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zinc fingers and homeoboxes protein 3 isoform a [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
zf_C2H2_ZHX | pfam18387 | Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ... |
105-155 | 2.94e-22 | ||
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3. : Pssm-ID: 465737 Cd Length: 53 Bit Score: 90.47 E-value: 2.94e-22
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
500-553 | 6.70e-12 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. : Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 61.11 E-value: 6.70e-12
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
621-666 | 5.39e-11 | ||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes : Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 58.80 E-value: 5.39e-11
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
313-363 | 2.79e-08 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. : Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 51.09 E-value: 2.79e-08
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
769-823 | 7.66e-08 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. : Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 49.93 E-value: 7.66e-08
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Homez super family | cl13082 | Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ... |
850-886 | 3.79e-07 | ||
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network. The actual alignment was detected with superfamily member pfam11569: Pssm-ID: 463297 Cd Length: 57 Bit Score: 47.68 E-value: 3.79e-07
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Name | Accession | Description | Interval | E-value | ||
zf_C2H2_ZHX | pfam18387 | Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ... |
105-155 | 2.94e-22 | ||
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3. Pssm-ID: 465737 Cd Length: 53 Bit Score: 90.47 E-value: 2.94e-22
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
500-553 | 6.70e-12 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 61.11 E-value: 6.70e-12
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
497-550 | 1.27e-11 | ||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 60.34 E-value: 1.27e-11
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
621-666 | 5.39e-11 | ||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 58.80 E-value: 5.39e-11
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
621-666 | 1.33e-10 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 57.64 E-value: 1.33e-10
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
313-363 | 2.79e-08 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 51.09 E-value: 2.79e-08
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
317-359 | 3.40e-08 | ||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 50.71 E-value: 3.40e-08
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
769-823 | 7.66e-08 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 49.93 E-value: 7.66e-08
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Homez | pfam11569 | Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ... |
850-886 | 3.79e-07 | ||
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network. Pssm-ID: 463297 Cd Length: 57 Bit Score: 47.68 E-value: 3.79e-07
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
769-820 | 3.98e-07 | ||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 47.63 E-value: 3.98e-07
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Homeodomain | pfam00046 | Homeodomain; |
502-546 | 4.97e-07 | ||
Homeodomain; Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 47.49 E-value: 4.97e-07
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Homeodomain | pfam00046 | Homeodomain; |
621-666 | 1.69e-06 | ||
Homeodomain; Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 45.95 E-value: 1.69e-06
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Homeodomain | pfam00046 | Homeodomain; |
319-359 | 5.91e-04 | ||
Homeodomain; Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 38.64 E-value: 5.91e-04
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Name | Accession | Description | Interval | E-value | ||
zf_C2H2_ZHX | pfam18387 | Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ... |
105-155 | 2.94e-22 | ||
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3. Pssm-ID: 465737 Cd Length: 53 Bit Score: 90.47 E-value: 2.94e-22
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
500-553 | 6.70e-12 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 61.11 E-value: 6.70e-12
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
497-550 | 1.27e-11 | ||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 60.34 E-value: 1.27e-11
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
621-666 | 5.39e-11 | ||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 58.80 E-value: 5.39e-11
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
621-666 | 1.33e-10 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 57.64 E-value: 1.33e-10
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
313-363 | 2.79e-08 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 51.09 E-value: 2.79e-08
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
317-359 | 3.40e-08 | ||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 50.71 E-value: 3.40e-08
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
769-823 | 7.66e-08 | ||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 49.93 E-value: 7.66e-08
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Homez | pfam11569 | Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ... |
850-886 | 3.79e-07 | ||
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network. Pssm-ID: 463297 Cd Length: 57 Bit Score: 47.68 E-value: 3.79e-07
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
769-820 | 3.98e-07 | ||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 47.63 E-value: 3.98e-07
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Homeodomain | pfam00046 | Homeodomain; |
502-546 | 4.97e-07 | ||
Homeodomain; Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 47.49 E-value: 4.97e-07
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Homeodomain | pfam00046 | Homeodomain; |
621-666 | 1.69e-06 | ||
Homeodomain; Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 45.95 E-value: 1.69e-06
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Homeodomain | pfam00046 | Homeodomain; |
319-359 | 5.91e-04 | ||
Homeodomain; Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 38.64 E-value: 5.91e-04
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