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Conserved domains on  [gi|1883684770|ref|NP_001372921|]
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protein FAM13B isoform 8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-205 3.92e-104

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


:

Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 320.18  E-value: 3.92e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  19 KIFGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLL 98
Cdd:cd04393     1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHG-LEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  99 RFFLQELPEPVIPGSLHIHLMQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH-EEIWSANSLAAVF 177
Cdd:cd04393    80 RLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHhENRMTAENLAAVF 159

                         170       180
                  ....*....|....*....|....*...
gi 1883684770 178 GPDVFHIYTDVEDMKEQEIVSRIMAGLL 205
Cdd:cd04393   160 GPDVFHVYTDVEDMKEQEICSRIMAKLL 187
RecQL4_SLD2_NTD super family cl44467
N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA ...
 827-866 7.91e-04

N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins; RecQL4, also called ATP-dependent DNA helicase Q4, or DNA helicase, RecQ-like type 4 (RecQ4), or RTS, is a DNA-dependent ATPase that may modulate chromosome segregation. This family also includes fungal DNA replication regulator SLD2, also known as DNA replication and checkpoint protein 1 (DRC1), which functions with DPB11 to control DNA replication and the S-phase checkpoint. It is also required for the proper activation of RAD53 in response to DNA damage and replication blocks. This model corresponds to the N-terminal domain of RecQL4 and SLD2, which is a homeodomain-like DNA interaction motif.


The actual alignment was detected with superfamily member cd22289:

Pssm-ID: 412085  Cd Length: 49  Bit Score: 37.99  E-value: 7.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1883684770 827 KLRKTLREFEEAFYQQNGRNAQKEDRVPVLEE----YREYKKIK 866
Cdd:cd22289     5 ELKIALKTWERAFAKKHGRKPTKDDIKAAPEEikdlYKEYAKLK 48
 
Name Accession Description Interval E-value
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-205 3.92e-104

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 320.18  E-value: 3.92e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  19 KIFGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLL 98
Cdd:cd04393     1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHG-LEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  99 RFFLQELPEPVIPGSLHIHLMQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH-EEIWSANSLAAVF 177
Cdd:cd04393    80 RLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHhENRMTAENLAAVF 159

                         170       180
                  ....*....|....*....|....*...
gi 1883684770 178 GPDVFHIYTDVEDMKEQEIVSRIMAGLL 205
Cdd:cd04393   160 GPDVFHVYTDVEDMKEQEICSRIMAKLL 187
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 39-184 1.88e-42

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 151.54  E-value: 1.88e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  39 PFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDL-VKEADVPSAISLLRFFLQELPEPVIPGSLHIH 117
Cdd:pfam00620   1 PLIVRKCVEYLEKRG-LDTEGIFRVSGSASRIKELREAFDRGPDVDLdLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1883684770 118 LMQLSqDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVFHI 184
Cdd:pfam00620  80 FIEAA-KLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVnKMNAHNLAIVFGPTLLRP 146
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 37-201 2.19e-38

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 140.86  E-value: 2.19e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770   37 EVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLV-KEADVPSAISLLRFFLQELPEPVIPGSLH 115
Cdd:smart00324   2 PIPIIVEKCIEYLEKRG-LDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  116 IHLMQLSQDyNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVFH-IYTDVEDMKE 193
Cdd:smart00324  81 EEFIEAAKL-EDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEEnKMTARNLAIVFGPTLLRpPDGEVASLKD 159


                   ....*...
gi 1883684770  194 QEIVSRIM 201
Cdd:smart00324 160 IRHQNTVI 167
RecQL4_SLD2_NTD cd22289
N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA ...
 827-866 7.91e-04

N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins; RecQL4, also called ATP-dependent DNA helicase Q4, or DNA helicase, RecQ-like type 4 (RecQ4), or RTS, is a DNA-dependent ATPase that may modulate chromosome segregation. This family also includes fungal DNA replication regulator SLD2, also known as DNA replication and checkpoint protein 1 (DRC1), which functions with DPB11 to control DNA replication and the S-phase checkpoint. It is also required for the proper activation of RAD53 in response to DNA damage and replication blocks. This model corresponds to the N-terminal domain of RecQL4 and SLD2, which is a homeodomain-like DNA interaction motif.


Pssm-ID: 412085  Cd Length: 49  Bit Score: 37.99  E-value: 7.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1883684770 827 KLRKTLREFEEAFYQQNGRNAQKEDRVPVLEE----YREYKKIK 866
Cdd:cd22289     5 ELKIALKTWERAFAKKHGRKPTKDDIKAAPEEikdlYKEYAKLK 48
 
Name Accession Description Interval E-value
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-205 3.92e-104

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 320.18  E-value: 3.92e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  19 KIFGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLL 98
Cdd:cd04393     1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHG-LEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  99 RFFLQELPEPVIPGSLHIHLMQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH-EEIWSANSLAAVF 177
Cdd:cd04393    80 RLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHhENRMTAENLAAVF 159

                         170       180
                  ....*....|....*....|....*...
gi 1883684770 178 GPDVFHIYTDVEDMKEQEIVSRIMAGLL 205
Cdd:cd04393   160 GPDVFHVYTDVEDMKEQEICSRIMAKLL 187
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 39-184 1.88e-42

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 151.54  E-value: 1.88e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  39 PFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDL-VKEADVPSAISLLRFFLQELPEPVIPGSLHIH 117
Cdd:pfam00620   1 PLIVRKCVEYLEKRG-LDTEGIFRVSGSASRIKELREAFDRGPDVDLdLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1883684770 118 LMQLSqDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVFHI 184
Cdd:pfam00620  80 FIEAA-KLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVnKMNAHNLAIVFGPTLLRP 146
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 37-201 2.19e-38

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 140.86  E-value: 2.19e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770   37 EVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLV-KEADVPSAISLLRFFLQELPEPVIPGSLH 115
Cdd:smart00324   2 PIPIIVEKCIEYLEKRG-LDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  116 IHLMQLSQDyNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVFH-IYTDVEDMKE 193
Cdd:smart00324  81 EEFIEAAKL-EDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEEnKMTARNLAIVFGPTLLRpPDGEVASLKD 159


                   ....*...
gi 1883684770  194 QEIVSRIM 201
Cdd:smart00324 160 IRHQNTVI 167
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 39-205 1.74e-35

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 132.43  E-value: 1.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  39 PFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLHIHL 118
Cdd:cd00159     1 PLIIEKCIEYLEKNG-LNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 119 MQLSQDYNNEDEFgRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVFHI-YTDVEDMKEQEI 196
Cdd:cd00159    80 IELAKIEDEEERI-EALKELLKSLPPENRDLLKYLLKLLHKISQNSEVnKMTASNLAIVFAPTLLRPpDSDDELLEDIKK 158


                  ....*....
gi 1883684770 197 VSRIMAGLL 205
Cdd:cd00159   159 LNEIVEFLI 167
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 16-180 8.48e-28

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 111.28  E-value: 8.48e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  16 LANKIFGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAI 95
Cdd:cd04404     1 LPTQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHA-LTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  96 SLLRFFLQELPEPVIPGSLHIHLMQLSQdyNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLA 174
Cdd:cd04404    80 VILKTFLRELPEPLLTFDLYDDIVGFLN--VDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQnKMTNSNLA 157


                  ....*.
gi 1883684770 175 AVFGPD 180
Cdd:cd04404   158 VVFGPN 163
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 38-201 1.22e-26

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 107.91  E-value: 1.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  38 VPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLHIH 117
Cdd:cd04390    22 VPILVEQCVDFIREHG-LKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYED 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 118 LMQLSQDYNNEDEFGR-KLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVFHiyTDVED----M 191
Cdd:cd04390   101 FLSCAQLLSKDEEKGLgELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVnKMSVQNLATVFGPNILR--PKVEDpatiM 178

                         170
                  ....*....|
gi 1883684770 192 KEQEIVSRIM 201
Cdd:cd04390   179 EGTPQIQQLM 188
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 34-179 4.90e-22

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 94.80  E-value: 4.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  34 PDnEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEevDLVKEADV-PSAIS-LLRFFLQELPEPVIP 111
Cdd:cd04378    13 PD-EVPFIIKKCTSEIENRA-LGVQGIYRVSGSKARVEKLCQAFENGK--DLVELSELsPHDISsVLKLFLRQLPEPLIL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 112 GSLHIHLMQLSQDYNNEDEFG-------------RKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVF 177
Cdd:cd04378    89 FRLYNDFIALAKEIQRDTEEDkapntpievnriiRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEEnKMSPNNLGIVF 168


                  ..
gi 1883684770 178 GP 179
Cdd:cd04378   169 GP 170
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 21-183 1.07e-21

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 93.61  E-value: 1.07e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQggHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDL--VKEADVPSAISLL 98
Cdd:cd04403     1 FGCHLEALCQ--RENSTVPKFVRLCIEAVEKRG-LDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLddSKWEDIHVITGAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  99 RFFLQELPEPVIPGSLHIHLMQLSQDYNNEDEFgRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVF 177
Cdd:cd04403    78 KLFFRELPEPLFPYSLFNDFVAAIKLSDYEQRV-SAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKnRMTTQNLAIVF 156


                  ....*.
gi 1883684770 178 GPDVFH 183
Cdd:cd04403   157 GPTLLR 162
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-193 2.13e-20

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 89.82  E-value: 2.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQgghPDNEVPFIVRHVVDYIEEhGGLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLV-KEADVPSAISLLR 99
Cdd:cd04373     1 FGVPLANVVT---SEKPIPIFLEKCVEFIEA-TGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVsKDFTVNAVAGALK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 100 FFLQELPEPVIPGSLHIHLMQLSQdYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAVFG 178
Cdd:cd04373    77 SFFSELPDPLIPYSMHLELVEAAK-INDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKvNLMTSENLSICFW 155

                         170
                  ....*....|....*
gi 1883684770 179 PDVFHIytDVEDMKE 193
Cdd:cd04373   156 PTLMRP--DFTSMEA 168
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-205 1.93e-19

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 87.07  E-value: 1.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQGGHpDNeVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSG-EEVDLVK----EADVPSAI 95
Cdd:cd04398     1 FGVPLEDLILREG-DN-VPNIVYQCIQAIENFG-LNLEGIYRLSGNVSRVNKLKELFDKDpLNVLLISpedyESDIHSVA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  96 SLLRFFLQELPEPVIPGSLHIHLMQLSQdynNEDEFGRK--LRFLLQQLPPVNYSLLKFLCRFLANVAShHEEI--WSAN 171
Cdd:cd04398    78 SLLKLFFRELPEPLLTKALSREFIEAAK---IEDESRRRdaLHGLINDLPDANYATLRALMFHLARIKE-HESVnrMSVN 153

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1883684770 172 SLAAVFGPDVFHI-YTDVEDMKEQeivSRIMAGLL 205
Cdd:cd04398   154 NLAIIWGPTLMNAaPDNAADMSFQ---SRVIETLL 185
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-197 3.97e-19

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 86.30  E-value: 3.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQGgHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSG-EEVDLVKEA--DVPSAISL 97
Cdd:cd04395     2 FGVPLDDCPPS-SENPYVPLIVEVCCNIVEARG-LETVGIYRVPGNNAAISALQEELNRGgFDIDLQDPRwrDVNVVSSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  98 LRFFLQELPEPVIPGSLHIHLMQLSQDYNNEDEFgRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAV 176
Cdd:cd04395    80 LKSFFRKLPEPLFTNELYPDFIEANRIEDPVERL-KELRRLIHSLPDHHYETLKHLIRHLKTVADNSEvNKMEPRNLAIV 158

                         170       180
                  ....*....|....*....|....*..
gi 1883684770 177 FGPDVFHIYTD-----VEDMKEQ-EIV 197
Cdd:cd04395   159 FGPTLVRTSDDnmetmVTHMPDQcKIV 185
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 20-163 5.41e-19

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 85.87  E-value: 5.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  20 IFGIPLDE-LQQGGHPDN--EVPFIVRHVVDYIEEHGGLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEA---DVPS 93
Cdd:cd04400     1 IFGSPLEEaVELSSHKYNgrDLPSVVYRCIEYLDKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSlypDVHT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  94 AISLLRFFLQELPEPVIPGSLHIHLMQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASH 163
Cdd:cd04400    81 VAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEH 150
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-182 9.99e-19

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 85.25  E-value: 9.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  19 KIFGIPLDELQQGGHPDneVPFIVRHVVDYIEEHGGLEqqGLFQVNGNAETVEWLRQRYDSGEEVDLVKEA---DVPSAI 95
Cdd:cd04384     1 RVFGCDLTEHLLNSGQD--VPQVLKSCTEFIEKHGIVD--GIYRLSGIASNIQRLRHEFDSEQIPDLTKDVyiqDIHSVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  96 SLLRFFLQELPEPVIPGSLHIHLMQLSQdYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEEI-WSANSLA 174
Cdd:cd04384    77 SLCKLYFRELPNPLLTYQLYEKFSEAVS-AASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITnMHAKNLA 155


