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Conserved domains on  [gi|1829778958|ref|NP_001366593|]
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terminal uridylyltransferase 4 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TUTase pfam19088
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
274-491 2.72e-134

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


:

Pssm-ID: 465974  Cd Length: 218  Bit Score: 414.91  E-value: 2.72e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  274 EMDYLENATVIDESALTPEQRLGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIHIENIQGAHKHIKEKRHKKNIL 353
Cdd:pfam19088    1 DQDEDEDGPVIDESNLTAEQQLGLRQAEERLKRDYIHRLKKRSPEYPNFQYLCKLCSVHIENIQGAHKHIKEKRHKKNIM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  354 EKQEESELRSLPSPSSAHLAALSVAVVELAKEQGITDDDLRIRQDIVEEMSKVIMTFLPECSLRLYGSSLTKFALKSSDV 433
Cdd:pfam19088   81 EKQEENELRALPPPSPAQLKALGAAVLEVAQEHGISDEDFEVRQEIVTRMEKIIQQHLPDCSLRLYGSCLTRFAFKTSDI 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1829778958  434 NIDIKFPPKMNHPDLLIQVLGILKKSALYIDVESDFHAKVPVVVCKDRKSALLCRVSA 491
Cdd:pfam19088  161 NIDVQFPSTMTQPDVLIQVLEILKNSESYSDVESDFHAKVPVVFCRDKQSGLMCKVSA 218
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
988-1106 3.83e-38

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


:

Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 138.84  E-value: 3.83e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  988 NREQILIGLEKFIQKEYdEKARLCLFGSSKNGFGFRDSDLDICMTLEGHenaeKLNCKEIIENLAKILKRHPGLRNILPI 1067
Cdd:cd05402      1 KREEVLDRLQELIKEWF-PGAKLYPFGSYVTGLGLPGSDIDLCLLGPNH----RVDREDFLRKLAKLLKKSGEVVEVEPI 75
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1829778958 1068 TTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYA 1106
Cdd:cd05402     76 INARVPIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 super family cl34961
DNA polymerase sigma [Replication, recombination and repair];
946-1278 6.50e-36

DNA polymerase sigma [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG5260:

Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 143.76  E-value: 6.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  946 PEDFRKIDLKPLPP--MTNRFREILDLVCKRC---FDELSPPCSEQHNREQILIGLEKFIQKEYDEkARLCLFGSSKNGF 1020
Cdd:COG5260     30 PLDAKKVSIQELLElsIDSVFNEESDELTSELlefYDYIAPSDEELKRRKALLEKLRTLLKKEFPD-ADLKVFGSTETGL 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1021 GFRDSDLDICMTLEGHENAEKLNCKEiienLAKILKRHPGLRNILPITTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTR 1100
Cdd:COG5260    109 ALPKSDIDLCIISDPRGYKETRNAGS----LASHLFKKNLAKEVVVVSTARVPIIKLVDPQSGLHCDISFNNTNGIVNAK 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1101 MLATYAAIDPRVQYLGYTMKVFAKRCDIGDASRGSLSSYAYILMVLYFLQQRKPPviPVLQEIFDGKQIPQRMVDGWNAF 1180
Cdd:COG5260    185 LIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPF--LFFDNGLLSPLKYNKNIDNLGVL 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1181 FFDKTEelkkrlpslgknteslgelwlgllrFYTEEFDFKEYVISIRQ-KKLLTTFEKQW--TSKC--IAIEDPF-DLNH 1254
Cdd:COG5260    263 FDDFFE-------------------------LYGKSFNYSLVVLSINSgDFYLPKYEKGWlkPSKPnsLSIQDPGtDRNN 317
                          330       340
                   ....*....|....*....|....
gi 1829778958 1255 NLGAgVSRKMtNFIMKAFINGRKL 1278
Cdd:COG5260    318 DISA-VSFNI-KDIKAAFIRAFEL 339
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
648-697 1.02e-12

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


:

Pssm-ID: 427532  Cd Length: 60  Bit Score: 64.13  E-value: 1.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1829778958  648 PLGQLWLELLKFYTLDFALEEYVICVRIQDILTRENKNWPKR------RIAIEDPF 697
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLRNegrrpfLLCIEDPF 56
PTZ00368 super family cl31762
universal minicircle sequence binding protein (UMSBP); Provisional
1297-1379 4.69e-06

universal minicircle sequence binding protein (UMSBP); Provisional


The actual alignment was detected with superfamily member PTZ00368:

Pssm-ID: 173561 [Multi-domain]  Cd Length: 148  Bit Score: 48.26  E-value: 4.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1297 SRVLTDGELAPNDRCCRVCGKIGHYMKDCPKRKSllfrlkkkdseeekegneeekdsrdllDSRDLRCFICGDAGHVRRE 1376
Cdd:PTZ00368    40 SRECPSAPGGRGERSCYNCGKTGHLSRECPEAPP---------------------------GSGPRSCYNCGQTGHISRE 92

                   ...
gi 1829778958 1377 CPE 1379
Cdd:PTZ00368    93 CPN 95
rad2 super family cl36701
DNA excision repair protein (rad2); All proteins in this family for which functions are known ...
2-366 1.59e-04

DNA excision repair protein (rad2); All proteins in this family for which functions are known are flap endonucleases that generate the 3' incision next to DNA damage as part of nucleotide excision repair. This family is related to many other flap endonuclease families including the fen1 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


The actual alignment was detected with superfamily member TIGR00600:

Pssm-ID: 273166 [Multi-domain]  Cd Length: 1034  Bit Score: 46.43  E-value: 1.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958    2 EEPKTSKNENHEPKKNIICEESKAVKIIS----NQTLKPRNDKSEIGTSSLNRNSSKKTK----------------QNDI 61
Cdd:TIGR00600  367 DSDESEWERQELKRNNVAFVDDGSLSPRTlqaiGQALDDDEDKKVSASSDDQASPSKKTKmllisrievedddldyLDQG 446
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958   62 CIEKTEAKSCKVNAASVPGPKDLGLVHRDQSHCKMKKLPNSPMKAQKGSSQTKLEKTPS--LQTKAEKVPKSPNLPVKAE 139
Cdd:TIGR00600  447 EGIPLMAALQLSSVNSKPEAVASTKIAREVTSSGHEAVPKAVQSLLLGATNDSPIPSEFtiLDRKSELSIERTVKPVSSE 526
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  140 KAPCTTAEAT----TEKALNSQRKEENTPTSqmkLQKTPRSPLEPENVPSLLLKEnvKQTESQQTGKKLTSSFVSMDkrk 215
Cdd:TIGR00600  527 FGLPSQREDKlaipTEGTQNLQGISDHPEQF---EFQNELSPLETKNNESNLSSD--AETEGSPNPEMPSWSSVTVP--- 598
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  216 SEALQG-EKSALENSSLSQKQQ---TQTDNIADSDDSASGIEDTADDLSKMKSEESNKENSS-EMDYL---ENATVIDES 287
Cdd:TIGR00600  599 SEALDNyETTNPSNAKEVRNFAetgIQTTNVGESADLLLISNPMEVEPMESEKEESESDGSFiEVDSVsstLELQVPSKS 678
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  288 ALTPEQRLGLKQAEERLERDH---IFRLEKRSPEytncrylcklclihIENIQGAHKHIKEKRHKKNILEKQEESELRSL 364
Cdd:TIGR00600  679 QPTDESEENAENKVASIEGEHrkeIEDLLFDESE--------------EDNIVGMIEEEKDADDFKNEWQDISLEELEAL 744

                   ..
gi 1829778958  365 PS 366
Cdd:TIGR00600  745 EA 746
 
Name Accession Description Interval E-value
TUTase pfam19088
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
274-491 2.72e-134

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


Pssm-ID: 465974  Cd Length: 218  Bit Score: 414.91  E-value: 2.72e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  274 EMDYLENATVIDESALTPEQRLGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIHIENIQGAHKHIKEKRHKKNIL 353
Cdd:pfam19088    1 DQDEDEDGPVIDESNLTAEQQLGLRQAEERLKRDYIHRLKKRSPEYPNFQYLCKLCSVHIENIQGAHKHIKEKRHKKNIM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  354 EKQEESELRSLPSPSSAHLAALSVAVVELAKEQGITDDDLRIRQDIVEEMSKVIMTFLPECSLRLYGSSLTKFALKSSDV 433
Cdd:pfam19088   81 EKQEENELRALPPPSPAQLKALGAAVLEVAQEHGISDEDFEVRQEIVTRMEKIIQQHLPDCSLRLYGSCLTRFAFKTSDI 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1829778958  434 NIDIKFPPKMNHPDLLIQVLGILKKSALYIDVESDFHAKVPVVVCKDRKSALLCRVSA 491
Cdd:pfam19088  161 NIDVQFPSTMTQPDVLIQVLEILKNSESYSDVESDFHAKVPVVFCRDKQSGLMCKVSA 218
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
988-1106 3.83e-38

