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Conserved domains on  [gi|1905437354|ref|NP_001373857|]
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protein Churchill isoform 2 [Homo sapiens]

Protein Classification

Churchill domain-containing protein( domain architecture ID 10534945)

Churchill domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Churchill pfam06573
Churchill protein; This family consists of several eukaryotic Churchill proteins. This protein ...
 1-111 8.00e-71

Churchill protein; This family consists of several eukaryotic Churchill proteins. This protein contains a novel zinc binding region that mediates FGF signaling during neural development (unpublished obs Sheng G and Stern C).


:

Pssm-ID: 461950  Cd Length: 111  Bit Score: 206.45  E-value: 8.00e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437354   1 MCGDCVEKEYPNRGNTCLENGSFLLNFTGCAVCSKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDE 80
Cdd:pfam06573   1 MCGDCVKEEYPDRGNTCLENGSYLLNFKGCASCQKRDFVLIVNKTAEEEDGEEVITYDHVCKNCHHVIAEHEYTFSVEDD 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1905437354  81 FQEYTMLCLLCGKAEDTISILPDDPRQMTLL 111
Cdd:pfam06573  81 YQEYTMLCLLCGKAEDSISVLPDDPRKMAPL 111
 
Name Accession Description Interval E-value
Churchill pfam06573
Churchill protein; This family consists of several eukaryotic Churchill proteins. This protein ...
 1-111 8.00e-71

Churchill protein; This family consists of several eukaryotic Churchill proteins. This protein contains a novel zinc binding region that mediates FGF signaling during neural development (unpublished obs Sheng G and Stern C).


Pssm-ID: 461950  Cd Length: 111  Bit Score: 206.45  E-value: 8.00e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437354   1 MCGDCVEKEYPNRGNTCLENGSFLLNFTGCAVCSKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDE 80
Cdd:pfam06573   1 MCGDCVKEEYPDRGNTCLENGSYLLNFKGCASCQKRDFVLIVNKTAEEEDGEEVITYDHVCKNCHHVIAEHEYTFSVEDD 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1905437354  81 FQEYTMLCLLCGKAEDTISILPDDPRQMTLL 111
Cdd:pfam06573  81 YQEYTMLCLLCGKAEDSISVLPDDPRKMAPL 111
 
Name Accession Description Interval E-value
Churchill pfam06573
Churchill protein; This family consists of several eukaryotic Churchill proteins. This protein ...
 1-111 8.00e-71

Churchill protein; This family consists of several eukaryotic Churchill proteins. This protein contains a novel zinc binding region that mediates FGF signaling during neural development (unpublished obs Sheng G and Stern C).


Pssm-ID: 461950  Cd Length: 111  Bit Score: 206.45  E-value: 8.00e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437354   1 MCGDCVEKEYPNRGNTCLENGSFLLNFTGCAVCSKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDE 80
Cdd:pfam06573   1 MCGDCVKEEYPDRGNTCLENGSYLLNFKGCASCQKRDFVLIVNKTAEEEDGEEVITYDHVCKNCHHVIAEHEYTFSVEDD 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1905437354  81 FQEYTMLCLLCGKAEDTISILPDDPRQMTLL 111
Cdd:pfam06573  81 YQEYTMLCLLCGKAEDSISVLPDDPRKMAPL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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