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Conserved domains on  [gi|1864355959|ref|NP_001371925|]
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fidgetin-like protein 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 393-555 4.94e-82

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 255.96  E-value: 4.94e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARL 472
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 473 LQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLR 552
Cdd:cd19523    81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSKR 160


                  ...
gi 1864355959 553 FYV 555
Cdd:cd19523   161 LLV 163
HflB super family cl33892
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
529-606 6.16e-03

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0465:

Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 39.63  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 529 VLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQ-----RALAqqgcalSERELAALVQGTQGFSGGELGQL 601
Cdd:COG0465   281 VIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAILKvharkKPLA------PDVDLEVIARRTPGFSGADLANL 354


                  ....*
gi 1864355959 602 CQQAA 606
Cdd:COG0465   355 VNEAA 359
 
Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 393-555 4.94e-82

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 255.96  E-value: 4.94e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARL 472
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 473 LQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLR 552
Cdd:cd19523    81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSKR 160


                  ...
gi 1864355959 553 FYV 555
Cdd:cd19523   161 LLV 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 391-630 1.37e-40

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 152.76  E-value: 1.37e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 391 WADVAGQGALKAALEEELVWPLLRPPAYP-GSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEG 469
Cdd:COG0464   156 LDDLGGLEEVKEELRELVALPLKRPELREeYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGET 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 470 ARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVP-LLACLdggcGAGADGVLVVGTTSRPAALDEATRRR 548
Cdd:COG0464   236 EKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNtLLTEM----EELRSDVVVIAATNRPDLLDPALLRR 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 549 FSLRFYVALPDSPARGQILQRALAQQGCAlSERELAALVQGTQGFSGGELGQLCQQAAAGAgLPGLQRPLSYKDLEAALA 628
Cdd:COG0464   312 FDEIIFFPLPDAEERLEIFRIHLRKRPLD-EDVDLEELAEATEGLSGADIRNVVRRAALQA-LRLGREPVTTEDLLEALE 389


                  ..
gi 1864355959 629 KV 630
Cdd:COG0464   390 RE 391
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 365-650 1.64e-29

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 124.63  E-value: 1.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 365 ETPKGVDPGALELVTSKMvdcgPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGR 443
Cdd:TIGR01243 430 EALKMVEPSAIREVLVEV----PNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKmGIRPPKGVLLFGPPGTGKTLLAK 505

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 444 CLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPAR--DDGAAAGGALQVPLLACLdgG 521
Cdd:TIGR01243 506 AVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARgaRFDTSVTDRIVNQLLTEM--D 583

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 522 CGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQraLAQQGCALSER-ELAALVQGTQGFSGGEL 598
Cdd:TIGR01243 584 GIQELSNVVVIAATNRPDILDPALLRpgRFDRLILVPPPDEEARKEIFK--IHTRSMPLAEDvDLEELAEMTEGYTGADI 661

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864355959 599 GQLCQQAAAGAGLPGLQRP-----------------LSYKDLEAALAKVGPRASAKELDSFVEWDKMYG 650
Cdd:TIGR01243 662 EAVCREAAMAALRESIGSPakeklevgeeeflkdlkVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 428-555 2.96e-21

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 89.96  E-value: 2.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 428 VLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGaaAG 507
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSG--GD 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1864355959 508 GALQVP---LLACLdGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYV 555
Cdd:pfam00004  79 SESRRVvnqLLTEL-DGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEF 128
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 374-650 6.73e-20

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 92.20  E-value: 6.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 374 ALELVTSkmvdcgPPVQWADVAGqgaLKAALEE-----ELvwPLLRPPAYP--GsLRPPRTVLLFGPRGAGKALLGRCLA 446
Cdd:PRK03992  119 AMEVIES------PNVTYEDIGG---LEEQIREvreavEL--PLKKPELFEevG-IEPPKGVLLYGPPGTGKTLLAKAVA 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 447 TQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGA------LQvpLLACLdg 520
Cdd:PRK03992  187 HETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSGDRevqrtlMQ--LLAEM-- 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 521 GCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQraLAQQGCALSE----RELAALvqgTQGFS 594
Cdd:PRK03992  263 DGFDPRGNVKIIAATNRIDILDPAILRpgRFDRIIEVPLPDEEGRLEILK--IHTRKMNLADdvdlEELAEL---TEGAS 337

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1864355959 595 GGELGQLCQQaaagAGLPGLQRPLSY---KDLEAALAKVgprASAKELDSFVEWDKMYG 650
Cdd:PRK03992  338 GADLKAICTE----AGMFAIRDDRTEvtmEDFLKAIEKV---MGKEEKDSMEEPGVMFA 389
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 424-559 2.06e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 53.53  E-value: 2.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959  424 PPRTVLLFGPRGAGKALLGRCLATQLGAT-----------------LLRLRGATLAAPGAAEGARLLQAAFAAARCRPPS 486
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggviyidgedileevlDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1864355959  487 VLLISELEALLPARDDgaaaggALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEA-TRRRFSLRFYVALPD 559
Cdd:smart00382  81 VLILDEITSLLDAEQE------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
529-606 6.16e-03

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 39.63  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 529 VLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQ-----RALAqqgcalSERELAALVQGTQGFSGGELGQL 601
Cdd:COG0465   281 VIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAILKvharkKPLA------PDVDLEVIARRTPGFSGADLANL 354


                  ....*
gi 1864355959 602 CQQAA 606
Cdd:COG0465   355 VNEAA 359
 
Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 393-555 4.94e-82

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 255.96  E-value: 4.94e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARL 472
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 473 LQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLR 552
Cdd:cd19523    81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSKR 160


                  ...
gi 1864355959 553 FYV 555
Cdd:cd19523   161 LLV 163
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 371-555 2.59e-50

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 172.87  E-value: 2.59e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 371 DPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLG 450
Cdd:cd19525     1 EPKMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 451 ATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGA-AAGGALQVPLLACLDGGCGAGADGV 529
Cdd:cd19525    81 ATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEhESSRRIKTEFLVQLDGATTSSEDRI 160

                         170       180
                  ....*....|....*....|....*.
gi 1864355959 530 LVVGTTSRPAALDEATRRRFSLRFYV 555
Cdd:cd19525   161 LVVGATNRPQEIDEAARRRLVKRLYI 186
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 394-555 1.06e-40

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 145.96  E-value: 1.06e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 394 VAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLL 473
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 474 QAAFAAARCRPPSVLLISELEALLPARDDGAAAGGA-LQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLR 552
Cdd:cd19509    81 RALFALARELQPSIIFIDEIDSLLSERGSGEHEASRrVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFEKR 160


                  ...
gi 1864355959 553 FYV 555
Cdd:cd19509   161 IYI 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 391-630 1.37e-40

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 152.76  E-value: 1.37e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 391 WADVAGQGALKAALEEELVWPLLRPPAYP-GSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEG 469
Cdd:COG0464   156 LDDLGGLEEVKEELRELVALPLKRPELREeYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGET 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 470 ARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVP-LLACLdggcGAGADGVLVVGTTSRPAALDEATRRR 548
Cdd:COG0464   236 EKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNtLLTEM----EELRSDVVVIAATNRPDLLDPALLRR 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 549 FSLRFYVALPDSPARGQILQRALAQQGCAlSERELAALVQGTQGFSGGELGQLCQQAAAGAgLPGLQRPLSYKDLEAALA 628
Cdd:COG0464   312 FDEIIFFPLPDAEERLEIFRIHLRKRPLD-EDVDLEELAEATEGLSGADIRNVVRRAALQA-LRLGREPVTTEDLLEALE 389


                  ..
gi 1864355959 629 KV 630
Cdd:COG0464   390 RE 391
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 387-635 2.45e-40

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 150.16  E-value: 2.45e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYP--GsLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAP 464
Cdd:COG1222    73 PDVTFDDIGGLDEQIEEIREAVELPLKNPELFRkyG-IEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSK 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 465 GAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGaAAGGALQ--VP-LLACLdgGCGAGADGVLVVGTTSRPAAL 541
Cdd:COG1222   152 YIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDD-GTSGEVQrtVNqLLAEL--DGFESRGDVLIIAATNRPDLL 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 542 DEATRR--RFSLRFYVALPDSPARGQILQRALaqQGCALSERE-LAALVQGTQGFSGGELGQLCQQAAAGAGLPGLQRpL 618
Cdd:COG1222   229 DPALLRpgRFDRVIEVPLPDEEAREEILKIHL--RDMPLADDVdLDKLAKLTEGFSGADLKAIVTEAGMFAIREGRDT-V 305

                         250
                  ....*....|....*..
gi 1864355959 619 SYKDLEAALAKVGPRAS 635
Cdd:COG1222   306 TMEDLEKAIEKVKKKTE 322
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 393-555 1.91e-30

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 117.26  E-value: 1.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARL 472
Cdd:cd19524     1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 473 LQAAFAAARCRPPSVLLISELEALLPARDDGAA-AGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSL 551
Cdd:cd19524    81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHeASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRFTK 160


                  ....
gi 1864355959 552 RFYV 555
Cdd:cd19524   161 RVYV 164
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 365-650 1.64e-29

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 124.63  E-value: 1.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 365 ETPKGVDPGALELVTSKMvdcgPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGR 443
Cdd:TIGR01243 430 EALKMVEPSAIREVLVEV----PNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKmGIRPPKGVLLFGPPGTGKTLLAK 505

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 444 CLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPAR--DDGAAAGGALQVPLLACLdgG 521
Cdd:TIGR01243 506 AVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARgaRFDTSVTDRIVNQLLTEM--D 583

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 522 CGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQraLAQQGCALSER-ELAALVQGTQGFSGGEL 598
Cdd:TIGR01243 584 GIQELSNVVVIAATNRPDILDPALLRpgRFDRLILVPPPDEEARKEIFK--IHTRSMPLAEDvDLEELAEMTEGYTGADI 661

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864355959 599 GQLCQQAAAGAGLPGLQRP-----------------LSYKDLEAALAKVGPRASAKELDSFVEWDKMYG 650
Cdd:TIGR01243 662 EAVCREAAMAALRESIGSPakeklevgeeeflkdlkVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 387-555 4.06e-27

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 108.03  E-value: 4.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGA 466
Cdd:cd19521     2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 467 AEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAA-AGGALQVPLLACLdGGCGAGADGVLVVGTTSRPAALDEAT 545
Cdd:cd19521    82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESeASRRIKTELLVQM-NGVGNDSQGVLVLGATNIPWQLDSAI 160

                         170
                  ....*....|
gi 1864355959 546 RRRFSLRFYV 555
Cdd:cd19521   161 RRRFEKRIYI 170
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 400-555 2.04e-25

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 102.75  E-value: 2.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 400 LKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAA 479
Cdd:cd19481     1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 480 ARCRPPSVLLISELEALLPARDDGAAAGGALQV--PLLACLdgGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYV 555
Cdd:cd19481    81 ARRLAPCILFIDEIDAIGRKRDSSGESGELRRVlnQLLTEL--DGVNSRSKVLVIAATNRPDLLDPALLRpgRFDEVIEF 158
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
391-629 4.67e-24

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 101.50  E-value: 4.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 391 WADVAGQ----GALKAALEEELVWPLLRppAYpgSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGA 466
Cdd:COG1223     1 LDDVVGQeeakKKLKLIIKELRRRENLR--KF--GLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 467 AEGARLLQAAFAAARCRPpSVLLISELEALLPARDDGAAAGGALQV--PLLACLDGGCGAgadgVLVVGTTSRPAALDEA 544
Cdd:COG1223    77 GETARNLRKLFDFARRAP-CVIFFDEFDAIAKDRGDQNDVGEVKRVvnALLQELDGLPSG----SVVIAATNHPELLDSA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 545 TRRRFSLRFYVALPDSPARGQILQRALaqQGCALS-ERELAALVQGTQGFSGGELGQLCQQAAAGAGLPGLQRpLSYKDL 623
Cdd:COG1223   152 LWRRFDEVIEFPLPDKEERKEILELNL--KKFPLPfELDLKKLAKKLEGLSGADIEKVLKTALKKAILEDREK-VTKEDL 228


                  ....*.
gi 1864355959 624 EAALAK 629
Cdd:COG1223   229 EEALKQ 234
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 387-648 9.59e-24

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 106.53  E-value: 9.59e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPG 465
Cdd:TIGR01243 173 PKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHlGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKY 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 466 AAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDgaaAGGALQVPLLACLDGG--CGAGADGVLVVGTTSRPAALDE 543
Cdd:TIGR01243 253 YGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREE---VTGEVEKRVVAQLLTLmdGLKGRGRVIVIGATNRPDALDP 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 544 ATRR--RFSLRFYVALPDSPARGQILQRALAQQGCAlSERELAALVQGTQGFSGGELGQLCQQAAAGAglpgLQR--PLS 619
Cdd:TIGR01243 330 ALRRpgRFDREIVIRVPDKRARKEILKVHTRNMPLA-EDVDLDKLAEVTHGFVGADLAALAKEAAMAA----LRRfiREG 404

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1864355959 620 YKDLEaalAKVGPRASAKEL----DSFVEWDKM 648
Cdd:TIGR01243 405 KINFE---AEEIPAEVLKELkvtmKDFMEALKM 434
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 393-555 6.47e-23

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 95.82  E-value: 6.47e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARL 472
Cdd:cd19522     1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 473 LQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVP--LLACL-----DGGCGAGADGVLVVGTTSRPAALDEAT 545
Cdd:cd19522    81 VRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKseLLVQMdgvggASENDDPSKMVMVLAATNFPWDIDEAL 160

                         170
                  ....*....|
gi 1864355959 546 RRRFSLRFYV 555
Cdd:cd19522   161 RRRLEKRIYI 170
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 393-555 6.94e-23

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 95.57  E-value: 6.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELVWPLLRPPAYPGS--LRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGA 470
Cdd:cd19520     1 DIGGLDEVITELKELVILPLQRPELFDNSrlLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 471 RLLQAAFAAARCRPPSVLLISELEALLPARDDGA-AAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRF 549
Cdd:cd19520    81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDhEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                  ....*.
gi 1864355959 550 SLRFYV 555
Cdd:cd19520   161 PKRFHI 166
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 393-549 1.20e-21

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 91.97  E-value: 1.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGAR 471
Cdd:cd19503     1 DIGGLDEQIASLKELIELPLKYPELFRAlGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 472 LLQAAFAAARCRPPSVLLISELEALLPARD-DGAAAGGALQVPLLACLdgGCGAGADGVLVVGTTSRPAALDEATRR--R 548
Cdd:cd19503    81 NLREIFEEARSHAPSIIFIDEIDALAPKREeDQREVERRVVAQLLTLM--DGMSSRGKVVVIAATNRPDAIDPALRRpgR 158


                  .
gi 1864355959 549 F 549
Cdd:cd19503   159 F 159
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 400-555 2.63e-21

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 90.81  E-value: 2.63e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 400 LKAALEEELVWPLLRPPAYP-GSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFA 478
Cdd:cd19511     1 VKRELKEAVEWPLKHPDAFKrLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 479 AARCRPPSVLLISELEALLPARDDGAAAGGALQV--PLLACLdgGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFY 554
Cdd:cd19511    81 KARQAAPCIIFFDEIDSLAPRRGQSDSSGVTDRVvsQLLTEL--DGIESLKGVVVIAATNRPDMIDPALLRpgRLDKLIY 158


                  .
gi 1864355959 555 V 555
Cdd:cd19511   159 V 159
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 428-555 2.96e-21

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 89.96  E-value: 2.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 428 VLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGaaAG 507
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSG--GD 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1864355959 508 GALQVP---LLACLdGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYV 555
Cdd:pfam00004  79 SESRRVvnqLLTEL-DGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEF 128
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 374-650 6.73e-20

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 92.20  E-value: 6.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 374 ALELVTSkmvdcgPPVQWADVAGqgaLKAALEE-----ELvwPLLRPPAYP--GsLRPPRTVLLFGPRGAGKALLGRCLA 446
Cdd:PRK03992  119 AMEVIES------PNVTYEDIGG---LEEQIREvreavEL--PLKKPELFEevG-IEPPKGVLLYGPPGTGKTLLAKAVA 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 447 TQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGA------LQvpLLACLdg 520
Cdd:PRK03992  187 HETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSGDRevqrtlMQ--LLAEM-- 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 521 GCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQraLAQQGCALSE----RELAALvqgTQGFS 594
Cdd:PRK03992  263 DGFDPRGNVKIIAATNRIDILDPAILRpgRFDRIIEVPLPDEEGRLEILK--IHTRKMNLADdvdlEELAEL---TEGAS 337

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1864355959 595 GGELGQLCQQaaagAGLPGLQRPLSY---KDLEAALAKVgprASAKELDSFVEWDKMYG 650
Cdd:PRK03992  338 GADLKAICTE----AGMFAIRDDRTEvtmEDFLKAIEKV---MGKEEKDSMEEPGVMFA 389
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 401-555 2.14e-18

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 82.54  E-value: 2.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 401 KAALEEELVWPLLRPPAYPGS-LRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAA 479
Cdd:cd19529     2 KQELKEAVEWPLLKPEVFKRLgIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 480 ARCRPPSVLLISELEALLPARDDGAAAGGALQV--PLLACLdgGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYV 555
Cdd:cd19529    82 ARQVAPCVIFFDEIDSIAPRRGTTGDSGVTERVvnQLLTEL--DGLEEMNGVVVIAATNRPDIIDPALLRagRFDRLIYI 159
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 391-547 2.45e-17

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 80.07  E-value: 2.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 391 WADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEG 469
Cdd:cd19502     2 YEDIGGLDEQIREIREVVELPLKHPELFEElGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 470 ARLLQAAFAAARCRPPSVLLISELEALLPAR-DDGAAAGGALQVPLLACLDGGCG-AGADGVLVVGTTSRPAALDEATRR 547
Cdd:cd19502    82 ARLVRELFEMAREKAPSIIFIDEIDAIGAKRfDSGTGGDREVQRTMLELLNQLDGfDPRGNIKVIMATNRPDILDPALLR 161
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
391-630 3.68e-17

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 85.47  E-value: 3.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 391 WADVAGQGALKAALEEELVWplLRPPAYPGSL--RPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAE 468
Cdd:PRK10733  151 FADVAGCDEAKEEVAELVEY--LREPSRFQKLggKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGV 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 469 GARLLQAAFAAARCRPPSVLLISELEALlpARDDGAAAGGAL----QVPLLACLDGGCGAGADGVLVVGTTSRPAALDEA 544
Cdd:PRK10733  229 GASRVRDMFEQAKKAAPCIIFIDEIDAV--GRQRGAGLGGGHdereQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPA 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 545 TRR--RFSLRFYVALPDSPARGQILQRALAQQGCAlSERELAALVQGTQGFSGGELGQLCQQAAAGAGlPGLQRPLSYKD 622
Cdd:PRK10733  307 LLRpgRFDRQVVVGLPDVRGREQILKVHMRRVPLA-PDIDAAIIARGTPGFSGADLANLVNEAALFAA-RGNKRVVSMVE 384


                  ....*...
gi 1864355959 623 LEAALAKV 630
Cdd:PRK10733  385 FEKAKDKI 392
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 393-549 8.95e-17

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 78.25  E-value: 8.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGAR 471
Cdd:cd19519     1 DIGGCRKQLAQIREMVELPLRHPELFKAiGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 472 LLQAAFAAARCRPPSVLLISELEALLPARDDgaaAGGALQVPLLACLDGG--CGAGADGVLVVGTTSRPAALDEATRR-- 547
Cdd:cd19519    81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREK---THGEVERRIVSQLLTLmdGLKQRAHVIVMAATNRPNSIDPALRRfg 157


                  ..
gi 1864355959 548 RF 549
Cdd:cd19519   158 RF 159
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 387-605 2.09e-16

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 81.73  E-value: 2.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPG 465
Cdd:PTZ00454  140 PDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQiGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKY 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 466 AAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDgaAAGGA---LQVPLLACLDGGCG-AGADGVLVVGTTSRPAAL 541
Cdd:PTZ00454  220 LGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFD--AQTGAdreVQRILLELLNQMDGfDQTTNVKVIMATNRADTL 297

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864355959 542 DEATRR--RFSLRFYVALPDSPARGQILQRALAQQGCAlSERELAALVQGTQGFSGGELGQLCQQA 605
Cdd:PTZ00454  298 DPALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMNLS-EEVDLEDFVSRPEKISAADIAAICQEA 362
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 370-605 6.01e-16

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 80.59  E-value: 6.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 370 VDPgaleLVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLATQ 448
Cdd:PTZ00361  165 VDP----LVSVMKVDKAPLESYADIGGLEQQIQEIKEAVELPLTHPELYDDiGIKPPKGVILYGPPGTGKTLLAKAVANE 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 449 LGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDgAAAGGA--LQVPLLACLDGGCG-AG 525
Cdd:PTZ00361  241 TSATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYD-ATSGGEkeIQRTMLELLNQLDGfDS 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 526 ADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQRALAQQGCAlSERELAALVQGTQGFSGGELGQLCQ 603
Cdd:PTZ00361  320 RGDVKVIMATNRIESLDPALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSKMTLA-EDVDLEEFIMAKDELSGADIKAICT 398


                  ..
gi 1864355959 604 QA 605
Cdd:PTZ00361  399 EA 400
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 398-549 1.01e-15

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 75.13  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 398 GALKAALEE--ELVWPLLRPPAYPGSL--RPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLL 473
Cdd:cd19518     3 GGMDSTLKElcELLIHPILPPEYFQHLgvEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEKI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 474 QAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVP-LLACL--DGGCGAGADGVLVVGTTSRPAALDEATRR--R 548
Cdd:cd19518    83 RELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSqLLTCMdeLNNEKTAGGPVLVIGATNRPDSLDPALRRagR 162


                  .
gi 1864355959 549 F 549
Cdd:cd19518   163 F 163
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 404-555 1.45e-14

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 71.75  E-value: 1.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 404 LEEELVWPLLRPPAYPG-----SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFA 478
Cdd:cd19530     4 VREELTMSILRPIKRPDiykalGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQ 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864355959 479 AARCRPPSVLLISELEALLPARDDGAAAGGALQVPLLaCLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYV 555
Cdd:cd19530    84 RARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQL-LTEMDGLEERSNVFVIAATNRPDIIDPAMLRpgRLDKTLYV 161
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 400-555 1.46e-14

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 71.78  E-value: 1.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 400 LKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAA 479
Cdd:cd19527     1 VKKEILDTIQLPLEHPELFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 480 ARCRPPSVLLISELEALLPARDDGAAAGGALQ--VPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYV 555
Cdd:cd19527    81 ARDAKPCVIFFDELDSLAPSRGNSGDSGGVMDrvVSQLLAELDGMSSSGQDVFVIGATNRPDLLDPALLRpgRFDKLLYL 160
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 393-554 7.47e-14

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 69.85  E-value: 7.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLATQLGA-----TLLRLRGATLAAPGA 466
Cdd:cd19517     1 DIGGLSHYINQLKEMVFFPLLYPEVFAKfKITPPRGVLFHGPPGTGKTLMARALAAECSKggqkvSFFMRKGADCLSKWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 467 AEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLdGGCGAGADGVLVVGTTSRPAALDEATR 546
Cdd:cd19517    81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLAL-MDGLDNRGQVVVIGATNRPDALDPALR 159

                         170
                  ....*....|
gi 1864355959 547 R--RFSLRFY 554
Cdd:cd19517   160 RpgRFDREFY 169
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 389-555 2.43e-11

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 62.64  E-value: 2.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 389 VQWADVAGQGALKAALEEeLVWPLLRPPAYP--GSlRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGA 466
Cdd:cd19501     1 VTFKDVAGCEEAKEELKE-VVEFLKNPEKFTklGA-KIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 467 AEGARLLQAAFAAARCRPPSVLLISELEALlpARDDGAAAGGALQV------PLLACLdgGCGAGADGVLVVGTTSRPAA 540
Cdd:cd19501    79 GVGASRVRDLFEQAKKNAPCIVFIDEIDAV--GRKRGAGLGGGHDEreqtlnQLLVEM--DGFESNTGVIVIAATNRPDV 154

