NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1843978494|ref|NP_001369693|]
View 

fibrinogen beta chain isoform 8 preproprotein [Homo sapiens]

Protein Classification

Fib_alpha and FReD domain-containing protein( domain architecture ID 10554875)

Fib_alpha and FReD domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 91-234 3.34e-67

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


:

Pssm-ID: 462570  Cd Length: 143  Bit Score: 208.16  E-value: 3.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494  91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVN 170
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978494 171 EYSSELEKHQLYIDETVNSNIpTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIP 234
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQE-SNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
FReD super family cl00085
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 238-359 1.68e-56

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


The actual alignment was detected with superfamily member cd00087:

Pssm-ID: 412152 [Multi-domain]  Cd Length: 215  Bit Score: 183.60  E-value: 1.68e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494 238 GKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknycg 317
Cdd:cd00087     3 PRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD---------- 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1843978494 318 lpGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGF 359
Cdd:cd00087    73 --GEFWLGLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSF 112
 
Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 91-234 3.34e-67

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 208.16  E-value: 3.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494  91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVN 170
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978494 171 EYSSELEKHQLYIDETVNSNIpTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIP 234
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQE-SNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 238-359 1.68e-56

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 183.60  E-value: 1.68e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494 238 GKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknycg 317
Cdd:cd00087     3 PRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD---------- 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1843978494 318 lpGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGF 359
Cdd:cd00087    73 --GEFWLGLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSF 112
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 237-360 4.27e-55

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 179.78  E-value: 4.27e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494  237 SGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknyc 316
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA--------- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1843978494  317 glpGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFT 360
Cdd:smart00186  72 ---GEFWLGNENIHLLTSQGKYELRIDLEDWEGNTAYALYDSFK 112
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
237-360 3.01e-54

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 178.10  E-value: 3.01e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494 237 SGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknyc 316
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLS--------- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1843978494 317 glPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFT 360
Cdd:pfam00147  72 --PGEFWLGNDKIHLLTKQGPYVLRIDLEDWNGETVFALYDSFK 113
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 241-282 1.12e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 50.64  E-value: 1.12e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1843978494 241 CEEIIRKGGET-SEMYLIQPDSS--VKPYRVYCDMNTENGGWTVI 282
Cdd:NF040941    2 CWEILQAGPSApSGVYWIDPDGMggLAPFQVYCDMTTDGGGWTLV 46
 
Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 91-234 3.34e-67

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 208.16  E-value: 3.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494  91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVN 170
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978494 171 EYSSELEKHQLYIDETVNSNIpTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIP 234
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQE-SNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 238-359 1.68e-56

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 183.60  E-value: 1.68e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494 238 GKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknycg 317
Cdd:cd00087     3 PRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD---------- 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1843978494 318 lpGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGF 359
Cdd:cd00087    73 --GEFWLGLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSF 112
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 237-360 4.27e-55

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 179.78  E-value: 4.27e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494  237 SGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknyc 316
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA--------- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1843978494  317 glpGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFT 360
Cdd:smart00186  72 ---GEFWLGNENIHLLTSQGKYELRIDLEDWEGNTAYALYDSFK 112
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
237-360 3.01e-54

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 178.10  E-value: 3.01e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978494 237 SGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknyc 316
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLS--------- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1843978494 317 glPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFT 360
Cdd:pfam00147  72 --PGEFWLGNDKIHLLTKQGPYVLRIDLEDWNGETVFALYDSFK 113
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 241-282 1.12e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 50.64  E-value: 1.12e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1843978494 241 CEEIIRKGGET-SEMYLIQPDSS--VKPYRVYCDMNTENGGWTVI 282
Cdd:NF040941    2 CWEILQAGPSApSGVYWIDPDGMggLAPFQVYCDMTTDGGGWTLV 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH