNVHIRDANGNTALWNAISAKHHKIF 607

                          90
                  ....*....|....*...
gi 1829519622 823 SMLYsrmnikcSFAPMSD 840
Cdd:PLN03192  608 RILY-------HFASISD 618
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 739-767 1.08e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.88  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|....*....
gi 1829519622  739 GQTALMLAVSHGRVDVVKALLACEADVNV 767
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 660-831 1.59e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALATlkTQDDIETVLQLFRLGNINakaSQAG 739
Cdd:PHA02874  117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIKHN--FFDIIKLLLEKGAYANVK---DNNG 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 740 QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAgllLAVPSCDISLTDRDGSTALMVALDAGQS 819
Cdd:PHA02874  191 ESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIE---LLINNASINDQDIDGSTPLHHAINPPCD 267

                         170
                  ....*....|....
gi 1829519622 820 E--IASMLYSRMNI 831
Cdd:PHA02874  268 IdiIDILLYHKADI 281
PHA03095 PHA03095
ankyrin-like protein; Provisional
 660-814 1.76e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 660 VNIADSNGNTALH-Y-SVSHANFPVVQQLLDSG--VCKVDKQnraGYSPI----------------MLTALATLKTQDDI 719
Cdd:PHA03095  110 VNAKDKVGRTPLHvYlSGFNINPKVIRLLLRKGadVNALDLY---GMTPLavllksrnanvellrlLIDAGADVYAVDDR 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 720 ETVL----------------QLFRLGNINAKASQAGQTAL--MLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACE 781
Cdd:PHA03095  187 FRSLlhhhlqsfkprarivrELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAV 266

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1829519622 782 HGHKEIAGLLLAVpSCDISLTDRDGSTALMVAL 814
Cdd:PHA03095  267 FNNPRACRRLIAL-GADINAVSSDGNTPLSLMV 298
PHA03095 PHA03095
ankyrin-like protein; Provisional
 645-793 2.00e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 645 LVTFRAMSARLLDYVVNI------ADSNGNTALHYsvsHANFP-----VVQQLLDSGvCKVDKQNRAGYSPimLTALATL 713
Cdd:PHA03095  159 LLKSRNANVELLRLLIDAgadvyaVDDRFRSLLHH---HLQSFkprarIVRELIRAG-CDPAATDMLGNTP--LHSMATG 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 714 KTQDDIetVLQLFRLGN--INAKaSQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLL 791
Cdd:PHA03095  233 SSCKRS--LVLPLLIAGisINAR-NRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAA 309


                  ..
gi 1829519622 792 LA 793
Cdd:PHA03095  310 LA 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
628-698 3.07e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 3.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1829519622 628 LRLACRSDaHPELVRRhlvtframsarLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGvCKVDKQN 698
Cdd:pfam12796  34 LHLAAKNG-HLEIVKL-----------LLEHADVNLKDNGRTALHYAARSGHLEIVKLLLEKG-ADINVKD 91
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 660-776 4.38e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 4.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 660 VNIADSNGNTALHYSVS---HANFPVVQQLldsgvCKVDKQNRAGyspimlTALATLKTQDDIETVLQLFRLG-NINAKA 735
Cdd:PLN03192  584 VHIRDANGNTALWNAISakhHKIFRILYHF-----ASISDPHAAG------DLLCTAAKRNDLTAMKELLKQGlNVDSED 652

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1829519622 736 SQaGQTALMLAVSHGRVDVVKALLACEADV---NVQDDDGSTAL 776
Cdd:PLN03192  653 HQ-GATALQVAMAEDHVDMVRLLIMNGADVdkaNTDDDFSPTEL 695
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 716-838 2.71e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 716 QDDIETVLQLFRLGNINAKASQagqTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAvP 795
Cdd:PHA02874  104 KDMIKTILDCGIDVNIKDAELK---TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE-K 179

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1829519622 796 SCDISLTDRDGSTALMVALDAGQSEIASMLY---SRMNIKCS--FAPM 838
Cdd:PHA02874  180 GAYANVKDNNGESPLHNAAEYGDYACIKLLIdhgNHIMNKCKngFTPL 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 658-814 5.87e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 5.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 658 YVVNIADSNGNTALHYSVSHANFP-VVQQLLDSGVcKVDKQNRAGYSPIMLTAlatlKTQDDIETVLQLFRLG-NINAkA 735
Cdd:PHA02876  264 FSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGA-DVNAKNIKGETPLYLMA----KNGYDTENIRTLIMLGaDVNA-A 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519622 736 SQAGQTALMLAVSHGRV-DVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVpSCDISLTDRDGSTALMVAL 814
Cdd:PHA02876  338 DRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDY-GADIEALSQKIGTALHFAL 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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