                  ....*...
gi 1883684770 175 AVFGPDVF 182
Cdd:cd04384   156 IVWAPNLL 163
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 37-179 2.01e-17

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 81.40  E-value: 2.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  37 EVPFIVRHVVDYIEeHGGLEQQGLFQVNGNAETVEWLRQRYDSGEE-VDLVKEAdvPSAI-SLLRFFLQELPEPVIPGSL 114
Cdd:cd04408    15 EVPFVVVRCTAEIE-NRALGVQGIYRISGSKARVEKLCQAFENGRDlVDLSGHS--PHDItSVLKHFLKELPEPVLPFQL 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1883684770 115 HIHLMQLSQDYN-------NEDEFG----RKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGP 179
Cdd:cd04408    92 YDDFIALAKELQrdsekaaESPSIVeniiRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDnKMSPNNLGIVFGP 168
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 35-183 6.19e-17

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 79.66  E-value: 6.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  35 DNEVPFIVRHVVDYIEEHGgLEQQGLFQVNG--------------NAETVEWLRQRYDsgeevdlvkEADVPSAislLRF 100
Cdd:cd04385    12 DNDIPVIVDKCIDFITQHG-LMSEGIYRKNGknssvkklleafrkDARSVQLREGEYT---------VHDVADV---LKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 101 FLQELPEPVIPGSLHIHLMQLSqDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGP 179
Cdd:cd04385    79 FLRDLPDPLLTSELHAEWIEAA-ELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDEnQMSVHNLALVFGP 157


                  ....
gi 1883684770 180 DVFH 183
Cdd:cd04385   158 TLFQ 161
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 20-191 6.43e-17

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 80.21  E-value: 6.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  20 IFGIPLDELQQGGHPDNE-VPFIVRHVVDYIEEHggLEQQGLFQVNGNAETVEWLRQRYDSGEEVDlvkEADVPSAIS-L 97
Cdd:cd04394     1 VFGVPLHSLPHSTVPEYGnVPKFLVDACTFLLDH--LSTEGLFRKSGSVVRQKELKAKLEGGEACL---SSALPCDVAgL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  98 LRFFLQELPEPVIPGSLHIHLMQlSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASH-HEEIWSANSLAAV 176
Cdd:cd04394    76 LKQFFRELPEPLLPYDLHEALLK-AQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRcSENKMDSSNLAVI 154

                         170
                  ....*....|....*
gi 1883684770 177 FGPDVFHIYTDVEDM 191
Cdd:cd04394   155 FAPNLFQSEEGGEKM 169
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 37-183 1.31e-16

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 79.41  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  37 EVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLHI 116
Cdd:cd04376     8 QVPRLVESCCQHLEKHG-LQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYT 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1883684770 117 HLMQlSQDYNNEDEFGrKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEEI------------WSANSLAAVFGPDVFH 183
Cdd:cd04376    87 AFIG-TALLEPDEQLE-ALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSidedgqevsgnkMTSLNLATIFGPNLLH 163
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 38-205 3.96e-16

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 77.72  E-value: 3.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  38 VPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLHIH 117
Cdd:cd04382    17 IPALIVHCVNEIEARG-LTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 118 LMQLSQDYnNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEEIWSANSLAAVFGPDVF-HIYTDVEDMKE-QE 195
Cdd:cd04382    96 FMEAAEIL-DEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSPECKMDINNLARVFGPTIVgYSVPNPDPMTIlQD 174

                         170
                  ....*....|..
gi 1883684770 196 IVS--RIMAGLL 205
Cdd:cd04382   175 TVRqpRVVERLL 186
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 20-180 1.14e-15

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 76.34  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  20 IFGIPLDElqqggH---PDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGE-EVDLVKEADVPSAI 95
Cdd:cd04386     4 VFGTPLEE-----HlkrTGREIALPIEACVMCLLETG-MNEEGLFRVGGGASKLKRLKAALDAGTfSLPLDEFYSDPHAV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  96 -SLLRFFLQELPEPVIPGSLHIHLMQLSqdyNNEDEFGRK--LRFLLQQLPPVNYSLLKFLCRFLANVASHHEEI-WSAN 171
Cdd:cd04386    78 aSALKSYLRELPDPLLTYNLYEDWVQAA---NKPDEDERLqaIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENkMSPS 154


                  ....*....
gi 1883684770 172 SLAAVFGPD 180
Cdd:cd04386   155 NIAIVLAPN 163
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 34-179 1.63e-15

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 76.38  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  34 PDNeVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGS 113
Cdd:cd04409    13 PDG-IPFIIKKCTSEIESRA-LCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLYLRQLPEPLILFR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 114 LHIHLMQLSQDYNNEDEFGR---------------------KLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSAN 171
Cdd:cd04409    91 LYNEFIGLAKESQHVNETQEakknsdkkwpnmctelnrillKSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEEnKMSAS 170


                  ....*...
gi 1883684770 172 SLAAVFGP 179
Cdd:cd04409   171 NLGIIFGP 178
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-201 1.65e-15

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 75.63  E-value: 1.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQGgHPdNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYD-SGEEVDLVKEA--DVPSAISL 97
Cdd:cd04372     1 YGCDLTTLVKA-HN-TQRPMVVDMCIREIEARG-LQSEGLYRVSGFAEEIEDVKMAFDrDGEKADISATVypDINVITGA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  98 LRFFLQELPEPVIPGSLHIHLMQLSQdYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAV 176
Cdd:cd04372    78 LKLYFRDLPIPVITYDTYPKFIDAAK-ISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDnKMNAENLGIV 156

                         170       180       190
                  ....*....|....*....|....*....|
gi 1883684770 177 FGPDVF-----HIYTDVEDMKEQEIVSRIM 201
Cdd:cd04372   157 FGPTLMrppedSALTTLNDMRYQILIVQLL 186
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-184 1.01e-14

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 73.24  E-value: 1.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQGG--HPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLvKEADVPSAISLL 98
Cdd:cd04381     1 FGASLSLAVERSrcHDGIDLPLVFRECIDYVEKHG-MKCEGIYKVSGIKSKVDELKAAYNRRESPNL-EEYEPPTVASLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  99 RFFLQELPEPVIPGSLHIHLMQLSQdYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEEI-WSANSLAAVF 177
Cdd:cd04381    79 KQYLRELPEPLLTKELMPRFEEACG-RPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETkMNIQNISIVL 157


                  ....*..
gi 1883684770 178 GPdVFHI 184
Cdd:cd04381   158 SP-TVQI 163
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 21-179 1.03e-14

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 73.19  E-value: 1.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDEL---QQGGHPDNEVPFIVRHVVDYIEEHGGLEQQGLFQVNGNAETVEWLRQRYDSGeEVDLVKEADVPSAISL 97
Cdd:cd04389     1 FGSSLEEImdrQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQW-DYPLSGLEDPHVPASL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  98 LRFFLQELPEPVIPGSLHIHLMQLSQDYNNEDEfgrklrfLLQQLPPVNYSLLKFLCRFL------ANVAshHEEIWSAN 171
Cdd:cd04389    80 LKLWLRELEEPLIPDALYQQCISASEDPDKAVE-------IVQKLPIINRLVLCYLINFLqvfaqpENVA--HTKMDVSN 150


                  ....*...
gi 1883684770 172 sLAAVFGP 179
Cdd:cd04389   151 -LAMVFAP 157
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-184 2.13e-14

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 72.45  E-value: 2.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  19 KIFGIPLDE-LQQGGHpdnEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEE--VDLVKEADVPSAI 95
Cdd:cd04383     1 KLFNGSLEEyIQDSGQ---AIPLVVESCIRFINLYG-LQHQGIFRVSGSQVEVNDIKNAFERGEDplADDQNDHDINSVA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  96 SLLRFFLQELPEPVIPGSLHIHLMQLSQdYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLA 174
Cdd:cd04383    77 GVLKLYFRGLENPLFPKERFEDLMSCVK-LENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDEnMMDPYNLA 155

                         170
                  ....*....|
gi 1883684770 175 AVFGPDVFHI 184
Cdd:cd04383   156 ICFGPTLMPV 165
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-194 7.98e-14

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 70.54  E-value: 7.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQGGHPdneVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSG-EEVDLvKEADVPSAISLLR 99
Cdd:cd04377     1 FGVSLSSLTSEDRS---VPLVLEKLLEHIEMHG-LYTEGIYRKSGSANKIKELRQGLDTDpDSVNL-EDYPIHVITSVLK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 100 FFLQELPEPVIPGSLHIHLMQLSQDYNNEDEFgRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAVFG 178
Cdd:cd04377    76 QWLRELPEPLMTFELYENFLRAMELEEKQERV-RALYSVLEQLPRANLNTLERLIFHLVRVALQEEvNRMSANALAIVFA 154

                         170       180
                  ....*....|....*....|..
gi 1883684770 179 P------DVFHIYTDVEDMKEQ 194
Cdd:cd04377   155 PcilrcpDTADPLQSLQDVSKT 176
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 38-179 1.04e-13

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 70.73  E-value: 1.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  38 VPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSG--EEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLH 115
Cdd:cd04387    16 VPYIVRQCVEEVERRG-MEEVGIYRISGVATDIQALKAAFDTNnkDVSVMLSEMDVNAIAGTLKLYFRELPEPLFTDELY 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1883684770 116 IHL---MQLSQDYNNEDefgrKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGP 179
Cdd:cd04387    95 PNFaegIALSDPVAKES----CMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVnKMSLHNLATVFGP 158
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 21-182 4.43e-12

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 66.34  E-value: 4.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHgGLEQQGLFQVNGNAETVEWLRQRYDSGEE-VDLVKEA--DVPSAISL 97
Cdd:cd04379     1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERR-GLDVIGLYRLCGSAAKKKELRDAFERNSAaVELSEELypDINVITGV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  98 LRFFLQELPEPVIPGSLHIHLMQ-LSQDYNNEDEFGRKL-RFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLA 174
Cdd:cd04379    80 LKDYLRELPEPLITPQLYEMVLEaLAVALPNDVQTNTHLtLSIIDCLPLSAKATLLLLLDHLSLVLSNSErNKMTPQNLA 159


                  ....*...
gi 1883684770 175 AVFGPDVF 182
Cdd:cd04379   160 VCFGPVLM 167
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 20-182 5.05e-12

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 66.22  E-value: 5.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  20 IFGIPLDELQQGGH---PDNEVPFIVRHVVDYIEEhGGLEQQGLFQVNGNAETVEWLRQRYDS--GEEVDLVKEADVPSA 94
Cdd:cd04391     1 LFGVPLSTLLERDQkkvPGSKVPLIFQKLINKLEE-RGLETEGILRIPGSAQRVKFLCQELEAkfYEGTFLWDQVKQHDA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  95 ISLLRFFLQELPEPVIPgSLHIHLMQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSL 173
Cdd:cd04391    80 ASLLKLFIRELPQPLLT-VEYLPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKnKMNLWNV 158


                  ....*....
gi 1883684770 174 AAVFGPDVF 182
Cdd:cd04391   159 AMIMAPNLF 167
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 16-205 5.97e-12

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 66.21  E-value: 5.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  16 LANKIFGIPLDELQQGGHPD-NEVPF-IVR---HVVDYIEEHGgLEQQGLFQVNGN--------AETVEWLrqryDSGEE 82
Cdd:cd04380    23 LPDPGIRNLIDQLELGDNPDySEVPLsIPKeiwRLVDYLYTRG-LAQEGLFEEPGLpsepgellAEIRDAL----DTGSP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  83 VDLVKEADVPSAISLLrfFLQELPEPVIPGSLHIHLmqLSQDYNNEDefgRKLRFLLQQLPPVNYSLLKFLCRFLANVAS 162
Cdd:cd04380    98 FNSPGSAESVAEALLL--FLESLPDPIIPYSLYERL--LEAVANNEE---DKRQVIRISLPPVHRNVFVYLCSFLRELLS 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1883684770 163 HHEEI-WSANSLAAVFGPDVFHIYTDV---EDMKEQEIVSRIMAGLL 205
Cdd:cd04380   171 ESADRgLDENTLATIFGRVLLRDPPRAggkERRAERDRKRAFIEQFL 217
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 36-201 9.51e-12

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 65.11  E-value: 9.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  36 NEVPF-IVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWL-----RQRYDSGEEVDL-VKEADVPSAISLLRFFLQELPEP 108
Cdd:cd04374    25 DDIGFkFVRKCIEAVETRG-INEQGLYRVVGVNSKVQKLlslglDPKTSTPGDVDLdNSEWEIKTITSALKTYLRNLPEP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 109 VIPGSLHIHLMQLSQDYNNEDEFGrKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVFHIYTD 187
Cdd:cd04374   104 LMTYELHNDFINAAKSENLESRVN-AIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKnLMTVSNLGVVFGPTLLRPQEE 182

                         170
                  ....*....|....*...
gi 1883684770 188 ----VEDMKEQEIVSRIM 201
Cdd:cd04374   183 tvaaIMDIKFQNIVVEIL 200
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 20-183 6.31e-11

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 62.32  E-value: 6.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  20 IFGIPLDELQqgghPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAiSLLR 99
Cdd:cd04402     1 LFGQPLSNIC----EDDNLPKPILDMLSLLYQKG-PSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLA-SVLK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 100 FFLQELPEPVIPGSLHIHLMqLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASH-HEEIWSANSLAAVFG 178
Cdd:cd04402    75 DFLRNIPGSLLSSDLYEEWM-SALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNsETNKMDAFNLAVCIA 153


                  ....*
gi 1883684770 179 PDVFH 183
Cdd:cd04402   154 PSLLW 158
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-183 9.71e-10

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 59.74  E-value: 9.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  19 KIFGIPLD-ELQQGGHPdneVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISL 97
Cdd:cd04375     3 NVFGVPLLvNLQRTGQP---LPRSIQQAMRWLRNNA-LDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  98 LRFFLQELPEPVIPGSLH---IHLMQlsqdYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASH-HEEIWSANSL 173
Cdd:cd04375    79 LKQYFRDLPEPLLTNKLSetfIAIFQ----YVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANsQENQMTATNL 154

                         170
                  ....*....|
gi 1883684770 174 AAVFGPDVFH 183
Cdd:cd04375   155 AVCLAPSLFH 164
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 20-182 1.37e-09

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 59.35  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  20 IFGIPLDE-LQQGG------HPDNE------VPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEevDLV 86
Cdd:cd04396     1 VFGVSLEEsLKYASvaisivDEDGEqyvygyIPVVVAKCGVYLKENA-TEVEGIFRVAGSSKRIRELQLIFSTPP--DYG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  87 KEAD-----VPSAISLLRFFLQELPEPVIPGSLH--------------IHLMQLSQDYNNEDEFGRKLRF--LLQQLPPV 145
Cdd:cd04396    78 KSFDwdgytVHDAASVLRRYLNNLPEPLVPLDLYeefrnplrkrprilQYMKGRINEPLNTDIDQAIKEYrdLITRLPNL 157

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1883684770 146 NYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVF 182
Cdd:cd04396   158 NRQLLLYLLDLLAVFARNSDKnLMTASNLAAIFQPGIL 195
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-179 4.49e-09

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 56.92  E-value: 4.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQGGHPdneVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRF 100
Cdd:cd04407     1 FGVRVGSLTSNKTS---VPIVLEKLLEHVEMHG-LYTEGIYRKSGSANRMKELHQLLQADPENVKLENYPIHAITGLLKQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 101 FLQELPEPvipgslhihLMQLSQ--DYNNEDEFGRKLRFL------LQQLPPVNYSLLKFLCRFLANVASHHE-EIWSAN 171
Cdd:cd04407    77 WLRELPEP---------LMTFAQynDFLRAVELPEKQEQLqaiyrvLEQLPTANHNTLERLIFHLVKVALEEDvNRMSPN 147


                  ....*...
gi 1883684770 172 SLAAVFGP 179
Cdd:cd04407   148 ALAIVFAP 155
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 25-196 7.46e-09

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 56.42  E-value: 7.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  25 LDELQQGGHPDNEVPFIVRhVVDYIEEHGgLEQQGLFQVNGNAETVEWlRQRYDSGEEVDLVKEADVPSAISLLRFFLQE 104
Cdd:cd04388     3 PDLTEQFSPPDVAPPLLIK-LVEAIEKKG-LESSTLYRTQSSSSLTEL-RQILDCDAASVDLEQFDVAALADALKRYLLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 105 LPEPVIPGSLHIHLMQLSQDYNNEDEFGRKLRFLLQ--QLPPVNYSLLKFLCRFLANVA-SHHEEIWSANSLAAVFGPDV 181
Cdd:cd04388    80 LPNPVIPAPVYSEMISRAQEVQSSDEYAQLLRKLIRspNLPHQYWLTLQYLLKHFFRLCqSSSKNLLSARALAEIFSPLL 159

                         170
                  ....*....|....*
gi 1883684770 182 FHIYTDVEDMKEQEI 196
Cdd:cd04388   160 FRFQPASSDSPEFHI 174
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 52-181 9.18e-09

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 56.32  E-value: 9.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  52 HGGLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLvKEADVPS--AISLLRFFLQELPEPVI-----PGSLHIHLMQLSQD 124
Cdd:cd04392    21 EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDL-ESGGFHAhdCATVLKGFLGELPEPLLthahyPAHLQIADLCQFDE 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1883684770 125 YNNEDEFGRK------LRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDV 181
Cdd:cd04392   100 KGNKTSAPDKerlleaLQLLLLLLPEENRNLLKLILDLLYQTAKHEDKnKMSADNLALLFTPHL 163
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-202 1.41e-07

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 52.70  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQgghPDNEVPFIVRHVVDYIEEHgGLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRF 100
Cdd:cd04406     1 FGVELSRLTS---EDRSVPLVVEKLINYIEMH-GLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770 101 FLQELPEPVIPGSLHIHLMQlSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAVFGP 179
Cdd:cd04406    77 WLRDLPNPLMTFELYEEFLR-AMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEEtNRMSANALAIVFAP 155

                         170       180
                  ....*....|....*....|...
gi 1883684770 180 DVFHIYTDVEDMKEQEIVSRIMA 202
Cdd:cd04406   156 CILRCPDTTDPLQSVQDISKTTT 178
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-193 1.88e-07

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 52.75  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIPLDELQQGGHPDNE---------VPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSG--EEVDLVKEA 89
Cdd:cd04397     1 FGVPLEILVEKFGADSTlgvgpgklrIPALIDDIISAMRQMD-MSVEGVFRKNGNIRRLKELTEEIDKNptEVPDLSKEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  90 DVPSAiSLLRFFLQELPEPVIPGSLHIHLMQlSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH---EE 166
Cdd:cd04397    80 PVQLA-ALLKKFLRELPDPLLTFKLYRLWIS-SQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFShidEE 157

                         170       180       190
                  ....*....|....*....|....*....|
gi 1883684770 167 IWS---ANSLAAVFGPDVFHIYTDVEDMKE 193
Cdd:cd04397   158 TGSkmdIHNLATVITPNILYSKTDNPNTGD 187
RecQL4_SLD2_NTD cd22289
N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA ...
 827-866 7.91e-04

N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins; RecQL4, also called ATP-dependent DNA helicase Q4, or DNA helicase, RecQ-like type 4 (RecQ4), or RTS, is a DNA-dependent ATPase that may modulate chromosome segregation. This family also includes fungal DNA replication regulator SLD2, also known as DNA replication and checkpoint protein 1 (DRC1), which functions with DPB11 to control DNA replication and the S-phase checkpoint. It is also required for the proper activation of RAD53 in response to DNA damage and replication blocks. This model corresponds to the N-terminal domain of RecQL4 and SLD2, which is a homeodomain-like DNA interaction motif.


Pssm-ID: 412085  Cd Length: 49  Bit Score: 37.99  E-value: 7.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1883684770 827 KLRKTLREFEEAFYQQNGRNAQKEDRVPVLEE----YREYKKIK 866
Cdd:cd22289     5 ELKIALKTWERAFAKKHGRKPTKDDIKAAPEEikdlYKEYAKLK 48
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-205 9.85e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 38.47  E-value: 9.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  21 FGIpldELQQGGHPDNE-VPFIVRHVVDYIEEH-----GGLEQQGLFQVNGNAETVEWLRQ----RYDSGEEVDLVKEAD 90
Cdd:cd04399     1 FGV---DLETRCRLDKKvVPLIVSAILSYLDQLypdliNDEVRRNVWTDPVSLKETHQLRNllnkPKKPDKEVIILKKFE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684770  91 VPSAISLLRFFLQELPEPVIPGSLHIHLMQLSQDY-----NNEDEFGRKLRFLLQQLPPVNY----SLLKFLCRF--LAN 159
Cdd:cd04399    78 PSTVASVLKLYLLELPDSLIPHDIYDLIRSLYSAYppsqeDSDTARIQGLQSTLSQLPKSHIatldAIITHFYRLieITK 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1883684770 160 VASHHEEIWS--ANSLAAVFGPDVFHIYTDVEDmkeqEIVSRIMAGLL 205
Cdd:cd04399   158 MGESEEEYADklATSLSREILRPIIESLLTIGD----KHGYKFFRDLL 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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