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Conserved domains on  [gi|1833303483|ref|NP_001368871|]
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thrombospondin-2 isoform 5 [Homo sapiens]

Protein Classification

TSP1 and TSP_C domain-containing protein( domain architecture ID 10430205)

protein containing domains VWC, TSP_1, TSP1, and TSP_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 897-1094 1.18e-122

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 373.89  E-value: 1.18e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303483  897 QIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ 976
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303483  977 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQV 1056
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1833303483 1057 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1094
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1-138 1.15e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member smart00210:

Pssm-ID: 473984  Cd Length: 184  Bit Score: 142.50  E-value: 1.15e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303483     1 MRQKEGFFLTAQLKQDGKSRGTLLALEGPgLSQRQFEIVSNGPADTLDLTY-WIDGTRHVVSLEDVGLADSQWKNVTVQV 79
Cdd:smart00210   48 SGLPEDFSLLTTFRQTPKSRGVLFAIYDA-QNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSV 126

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1833303483    80 AGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSAREsHFRGLLQNVHLVFEN 138
Cdd:smart00210  127 SGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVCDP 184
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 243-297 3.18e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 76.69  E-value: 3.18e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1833303483  243 CWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASP--SFVEGECCPSC 297
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 420-472 1.13e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 74.93  E-value: 1.13e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483   420 WSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 472
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 363-415 2.39e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 73.78  E-value: 2.39e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483   363 WSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCP 415
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
308-353 4.73e-13

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.36  E-value: 4.73e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1833303483  308 SPWAEWTQCSVTCGSGTQQRGRSCDVT---SNTCLGPSIQTRACSLSKC 353
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 770-807 1.34e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 54.29  E-value: 1.34e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1833303483  770 TDVDNDLVGDQCDNneDIDDDGHQNNQDNCPYISNANQ 807
Cdd:pfam02412    1 TDSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 712-746 5.10e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.67  E-value: 5.10e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1833303483  712 DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQ 746
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 575-614 5.03e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 5.03e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1833303483  575 CKDKTHNCHKHAECIYlghfSDPMYKCECQTGYAGDGLIC 614
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 897-1094 1.18e-122

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 373.89  E-value: 1.18e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303483  897 QIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ 976
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303483  977 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQV 1056
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1833303483 1057 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1094
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 1-138 1.15e-38

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 142.50  E-value: 1.15e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303483     1 MRQKEGFFLTAQLKQDGKSRGTLLALEGPgLSQRQFEIVSNGPADTLDLTY-WIDGTRHVVSLEDVGLADSQWKNVTVQV 79
Cdd:smart00210   48 SGLPEDFSLLTTFRQTPKSRGVLFAIYDA-QNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSV 126

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1833303483    80 AGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSAREsHFRGLLQNVHLVFEN 138
Cdd:smart00210  127 SGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVCDP 184
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 243-297 3.18e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 76.69  E-value: 3.18e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1833303483  243 CWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASP--SFVEGECCPSC 297
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 420-472 1.13e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 74.93  E-value: 1.13e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483   420 WSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 472
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 363-415 2.39e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 73.78  E-value: 2.39e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483   363 WSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCP 415
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
421-471 1.33e-15

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 71.68  E-value: 1.33e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1833303483  421 SPWSPWSACTVTCAGGIRERTRVCNSPEPqyGGKACVGDVQERQMCNKRSC 471
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
364-414 1.22e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 68.98  E-value: 1.22e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1833303483  364 SHWSPWSSCSVTCGVGNITRIRLCNSPVPqmGGKNCKGSGRETKACQGAPC 414
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
243-297 3.70e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 67.93  E-value: 3.70e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1833303483   243 CWQDGRFFAENETWVVDSCTTCTCKKFKTI-CHQITCPPAT-CASPS--FVEGECCPSC 297
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
308-353 4.73e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.36  E-value: 4.73e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1833303483  308 SPWAEWTQCSVTCGSGTQQRGRSCDVT---SNTCLGPSIQTRACSLSKC 353
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 307-354 1.64e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 60.29  E-value: 1.64e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483   307 WSPWAEWTQCSVTCGSGTQQRGRSCDVTSNT-----CLGPSIQTRACSLSKCD 354
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 770-807 1.34e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 54.29  E-value: 1.34e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1833303483  770 TDVDNDLVGDQCDNneDIDDDGHQNNQDNCPYISNANQ 807
Cdd:pfam02412    1 TDSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 712-746 5.10e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.67  E-value: 5.10e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1833303483  712 DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQ 746
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 575-614 5.03e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 5.03e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1833303483  575 CKDKTHNCHKHAECIYlghfSDPMYKCECQTGYAGDGLIC 614
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 309-329 1.15e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.03  E-value: 1.15e-03
                           10        20
                   ....*....|....*....|.
gi 1833303483  309 PWAEWTQCSVTCGSGTQQRGR 329
Cdd:PTZ00441   242 PWDEWTPCSVTCGKGTHSRSR 262
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 422-474 3.39e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.49  E-value: 3.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483  422 PWSPWSACTVTCAGGIRERTRvcnsPEPQYGgkaCVGDVQERqmCNKRSCPVD 474
Cdd:PTZ00441   242 PWDEWTPCSVTCGKGTHSRSR----PILHEG---CTTHMVEE--CEEEECPVE 285
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 897-1094 1.18e-122

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 373.89  E-value: 1.18e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303483  897 QIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ 976
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303483  977 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQV 1056
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1833303483 1057 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1094
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 1-138 1.15e-38

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 142.50  E-value: 1.15e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303483     1 MRQKEGFFLTAQLKQDGKSRGTLLALEGPgLSQRQFEIVSNGPADTLDLTY-WIDGTRHVVSLEDVGLADSQWKNVTVQV 79
Cdd:smart00210   48 SGLPEDFSLLTTFRQTPKSRGVLFAIYDA-QNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSV 126

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1833303483    80 AGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSAREsHFRGLLQNVHLVFEN 138
Cdd:smart00210  127 SGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVCDP 184
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 243-297 3.18e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 76.69  E-value: 3.18e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1833303483  243 CWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASP--SFVEGECCPSC 297
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 420-472 1.13e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 74.93  E-value: 1.13e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483   420 WSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 472
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 363-415 2.39e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 73.78  E-value: 2.39e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483   363 WSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCP 415
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
421-471 1.33e-15

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 71.68  E-value: 1.33e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1833303483  421 SPWSPWSACTVTCAGGIRERTRVCNSPEPqyGGKACVGDVQERQMCNKRSC 471
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
364-414 1.22e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 68.98  E-value: 1.22e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1833303483  364 SHWSPWSSCSVTCGVGNITRIRLCNSPVPqmGGKNCKGSGRETKACQGAPC 414
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
243-297 3.70e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 67.93  E-value: 3.70e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1833303483   243 CWQDGRFFAENETWVVDSCTTCTCKKFKTI-CHQITCPPAT-CASPS--FVEGECCPSC 297
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
308-353 4.73e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.36  E-value: 4.73e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1833303483  308 SPWAEWTQCSVTCGSGTQQRGRSCDVT---SNTCLGPSIQTRACSLSKC 353
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 307-354 1.64e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 60.29  E-value: 1.64e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483   307 WSPWAEWTQCSVTCGSGTQQRGRSCDVTSNT-----CLGPSIQTRACSLSKCD 354
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 421-471 2.84e-10

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 56.52  E-value: 2.84e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1833303483  421 SPWSPWSACTVTCAGGIRERTRVCNSPePQYGGKACvGDVQERQMCNKRSC 471
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 770-807 1.34e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 54.29  E-value: 1.34e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1833303483  770 TDVDNDLVGDQCDNneDIDDDGHQNNQDNCPYISNANQ 807
Cdd:pfam02412    1 TDSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 364-414 6.82e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 52.67  E-value: 6.82e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1833303483  364 SHWSPWSSCSVTCGVGNITRIRLCNSPvPQMGGKNCkGSGRETKACQGAPC 414
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 712-746 5.10e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.67  E-value: 5.10e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1833303483  712 DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQ 746
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 575-614 5.03e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 5.03e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1833303483  575 CKDKTHNCHKHAECIYlghfSDPMYKCECQTGYAGDGLIC 614
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 308-353 2.52e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 2.52e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1833303483  308 SPWAEWTQCSVTCGSGTQQR-----------GRSCdvtsntclGPSIQTRACSLSKC 353
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRtrtvivepqngGRPC--------PELLERRPCNLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 368-414 5.00e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.97  E-value: 5.00e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1833303483  368 PWSSCSVTCGVGNITRIRLCNSPVPQ--MGGKNCKGSGR--ETKACQGAPC 414
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 309-329 1.15e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.03  E-value: 1.15e-03
                           10        20
                   ....*....|....*....|.
gi 1833303483  309 PWAEWTQCSVTCGSGTQQRGR 329
Cdd:PTZ00441   242 PWDEWTPCSVTCGKGTHSRSR 262
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 422-474 3.39e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.49  E-value: 3.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1833303483  422 PWSPWSACTVTCAGGIRERTRvcnsPEPQYGgkaCVGDVQERqmCNKRSCPVD 474
Cdd:PTZ00441   242 PWDEWTPCSVTCGKGTHSRSR----PILHEG---CTTHMVEE--CEEEECPVE 285
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 425-471 6.05e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.89  E-value: 6.05e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1833303483  425 PWSACTVTCAGGIRERTRVCNspepQYGGKACVGDVQ--------ERQMCNKRSC 471
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCV----QKGGGSIVPDSEcsaqkkppETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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