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Conserved domains on  [gi|1832602290|ref|NP_001368829|]
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zinc finger protein 711 isoform 2 [Mus musculus]

Protein Classification

Zfx_Zfy_act and COG5048 domain-containing protein( domain architecture ID 12057209)

Zfx_Zfy_act and COG5048 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
65-367 1.94e-108

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 333.75  E-value: 1.94e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290  65 GLAAEVVHGPDIITETDVVtEGVIVPEAVLEADVAIEED-LEEDDGDHILTSELITETVRVPEQVFVADLVSGPD-GHLE 142
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVS-EGVIIPEQVLDSEVAIEVSlDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEvGHLE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 143 HVVQDC----VSGVDSPTMVSEEVLVTNSDTETVIQAgggvpgSTVTIKTEEDDdddvKSTSEDYLMISLDDvGEKLEHM 218
Cdd:pfam04704  80 HVIHDSereiVTDALTADMVSEEVLVADCASEAVIDA------SGVPLETQDDD----KSNCEDYLMISLDD-GEKLDHI 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 219 GNTPLKIASDGSQEDVKEDAFGSEVIKVYIFKAEAEDDvEIGGTEIVTESEYSSGHSVaGVLDQS---RMQREKMVYMAV 295
Cdd:pfam04704 149 GSTPLTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGED-DLGGTEDIVESEFENGHGV-LLLEQGssgRLPREKMVYMAV 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 296 KDSSQEQDDINERRVSRR-YEEC------------------------------QAPGNTFDsALENRNTTAAQYLQICDS 344
Cdd:pfam04704 227 KDSQQEDEDLNVAEIADEvYMEVivgeedaavaheqqlddsevnktfmpiawaAAYGNNTD-GIENKNGTASALLHIDES 305
                         330       340
                  ....*....|....*....|...
gi 1832602290 345 MNTNKVLKQKIKKRRRGETRQWQ 367
Cdd:pfam04704 306 ASLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
380-760 8.10e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 8.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 380 TVYPCHICTKKFKSRGFLKRHMKNHPDHlmrKKYQCTDCDFTTNKKvsfhNHLESHKLINKVDKTHEFTEYTRRYREASP 459
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGE---KPSQCSYSGCDKSFS----RPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 460 LSSNKLIL----RDKEPKMHKCKYCDyetaEQGLLNRHLLAVHSKSFPHVCVEC-GKGFRHPSELKKHMR---------- 524
Cdd:COG5048   105 ASSSSLSSsssnSNDNNLLSSHSLPP----SSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPlpanslskdp 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 525 ------------THTGEKPYQCQYCAFRcADQSNLKTHIKSKHgSNLPYKCEHCPQAFGDERELQRHLDLFQGHKTHQCP 592
Cdd:COG5048   181 ssnlsllissnvSTSIPSSSENSPLSSS-YSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 593 HCDHKSTNSSDLKRHIISVH------TKDFPHKCEVCDKGFHRPSELKKH--SDIH--KGRKIHQCRH--CDFKTSDPFI 660
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESdsssekGFSLPIKSKQCNISFSRSSPLTRHlrSVNHsgESLKPFSCPYslCGKLFSRNDA 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 661 LSGHILsVHTKDQSLKCKRCKRGFRQQNELKK-------HMKTHTGRKIYQCEY--CEYSTTDASGFKRHvISIHTKDYP 731
Cdd:COG5048   339 LKRHIL-LHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRP 416
                         410       420       430
                  ....*....|....*....|....*....|.
gi 1832602290 732 HRCEF--CKKGFRRPSEKKQHiMRHHKETLM 760
Cdd:COG5048   417 YNCKNppCSKSFNRHYNLIPH-KKIHTNHAP 446
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
65-367 1.94e-108

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 333.75  E-value: 1.94e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290  65 GLAAEVVHGPDIITETDVVtEGVIVPEAVLEADVAIEED-LEEDDGDHILTSELITETVRVPEQVFVADLVSGPD-GHLE 142
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVS-EGVIIPEQVLDSEVAIEVSlDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEvGHLE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 143 HVVQDC----VSGVDSPTMVSEEVLVTNSDTETVIQAgggvpgSTVTIKTEEDDdddvKSTSEDYLMISLDDvGEKLEHM 218
Cdd:pfam04704  80 HVIHDSereiVTDALTADMVSEEVLVADCASEAVIDA------SGVPLETQDDD----KSNCEDYLMISLDD-GEKLDHI 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 219 GNTPLKIASDGSQEDVKEDAFGSEVIKVYIFKAEAEDDvEIGGTEIVTESEYSSGHSVaGVLDQS---RMQREKMVYMAV 295
Cdd:pfam04704 149 GSTPLTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGED-DLGGTEDIVESEFENGHGV-LLLEQGssgRLPREKMVYMAV 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 296 KDSSQEQDDINERRVSRR-YEEC------------------------------QAPGNTFDsALENRNTTAAQYLQICDS 344
Cdd:pfam04704 227 KDSQQEDEDLNVAEIADEvYMEVivgeedaavaheqqlddsevnktfmpiawaAAYGNNTD-GIENKNGTASALLHIDES 305
                         330       340
                  ....*....|....*....|...
gi 1832602290 345 MNTNKVLKQKIKKRRRGETRQWQ 367
Cdd:pfam04704 306 ASLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
380-760 8.10e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 8.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 380 TVYPCHICTKKFKSRGFLKRHMKNHPDHlmrKKYQCTDCDFTTNKKvsfhNHLESHKLINKVDKTHEFTEYTRRYREASP 459
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGE---KPSQCSYSGCDKSFS----RPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 460 LSSNKLIL----RDKEPKMHKCKYCDyetaEQGLLNRHLLAVHSKSFPHVCVEC-GKGFRHPSELKKHMR---------- 524
Cdd:COG5048   105 ASSSSLSSsssnSNDNNLLSSHSLPP----SSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPlpanslskdp 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 525 ------------THTGEKPYQCQYCAFRcADQSNLKTHIKSKHgSNLPYKCEHCPQAFGDERELQRHLDLFQGHKTHQCP 592
Cdd:COG5048   181 ssnlsllissnvSTSIPSSSENSPLSSS-YSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 593 HCDHKSTNSSDLKRHIISVH------TKDFPHKCEVCDKGFHRPSELKKH--SDIH--KGRKIHQCRH--CDFKTSDPFI 660
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESdsssekGFSLPIKSKQCNISFSRSSPLTRHlrSVNHsgESLKPFSCPYslCGKLFSRNDA 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 661 LSGHILsVHTKDQSLKCKRCKRGFRQQNELKK-------HMKTHTGRKIYQCEY--CEYSTTDASGFKRHvISIHTKDYP 731
Cdd:COG5048   339 LKRHIL-LHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRP 416
                         410       420       430
                  ....*....|....*....|....*....|.
gi 1832602290 732 HRCEF--CKKGFRRPSEKKQHiMRHHKETLM 760
Cdd:COG5048   417 YNCKNppCSKSFNRHYNLIPH-KKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-542 3.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.09e-04
                          10        20
                  ....*....|....*....|....*
gi 1832602290 518 ELKKHMRTHTGEKPYQCQYCAFRCA 542
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
65-367 1.94e-108

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 333.75  E-value: 1.94e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290  65 GLAAEVVHGPDIITETDVVtEGVIVPEAVLEADVAIEED-LEEDDGDHILTSELITETVRVPEQVFVADLVSGPD-GHLE 142
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVS-EGVIIPEQVLDSEVAIEVSlDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEvGHLE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 143 HVVQDC----VSGVDSPTMVSEEVLVTNSDTETVIQAgggvpgSTVTIKTEEDDdddvKSTSEDYLMISLDDvGEKLEHM 218
Cdd:pfam04704  80 HVIHDSereiVTDALTADMVSEEVLVADCASEAVIDA------SGVPLETQDDD----KSNCEDYLMISLDD-GEKLDHI 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 219 GNTPLKIASDGSQEDVKEDAFGSEVIKVYIFKAEAEDDvEIGGTEIVTESEYSSGHSVaGVLDQS---RMQREKMVYMAV 295
Cdd:pfam04704 149 GSTPLTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGED-DLGGTEDIVESEFENGHGV-LLLEQGssgRLPREKMVYMAV 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 296 KDSSQEQDDINERRVSRR-YEEC------------------------------QAPGNTFDsALENRNTTAAQYLQICDS 344
Cdd:pfam04704 227 KDSQQEDEDLNVAEIADEvYMEVivgeedaavaheqqlddsevnktfmpiawaAAYGNNTD-GIENKNGTASALLHIDES 305
                         330       340
                  ....*....|....*....|...
gi 1832602290 345 MNTNKVLKQKIKKRRRGETRQWQ 367
Cdd:pfam04704 306 ASLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
380-760 8.10e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 8.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 380 TVYPCHICTKKFKSRGFLKRHMKNHPDHlmrKKYQCTDCDFTTNKKvsfhNHLESHKLINKVDKTHEFTEYTRRYREASP 459
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGE---KPSQCSYSGCDKSFS----RPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 460 LSSNKLIL----RDKEPKMHKCKYCDyetaEQGLLNRHLLAVHSKSFPHVCVEC-GKGFRHPSELKKHMR---------- 524
Cdd:COG5048   105 ASSSSLSSsssnSNDNNLLSSHSLPP----SSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPlpanslskdp 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 525 ------------THTGEKPYQCQYCAFRcADQSNLKTHIKSKHgSNLPYKCEHCPQAFGDERELQRHLDLFQGHKTHQCP 592
Cdd:COG5048   181 ssnlsllissnvSTSIPSSSENSPLSSS-YSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 593 HCDHKSTNSSDLKRHIISVH------TKDFPHKCEVCDKGFHRPSELKKH--SDIH--KGRKIHQCRH--CDFKTSDPFI 660
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESdsssekGFSLPIKSKQCNISFSRSSPLTRHlrSVNHsgESLKPFSCPYslCGKLFSRNDA 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 661 LSGHILsVHTKDQSLKCKRCKRGFRQQNELKK-------HMKTHTGRKIYQCEY--CEYSTTDASGFKRHvISIHTKDYP 731
Cdd:COG5048   339 LKRHIL-LHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRP 416
                         410       420       430
                  ....*....|....*....|....*....|.
gi 1832602290 732 HRCEF--CKKGFRRPSEKKQHiMRHHKETLM 760
Cdd:COG5048   417 YNCKNppCSKSFNRHYNLIPH-KKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-542 3.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.09e-04
                          10        20
                  ....*....|....*....|....*
gi 1832602290 518 ELKKHMRTHTGEKPYQCQYCAFRCA 542
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
689-713 3.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.66e-04
                          10        20
                  ....*....|....*....|....*
gi 1832602290 689 ELKKHMKTHTGRKIYQCEYCEYSTT 713
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
504-526 6.19e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 6.19e-04
                          10        20
                  ....*....|....*....|...
gi 1832602290 504 HVCVECGKGFRHPSELKKHMRTH 526
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
537-655 1.62e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 41.54  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 537 CAFRCADQSNLKTHIKSKHGSNLPYKCEHCPQAFGDERELQRHLDL------------FQGHKthQCPHCDHKSTNSSDL 604
Cdd:COG5236   159 CHRRCGSLKELKKHYKAQHGFVLCSECIGNKKDFWNEIRLFRSSTLrdhknggleeegFKGHP--LCIFCKIYFYDDDEL 236
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1832602290 605 KRHIISVHtkdfpHKCEVCDK-GFHRPSELKKHSDIHKG-RKIHQCrhCDFKT 655
Cdd:COG5236   237 RRHCRLRH-----EACHICDMvGPIRYQYFKSYEDLEAHfRNAHYC--CTFQT 282
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
598-711 5.48e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 5.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832602290 598 STNSSDLKRHIISVHTKDFPHKCEVCDKGFHRPSELKKHSDIHKGRKIHQCRH--CDFKTSDPFILSGHILSVHTKDQSL 675
Cdd:COG5048    14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDL 93
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1832602290 676 KCKRCKRGFRQQNELKKHMKTHTGRKIYQCEYCEYS 711
Cdd:COG5048    94 NSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLP 129
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
382-404 6.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.85e-03
                          10        20
                  ....*....|....*....|...
gi 1832602290 382 YPCHICTKKFKSRGFLKRHMKNH 404
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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