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Conserved domains on  [gi|1862359058|ref|NP_001371641|]
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glycosyltransferase 8 domain-containing protein 2 isoform 2 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 56-341 1.25e-68

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06429:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 257  Bit Score: 215.72  E-value: 1.25e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  56 IPVVIcAAAGRMGATMAAINSIYSNTD-ANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDS--- 131
Cdd:cd06429     1 IHVVI-FSDNRLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 132 ------------SRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdin 199
Cdd:cd06429    80 leseadtsnlkqRKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 200 rlvglqntymgyldyrkkaikdlgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPML 279
Cdd:cd06429   149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGL 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1862359058 280 IVFHGKYSTINPLWHIRHLGWNPDARysEHFLQEAKLLHWNGRHKPWDFPSVHN--DLWESWFV 341
Cdd:cd06429   196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPSykELWEKYLS 257
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 56-341 1.25e-68

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 215.72  E-value: 1.25e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  56 IPVVIcAAAGRMGATMAAINSIYSNTD-ANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDS--- 131
Cdd:cd06429     1 IHVVI-FSDNRLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 132 ------------SRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdin 199
Cdd:cd06429    80 leseadtsnlkqRKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 200 rlvglqntymgyldyrkkaikdlgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPML 279
Cdd:cd06429   149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGL 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1862359058 280 IVFHGKYSTINPLWHIRHLGWNPDARysEHFLQEAKLLHWNGRHKPWDFPSVHN--DLWESWFV 341
Cdd:cd06429   196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPSykELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 57-326 3.81e-43

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 149.78  E-value: 3.81e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  57 PVVICAAAGRMGATMAAINSIYSNT-DANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDSSRPE 135
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 136 LLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDcdlpsaqdinrlvglqnTYMGYLDYR 215
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 216 KKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMqkNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLWHI 295
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWL--NLNENRTLWKLG---DQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1862359058 296 RHLGWNPDARYSEHFLQEAKLLHWNGRHKPW 326
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPW 248
PLN02659 PLN02659
Probable galacturonosyltransferase
 106-339 4.72e-25

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 105.88  E-value: 4.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 106 SKLREINFKIVEFN---PMVLKGKIRPDSsrPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGH 182
Cdd:PLN02659  295 SQFRGGSSAIVANNtekPHVIAAKLQALS--PKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GK 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 183 AAAFSDDCdlpSAQDinRLVgLQNTYMGYLDYRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEE 262
Cdd:PLN02659  372 VNGAVETC---RGED--KFV-MSKKLKSYLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKS 444

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 263 NLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW---DFPSVHnDLWESW 339
Cdd:PLN02659  445 DLSLWQLG---TLPPGLIAFHGHVHVIDPFWHMLGLGYQENTSLAD--AESAGVVHFNGRAKPWldiAFPQLR-PLWAKY 518
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 56-336 2.64e-22

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 95.43  E-value: 2.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  56 IPVVICAAAGRMGATMAAINSIY-SNTDANILFYVV--GLRN-TLTRIRKWIE--HSKLREINFKIVEFNPMVLKGKIRP 129
Cdd:COG1442     6 INIVFAIDDNYLPGLGVSIASLLeNNPDRPYDFHILtdGLSDeNKERLEALAAkyNVSIEFIDVDDELLKDLPVSKHISK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 130 DSsrpellqplnFVRFYLP-LLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSaqdinrlvglqnty 208
Cdd:COG1442    86 AT----------YYRLLIPeLLPDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG-------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 209 mgyldYRKKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssslgggvatsP----MLIVFHG 284
Cdd:COG1442   141 -----SQKKRAKRLGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGG 204

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1862359058 285 KYSTINPLW-----HIRHLGWNPDARYSEHFLQEAKLLHWNGRHKPWDFPSVHN--DLW 336
Cdd:COG1442   205 KVKFLPPRYnyqysLYYELKDKSNKKELLEARKNPVIIHYTGPTKPWHKWCTHPyaDLY 263
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 56-341 1.25e-68

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 215.72  E-value: 1.25e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  56 IPVVIcAAAGRMGATMAAINSIYSNTD-ANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDS--- 131
Cdd:cd06429     1 IHVVI-FSDNRLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 132 ------------SRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdin 199
Cdd:cd06429    80 leseadtsnlkqRKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 200 rlvglqntymgyldyrkkaikdlgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPML 279
Cdd:cd06429   149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGL 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1862359058 280 IVFHGKYSTINPLWHIRHLGWNPDARysEHFLQEAKLLHWNGRHKPWDFPSVHN--DLWESWFV 341
Cdd:cd06429   196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPSykELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 57-326 3.81e-43

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 149.78  E-value: 3.81e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  57 PVVICAAAGRMGATMAAINSIYSNT-DANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDSSRPE 135
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 136 LLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDcdlpsaqdinrlvglqnTYMGYLDYR 215
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 216 KKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMqkNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLWHI 295
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWL--NLNENRTLWKLG---DQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1862359058 296 RHLGWNPDARYSEHFLQEAKLLHWNGRHKPW 326
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPW 248
Glyco_transf_8 cd00505
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ...
 58-327 9.54e-35

Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.


Pssm-ID: 132996 [Multi-domain]  Cd Length: 246  Bit Score: 127.56  E-value: 9.54e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  58 VVICAAAGRMGATMAAINSIYSNTDANILFYVVGLrNTLTRIRKWIEHskLREINFKIVEFNPMVLKGKIRPDS-SRPEL 136
Cdd:cd00505     4 VIVATGDEYLRGAIVLMKSVLRHRTKPLRFHVLTN-PLSDTFKAALDN--LRKLYNFNYELIPVDILDSVDSEHlKRPIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 137 lqPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDlpsaqdinrlvglqnTYMGYLDYRK 216
Cdd:cd00505    81 --IVTLTKLHLPNLVPDYDKILYVDADILVLTDIDELWDTPLGGQELAAAPDPGD---------------RREGKYYRQK 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 217 KAIKDLgispsTCSFNPGVIVANMTEW-KHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHgkystINPLWHI 295
Cdd:cd00505   144 RSHLAG-----PDYFNSGVFVVNLSKErRNQLLKVALEKWLQSLSSLSGGDQDLLNTFFKQVPFIVKS-----LPCIWNV 213

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1862359058 296 RHLGWNPDARYSEHFLQEAKLLHWNGRHKPWD 327
Cdd:cd00505   214 RLTGCYRSLNCFKAFVKNAKVIHFNGPTKPWN 245
PLN02659 PLN02659
Probable galacturonosyltransferase
 106-339 4.72e-25

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 105.88  E-value: 4.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 106 SKLREINFKIVEFN---PMVLKGKIRPDSsrPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGH 182
Cdd:PLN02659  295 SQFRGGSSAIVANNtekPHVIAAKLQALS--PKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GK 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 183 AAAFSDDCdlpSAQDinRLVgLQNTYMGYLDYRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEE 262
Cdd:PLN02659  372 VNGAVETC---RGED--KFV-MSKKLKSYLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKS 444

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 263 NLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW---DFPSVHnDLWESW 339
Cdd:PLN02659  445 DLSLWQLG---TLPPGLIAFHGHVHVIDPFWHMLGLGYQENTSLAD--AESAGVVHFNGRAKPWldiAFPQLR-PLWAKY 518
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 56-336 2.64e-22

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 95.43  E-value: 2.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  56 IPVVICAAAGRMGATMAAINSIY-SNTDANILFYVV--GLRN-TLTRIRKWIE--HSKLREINFKIVEFNPMVLKGKIRP 129
Cdd:COG1442     6 INIVFAIDDNYLPGLGVSIASLLeNNPDRPYDFHILtdGLSDeNKERLEALAAkyNVSIEFIDVDDELLKDLPVSKHISK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 130 DSsrpellqplnFVRFYLP-LLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSaqdinrlvglqnty 208
Cdd:COG1442    86 AT----------YYRLLIPeLLPDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG-------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 209 mgyldYRKKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssslgggvatsP----MLIVFHG 284
Cdd:COG1442   141 -----SQKKRAKRLGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGG 204

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1862359058 285 KYSTINPLW-----HIRHLGWNPDARYSEHFLQEAKLLHWNGRHKPWDFPSVHN--DLW 336
Cdd:COG1442   205 KVKFLPPRYnyqysLYYELKDKSNKKELLEARKNPVIIHYTGPTKPWHKWCTHPyaDLY 263
PLN02870 PLN02870
Probable galacturonosyltransferase
 117-326 3.09e-21

Probable galacturonosyltransferase


Pssm-ID: 215468 [Multi-domain]  Cd Length: 533  Bit Score: 94.62  E-value: 3.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 117 EFNPMVLKGKIRPDSsrPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSAQ 196
Cdd:PLN02870  308 ETTPRTFASKLQARS--PKYISLLNHLRIYLPELFPNLDKVVFLDDDVVIQRDLSPLWDIDLG-GKVNGAVETCRGEDEW 384

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 197 DINRlvglqnTYMGYLDYRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATS 276
Cdd:PLN02870  385 VMSK------RFRNYFNFSHPLIAK-NLDPEECAWAYGMNIFDLRAWRKTNIRETYHSWLKENLKSNLTMWKLG---TLP 454

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1862359058 277 PMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 326
Cdd:PLN02870  455 PALIAFKGHVHPIDPSWHMLGLGYQSKTNIES--VKKAAVIHYNGQSKPW 502
PLN02742 PLN02742
Probable galacturonosyltransferase
 134-326 7.34e-21

Probable galacturonosyltransferase


Pssm-ID: 215395 [Multi-domain]  Cd Length: 534  Bit Score: 93.68  E-value: 7.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 134 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsAQDINRlvglqntYMGYLD 213
Cdd:PLN02742  333 PKYLSMLNHLRFYIPEIYPALEKVVFLDDDVVVQKDLTPLFSIDLH-GNVNGAVETC----LETFHR-------YHKYLN 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 214 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLW 293
Cdd:PLN02742  401 FSHPLISS-HFDPDACGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVDRTLW--KLG---TLPPGLLTFYGLTEPLDRRW 474

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1862359058 294 HIRHLGWNPDArySEHFLQEAKLLHWNGRHKPW 326
Cdd:PLN02742  475 HVLGLGYDTNI--DPRLIESAAVLHFNGNMKPW 505
PLN02523 PLN02523
galacturonosyltransferase
 134-326 1.40e-19

galacturonosyltransferase


Pssm-ID: 215286 [Multi-domain]  Cd Length: 559  Bit Score: 89.93  E-value: 1.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 134 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsaqdinrlVGLQNTYMGYLD 213
Cdd:PLN02523  357 PKYLSMLNHLRFYLPEMYPKLHRILFLDDDVVVQKDLTGLWKIDMD-GKVNGAVETC-----------FGSFHRYAQYLN 424

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 214 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFhgkYSTINPL- 292
Cdd:PLN02523  425 FSHPLIKE-KFNPKACAWAYGMNIFDLDAWRREKCTEQYHYWQNLNENRTLW--KLG---TLPPGLITF---YSTTKPLd 495

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1862359058 293 --WHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 326
Cdd:PLN02523  496 ksWHVLGLGYNPSISMDE--IRNAAVIHFNGNMKPW 529
GT8_A4GalT_like cd04194
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ...
 56-328 3.12e-19

A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.


Pssm-ID: 133037 [Multi-domain]  Cd Length: 248  Bit Score: 85.73  E-value: 3.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  56 IPVVICAAAGRMGATMAAINSIYSNTDA-NILFYVV--GL-RNTLTRIRKWIE--HSKLREINFKIVEFNPMVLKGKIRP 129
Cdd:cd04194     1 MNIVFAIDDNYAPYLAVTIKSILANNSKrDYDFYILndDIsEENKKKLKELLKkyNSSIEFIKIDNDDFKFFPATTDHIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 130 DSSrpellqplnFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsaqdinrlvglqntym 209
Cdd:cd04194    81 YAT---------YYRLLIPDLLPDYDKVLYLDADIIVLGDLSELFDIDLG-DNLLAAVRDP------------------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 210 gYLDYRKKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssslgggvatsP----MLIVFHGK 285
Cdd:cd04194   132 -FIEQEKKRKRRLGGYDDGSYFNSGVLLINLKKWREENITEKLLELIKEYGGRLIY-----------PdqdiLNAVLKDK 199

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1862359058 286 YSTINPLW--HIRHLGWNPDARYSEHFLQEA----KLLHWNGRHKPWDF 328
Cdd:cd04194   200 ILYLPPRYnfQTGFYYLLKKKSKEEQELEEArknpVIIHYTGSDKPWNK 248
PLN02867 PLN02867
Probable galacturonosyltransferase
 134-336 6.44e-19

Probable galacturonosyltransferase


Pssm-ID: 178458 [Multi-domain]  Cd Length: 535  Bit Score: 87.65  E-value: 6.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 134 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpSAQDINRLVGLQntYMGYLD 213
Cdd:PLN02867  325 PSCLSLLNHLRIYIPELFPDLNKIVFLDDDVVVQHDLSSLWELDLNGKVVGAVVD-----SWCGDNCCPGRK--YKDYLN 397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 214 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLW 293
Cdd:PLN02867  398 FSHPLISS-NLDQERCAWLYGMNVFDLKAWRRTNITEAYHKWLKLSLNSGLQLWQPG---ALPPALLAFKGHVHPIDPSW 473

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1862359058 294 HIRHLGWNPdARYSEHFLQEAKLLHWNGRHKPW---DFPSVHNdLW 336
Cdd:PLN02867  474 HVAGLGSRP-PEVPREILESAAVLHFSGPAKPWleiGFPEVRS-LW 517
PLN02829 PLN02829
Probable galacturonosyltransferase
 134-326 2.82e-18

Probable galacturonosyltransferase


Pssm-ID: 215443 [Multi-domain]  Cd Length: 639  Bit Score: 86.06  E-value: 2.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 134 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsAQDINRlvglqntYMGYLD 213
Cdd:PLN02829  437 PKYLSILNHLRFYLPEIFPKLNKVLFLDDDIVVQKDLTGLWSIDLK-GNVNGAVETC----GESFHR-------FDRYLN 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 214 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLW 293
Cdd:PLN02829  505 FSNPLISK-NFDPHACGWAYGMNVFDLDEWKRQNITEVYHSWQKLNHDRQLW--KLG---TLPPGLITFWKRTYPLDRSW 578

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1862359058 294 HIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 326
Cdd:PLN02829  579 HVLGLGYNPNVNQRD--IERAAVIHYNGNMKPW 609
PLN02910 PLN02910
polygalacturonate 4-alpha-galacturonosyltransferase
 134-326 9.60e-18

polygalacturonate 4-alpha-galacturonosyltransferase


Pssm-ID: 215493 [Multi-domain]  Cd Length: 657  Bit Score: 84.61  E-value: 9.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 134 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDlpsaQDINRlvglqntYMGYLD 213
Cdd:PLN02910  455 PKYLSMLNHLRFYLPEVYPKLEKILFLDDDIVVQKDLTPLWSIDMQ-GMVNGAVETCK----ESFHR-------FDKYLN 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 214 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLW 293
Cdd:PLN02910  523 FSNPKISE-NFDPNACGWAFGMNMFDLKEWRKRNITGIYHYWQDLNEDRTLW--KLG---SLPPGLITFYNLTYPLDRSW 596

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1862359058 294 HIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 326
Cdd:PLN02910  597 HVLGLGYDPALNQTE--IENAAVVHYNGNYKPW 627
PLN02718 PLN02718
Probable galacturonosyltransferase
 69-326 5.05e-14

Probable galacturonosyltransferase


Pssm-ID: 178320 [Multi-domain]  Cd Length: 603  Bit Score: 73.00  E-value: 5.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058  69 ATMAAINSIYSNTD--ANILFYVVGLRNTLTRIRKW----------IEHSKLREINFKIVEFNPMVLKgkirPDSSRPEL 136
Cdd:PLN02718  325 ACSVVVNSTISSSKepEKIVFHVVTDSLNYPAISMWfllnppgkatIQILNIDDMNVLPADYNSLLMK----QNSHDPRY 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 137 LQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDC--DLPSAQDINRLVGLQNTYMGyldy 214
Cdd:PLN02718  401 ISALNHARFYLPDIFPGLNKIVLFDHDVVVQRDLSRLWSLDMK-GKVVGAVETCleGEPSFRSMDTFINFSDPWVA---- 475

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 215 rKKaikdlgISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSS-SLGGGVATspmlivFHGKYSTINPLW 293
Cdd:PLN02718  476 -KK------FDPKACTWAFGMNLFDLEEWRRQKLTSVYHKYLQLGVKRPLWKAgSLPIGWLT------FYNQTVALDKRW 542

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1862359058 294 HIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 326
Cdd:PLN02718  543 HVLGLGHESGVGASD--IEQAAVIHYDGVMKPW 573
PLN02769 PLN02769
Probable galacturonosyltransferase
 145-326 2.46e-09

Probable galacturonosyltransferase


Pssm-ID: 215412 [Multi-domain]  Cd Length: 629  Bit Score: 58.55  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 145 FYLPLLIHQHEKVIYLDDDVIVQGDIQELYDttLALGH----AAAFsddCDLpsaqdinRLVGLQNtYMGyldyrkkaik 220
Cdd:PLN02769  443 FLLPEIFKKLKKVVVLDDDVVVQRDLSFLWN--LDMGGkvngAVQF---CGV-------RLGQLKN-YLG---------- 499

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 221 DLGISPSTCSFNPGVIVANMTEWKHQRITK---QLEKWMQKNVEENLyssslgGGVATSPMLIVFHgkySTINPL---WH 294
Cdd:PLN02769  500 DTNFDTNSCAWMSGLNVIDLDKWRELDVTEtylKLLQKFSKDGEESL------RAAALPASLLTFQ---DLIYPLddrWV 570

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1862359058 295 IRHLGWnpDARYSEHFLQEAKLLHWNGRHKPW 326
Cdd:PLN02769  571 LSGLGH--DYGIDEQAIKKAAVLHYNGNMKPW 600
PRK15171 PRK15171
lipopolysaccharide 3-alpha-galactosyltransferase;
151-251 4.75e-07

lipopolysaccharide 3-alpha-galactosyltransferase;


Pssm-ID: 185093 [Multi-domain]  Cd Length: 334  Bit Score: 50.91  E-value: 4.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862359058 151 IHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLPSAQdiNRLVGLQNTYM--GYldyrkkaikdlgispst 228
Cdd:PRK15171  118 IDKTDKVLYLDADIACKGSIKELIDLDFAENEIAAVVAEGDAEWWS--KRAQSLQTPGLasGY----------------- 178

                          90       100
                  ....*....|....*....|...
gi 1862359058 229 csFNPGVIVANMTEWKHQRITKQ 251
Cdd:PRK15171  179 --FNSGFLLINIPAWAQENISAK 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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