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Conserved domains on  [gi|1862723004|ref|NP_001371722|]
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microtubule-associated protein 4 isoform 105 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
890-919 1.15e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.15e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862723004  890 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 919
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
921-951 2.50e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 2.50e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862723004  921 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 951
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
629-881 3.97e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  629 PCNSQPSELSSETsgiARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGgLNKKPMSLASGLVPAAPPKRPA 708
Cdd:PHA03247  2609 RGPAPPSPLPPDT---HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS-RPRRARRLGRAAQASSPPQRPR 2684
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  709 VASARPSILPSKDvkpkpIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllPKKPTAI 788
Cdd:PHA03247  2685 RRAARPTVGSLTS-----LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT--PGGPARP 2757
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  789 KTEGKPAEVKKMTAKSVPADLSRPKSTstssmkktttlsgtAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTT 868
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLT--------------RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
                          250
                   ....*....|...
gi 1862723004  869 PRLSRLATNTSAP 881
Cdd:PHA03247  2824 PAGPLPPPTSAQP 2836
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
890-919 1.15e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.15e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862723004  890 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 919
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
921-951 2.50e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 2.50e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862723004  921 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 951
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
629-881 3.97e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  629 PCNSQPSELSSETsgiARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGgLNKKPMSLASGLVPAAPPKRPA 708
Cdd:PHA03247  2609 RGPAPPSPLPPDT---HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS-RPRRARRLGRAAQASSPPQRPR 2684
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  709 VASARPSILPSKDvkpkpIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllPKKPTAI 788
Cdd:PHA03247  2685 RRAARPTVGSLTS-----LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT--PGGPARP 2757
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  789 KTEGKPAEVKKMTAKSVPADLSRPKSTstssmkktttlsgtAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTT 868
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLT--------------RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
                          250
                   ....*....|...
gi 1862723004  869 PRLSRLATNTSAP 881
Cdd:PHA03247  2824 PAGPLPPPTSAQP 2836
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
653-1003 7.92e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.83  E-value: 7.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  653 VVSGTGNDITTPPNKEL-PPSPEKKTKPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK 731
Cdd:pfam05109  404 IITRTATNATTTTHKVIfSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTS 483
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  732 ApekrASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSR 811
Cdd:pfam05109  484 G----ASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPT 559
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  812 PKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPmPSRPSTTPFIDKKPTSAKPSSTTPRLsrlatnTSAPdlKNVRSKVQ 891
Cdd:pfam05109  560 PAVTTPTPNATIPTLGKTSPTSAVTTPTPNATS-PTVGETSPQANTTNHTLGGTSSTPVV------TSPP--KNATSAVT 630
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  892 IQNKKVDISKVSSKCGSKANIkhkpgggdvkiesqklnfkEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAG 971
Cdd:pfam05109  631 TGQHNITSSSTSSMSLRPSSI-------------------SETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTST 691
                          330       340       350
                   ....*....|....*....|....*....|..
gi 1862723004  972 EEPAISEAAPEAGAPTSASGLNGHPTLSGGGD 1003
Cdd:pfam05109  692 HHVSTSSPAPRPGTTSQASGPGNSSTSTKPGE 723
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
890-919 1.15e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.15e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862723004  890 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 919
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
921-951 2.50e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 2.50e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862723004  921 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 951
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
629-881 3.97e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  629 PCNSQPSELSSETsgiARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGgLNKKPMSLASGLVPAAPPKRPA 708
Cdd:PHA03247  2609 RGPAPPSPLPPDT---HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS-RPRRARRLGRAAQASSPPQRPR 2684
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  709 VASARPSILPSKDvkpkpIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllPKKPTAI 788
Cdd:PHA03247  2685 RRAARPTVGSLTS-----LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT--PGGPARP 2757
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  789 KTEGKPAEVKKMTAKSVPADLSRPKSTstssmkktttlsgtAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTT 868
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLT--------------RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
                          250
                   ....*....|...
gi 1862723004  869 PRLSRLATNTSAP 881
Cdd:PHA03247  2824 PAGPLPPPTSAQP 2836
PHA03247 PHA03247
large tegument protein UL36; Provisional
551-869 1.39e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  551 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 629
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  630 CNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASglvPAAPPKRPAV 709
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL---PAAPAPPAVP 2745
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  710 ASArpsILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSgskSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIK 789
Cdd:PHA03247  2746 AGP---ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL---TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  790 TEGKPAEVKKMTAKSVPADLSRPKSTSTSSmkktTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 869
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPS----LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
653-1003 7.92e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.83  E-value: 7.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  653 VVSGTGNDITTPPNKEL-PPSPEKKTKPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK 731
Cdd:pfam05109  404 IITRTATNATTTTHKVIfSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTS 483
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  732 ApekrASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSR 811
Cdd:pfam05109  484 G----ASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPT 559
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  812 PKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPmPSRPSTTPFIDKKPTSAKPSSTTPRLsrlatnTSAPdlKNVRSKVQ 891
Cdd:pfam05109  560 PAVTTPTPNATIPTLGKTSPTSAVTTPTPNATS-PTVGETSPQANTTNHTLGGTSSTPVV------TSPP--KNATSAVT 630
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  892 IQNKKVDISKVSSKCGSKANIkhkpgggdvkiesqklnfkEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAG 971
Cdd:pfam05109  631 TGQHNITSSSTSSMSLRPSSI-------------------SETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTST 691
                          330       340       350
                   ....*....|....*....|....*....|..
gi 1862723004  972 EEPAISEAAPEAGAPTSASGLNGHPTLSGGGD 1003
Cdd:pfam05109  692 HHVSTSSPAPRPGTTSQASGPGNSSTSTKPGE 723
PHA03247 PHA03247
large tegument protein UL36; Provisional
629-880 1.45e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  629 PCNSQPSELSSETSGIARPEEGRPVVSG--TGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPmslASGLVPAAPPKR 706
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD---PHPPPTVPPPER 2651
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  707 PAVASARPSILPSKDVKPKpiadAKAPEKRASPSKPaSAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPT 786
Cdd:PHA03247  2652 PRDDPAPGRVSRPRRARRL----GRAAQASSPPQRP-RRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPA 2726
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  787 AIKTEGKPAevkkmtaksvPADLSRPKSTstssmkktttlsgTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSS 866
Cdd:PHA03247  2727 AARQASPAL----------PAAPAPPAVP-------------AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL 2783
                          250
                   ....*....|....
gi 1862723004  867 TTPRLSRLATNTSA 880
Cdd:PHA03247  2784 TRPAVASLSESRES 2797
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
679-869 7.33e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 7.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  679 PAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSilPSKDVKPKPIADAKAPeKRASPSKPASAPASRSGSkstqtv 758
Cdd:PRK07003   360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAV--PAVTAVTGAAGAALAP-KAAAAAAATRAEAPPAAP------ 430
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  759 aktTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEvkkmtAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPS 838
Cdd:PRK07003   431 ---APPATADRGDDAADGDAPVPAKANARASADSRCDE-----RDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAA 502
                          170       180       190
                   ....*....|....*....|....*....|.
gi 1862723004  839 RVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 869
Cdd:PRK07003   503 TPAAVPDARAPAAASREDAPAAAAPPAPEAR 533
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
703-864 2.47e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.98  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  703 PPKRPAvASARPsilpskdvkPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS-----SRSP 777
Cdd:PTZ00449   510 PPEGPE-ASGLP---------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKP 579
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  778 StlLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTL--SGTAPAAGVVPSRVKAtpmPSRPSTT--P 853
Cdd:PTZ00449   580 E--FPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRpeSPKSPKRPPPPQRPSS---PERPEGPkiI 654
                          170
                   ....*....|.
gi 1862723004  854 FIDKKPTSAKP 864
Cdd:PTZ00449   655 KSPKPPKSPKP 665
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
628-750 3.52e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 3.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  628 KPCNSQPSELSSETSGIARPEEGRPVVSgtgndittppnkelpPSPEKKTKPAPTTIGGLNKKPMslASGLVPAAPPKRP 707
Cdd:PRK14951   365 KPAAAAEAAAPAEKKTPARPEAAAPAAA---------------PVAQAAAAPAPAAAPAAAASAP--AAPPAAAPPAPVA 427
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1862723004  708 AVASARPSILPSKDVKPKPIADA----KAPEKRASPSKPASAPASRS 750
Cdd:PRK14951   428 APAAAAPAAAPAAAPAAVALAPAppaqAAPETVAIPVRVAPEPAVAS 474
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
629-865 4.95e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 4.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  629 PCNSQPSELSSETS-GIARPEEGRPVVSGTGNDITTPPNkelpPSPEKKtkpaPTTIGGLNKKPmslaSGLVPAAPPKRp 707
Cdd:PTZ00449   524 PGDKEGEEGEHEDSkESDEPKEGGKPGETKEGEVGKKPG----PAKEHK----PSKIPTLSKKP----EFPKDPKHPKD- 590
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  708 avasarpsilPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPsSRSPSTLLPKKPTA 787
Cdd:PTZ00449   591 ----------PEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSP-ERPEGPKIIKSPKP 659
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  788 IKTEGKP--AEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPM---PSRPSTTPFID---KKP 859
Cdd:PTZ00449   660 PKSPKPPfdPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRplpPKLPRDEEFPFepiGDP 739

                   ....*.
gi 1862723004  860 TSAKPS 865
Cdd:PTZ00449   740 DAEQPD 745
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
629-873 5.49e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 5.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  629 PCNSQPSELSSETSGIARPEEGRP--VVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASGLVPAAPPKR 706
Cdd:PHA03307   148 PAASPPAAGASPAAVASDAASSRQaaLPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRS 227
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  707 PAV--ASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAaavaSTGPSSRSPSTLlPKK 784
Cdd:PHA03307   228 AADdaGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASS----SSSPRERSPSPS-PSS 302
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  785 PTAIKTEGKPAEVKKMTAKSvPADLSRPKSTSTSSMKKTTTlSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKP 864
Cdd:PHA03307   303 PGSGPAPSSPRASSSSSSSR-ESSSSSTSSSSESSRGAAVS-PGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAA 380

                   ....*....
gi 1862723004  865 SSTTPRLSR 873
Cdd:PHA03307   381 SAGRPTRRR 389
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
664-885 5.97e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 40.29  E-value: 5.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  664 PPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASGLVPAAPpkrpavasarpsilpsKDVKPKPIADAKAPEKRASPSKPA 743
Cdd:PLN03209   324 PSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEPPQP----------------KAVVPRPLSPYTAYEDLKPPTSPI 387
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  744 saPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE--------GKPAEVKKMTAKSVPADLsrPKST 815
Cdd:PLN03209   388 --PTPPSSSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKktrplspyARYEDLKPPTSPSPTAPT--GVSP 463
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1862723004  816 STSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFID--KKPTSAKPSSTTPRLSRLATNTSAPDLKN 885
Cdd:PLN03209   464 SVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDdlKPPTSPSPAAPVGKVAPSSTNEVVKVGNS 535
PHA03247 PHA03247
large tegument protein UL36; Provisional
641-877 6.06e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 6.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  641 TSGIARPEEGRPVVSGTGNDITTPPNKEL---------PPSPEKKTKPAPTTIGGLNKK-----PMSLASGLVPAAPPKR 706
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLsesreslpsPWDPADPPAAVLAPAAALPPAaspagPLPPPTSAQPTAPPPP 2842
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  707 PA-VASARP---SILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLP 782
Cdd:PHA03247  2843 PGpPPPSLPlggSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  783 KKPTAIKTegkPAEVKKMTAKSVPADLSRPKSTSTSS-MKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPfidkkPTS 861
Cdd:PHA03247  2923 PPPPPQPQ---PPPPPPPRPQPPLAPTTDPAGAGEPSgAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS-----STP 2994
                          250
                   ....*....|....*.
gi 1862723004  862 AKPSSTTPRLSRLATN 877
Cdd:PHA03247  2995 PLTGHSLSRVSSWASS 3010
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
544-881 9.12e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 9.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  544 NNVTPAKDVPPLSETEAT-PVPikdmeiAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGT---GKKCSLPA---- 615
Cdd:pfam05109  457 NLTAPASTGPTVSTADVTsPTP------AGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTptpNATSPTPAvttp 530
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  616 EEDSVLEKLGERKPCNSQPSELSSETS-----GIARPEEGRPVVSGTG--NDITTP-PNKELPPSPEKKTKPAPT--TIG 685
Cdd:pfam05109  531 TPNATSPTLGKTSPTSAVTTPTPNATSptpavTTPTPNATIPTLGKTSptSAVTTPtPNATSPTVGETSPQANTTnhTLG 610
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  686 GLNKKPmslasglVPAAPPKRP--AVASARPSILPSK----DVKPKPIADAKAPEK--RASPSKPASAPASRSGSKSTQT 757
Cdd:pfam05109  611 GTSSTP-------VVTSPPKNAtsAVTTGQHNITSSStssmSLRPSSISETLSPSTsdNSTSHMPLLTSAHPTGGENITQ 683
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723004  758 VAKTTTAAAVASTG-PSSRSPSTLLPKKPTAIKTEGKPAEV--------KKMTAKSVPADLSRPKSTSTSSMKKTTTLSG 828
Cdd:pfam05109  684 VTPASTSTHHVSTSsPAPRPGTTSQASGPGNSSTSTKPGEVnvtkgtppKNATSPQAPSGQKTAVPTVTSTGGKANSTTG 763
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1862723004  829 TAPAAGVvPSRVKATPMPSR--PSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 881
Cdd:pfam05109  764 GKHTTGH-GARTSTEPTTDYggDSTTPRTRYNATTYLPPSTSSKLRPRWTFTSPP 817
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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