                         170
                  ....*....|....*..
gi 1864355959 541 LDEATRR--RFSLRFYV 555
Cdd:cd19501   155 LDPALLRpgRFDRQVYV 171
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 401-547 4.26e-10

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 58.59  E-value: 4.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 401 KAALEEELVWPLLRPPAYPGS-LRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAP--GAAE-GARLLqaa 476
Cdd:cd19526     2 KKALEETIEWPSKYPKIFASSpLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKyiGASEqNVRDL--- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1864355959 477 FAAARCRPPSVLLISELEALLPAR-DDGAAAGGALQVPLLACLdgGCGAGADGVLVVGTTSRPAALDEATRR 547
Cdd:cd19526    79 FSRAQSAKPCILFFDEFDSIAPKRgHDSTGVTDRVVNQLLTQL--DGVEGLDGVYVLAATSRPDLIDPALLR 148
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 422-557 7.11e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 57.93  E-value: 7.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 422 LRPPRTVLLFGPRGAGKALLGRCLATQL---GATLLRLRGATLAAPGAAEGAR---LLQAAFAAARCRPPSVLLISELEA 495
Cdd:cd00009    16 LPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPGVLFIDEIDS 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1864355959 496 LLPARDDGaaaggalQVPLLAcLDGGCGAGADGVLVVGTTSRPAA--LDEATRRRFSLRFYVAL 557
Cdd:cd00009    96 LSRGAQNA-------LLRVLE-TLNDLRIDRENVRVIGATNRPLLgdLDRALYDRLDIRIVIPL 151
ftsH CHL00176
cell division protein; Validated
 393-606 1.70e-09

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 60.83  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEelVWPLLRPPAYPGSL--RPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGA 470
Cdd:CHL00176  184 DIAGIEEAKEEFEE--VVSFLKKPERFTAVgaKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVGVGA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 471 RLLQAAFAAARCRPPSVLLISELEALlpARDDGAAAGGA----LQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATR 546
Cdd:CHL00176  262 ARVRDLFKKAKENSPCIVFIDEIDAV--GRQRGAGIGGGnderEQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAALL 339

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1864355959 547 R--RFSLRFYVALPDSPARGQILqRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAA 606
Cdd:CHL00176  340 RpgRFDRQITVSLPDREGRLDIL-KVHARNKKLSPDVSLELIARRTPGFSGADLANLLNEAA 400
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 424-559 2.06e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 53.53  E-value: 2.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959  424 PPRTVLLFGPRGAGKALLGRCLATQLGAT-----------------LLRLRGATLAAPGAAEGARLLQAAFAAARCRPPS 486
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggviyidgedileevlDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1864355959  487 VLLISELEALLPARDDgaaaggALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEA-TRRRFSLRFYVALPD 559
Cdd:smart00382  81 VLILDEITSLLDAEQE------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 393-555 1.66e-06

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 48.52  E-value: 1.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 393 DVAGQGALKAALEEELvwPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARL 472
Cdd:cd19507     1 DVGGLDNLKDWLKKRK--AAFSKQASAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 473 LQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVplLACLDGGCGAGADGVLVVGTTSRPAAL-DEATRR-RFS 550
Cdd:cd19507    79 LRQMIQTAEAIAPCVLWIDEIEKGFSNADSKGDSGTSSRV--LGTFLTWLQEKKKPVFVVATANNVQSLpPELLRKgRFD 156


                  ....*
gi 1864355959 551 LRFYV 555
Cdd:cd19507   157 EIFFV 161
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 426-494 9.11e-05

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 43.29  E-value: 9.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864355959 426 RTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAA--PGAAEGARLLQAAFAAARCRPPSVLLISELE 494
Cdd:cd19506    27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGkyPGKNGLQMMLHLVLKVARQLQPSVIWIGDAE 97
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
529-606 6.16e-03

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 39.63  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864355959 529 VLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQ-----RALAqqgcalSERELAALVQGTQGFSGGELGQL 601
Cdd:COG0465   281 VIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAILKvharkKPLA------PDVDLEVIARRTPGFSGADLANL 354


                  ....*
gi 1864355959 602 CQQAA 606
Cdd:COG0465   355 VNEAA 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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