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Conserved domains on  [gi|1862353434|ref|NP_001371690|]
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microtubule-associated protein 4 isoform 83 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
929-958 1.26e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.26e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862353434  929 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 958
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
960-990 2.75e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 2.75e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862353434  960 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 990
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
906-927 1.51e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 51.26  E-value: 1.51e-08
                           10        20
                   ....*....|....*....|..
gi 1862353434  906 DLKNVRSKVGSTENIKHQPGGG 927
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
653-905 3.73e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.73e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  653 PCNSQPSELSSETsgiARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGgLNKKPMSLASGLVPAAPPKRPA 732
Cdd:PHA03247  2609 RGPAPPSPLPPDT---HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS-RPRRARRLGRAAQASSPPQRPR 2684
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  733 VASARPSILPSKDvkpkpIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllPKKPTAI 812
Cdd:PHA03247  2685 RRAARPTVGSLTS-----LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT--PGGPARP 2757
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  813 KTEGKPAEVKKMTAKSVPADLSRPKSTstssmkktttlsgtAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTT 892
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLT--------------RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
                          250
                   ....*....|...
gi 1862353434  893 PRLSRLATNTSAP 905
Cdd:PHA03247  2824 PAGPLPPPTSAQP 2836
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
929-958 1.26e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.26e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862353434  929 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 958
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
960-990 2.75e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 2.75e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862353434  960 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 990
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
906-927 1.51e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 51.26  E-value: 1.51e-08
                           10        20
                   ....*....|....*....|..
gi 1862353434  906 DLKNVRSKVGSTENIKHQPGGG 927
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
653-905 3.73e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.73e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  653 PCNSQPSELSSETsgiARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGgLNKKPMSLASGLVPAAPPKRPA 732
Cdd:PHA03247  2609 RGPAPPSPLPPDT---HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS-RPRRARRLGRAAQASSPPQRPR 2684
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  733 VASARPSILPSKDvkpkpIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllPKKPTAI 812
Cdd:PHA03247  2685 RRAARPTVGSLTS-----LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT--PGGPARP 2757
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  813 KTEGKPAEVKKMTAKSVPADLSRPKSTstssmkktttlsgtAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTT 892
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLT--------------RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
                          250
                   ....*....|...
gi 1862353434  893 PRLSRLATNTSAP 905
Cdd:PHA03247  2824 PAGPLPPPTSAQP 2836
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
768-1042 2.02e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 2.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  768 SAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllpkkptaiKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKT 847
Cdd:pfam05109  459 TAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSP---------RDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTT 529
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  848 TTLSGTAPAAG-VVPSRVKATPMPSRPSTTPFIdkkpTSAKPSSTTPRLSRLATNT--SAPDLKNVRSKVGSTE----NI 920
Cdd:pfam05109  530 PTPNATSPTLGkTSPTSAVTTPTPNATSPTPAV----TTPTPNATIPTLGKTSPTSavTTPTPNATSPTVGETSpqanTT 605
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  921 KHQPGGgrvqIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSE 1000
Cdd:pfam05109  606 NHTLGG----TSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENI 681
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1862353434 1001 APLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGD 1042
Cdd:pfam05109  682 TQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGE 723
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
929-958 1.26e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.26e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862353434  929 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 958
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
960-990 2.75e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 2.75e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862353434  960 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 990
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
906-927 1.51e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 51.26  E-value: 1.51e-08
                           10        20
                   ....*....|....*....|..
gi 1862353434  906 DLKNVRSKVGSTENIKHQPGGG 927
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
653-905 3.73e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.73e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  653 PCNSQPSELSSETsgiARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGgLNKKPMSLASGLVPAAPPKRPA 732
Cdd:PHA03247  2609 RGPAPPSPLPPDT---HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS-RPRRARRLGRAAQASSPPQRPR 2684
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  733 VASARPSILPSKDvkpkpIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllPKKPTAI 812
Cdd:PHA03247  2685 RRAARPTVGSLTS-----LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT--PGGPARP 2757
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  813 KTEGKPAEVKKMTAKSVPADLSRPKSTstssmkktttlsgtAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTT 892
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLT--------------RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
                          250
                   ....*....|...
gi 1862353434  893 PRLSRLATNTSAP 905
Cdd:PHA03247  2824 PAGPLPPPTSAQP 2836
PHA03247 PHA03247
large tegument protein UL36; Provisional
575-893 1.37e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  575 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 653
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  654 CNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASglvPAAPPKRPAV 733
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL---PAAPAPPAVP 2745
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  734 ASArpsILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSgskSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIK 813
Cdd:PHA03247  2746 AGP---ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL---TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  814 TEGKPAEVKKMTAKSVPADLSRPKSTSTSSmkktTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 893
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPS----LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
PHA03247 PHA03247
large tegument protein UL36; Provisional
653-904 1.41e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  653 PCNSQPSELSSETSGIARPEEGRPVVSG--TGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPmslASGLVPAAPPKR 730
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD---PHPPPTVPPPER 2651
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  731 PAVASARPSILPSKDVKPKpiadAKAPEKRASPSKPaSAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPT 810
Cdd:PHA03247  2652 PRDDPAPGRVSRPRRARRL----GRAAQASSPPQRP-RRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPA 2726
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  811 AIKTEGKPAevkkmtaksvPADLSRPKSTstssmkktttlsgTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSS 890
Cdd:PHA03247  2727 AARQASPAL----------PAAPAPPAVP-------------AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL 2783
                          250
                   ....*....|....
gi 1862353434  891 TTPRLSRLATNTSA 904
Cdd:PHA03247  2784 TRPAVASLSESRES 2797
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
768-1042 2.02e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 2.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  768 SAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllpkkptaiKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKT 847
Cdd:pfam05109  459 TAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSP---------RDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTT 529
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  848 TTLSGTAPAAG-VVPSRVKATPMPSRPSTTPFIdkkpTSAKPSSTTPRLSRLATNT--SAPDLKNVRSKVGSTE----NI 920
Cdd:pfam05109  530 PTPNATSPTLGkTSPTSAVTTPTPNATSPTPAV----TTPTPNATIPTLGKTSPTSavTTPTPNATSPTVGETSpqanTT 605
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  921 KHQPGGgrvqIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSE 1000
Cdd:pfam05109  606 NHTLGG----TSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENI 681
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1862353434 1001 APLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGD 1042
Cdd:pfam05109  682 TQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGE 723
PHA03247 PHA03247
large tegument protein UL36; Provisional
660-894 3.48e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  660 ELSSETSGIARPEEGrPVVSGTGNDITTPPNKELPPSPEkktkPAPTTIGGLNKKPMSLASGLVPAAPPKRPAvASARPS 739
Cdd:PHA03247  2542 ELASDDAGDPPPPLP-PAAPPAAPDRSVPPPRPAPRPSE----PAVTSRARRPDAPPQSARPRAPVDDRGDPR-GPAPPS 2615
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  740 ILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIktegkPA 819
Cdd:PHA03247  2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAA-----RP 2690
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  820 EVKKMTAKSVPADLSR---PKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKP-----TSAKPSST 891
Cdd:PHA03247  2691 TVGSLTSLADPPPPPPtpePAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARParpptTAGPPAPA 2770

                   ...
gi 1862353434  892 TPR 894
Cdd:PHA03247  2771 PPA 2773
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
703-893 6.68e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 6.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  703 PAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSilPSKDVKPKPIADAKAPeKRASPSKPASAPASRSGSkstqtv 782
Cdd:PRK07003   360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAV--PAVTAVTGAAGAALAP-KAAAAAAATRAEAPPAAP------ 430
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  783 aktTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEvkkmtAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPS 862
Cdd:PRK07003   431 ---APPATADRGDDAADGDAPVPAKANARASADSRCDE-----RDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAA 502
                          170       180       190
                   ....*....|....*....|....*....|.
gi 1862353434  863 RVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 893
Cdd:PRK07003   503 TPAAVPDARAPAAASREDAPAAAAPPAPEAR 533
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
727-888 2.03e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 2.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  727 PPKRPAvASARPsilpskdvkPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS-----SRSP 801
Cdd:PTZ00449   510 PPEGPE-ASGLP---------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKP 579
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  802 StlLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTL--SGTAPAAGVVPSRVKAtpmPSRPSTT--P 877
Cdd:PTZ00449   580 E--FPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRpeSPKSPKRPPPPQRPSS---PERPEGPkiI 654
                          170
                   ....*....|.
gi 1862353434  878 FIDKKPTSAKP 888
Cdd:PTZ00449   655 KSPKPPKSPKP 665
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
652-774 3.43e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 3.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  652 KPCNSQPSELSSETSGIARPEEGRPVVSgtgndittppnkelpPSPEKKTKPAPTTIGGLNKKPMslASGLVPAAPPKRP 731
Cdd:PRK14951   365 KPAAAAEAAAPAEKKTPARPEAAAPAAA---------------PVAQAAAAPAPAAAPAAAASAP--AAPPAAAPPAPVA 427
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1862353434  732 AVASARPSILPSKDVKPKPIADA----KAPEKRASPSKPASAPASRS 774
Cdd:PRK14951   428 APAAAAPAAAPAAAPAAVALAPAppaqAAPETVAIPVRVAPEPAVAS 474
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
653-889 3.84e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.21  E-value: 3.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  653 PCNSQPSELSSETS-GIARPEEGRPVVSGTGNDITTPPNkelpPSPEKKtkpaPTTIGGLNKKPmslaSGLVPAAPPKRp 731
Cdd:PTZ00449   524 PGDKEGEEGEHEDSkESDEPKEGGKPGETKEGEVGKKPG----PAKEHK----PSKIPTLSKKP----EFPKDPKHPKD- 590
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  732 avasarpsilPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPsSRSPSTLLPKKPTA 811
Cdd:PTZ00449   591 ----------PEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSP-ERPEGPKIIKSPKP 659
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  812 IKTEGKP--AEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPM---PSRPSTTPFID---KKP 883
Cdd:PTZ00449   660 PKSPKPPfdPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRplpPKLPRDEEFPFepiGDP 739

                   ....*.
gi 1862353434  884 TSAKPS 889
Cdd:PTZ00449   740 DAEQPD 745
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
688-909 5.25e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 40.68  E-value: 5.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  688 PPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASGLVPAAPpkrpavasarpsilpsKDVKPKPIADAKAPEKRASPSKPA 767
Cdd:PLN03209   324 PSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEPPQP----------------KAVVPRPLSPYTAYEDLKPPTSPI 387
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  768 saPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE-GKP-------AEVKKMTAKSVPADLsrPKST 839
Cdd:PLN03209   388 --PTPPSSSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKkTRPlspyaryEDLKPPTSPSPTAPT--GVSP 463
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1862353434  840 STSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFID--KKPTSAKPSSTTPRLSRLATNTSAPDLKN 909
Cdd:PLN03209   464 SVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDdlKPPTSPSPAAPVGKVAPSSTNEVVKVGNS 535
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
653-897 5.59e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 5.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  653 PCNSQPSELSSETSGIARPEEGRP--VVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASGLVPAAPPKR 730
Cdd:PHA03307   148 PAASPPAAGASPAAVASDAASSRQaaLPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRS 227
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  731 PAV--ASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAaavaSTGPSSRSPSTLlPKK 808
Cdd:PHA03307   228 AADdaGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASS----SSSPRERSPSPS-PSS 302
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  809 PTAIKTEGKPAEVKKMTAKSvPADLSRPKSTSTSSMKKTTTlSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKP 888
Cdd:PHA03307   303 PGSGPAPSSPRASSSSSSSR-ESSSSSTSSSSESSRGAAVS-PGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAA 380

                   ....*....
gi 1862353434  889 SSTTPRLSR 897
Cdd:PHA03307   381 SAGRPTRRR 389
PHA03247 PHA03247
large tegument protein UL36; Provisional
665-901 5.77e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  665 TSGIARPEEGRPVVSGTGNDITTPPNKEL---------PPSPEKKTKPAPTTIGGLNKK-----PMSLASGLVPAAPPKR 730
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLsesreslpsPWDPADPPAAVLAPAAALPPAaspagPLPPPTSAQPTAPPPP 2842
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  731 PA-VASARP---SILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLP 806
Cdd:PHA03247  2843 PGpPPPSLPlggSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862353434  807 KKPTAIKTegkPAEVKKMTAKSVPADLSRPKSTSTSS-MKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPfidkkPTS 885
Cdd:PHA03247  2923 PPPPPQPQ---PPPPPPPRPQPPLAPTTDPAGAGEPSgAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS-----STP 2994
                          250
                   ....*....|....*.
gi 1862353434  886 AKPSSTTPRLSRLATN 901
Cdd:PHA03247  2995 PLTGHSLSRVSSWASS 3010
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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