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Conserved domains on  [gi|1847679010|ref|NP_001371082|]
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lymphocyte antigen 6 complex, locus G6G isoform 1 precursor [Mus musculus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 16-92 2.66e-21

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467072  Cd Length: 79  Bit Score: 80.54  E-value: 2.66e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1847679010  16 SLARALHCHVCCGHENCESLVECALTDKYCVITRATNPGGILVMKSCAPTCPNSTVS--SDGRALSVSCCQGSQCNRSA 92
Cdd:cd23542     1 GPANALQCHVCNSSSNCTNPVNCEGSERYCKTTTVVQPSGNLVKKGCAETCPPSTSRqqVGSGISSVTCCQGDLCNSKL 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 16-92 2.66e-21

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 80.54  E-value: 2.66e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1847679010  16 SLARALHCHVCCGHENCESLVECALTDKYCVITRATNPGGILVMKSCAPTCPNSTVS--SDGRALSVSCCQGSQCNRSA 92
Cdd:cd23542     1 GPANALQCHVCNSSSNCTNPVNCEGSERYCKTTTVVQPSGNLVKKGCAETCPPSTSRqqVGSGISSVTCCQGDLCNSKL 79
Toxin_TOLIP pfam00087
Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins ...
 21-89 4.70e-05

Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins and cytotoxins from snakes, but also structurally similar (non-snake) toxin-like proteins (TOLIPs) such as Lymphocyte antigen 6D and Ly6/PLAUR domain-containing protein. Snake toxins are short proteins with a compact, disulphide-rich structure. TOLIPs have similar structural features (abundance of spaced cysteine residues, a high frequency of charge residues, a signal peptide for secretion and a compact structure) but, are not associated with a venom gland or poisonous function. They are endogenous animal proteins that are not restricted to poisonous animals.


Pssm-ID: 395040  Cd Length: 70  Bit Score: 38.75  E-value: 4.70e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847679010  21 LHCHVCCGHENCESLVECALTDKYCVITRATNPGG-ILVMKSCAPTCPNSTVSSDGRALSVSCCQGSQCN 89
Cdd:pfam00087   1 LRCHNCAAAGNCVQPETCQDNTRYCLTLWNSPPGHrTHVIKGCAYTCPVTQESLNISRASDCCCETDLCN 70
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 16-92 2.66e-21

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 80.54  E-value: 2.66e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1847679010  16 SLARALHCHVCCGHENCESLVECALTDKYCVITRATNPGGILVMKSCAPTCPNSTVS--SDGRALSVSCCQGSQCNRSA 92
Cdd:cd23542     1 GPANALQCHVCNSSSNCTNPVNCEGSERYCKTTTVVQPSGNLVKKGCAETCPPSTSRqqVGSGISSVTCCQGDLCNSKL 79
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 20-89 5.22e-10

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 51.59  E-value: 5.22e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1847679010  20 ALHCHVCCGHE---NCESLVECALTDKYCVITRAT----NPGGILVMKSCAPTCPNSTVSSDGRALSVSCCQGSQCN 89
Cdd:cd23543     2 SLYCYTCENQSsnwNCLKPTKCSDNDKYCVTTVASggtgSSSGVRITKKCSPKCPETNVNIGIASVSTSCCQSSLCN 78
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 19-93 7.51e-07

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 43.48  E-value: 7.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847679010  19 RALHCHVCCG---HENCESLVECALTDKYC--VITRATNPGGIL--VMKSCAPTCPNSTVSSDGRALSVSCCQGSQCNRS 91
Cdd:cd23575     1 HSLKCYTCVSahsNSDCLTETNCSSSDTYCktLVASASGGSGSLttITKWCASSCTPSTRTVEGTKVTVSCCQTDLCNVS 80


                  ..
gi 1847679010  92 AA 93
Cdd:cd23575    81 GA 82
TFP_LU_ECD_Ly6M cd23552
extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar ...
 16-89 5.41e-06

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467082  Cd Length: 80  Bit Score: 41.38  E-value: 5.41e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1847679010  16 SLARALHCHVCCGHENCESLVECALTDKYCVITRATNPG-GILVMKSCAPTCPNSTVSSDgrALSVSCCQGSQCN 89
Cdd:cd23552     2 SSAQALKCHECKGIEDCYNPTSCNNQSRYCLTTWYTPPGeKTTVTKSCAYTCPDAPESLA--NSKASCCNTDLCN 74
Toxin_TOLIP pfam00087
Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins ...
 21-89 4.70e-05

Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins and cytotoxins from snakes, but also structurally similar (non-snake) toxin-like proteins (TOLIPs) such as Lymphocyte antigen 6D and Ly6/PLAUR domain-containing protein. Snake toxins are short proteins with a compact, disulphide-rich structure. TOLIPs have similar structural features (abundance of spaced cysteine residues, a high frequency of charge residues, a signal peptide for secretion and a compact structure) but, are not associated with a venom gland or poisonous function. They are endogenous animal proteins that are not restricted to poisonous animals.


Pssm-ID: 395040  Cd Length: 70  Bit Score: 38.75  E-value: 4.70e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847679010  21 LHCHVCCGHENCESLVECALTDKYCVITRATNPGG-ILVMKSCAPTCPNSTVSSDGRALSVSCCQGSQCN 89
Cdd:pfam00087   1 LRCHNCAAAGNCVQPETCQDNTRYCLTLWNSPPGHrTHVIKGCAYTCPVTQESLNISRASDCCCETDLCN 70
TFP_LU_ECD_LYNX1 cd23585
extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; ...
 20-89 6.39e-05

extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467115  Cd Length: 74  Bit Score: 38.44  E-value: 6.39e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1847679010  20 ALHCHVCC-GHENCESLVECALTDKYCVITRAT-NPGGILVMKSCAPTCPNSTVSS-DGRALSVSCCQGSQCN 89
Cdd:cd23585     1 ALDCHVCAyNGDNCFNPMRCPAMVAYCMTTRTYyTPTRMKVSKSCVPRCFETVYDGySKHASTTSCCQYDLCN 73
TFP_LU_ECD_SLURP2 cd23561
extracellular domain (ECD) found in Secreted Ly-6/uPAR-related protein 2 (SLURP-2) and similar ...
 21-90 1.06e-04

extracellular domain (ECD) found in Secreted Ly-6/uPAR-related protein 2 (SLURP-2) and similar proteins; SLURP-2 (also called Lynx1, or secreted Ly-6/uPAR domain-containing protein 2, or secreted LY6/PLAUR domain-containing protein 2) binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. It may regulate keratinocytes proliferation, differentiation, and apoptosis. In vitro SLURP-2 moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly inhibits alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. It may act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner. SLURP-2 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467091  Cd Length: 75  Bit Score: 38.01  E-value: 1.06e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1847679010  21 LHCHVCCGHENCESLVECALTDKYCVITRATNPGGI----LVMKSCAPTCPNSTVSSDGRALSVSCCQGSQCNR 90
Cdd:cd23561     1 IWCHQCTGFGGCSHGSRCPRDSTHCVTTATRVLSNTedlpLVTKMCHIGCPDIPSLGLGPYVSIACCQTSLCNH 74
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-89 3.23e-04

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 36.75  E-value: 3.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1847679010  23 CHVCCGH--ENCESLVECALTDKYCVITRATNPGG----ILVMKSCA----PTCPNSTVSSDGRALSVSCCQGSQCN 89
Cdd:pfam00021   1 CYSCLGVsnEDCLSEVTCPLSDGQCVTTTLELPEGnlrgTVVSKGCArsscPRLLSDFINGGIISVSESCCQSDLCN 77
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 21-89 4.42e-03

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 33.83  E-value: 4.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847679010  21 LHCHVCCGHE--NCESLVECALTDKYCVITrATN--PGGILVMKSCAPTCPNSTVSSDGRA----------LSVSCCQGS 86
Cdd:cd23550     1 LTCHVCEVENsfNCTNPVTCTWEETYCVLA-AVRifPRFFLVSKQCSKYCPVVEVPPPPPKsfvlekpmpfLYIKCCREN 79


                  ...
gi 1847679010  87 QCN 89
Cdd:cd23550    80 LCN 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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