NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1847688283|ref|NP_001371065|]
View 

solute carrier family 12 member 1 isoform B [Homo sapiens]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
104-1099 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1480.34  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  104 NTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAEN----KEDDQAGVVKFGW 179
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  180 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLAVTVTGITGLSTSAIATNGCVRGGGAYYLISRSLGPEFGGS 259
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  260 IGLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAI 338
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  339 ANFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPRFTKGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTML 417
Cdd:TIGR00930  241 LNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  418 AIFITTVAYLGVAICVGACVVRDATGNMNDTIISgmnCNGSAACglgydFSRCRHEPCQYGLMNNFQVMSMVSGFGPLIT 497
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLIT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  498 AGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLA 577
Cdd:TIGR00930  392 AGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLA 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  578 SYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQA 657
Cdd:TIGR00930  472 SYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQA 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  658 LSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 737
Cdd:TIGR00930  552 LSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQT 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  738 WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQ 817
Cdd:TIGR00930  632 WLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSE 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  818 GFDISqVLQVQEELErleqerlaleatikdNECEEESggirglfkkagklnitktTPKKDGSINTSQSMHvgefnqklVE 897
Cdd:TIGR00930  712 GLPIS-VLQVQEELE---------------NDCSEDS------------------IELNDGKISTQPDMH--------LE 749
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  898 ASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIVMASLLSKFRIKFADIHII 976
Cdd:TIGR00930  750 ASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVL 829
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  977 GDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAE-KLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVL 1055
Cdd:TIGR00930  830 MDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVL 909
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 1847688283 1056 SLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:TIGR00930  910 SLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
104-1099 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1480.34  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  104 NTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAEN----KEDDQAGVVKFGW 179
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  180 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLAVTVTGITGLSTSAIATNGCVRGGGAYYLISRSLGPEFGGS 259
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  260 IGLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAI 338
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  339 ANFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPRFTKGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTML 417
Cdd:TIGR00930  241 LNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  418 AIFITTVAYLGVAICVGACVVRDATGNMNDTIISgmnCNGSAACglgydFSRCRHEPCQYGLMNNFQVMSMVSGFGPLIT 497
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLIT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  498 AGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLA 577
Cdd:TIGR00930  392 AGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLA 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  578 SYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQA 657
Cdd:TIGR00930  472 SYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQA 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  658 LSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 737
Cdd:TIGR00930  552 LSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQT 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  738 WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQ 817
Cdd:TIGR00930  632 WLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSE 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  818 GFDISqVLQVQEELErleqerlaleatikdNECEEESggirglfkkagklnitktTPKKDGSINTSQSMHvgefnqklVE 897
Cdd:TIGR00930  712 GLPIS-VLQVQEELE---------------NDCSEDS------------------IELNDGKISTQPDMH--------LE 749
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  898 ASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIVMASLLSKFRIKFADIHII 976
Cdd:TIGR00930  750 ASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVL 829
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  977 GDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAE-KLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVL 1055
Cdd:TIGR00930  830 MDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVL 909
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 1847688283 1056 SLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:TIGR00930  910 SLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
694-1099 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 596.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  694 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 773
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  774 PNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEE 853
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEELGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  854 SGGIRGLFKKAGK---------LNITKTTPKKDGSINTSQSMHVGEF--------NQKLVEASTQFKKKQEKGTIDVWWL 916
Cdd:pfam03522  159 SNSKQDDDKSKLSkkdsnlslsPDKSTKNPSGKDSSKSDKLKKKSPSiilrtasnEKEILNNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  917 FDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMI 995
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  996 EPYRLHESCKDLttaeklkrETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLE 1075
Cdd:pfam03522  319 EPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....
gi 1847688283 1076 ILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:pfam03522  391 TLTKDLPPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
219-649 1.22e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 135.41  E-value: 1.22e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  219 AVTVTGITGLSTSAIATNgCVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLkesdsmmvdPT 298
Cdd:COG0531     53 AGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYVLAVAAVAVAFGGYLSSLF---------PA 122
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  299 NDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGtvipsnnekksrGFFNYQASIFAeNFGPRFTKGE 378
Cdd:COG0531    123 GGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV------------GLFAFDPANFT-PFLPAGGGLS 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  379 GFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIisgmncngs 458
Cdd:COG0531    190 GVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVSLALTGVVPYDELAASGAPL--------- 260
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  459 aacglgydfsrcrhepcqyglmnnFQVMSMVSG--FGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIykALQFFAK 536
Cdd:COG0531    261 ------------------------ADAAEAVFGpwGAILIALGALLSLLGALNASILGASRLLYAMARDGL--LPKVFAK 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  537 GYGKNNEPLRGYILTFLIAMAFILI--AELNTIAPIISNFFLASYALINFSCFHASYaKSPGWRPAYGIYNMWVSLFGAV 614
Cdd:COG0531    315 VHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVLRR-RRPDLPRPFRVPLPLIPILGIL 393
                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1847688283  615 LCCAVMFVINWWA---AVITYVIEFFLYVYVTCKKPDV 649
Cdd:COG0531    394 LCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
104-1099 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1480.34  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  104 NTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAEN----KEDDQAGVVKFGW 179
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  180 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLAVTVTGITGLSTSAIATNGCVRGGGAYYLISRSLGPEFGGS 259
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  260 IGLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAI 338
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  339 ANFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPRFTKGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTML 417
Cdd:TIGR00930  241 LNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  418 AIFITTVAYLGVAICVGACVVRDATGNMNDTIISgmnCNGSAACglgydFSRCRHEPCQYGLMNNFQVMSMVSGFGPLIT 497
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLIT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  498 AGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLA 577
Cdd:TIGR00930  392 AGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLA 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  578 SYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQA 657
Cdd:TIGR00930  472 SYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQA 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  658 LSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 737
Cdd:TIGR00930  552 LSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQT 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  738 WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQ 817
Cdd:TIGR00930  632 WLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSE 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  818 GFDISqVLQVQEELErleqerlaleatikdNECEEESggirglfkkagklnitktTPKKDGSINTSQSMHvgefnqklVE 897
Cdd:TIGR00930  712 GLPIS-VLQVQEELE---------------NDCSEDS------------------IELNDGKISTQPDMH--------LE 749
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  898 ASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIVMASLLSKFRIKFADIHII 976
Cdd:TIGR00930  750 ASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVL 829
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  977 GDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAE-KLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVL 1055
Cdd:TIGR00930  830 MDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVL 909
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 1847688283 1056 SLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:TIGR00930  910 SLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
694-1099 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 596.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  694 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 773
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  774 PNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEE 853
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEELGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  854 SGGIRGLFKKAGK---------LNITKTTPKKDGSINTSQSMHVGEF--------NQKLVEASTQFKKKQEKGTIDVWWL 916
Cdd:pfam03522  159 SNSKQDDDKSKLSkkdsnlslsPDKSTKNPSGKDSSKSDKLKKKSPSiilrtasnEKEILNNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  917 FDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMI 995
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  996 EPYRLHESCKDLttaeklkrETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLE 1075
Cdd:pfam03522  319 EPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....
gi 1847688283 1076 ILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:pfam03522  391 TLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
182-685 2.94e-119