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 138.84  E-value: 3.83e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  988 NREQILIGLEKFIQKEYdEKARLCLFGSSKNGFGFRDSDLDICMTLEGHenaeKLNCKEIIENLAKILKRHPGLRNILPI 1067
Cdd:cd05402      1 KREEVLDRLQELIKEWF-PGAKLYPFGSYVTGLGLPGSDIDLCLLGPNH----RVDREDFLRKLAKLLKKSGEVVEVEPI 75
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1829778958 1068 TTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYA 1106
Cdd:cd05402     76 INARVPIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
946-1278 6.50e-36

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 143.76  E-value: 6.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  946 PEDFRKIDLKPLPP--MTNRFREILDLVCKRC---FDELSPPCSEQHNREQILIGLEKFIQKEYDEkARLCLFGSSKNGF 1020
Cdd:COG5260     30 PLDAKKVSIQELLElsIDSVFNEESDELTSELlefYDYIAPSDEELKRRKALLEKLRTLLKKEFPD-ADLKVFGSTETGL 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1021 GFRDSDLDICMTLEGHENAEKLNCKEiienLAKILKRHPGLRNILPITTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTR 1100
Cdd:COG5260    109 ALPKSDIDLCIISDPRGYKETRNAGS----LASHLFKKNLAKEVVVVSTARVPIIKLVDPQSGLHCDISFNNTNGIVNAK 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1101 MLATYAAIDPRVQYLGYTMKVFAKRCDIGDASRGSLSSYAYILMVLYFLQQRKPPviPVLQEIFDGKQIPQRMVDGWNAF 1180
Cdd:COG5260    185 LIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPF--LFFDNGLLSPLKYNKNIDNLGVL 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1181 FFDKTEelkkrlpslgknteslgelwlgllrFYTEEFDFKEYVISIRQ-KKLLTTFEKQW--TSKC--IAIEDPF-DLNH 1254
Cdd:COG5260    263 FDDFFE-------------------------LYGKSFNYSLVVLSINSgDFYLPKYEKGWlkPSKPnsLSIQDPGtDRNN 317
                          330       340
                   ....*....|....*....|....
gi 1829778958 1255 NLGAgVSRKMtNFIMKAFINGRKL 1278
Cdd:COG5260    318 DISA-VSFNI-KDIKAAFIRAFEL 339
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
395-507 8.14e-30

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 114.96  E-value: 8.14e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  395 IRQDIVEEMSKVIMTFLPECSLRLYGSSLTKFALKSSDVNIDIKFPP-KMNHPDLLIQVLGILKKSALYIDVESDFHAKV 473
Cdd:cd05402      1 KREEVLDRLQELIKEWFPGAKLYPFGSYVTGLGLPGSDIDLCLLGPNhRVDREDFLRKLAKLLKKSGEVVEVEPIINARV 80
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1829778958  474 PVVVCKDRKSALLCRVSAGNDMACLTTDLLAALG 507
Cdd:cd05402     81 PIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
341-558 8.54e-25

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 110.25  E-value: 8.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  341 KHIKEKRHKKNILEKQEEselRSLPSPSSAHLAALSVAVVELAKEQGITDDDLRIRQDIVEEMSKVIMTFLPECSLRLYG 420
Cdd:COG5260     26 KERRPLDAKKVSIQELLE---LSIDSVFNEESDELTSELLEFYDYIAPSDEELKRRKALLEKLRTLLKKEFPDADLKVFG 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  421 SSLTKFALKSSDVNIDIKFPPKMNHPDLLIQVLGI-LKKSALYIDVESDFHAKVPVVVCKDRKSALLCRVSAGNDMACLT 499
Cdd:COG5260    103 STETGLALPKSDIDLCIISDPRGYKETRNAGSLAShLFKKNLAKEVVVVSTARVPIIKLVDPQSGLHCDISFNNTNGIVN 182
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1829778958  500 TDLLAALGKVEPVFTPLVLAFRYWAKLCYIDSQTDGGIPSYCFALMVMFFLQQRKPPLL 558
Cdd:COG5260    183 AKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPFLF 241
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
1201-1254 6.07e-18

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 79.15  E-value: 6.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1201 SLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFEKQWT------SKCIAIEDPFDLNH 1254
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLrnegrrPFLLCIEDPFDLDN 60
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
648-697 1.02e-12

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 64.13  E-value: 1.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1829778958  648 PLGQLWLELLKFYTLDFALEEYVICVRIQDILTRENKNWPKR------RIAIEDPF 697
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLRNegrrpfLLCIEDPF 56
NTP_transf_2 pfam01909
Nucleotidyltransferase domain; Members of this family belong to a large family of ...
996-1081 4.72e-10

Nucleotidyltransferase domain; Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.


Pssm-ID: 396474  Cd Length: 91  Bit Score: 57.81  E-value: 4.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  996 LEKFIQ--KEYDEKARLCLFGSSKNGFGFRDSDLDICMTLEGHENAE-KLNCKEIIENLAKILKRHPGLRNILPITTAKV 1072
Cdd:pfam01909    1 LRKLREilKELFPVAEVVLFGSYARGTALPGSDIDLLVVFPEPVEEErLLKLAKIIKELEELLGLEVDLVTREKIEFPLV 80

                   ....*....
gi 1829778958 1073 PIVKFEHRR 1081
Cdd:pfam01909   81 KIDILEERI 89
PTZ00368 PTZ00368
universal minicircle sequence binding protein (UMSBP); Provisional
1297-1379 4.69e-06

universal minicircle sequence binding protein (UMSBP); Provisional


Pssm-ID: 173561 [Multi-domain]  Cd Length: 148  Bit Score: 48.26  E-value: 4.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1297 SRVLTDGELAPNDRCCRVCGKIGHYMKDCPKRKSllfrlkkkdseeekegneeekdsrdllDSRDLRCFICGDAGHVRRE 1376
Cdd:PTZ00368    40 SRECPSAPGGRGERSCYNCGKTGHLSRECPEAPP---------------------------GSGPRSCYNCGQTGHISRE 92

                   ...
gi 1829778958 1377 CPE 1379
Cdd:PTZ00368    93 CPN 95
AIR1 COG5082
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational ...
1293-1381 7.72e-05

Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227414 [Multi-domain]  Cd Length: 190  Bit Score: 45.23  E-value: 7.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1293 YFFDSRVLTDGELAPND-RCCRVCGKIGHYMKDCPKRksllfrlkkkdseeeKEGNEEEKDSRDLLDSRDLRCFICGDAG 1371
Cdd:COG5082     43 GRYEDRSVEDVSAIREEnPVCFNCGQNGHLRRDCPHS---------------ICYNCSWDGHRSNHCPKPKKCYNCGETG 107
                           90
                   ....*....|
gi 1829778958 1372 HVRRECPEVK 1381
Cdd:COG5082    108 HLSRDCNPSK 117
rad2 TIGR00600
DNA excision repair protein (rad2); All proteins in this family for which functions are known ...
2-366 1.59e-04

DNA excision repair protein (rad2); All proteins in this family for which functions are known are flap endonucleases that generate the 3' incision next to DNA damage as part of nucleotide excision repair. This family is related to many other flap endonuclease families including the fen1 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273166 [Multi-domain]  Cd Length: 1034  Bit Score: 46.43  E-value: 1.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958    2 EEPKTSKNENHEPKKNIICEESKAVKIIS----NQTLKPRNDKSEIGTSSLNRNSSKKTK----------------QNDI 61
Cdd:TIGR00600  367 DSDESEWERQELKRNNVAFVDDGSLSPRTlqaiGQALDDDEDKKVSASSDDQASPSKKTKmllisrievedddldyLDQG 446
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958   62 CIEKTEAKSCKVNAASVPGPKDLGLVHRDQSHCKMKKLPNSPMKAQKGSSQTKLEKTPS--LQTKAEKVPKSPNLPVKAE 139
Cdd:TIGR00600  447 EGIPLMAALQLSSVNSKPEAVASTKIAREVTSSGHEAVPKAVQSLLLGATNDSPIPSEFtiLDRKSELSIERTVKPVSSE 526
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  140 KAPCTTAEAT----TEKALNSQRKEENTPTSqmkLQKTPRSPLEPENVPSLLLKEnvKQTESQQTGKKLTSSFVSMDkrk 215
Cdd:TIGR00600  527 FGLPSQREDKlaipTEGTQNLQGISDHPEQF---EFQNELSPLETKNNESNLSSD--AETEGSPNPEMPSWSSVTVP--- 598
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  216 SEALQG-EKSALENSSLSQKQQ---TQTDNIADSDDSASGIEDTADDLSKMKSEESNKENSS-EMDYL---ENATVIDES 287
Cdd:TIGR00600  599 SEALDNyETTNPSNAKEVRNFAetgIQTTNVGESADLLLISNPMEVEPMESEKEESESDGSFiEVDSVsstLELQVPSKS 678
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  288 ALTPEQRLGLKQAEERLERDH---IFRLEKRSPEytncrylcklclihIENIQGAHKHIKEKRHKKNILEKQEESELRSL 364
Cdd:TIGR00600  679 QPTDESEENAENKVASIEGEHrkeIEDLLFDESE--------------EDNIVGMIEEEKDADDFKNEWQDISLEELEAL 744

                   ..
gi 1829778958  365 PS 366
Cdd:TIGR00600  745 EA 746
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
101-207 2.87e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 41.96  E-value: 2.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  101 NSPMKAQKGSSQTKLEKTPSLQTKAEKVPKSPnlPVKAEKAPCTTAEATTEKALNSQRKEENTPTSQMKLQ-KTPRSPLE 179
Cdd:pfam05539  199 PATQGHQTATANQRLSSTEPVGTQGTTTSSNP--EPQTEPPPSQRGPSGSPQHPPSTTSQDQSTTGDGQEHtQRRKTPPA 276
                           90       100
                   ....*....|....*....|....*...
gi 1829778958  180 PENVPSLLLKENVKQTESQQTGKKLTSS 207
Cdd:pfam05539  277 TSNRRSPHSTATPPPTTKRQETGRPTPR 304
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
15-274 7.59e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.19  E-value: 7.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958   15 KKNIICEESKAVKIIsnqtLKPRNDKSEIGTSSLNRNSSKKTKQndiciektEAKSCKVNAASVPGPKDLGLVHRDQSHC 94
Cdd:PTZ00108  1138 EEALEEQEEVEEKEI----AKEQRLKSKTKGKASKLRKPKLKKK--------EKKKKKSSADKSKKASVVGNSKRVDSDE 1205
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958   95 KMKKLPNSPMKAQKGSSQTKLEKTPSLQTKAEKVPKSPNLPVKAEKApctTAEATTEKALNSQRKEENTPTSQMKLQKTP 174
Cdd:PTZ00108  1206 KRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSK---SSEDNDEFSSDDLSKEGKPKNAPKRVSAVQ 1282
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  175 RSPLEPENVP------SLLLKENVKQTESQQTGKKLTSSFVSMDKRKSEALQGEKSALENSSLSQKQQTQTDNIADSDDS 248
Cdd:PTZ00108  1283 YSPPPPSKRPdgesngGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSD 1362
                          250       260
                   ....*....|....*....|....*.
gi 1829778958  249 ASGIEDTADDLSKMKSEESNKENSSE 274
Cdd:PTZ00108  1363 SSSEDDDDSEVDDSEDEDDEDDEDDD 1388
 
Name Accession Description Interval E-value
TUTase pfam19088
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
274-491 2.72e-134

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


Pssm-ID: 465974  Cd Length: 218  Bit Score: 414.91  E-value: 2.72e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  274 EMDYLENATVIDESALTPEQRLGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIHIENIQGAHKHIKEKRHKKNIL 353
Cdd:pfam19088    1 DQDEDEDGPVIDESNLTAEQQLGLRQAEERLKRDYIHRLKKRSPEYPNFQYLCKLCSVHIENIQGAHKHIKEKRHKKNIM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  354 EKQEESELRSLPSPSSAHLAALSVAVVELAKEQGITDDDLRIRQDIVEEMSKVIMTFLPECSLRLYGSSLTKFALKSSDV 433
Cdd:pfam19088   81 EKQEENELRALPPPSPAQLKALGAAVLEVAQEHGISDEDFEVRQEIVTRMEKIIQQHLPDCSLRLYGSCLTRFAFKTSDI 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1829778958  434 NIDIKFPPKMNHPDLLIQVLGILKKSALYIDVESDFHAKVPVVVCKDRKSALLCRVSA 491
Cdd:pfam19088  161 NIDVQFPSTMTQPDVLIQVLEILKNSESYSDVESDFHAKVPVVFCRDKQSGLMCKVSA 218
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
988-1106 3.83e-38

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 138.84  E-value: 3.83e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  988 NREQILIGLEKFIQKEYdEKARLCLFGSSKNGFGFRDSDLDICMTLEGHenaeKLNCKEIIENLAKILKRHPGLRNILPI 1067
Cdd:cd05402      1 KREEVLDRLQELIKEWF-PGAKLYPFGSYVTGLGLPGSDIDLCLLGPNH----RVDREDFLRKLAKLLKKSGEVVEVEPI 75
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1829778958 1068 TTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYA 1106
Cdd:cd05402     76 INARVPIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
946-1278 6.50e-36

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 143.76  E-value: 6.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  946 PEDFRKIDLKPLPP--MTNRFREILDLVCKRC---FDELSPPCSEQHNREQILIGLEKFIQKEYDEkARLCLFGSSKNGF 1020
Cdd:COG5260     30 PLDAKKVSIQELLElsIDSVFNEESDELTSELlefYDYIAPSDEELKRRKALLEKLRTLLKKEFPD-ADLKVFGSTETGL 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1021 GFRDSDLDICMTLEGHENAEKLNCKEiienLAKILKRHPGLRNILPITTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTR 1100
Cdd:COG5260    109 ALPKSDIDLCIISDPRGYKETRNAGS----LASHLFKKNLAKEVVVVSTARVPIIKLVDPQSGLHCDISFNNTNGIVNAK 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1101 MLATYAAIDPRVQYLGYTMKVFAKRCDIGDASRGSLSSYAYILMVLYFLQQRKPPviPVLQEIFDGKQIPQRMVDGWNAF 1180
Cdd:COG5260    185 LIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPF--LFFDNGLLSPLKYNKNIDNLGVL 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1181 FFDKTEelkkrlpslgknteslgelwlgllrFYTEEFDFKEYVISIRQ-KKLLTTFEKQW--TSKC--IAIEDPF-DLNH 1254
Cdd:COG5260    263 FDDFFE-------------------------LYGKSFNYSLVVLSINSgDFYLPKYEKGWlkPSKPnsLSIQDPGtDRNN 317
                          330       340
                   ....*....|....*....|....
gi 1829778958 1255 NLGAgVSRKMtNFIMKAFINGRKL 1278
Cdd:COG5260    318 DISA-VSFNI-KDIKAAFIRAFEL 339
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
395-507 8.14e-30

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 114.96  E-value: 8.14e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  395 IRQDIVEEMSKVIMTFLPECSLRLYGSSLTKFALKSSDVNIDIKFPP-KMNHPDLLIQVLGILKKSALYIDVESDFHAKV 473
Cdd:cd05402      1 KREEVLDRLQELIKEWFPGAKLYPFGSYVTGLGLPGSDIDLCLLGPNhRVDREDFLRKLAKLLKKSGEVVEVEPIINARV 80
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1829778958  474 PVVVCKDRKSALLCRVSAGNDMACLTTDLLAALG 507
Cdd:cd05402     81 PIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
341-558 8.54e-25

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 110.25  E-value: 8.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  341 KHIKEKRHKKNILEKQEEselRSLPSPSSAHLAALSVAVVELAKEQGITDDDLRIRQDIVEEMSKVIMTFLPECSLRLYG 420
Cdd:COG5260     26 KERRPLDAKKVSIQELLE---LSIDSVFNEESDELTSELLEFYDYIAPSDEELKRRKALLEKLRTLLKKEFPDADLKVFG 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  421 SSLTKFALKSSDVNIDIKFPPKMNHPDLLIQVLGI-LKKSALYIDVESDFHAKVPVVVCKDRKSALLCRVSAGNDMACLT 499
Cdd:COG5260    103 STETGLALPKSDIDLCIISDPRGYKETRNAGSLAShLFKKNLAKEVVVVSTARVPIIKLVDPQSGLHCDISFNNTNGIVN 182
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1829778958  500 TDLLAALGKVEPVFTPLVLAFRYWAKLCYIDSQTDGGIPSYCFALMVMFFLQQRKPPLL 558
Cdd:COG5260    183 AKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPFLF 241
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
1201-1254 6.07e-18

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 79.15  E-value: 6.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1201 SLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFEKQWT------SKCIAIEDPFDLNH 1254
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLrnegrrPFLLCIEDPFDLDN 60
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
648-697 1.02e-12

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 64.13  E-value: 1.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1829778958  648 PLGQLWLELLKFYTLDFALEEYVICVRIQDILTRENKNWPKR------RIAIEDPF 697
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLRNegrrpfLLCIEDPF 56
NTP_transf_2 pfam01909
Nucleotidyltransferase domain; Members of this family belong to a large family of ...
996-1081 4.72e-10

Nucleotidyltransferase domain; Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.


Pssm-ID: 396474  Cd Length: 91  Bit Score: 57.81  E-value: 4.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  996 LEKFIQ--KEYDEKARLCLFGSSKNGFGFRDSDLDICMTLEGHENAE-KLNCKEIIENLAKILKRHPGLRNILPITTAKV 1072
Cdd:pfam01909    1 LRKLREilKELFPVAEVVLFGSYARGTALPGSDIDLLVVFPEPVEEErLLKLAKIIKELEELLGLEVDLVTREKIEFPLV 80

                   ....*....
gi 1829778958 1073 PIVKFEHRR 1081
Cdd:pfam01909   81 KIDILEERI 89
PTZ00368 PTZ00368
universal minicircle sequence binding protein (UMSBP); Provisional
1297-1379 4.69e-06

universal minicircle sequence binding protein (UMSBP); Provisional


Pssm-ID: 173561 [Multi-domain]  Cd Length: 148  Bit Score: 48.26  E-value: 4.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1297 SRVLTDGELAPNDRCCRVCGKIGHYMKDCPKRKSllfrlkkkdseeekegneeekdsrdllDSRDLRCFICGDAGHVRRE 1376
Cdd:PTZ00368    40 SRECPSAPGGRGERSCYNCGKTGHLSRECPEAPP---------------------------GSGPRSCYNCGQTGHISRE 92

                   ...
gi 1829778958 1377 CPE 1379
Cdd:PTZ00368    93 CPN 95
AIR1 COG5082
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational ...
1293-1381 7.72e-05

Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227414 [Multi-domain]  Cd Length: 190  Bit Score: 45.23  E-value: 7.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1293 YFFDSRVLTDGELAPND-RCCRVCGKIGHYMKDCPKRksllfrlkkkdseeeKEGNEEEKDSRDLLDSRDLRCFICGDAG 1371
Cdd:COG5082     43 GRYEDRSVEDVSAIREEnPVCFNCGQNGHLRRDCPHS---------------ICYNCSWDGHRSNHCPKPKKCYNCGETG 107
                           90
                   ....*....|
gi 1829778958 1372 HVRRECPEVK 1381
Cdd:COG5082    108 HLSRDCNPSK 117
PTZ00368 PTZ00368
universal minicircle sequence binding protein (UMSBP); Provisional
1297-1380 1.11e-04

universal minicircle sequence binding protein (UMSBP); Provisional


Pssm-ID: 173561 [Multi-domain]  Cd Length: 148  Bit Score: 44.03  E-value: 1.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958 1297 SRVLTDGELAP--NDRCCRVCGKIGHYMKDCPKRKSllfrlkkkdseeekegneeekdsrdllDSRDLRCFICGDAGHVR 1374
Cdd:PTZ00368    13 SRECPNSAPAGaaKARPCYKCGEPGHLSRECPSAPG---------------------------GRGERSCYNCGKTGHLS 65

                   ....*.
gi 1829778958 1375 RECPEV 1380
Cdd:PTZ00368    66 RECPEA 71
rad2 TIGR00600
DNA excision repair protein (rad2); All proteins in this family for which functions are known ...
2-366 1.59e-04

DNA excision repair protein (rad2); All proteins in this family for which functions are known are flap endonucleases that generate the 3' incision next to DNA damage as part of nucleotide excision repair. This family is related to many other flap endonuclease families including the fen1 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273166 [Multi-domain]  Cd Length: 1034  Bit Score: 46.43  E-value: 1.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958    2 EEPKTSKNENHEPKKNIICEESKAVKIIS----NQTLKPRNDKSEIGTSSLNRNSSKKTK----------------QNDI 61
Cdd:TIGR00600  367 DSDESEWERQELKRNNVAFVDDGSLSPRTlqaiGQALDDDEDKKVSASSDDQASPSKKTKmllisrievedddldyLDQG 446
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958   62 CIEKTEAKSCKVNAASVPGPKDLGLVHRDQSHCKMKKLPNSPMKAQKGSSQTKLEKTPS--LQTKAEKVPKSPNLPVKAE 139
Cdd:TIGR00600  447 EGIPLMAALQLSSVNSKPEAVASTKIAREVTSSGHEAVPKAVQSLLLGATNDSPIPSEFtiLDRKSELSIERTVKPVSSE 526
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  140 KAPCTTAEAT----TEKALNSQRKEENTPTSqmkLQKTPRSPLEPENVPSLLLKEnvKQTESQQTGKKLTSSFVSMDkrk 215
Cdd:TIGR00600  527 FGLPSQREDKlaipTEGTQNLQGISDHPEQF---EFQNELSPLETKNNESNLSSD--AETEGSPNPEMPSWSSVTVP--- 598
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  216 SEALQG-EKSALENSSLSQKQQ---TQTDNIADSDDSASGIEDTADDLSKMKSEESNKENSS-EMDYL---ENATVIDES 287
Cdd:TIGR00600  599 SEALDNyETTNPSNAKEVRNFAetgIQTTNVGESADLLLISNPMEVEPMESEKEESESDGSFiEVDSVsstLELQVPSKS 678
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  288 ALTPEQRLGLKQAEERLERDH---IFRLEKRSPEytncrylcklclihIENIQGAHKHIKEKRHKKNILEKQEESELRSL 364
Cdd:TIGR00600  679 QPTDESEENAENKVASIEGEHrkeIEDLLFDESE--------------EDNIVGMIEEEKDADDFKNEWQDISLEELEAL 744

                   ..
gi 1829778958  365 PS 366
Cdd:TIGR00600  745 EA 746
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
101-207 2.87e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 41.96  E-value: 2.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  101 NSPMKAQKGSSQTKLEKTPSLQTKAEKVPKSPnlPVKAEKAPCTTAEATTEKALNSQRKEENTPTSQMKLQ-KTPRSPLE 179
Cdd:pfam05539  199 PATQGHQTATANQRLSSTEPVGTQGTTTSSNP--EPQTEPPPSQRGPSGSPQHPPSTTSQDQSTTGDGQEHtQRRKTPPA 276
                           90       100
                   ....*....|....*....|....*...
gi 1829778958  180 PENVPSLLLKENVKQTESQQTGKKLTSS 207
Cdd:pfam05539  277 TSNRRSPHSTATPPPTTKRQETGRPTPR 304
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
15-274 7.59e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.19  E-value: 7.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958   15 KKNIICEESKAVKIIsnqtLKPRNDKSEIGTSSLNRNSSKKTKQndiciektEAKSCKVNAASVPGPKDLGLVHRDQSHC 94
Cdd:PTZ00108  1138 EEALEEQEEVEEKEI----AKEQRLKSKTKGKASKLRKPKLKKK--------EKKKKKSSADKSKKASVVGNSKRVDSDE 1205
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958   95 KMKKLPNSPMKAQKGSSQTKLEKTPSLQTKAEKVPKSPNLPVKAEKApctTAEATTEKALNSQRKEENTPTSQMKLQKTP 174
Cdd:PTZ00108  1206 KRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSK---SSEDNDEFSSDDLSKEGKPKNAPKRVSAVQ 1282
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778958  175 RSPLEPENVP------SLLLKENVKQTESQQTGKKLTSSFVSMDKRKSEALQGEKSALENSSLSQKQQTQTDNIADSDDS 248
Cdd:PTZ00108  1283 YSPPPPSKRPdgesngGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSD 1362
                          250       260
                   ....*....|....*....|....*.
gi 1829778958  249 ASGIEDTADDLSKMKSEESNKENSSE 274
Cdd:PTZ00108  1363 SSSEDDDDSEVDDSEDEDDEDDEDDD 1388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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