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 375.50  E-value: 2.94e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  182 GVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLAVTVTGITGLSTSAIATNGcVRGGGAYYLISRSLGPEFGGSIG 261
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNG-PVSGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  262 L------IFAFANAVAVAMYVVGFAETVVDLLKESdsmmvdptndirIIGSITVVILLGISVAGMEWEAKAQVILLVILL 335
Cdd:pfam00324   80 WnywlswITVLALELTAASILIQFWELVPDIPYLW------------VWGAVFLVLLTIINLVGVKWYGEAEFWFALIKI 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  336 IAIANFFIGTVIPSNNEKKSRG--FFNYQASIFAENFGPRFTKGegFFSVFAIFFPAATGILAGANISGDLEDPQDAIPR 413
Cdd:pfam00324  148 IAIIGFIIVGIILLSGGNPNDGaiFRYLGDNGGKNNFPPGFGKG--FISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPK 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  414 GTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISgmncngsaacglgydfsrcrhepcqYGLMNNFQVMSMVSGFG 493
Cdd:pfam00324  226 AILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASA-------------------------ASPFVIFFKFLGISGLA 280
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  494 PLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKalqFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIapIISN 573
Cdd:pfam00324  281 PLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLALLLASLNPA--IVFN 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  574 FFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGS 653
Cdd:pfam00324  356 FLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGA 435
                          490       500       510
                   ....*....|....*....|....*....|..
gi 1847688283  654 STQALSYVSALDNALELTTVEDHVKNFRPQCI 685
Cdd:pfam00324  436 GSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
90-157 1.37e-36

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 132.18  E-value: 1.37e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283   90 DSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNV--AVTPSSADRVANGDG 157
Cdd:pfam08403    1 DTHGSTYYLQTFGHNTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKNSalAVAEGSVDGVENGDG 70
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
219-649 1.22e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 135.41  E-value: 1.22e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  219 AVTVTGITGLSTSAIATNgCVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLkesdsmmvdPT 298
Cdd:COG0531     53 AGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYVLAVAAVAVAFGGYLSSLF---------PA 122
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  299 NDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGtvipsnnekksrGFFNYQASIFAeNFGPRFTKGE 378
Cdd:COG0531    123 GGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV------------GLFAFDPANFT-PFLPAGGGLS 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  379 GFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIisgmncngs 458
Cdd:COG0531    190 GVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVSLALTGVVPYDELAASGAPL--------- 260
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  459 aacglgydfsrcrhepcqyglmnnFQVMSMVSG--FGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIykALQFFAK 536
Cdd:COG0531    261 ------------------------ADAAEAVFGpwGAILIALGALLSLLGALNASILGASRLLYAMARDGL--LPKVFAK 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  537 GYGKNNEPLRGYILTFLIAMAFILI--AELNTIAPIISNFFLASYALINFSCFHASYaKSPGWRPAYGIYNMWVSLFGAV 614
Cdd:COG0531    315 VHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVLRR-RRPDLPRPFRVPLPLIPILGIL 393
                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1847688283  615 LCCAVMFVINWWA---AVITYVIEFFLYVYVTCKKPDV 649
Cdd:COG0531    394 LCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
AA_permease_2 pfam13520
Amino acid permease;
240-643 2.95e-14

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 76.19  E-value: 2.95e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  240 RGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESdsmMVDPTNDIRIIGSITVVILLGISVAG 319
Cdd:pfam13520   60 RSGGIYVYLENAFGKFVAFLAGWSNWFAYVLGLASSASVAASYLLSALGPD---LVPTTWLTYGIAIAILIIFAIINIRG 136
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  320 MEWEAKAQVILLVILLIAIANFFIGTVIPsnneKKSRGFFNYqASIFAENFGPRFTKGegFFSVFAIFFPAATGILAGAN 399
Cdd:pfam13520  137 VRESAKIQNILGILKLLLPLILIIILGLV----TADGGGFNL-LSGEWHTFFPDGWPG--VFAGFLGVLWSFTGFESAAN 209
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  400 ISGdlEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGmncngsaacglgydfsrcrhepcqyGL 479
Cdd:pfam13520  210 VSE--EVKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEIALSSGLGQVA-------------------------AL 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  480 MNNFQVMSMVSGFgplITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKgYGKNNEPLRGYILTFLIAMAFI 559
Cdd:pfam13520  263 LFQAVGGKWGAII---VVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAK-VNKFGSPIRAIILTAILSLILL 338
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847688283  560 LI-----AELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRpaygIYNMWVSLFGAVLCCAVMFVINWWAAVITYVI 634
Cdd:pfam13520  339 LLfllspAAYNALLSLSAYGYLLSYLLPIIGLLILRKKRPDLGR----IPGRWPVAIFGILFSLFLIVALFFPPVGPATG 414

                   ....*....
gi 1847688283  635 EFFLYVYVT 643
Cdd:pfam13520  415 SSLNYAIIL 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH