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Conserved domains on  [gi|1905437418|ref|NP_001373875|]
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solute carrier organic anion transporter family member 1A2 isoform 7 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
1-518 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17458:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 527  Bit Score: 907.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17458     4 IFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLGC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGI 160
Cdd:cd17458    84 FLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMPLGI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:cd17458   164 SYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLAG 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMIS 317
Cdd:cd17458   244 LPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMIS 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 318 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVG 397
Cdd:cd17458   324 FMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVAG 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 398 INTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAV- 476
Cdd:cd17458   404 LTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQNs 483
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 1905437418 477 --LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 518
Cdd:cd17458   484 saVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
1-518 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 907.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17458     4 IFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLGC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGI 160
Cdd:cd17458    84 FLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMPLGI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:cd17458   164 SYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLAG 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMIS 317
Cdd:cd17458   244 LPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMIS 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 318 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVG 397
Cdd:cd17458   324 FMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVAG 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 398 INTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAV- 476
Cdd:cd17458   404 LTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQNs 483
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 1905437418 477 --LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 518
Cdd:cd17458   484 saVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-581 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 867.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:TIGR00805  33 MFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLG 159
Cdd:TIGR00805 113 LLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPSECQKQHKSLMWLLFLVSNILRGIGATPIFPLG 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 160 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 239
Cdd:TIGR00805 193 ISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALLT 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 240 AIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 319
Cdd:TIGR00805 273 SIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFL 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 320 PKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGIN 399
Cdd:TIGR00805 353 PKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVN 432
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 400 TsyEGIPQDLYVENDIfaDCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGL 479
Cdd:TIGR00805 433 N--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGL 508
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 480 CDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWG 559
Cdd:TIGR00805 509 CD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQ 586
                         570       580
                  ....*....|....*....|..
gi 1905437418 560 TLKCGESGACRIYDSTTFRLSF 581
Cdd:TIGR00805 587 TLKCGASGACRMYDNDNLRVIY 608
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
1-577 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 587.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvYVLVGNIVRGMGETPILPLGI 160
Cdd:pfam03137  81 LLFALPHFL--------------------------------------------------SFFLGQLLLGIGGTPIYTLGI 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:pfam03137 111 SYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVSIT---LTPKDPRWVGAWWLGFLIAGLLLLLTA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGIT---KDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMIS 317
Cdd:pfam03137 188 IPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGpslKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYAT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 318 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVG 397
Cdd:pfam03137 268 FLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAG 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 398 INTSYEGIPQdlyVENDIFADCNVDCNCPSKIWDPVCGNNG-LSYLSACLAGCETSIGTGINMVFQNCSCI----QTSGN 472
Cdd:pfam03137 348 ITVPYGGTQQ---LSGNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCScgsqDSGGN 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 473 SSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMD 552
Cdd:pfam03137 425 GSATPGKCP--SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALID 502
                         570       580
                  ....*....|....*....|....*
gi 1905437418 553 STCLHWGTlKCGESGACRIYDSTTF 577
Cdd:pfam03137 503 STCLLWGK-TCGGRGNCWLYDNDKL 526
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-385 2.09e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.85  E-value: 2.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSktLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:COG2814    12 LLALALGAFLSG--LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLkslphflmnqyeyestVSVSGNLSSnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGI 160
Cdd:COG2814    90 LL----------------CALAPSLWL---------------------------------LLAARFLQGLGAGALFPAAL 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLTA 240
Cdd:COG2814   121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLALLAL 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IP-FFFLPNTLPKEgletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 319
Cdd:COG2814   179 LLlLRLLPESRPAA----------------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1905437418 320 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKItvKQAAHIGCWLSLLEYLLYFLS 385
Cdd:COG2814   231 PLYLQEVLGLSASAAGLLLALFGLGGV-LGALLAGRLADRFGR--RRLLLIGLLLLALGLLLLALA 293
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
1-518 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 907.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17458     4 IFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLGC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGI 160
Cdd:cd17458    84 FLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMPLGI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:cd17458   164 SYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLAG 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMIS 317
Cdd:cd17458   244 LPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMIS 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 318 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVG 397
Cdd:cd17458   324 FMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVAG 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 398 INTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAV- 476
Cdd:cd17458   404 LTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQNs 483
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 1905437418 477 --LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 518
Cdd:cd17458   484 saVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-581 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 867.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:TIGR00805  33 MFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLG 159
Cdd:TIGR00805 113 LLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPSECQKQHKSLMWLLFLVSNILRGIGATPIFPLG 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 160 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 239
Cdd:TIGR00805 193 ISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALLT 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 240 AIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 319
Cdd:TIGR00805 273 SIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFL 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 320 PKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGIN 399
Cdd:TIGR00805 353 PKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVN 432
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 400 TsyEGIPQDLYVENDIfaDCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGL 479
Cdd:TIGR00805 433 N--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGL 508
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 480 CDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWG 559
Cdd:TIGR00805 509 CD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQ 586
                         570       580
                  ....*....|....*....|..
gi 1905437418 560 TLKCGESGACRIYDSTTFRLSF 581
Cdd:TIGR00805 587 TLKCGASGACRMYDNDNLRVIY 608
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
1-517 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 684.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17400     3 MFLLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGLGC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkSLMWVYVLVGNIVRGMGETPILPLGI 160
Cdd:cd17400    83 FLKALPHFFMNQYEY---------------------------------------SLMWIYVFVGNILRGIGETPILPLGI 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:cd17400   124 SYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGFLICGGVSVLTA 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISFMP 320
Cdd:cd17400   204 IPFFFLP------------------------------------------------PIYMLFILVSVIQFNSFVGMITYMP 235
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 321 KYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINT 400
Cdd:cd17400   236 KYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGLTT 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 401 SYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGLC 480
Cdd:cd17400   316 SYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVFYNCSCIQTSGNSSANLSLC 395
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1905437418 481 DKG----PDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17400   396 DGGcprdPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
1-518 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 594.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17459     3 IFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAIGT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRP-----TQDPSECTKEVKSLMWVYVLVGNIVRGMGETPI 155
Cdd:cd17459    83 FLIALPHFFMGRYKYETAIQSSSNSTVSISPCSLEPSPQLHSiessdSKTGTGCEKEPGSSMWIYVFLGNLLRGIGETPV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 156 LPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGV 235
Cdd:cd17459   163 QPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLIAGVI 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 236 NVLTAIPFFFLPNTLPkegletnadiiknenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNM 315
Cdd:cd17459   243 TLLSAVPFWFLPKSLP-------------------------------KDFLPSLKNLLGNPVYFLYLCTSILQFNSLIGM 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 316 ISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSV 395
Cdd:cd17459   292 VTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLLSFFAMGCENSDV 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 396 VGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCI----QTSG 471
Cdd:cd17459   372 AGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFHNCSCIgipsSASG 451
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1905437418 472 NSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 518
Cdd:cd17459   452 SSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
1-577 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 587.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvYVLVGNIVRGMGETPILPLGI 160
Cdd:pfam03137  81 LLFALPHFL--------------------------------------------------SFFLGQLLLGIGGTPIYTLGI 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:pfam03137 111 SYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVSIT---LTPKDPRWVGAWWLGFLIAGLLLLLTA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGIT---KDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMIS 317
Cdd:pfam03137 188 IPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGpslKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYAT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 318 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVG 397
Cdd:pfam03137 268 FLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAG 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 398 INTSYEGIPQdlyVENDIFADCNVDCNCPSKIWDPVCGNNG-LSYLSACLAGCETSIGTGINMVFQNCSCI----QTSGN 472
Cdd:pfam03137 348 ITVPYGGTQQ---LSGNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCScgsqDSGGN 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 473 SSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMD 552
Cdd:pfam03137 425 GSATPGKCP--SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALID 502
                         570       580
                  ....*....|....*....|....*
gi 1905437418 553 STCLHWGTlKCGESGACRIYDSTTF 577
Cdd:pfam03137 503 STCLLWGK-TCGGRGNCWLYDNDKL 526
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
1-517 6.96e-175

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 502.84  E-value: 6.96e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17457     3 MFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGLGS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMNQYEYEstvsvsgnlssnsflcmengtqilrptqdpseCTKEVKSLMWVYVLVGNIVRGMGETPILPLGI 160
Cdd:cd17457    83 VLTALPHFFMGYYKYG--------------------------------CLKESGSYMWVYVLMGNMLRGIGETPIVPLGI 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:cd17457   131 SYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSIISA 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMP 320
Cdd:cd17457   211 IPFFFLP------------------------------------GFFQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTYKP 254
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 321 KYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINT 400
Cdd:cd17457   255 KYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGCENKSVAGITM 334
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 401 SYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSG----NSSAV 476
Cdd:cd17457   335 TYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSCLEVTGsqnrNYSAH 414
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1905437418 477 LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17457   415 LGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
1-517 1.57e-132

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 393.14  E-value: 1.57e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17336     3 VFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyvLVGNIVRGMGETPILPLGI 160
Cdd:cd17336    83 FLLALPHFL----------------------------------------------------FVGQFLLGIGSSPLYTLGI 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:cd17336   111 TYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLG---ITPDDPRWIGAWWLGFLILGILLLIVS 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISFMP 320
Cdd:cd17336   188 IPLFFFP------------------------------------------------PIFILLLLAIVFESFAISGFSTFLP 219
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 321 KYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINT 400
Cdd:cd17336   220 KYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIAGVTT 299
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 401 SYEGIPqdlyveNDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQT-SGNSSAVLGL 479
Cdd:cd17336   300 PYGSSS------SPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAGNGTKTYSNCSCINSgTATSSGCPPD 373
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1905437418 480 CDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17336   374 CSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
11-517 7.73e-100

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 311.35  E-value: 7.73e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  11 VSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLM 90
Cdd:cd17461    14 LSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLALGAFLLTLPHFLS 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  91 NQYEYEstvsvsgnlssnsflcmengtqilrptqdpsectkevkslMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFE 170
Cdd:cd17461    94 EPYQYS----------------------------------------MWVLMVVAQLLAGIGTVPIQPFGISYVDDFAEPS 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 171 NSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTL 250
Cdd:cd17461   134 NSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGLLISSGLLVLTSLPYFFFPREM 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 251 PKE---GLETNADIIKNENEDKQKEEVkkekyGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQY 327
Cdd:cd17461   214 LVGkkpSPEGDMLRKKEDEKKEEGSLL-----DFIKRFPKMFVKLLLNPLFMLLVLAQCTFSSVIAGLSTFLNKFLEKQY 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 328 GISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQ 407
Cdd:cd17461   289 GASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVPLFFMGCSTQDVAGVYPKTSNSSD 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 408 DLYvendifADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSI---GTGINMVFQNCSCIQT-SGNSSAVLGLCDKg 483
Cdd:cd17461   369 GPH------LSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNmdsSTYRQQIYSNCSCIPDlSGEKPAKTGSCPN- 441
                         490       500       510
                  ....*....|....*....|....*....|....
gi 1905437418 484 pDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17461   442 -SCSHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
11-517 2.06e-95

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 300.15  E-value: 2.06e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  11 VSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLM 90
Cdd:cd17460    13 LSQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAGFLMALPHFIS 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  91 NQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwVYVLVGNIVRGMGETPILPLGISYIEDFAKFE 170
Cdd:cd17460    93 EPYEY-------------------------------------------GILFLGQLLLGIGGVPIQPFGISYIDDFASES 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 171 NSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTL 250
Cdd:cd17460   130 NSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGFLIAATLVALSAVPYFFFPREM 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 251 PKEGLE-------TNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLScNPIYMLFILVSVIQFNAFVNMISFMPKYL 323
Cdd:cd17460   210 PKEVVElqprekkLAKTMLKKLKSLSDILQNLSLLQFIKKFPRILLRTLR-NPIYLLVVLAQVNLSAMVAGLATFMGKFL 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 324 EQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIgCWLSLLEYLLYFLSFL-MTCENSSVVGINTSY 402
Cdd:cd17460   289 ERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAM-CVLGMLLCLFFALPLLfIGCSTQKIAGITHRT 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 403 EGIPQdlyveNDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET---SIGTGINMVFQNCSCIQTSGN-SSAVLG 478
Cdd:cd17460   368 SSSPG-----LELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSvnvQALDNSVVNYTDCSCVSEGGPvGAASPG 442
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1905437418 479 LCDKGpdCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17460   443 TCGSG--CSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
1-517 2.67e-88

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 280.28  E-value: 2.67e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17402     3 IFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMNQYEyestvsvsgnlssnsflcmengtqilrptqdpsectkevKSLMWVYVLVGNIVRGMGETPILPLGI 160
Cdd:cd17402    83 LLSALPEFLTHQYK---------------------------------------TNMMYLLLIGAQVLLGIGATPVQPLGV 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:cd17402   124 SYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFFSA 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPNTLPKegletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMP 320
Cdd:cd17402   204 LLMFGFPQSLQQ-----------------------------LRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLG 254
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 321 KYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINT 400
Cdd:cd17402   255 KYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTV 334
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 401 SYeGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGinmvfqnCSCIQT--SGNSSAVLG 478
Cdd:cd17402   335 PY-GNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSG-------CACLSSvpAENATVVPG 406
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1905437418 479 LCDKgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17402   407 KCPS-PGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
2-517 3.42e-87

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 276.93  E-value: 3.42e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   2 FLLAITC-AFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17404     3 FLVCMCLlIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIALGS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLPHFLMnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyvlVGNIVRGMGETPILPLGI 160
Cdd:cd17404    83 FLFSLPHFFI----------------------------------------------------LAQILIGMGGTPIFTLGT 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTgfvNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTA 240
Cdd:cd17404   111 TYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDP---LSTPPDISPGDPRWIGAWWGGFLLCGIALLLVA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPFFFLPNtlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISFMP 320
Cdd:cd17404   188 FPFFTFPK-----------------------------------------------MTFLVVSLGYCMELAIVSGFITFLP 220
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 321 KYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINT 400
Cdd:cd17404   221 KYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAGITI 300
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 401 SYEGIPQ-DLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMV-FQNCSCIQTSGNSS---- 474
Cdd:cd17404   301 PYTTGPSlSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVGNTSTGIRnYTNCACLQSRSSISpptv 380
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1905437418 475 AVLGLCDKGP--DCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17404   381 GQGSQLQAGPcsRTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
11-517 4.66e-87

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 277.11  E-value: 4.66e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  11 VSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLM 90
Cdd:cd17401    13 LCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAAGAFLLTLPHFIS 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  91 NQYEYEstvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvYVLVGNIVRGMGETPILPLGISYIEDFAKFE 170
Cdd:cd17401    93 EPYQYG-------------------------------------------IMVVAQLLLGIGGVPIQPFGISYIDDFAEPS 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 171 NSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTL 250
Cdd:cd17401   130 NSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLVLTSFPYFFFPRFI 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 251 pkegletnadiiknenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGIS 330
Cdd:cd17401   210 --------------------------------KRFPCIFLRTLRNPIFLLVVLAQVTLSSMIAGLATFLNKFLEKQFGTT 257
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 331 SSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGIN---TSYEGIPQ 407
Cdd:cd17401   258 ASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIGCSTPTIAGVYppsSSSSIHPQ 337
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 408 DlyvendifADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET----SIGTGINMVFQNCSCIqTSGNSSAVLGLCDKG 483
Cdd:cd17401   338 S--------PACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSNinmsTSATSKQVIYTNCSCV-TGGSASAKTGSCPSP 408
                         490       500       510
                  ....*....|....*....|....*....|....
gi 1905437418 484 pdCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17401   409 --CSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
8-517 3.52e-86

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 274.13  E-value: 3.52e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   8 CAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPH 87
Cdd:cd17403    11 FAFLQGMVVNGFVNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGIGSLVFALPH 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  88 FLMnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGISYIEDFA 167
Cdd:cd17403    91 FTV--------------------------------------------------FILAQLLHGAGATPLYTLGVTYLDENV 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 168 KFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVnTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLP 247
Cdd:cd17403   121 STKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQV-DSELGLTPDDPRWVGAWWLGFLISGALALIIAFPLLGFP 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 248 ntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISFMPKYLEQQY 327
Cdd:cd17403   200 ------------------------------------------------PTFMFLNLAGASEGMLLAGFATFLPKLIESQF 231
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 328 GISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLyFLSFLMTCENSSVVGINTSYEGIPq 407
Cdd:cd17403   232 SLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLF-SFILLIYCPNAPFAGVTVPYGNSP- 309
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 408 dLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ---TSGNSSAVLGLCDKGP 484
Cdd:cd17403   310 -LEGTSNLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKVYSNCSCIQsnsSKTSTAATGKACPCET 388
                         490       500       510
                  ....*....|....*....|....*....|...
gi 1905437418 485 DCSLMLQYFLILSAMSSFIYsLAAIPGYMVLLR 517
Cdd:cd17403   389 CCQKLYLFLAVFFLLIVFTF-MSSTPALSATLR 420
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
9-517 5.67e-63

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 213.54  E-value: 5.67e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   9 AFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHF 88
Cdd:cd17462    12 SFLQGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFALPHF 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  89 lmnqyeyesTVsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGISYIEDFAK 168
Cdd:cd17462    92 ---------TV-----------------------------------------FMLGQFLHGIGATPLYTLGVTYLDENVK 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 169 FENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGfVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPN 248
Cdd:cd17462   122 SNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIG-RQTE---LTPENPLWVGAWWIGFLGAGAAALLIALPILGYPR 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 249 TLPkegletnadiiknenedkqkeevkkekyGITKdflpfmkslscNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYG 328
Cdd:cd17462   198 QLP----------------------------GLLK-----------NPTFIFLCLAGATEATLIAGMSTFGPKFLESQFS 238
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 329 ISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIgCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEG--IP 406
Cdd:cd17462   239 LSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKF-CLICTVVSLLAIFIFSLHCPNVPMAGVTASYRGsvLP 317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 407 QDLYvenDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGIN--MVFQNCSCIqtSGNSSAVLGLCDKGP 484
Cdd:cd17462   318 EGSL---NLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYSDIRNgqKVYQDCSCV--AGNLSVGFGEASAGK 392
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1905437418 485 DCSLMLQYFLILSAMSSFIY--SLAAIPGYMVLLR 517
Cdd:cd17462   393 CTSNCNHMPLLLAFVFLVILftFLCSIPALTATLR 427
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
3-517 1.69e-61

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 209.60  E-value: 1.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   3 LLAITCAFVSKTLsgsyMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFL 82
Cdd:cd17463    10 LLAVVQGIVVNGL----VNISISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGSLV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  83 KSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwVYVLvGNIVRGMGETPILPLGISY 162
Cdd:cd17463    86 FSLPHFF-------------------------------------------------VFIL-GQLLLGVGGTPLYTLGTAY 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 163 IEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLiiTPTDTRWVGAWWFGFLICAGVNVLTAIP 242
Cdd:cd17463   116 IDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSVDL--TEEDPRWLGAWWIGFLMCWLIAWCLIAP 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 243 FFFLPNTLPkegletnadiiknenedkqkeevkkekyGITKdflpfmkslscNPIYMLFILVSVIQFNAFVNMISFMPKY 322
Cdd:cd17463   194 FSCFPKHLP----------------------------GLLK-----------NPVFMCLTISSCSEALITTGFATFLPKF 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 323 LEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSY 402
Cdd:cd17463   235 IENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVFIFAKCGNDPFAGVSETY 314
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 403 EGIPQdlyvENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ-TSGNSSAVLGLCD 481
Cdd:cd17463   315 NGTGK----IGNLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDKKKVYYNCSCIGnFTEEFSANTTKCE 390
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1905437418 482 KGPDCSLM---LQYFLILSAMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17463   391 EGKKCETTcknLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
28-517 6.30e-34

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 133.82  E-value: 6.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  28 ERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFlmnqyeyestvsvsgnlss 107
Cdd:cd17405    30 QVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGLGSMLFAFPFF------------------- 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 108 nsflcmengtqilrptqdpsectkevkslmwVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGP 187
Cdd:cd17405    91 -------------------------------TFHIAGQCIQGIAGMPIYILGITFIFDNIPTSSAGIYLGIAHSAYLIGY 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 188 LIGLLLASfcANVYVDtgfVNTDDLIITPTDT--RWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPkegletnadiikne 265
Cdd:cd17405   140 LLGYVGGL--PNFQPP---PNEKSVEIEVNKVyqLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLP-------------- 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 266 nedkqkeevkkekyGITKdflpfmkslscNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPP 345
Cdd:cd17405   201 --------------GLLK-----------NPLLLCQAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPG 255
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 346 ICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQdlyvENDIFADCNVDCNC 425
Cdd:cd17405   256 GAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGINEDYDGYGQ----LGNLTAPCNEYCDC 331
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 426 PSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSS--------AVLGLCDKgpDCsLMLQYFLILS 497
Cdd:cd17405   332 TSSLYTSICGRDEIEYFSPCFAGCKASKVSNTEKTYYNCSCIKEGLAAAddegdfidAIAGKCDS--KC-YKLPLFFAFY 408
                         490       500
                  ....*....|....*....|
gi 1905437418 498 AMSSFIYSLAAIPGYMVLLR 517
Cdd:cd17405   409 FSATVFSNMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
415-468 1.62e-22

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 90.83  E-value: 1.62e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1905437418 415 IFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ 468
Cdd:cd01330     1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
6-388 3.12e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 89.79  E-value: 3.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   6 ITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSL 85
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  86 PHflmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslMWVYVLVGNIVRGMGETPILPLGISYIED 165
Cdd:cd06174    81 AP-------------------------------------------------SFWLLLLGRFLLGLGSGLIDPAVLALIAD 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 166 FAKFENSPLYIGLVETGAIIGPLIGLLLASFCAnvyvdtgfvntddliitptdTRWVGAWWFGFLICAGVNVLTAIPFFF 245
Cdd:cd06174   112 LFPERERGRALGLLQAFGSVGGILGPLLGGILA--------------------SSLGFGWRAVFLIAAALALLAAILLLL 171
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 246 LPNTLPKEGLETNADIIKnenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQ 325
Cdd:cd06174   172 VVPDPPESARAKNEEASS-------------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1905437418 326 QYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLM 388
Cdd:cd06174   233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLL 295
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
420-466 4.03e-13

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 64.05  E-value: 4.03e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1905437418 420 NVDCNCPSKIWDPVCGNNGLSYLSAC---LAGCETSIGTGINMVFQNCSC 466
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-385 2.09e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.85  E-value: 2.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSktLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:COG2814    12 LLALALGAFLSG--LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLkslphflmnqyeyestVSVSGNLSSnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGI 160
Cdd:COG2814    90 LL----------------CALAPSLWL---------------------------------LLAARFLQGLGAGALFPAAL 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLTA 240
Cdd:COG2814   121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLALLAL 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IP-FFFLPNTLPKEgletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 319
Cdd:COG2814   179 LLlLRLLPESRPAA----------------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1905437418 320 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKItvKQAAHIGCWLSLLEYLLYFLS 385
Cdd:COG2814   231 PLYLQEVLGLSASAAGLLLALFGLGGV-LGALLAGRLADRFGR--RRLLLIGLLLLALGLLLLALA 293
MFS_1 pfam07690
Major Facilitator Superfamily;
8-388 2.31e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 56.27  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   8 CAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLkslph 87
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL----- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  88 flmnqyeyestvsvsGNLSSNSFLcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGISYIEDFA 167
Cdd:pfam07690  79 ---------------LLFASSLWL-----------------------------LLVLRVLQGLGAGALFPAALALIADWF 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 168 KFENSPLYIGLVETGAIIGPLIGLLLASFcanvyvdtgfvntddlIITPTDTRWVgawwfgFLICAGVNVLTAIPFFFLP 247
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGL----------------LASLFGWRAA------FLILAILSLLAAVLLLLPR 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 248 NTLPKEGLETNADIIknenedkqkeevkkekygitKDFLPFMKSLSCNPIyMLFILVSVIQFNAFVNMISFMPKYLEqQY 327
Cdd:pfam07690 173 PPPESKRPKPAEEAR--------------------LSLIVAWKALLRDPV-LWLLLALLLFGFAFFGLLTYLPLYQE-VL 230
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1905437418 328 GISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLM 388
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS 291
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
425-466 7.73e-08

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 48.81  E-value: 7.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1905437418 425 CPsKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSC 466
Cdd:cd00104     1 CP-KEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
138-358 1.36e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.49  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 138 WVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVET----GAIIGPLIGLLLASFcanvyvdtgfvntddli 213
Cdd:cd17325    84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSaiglGFLIGPLLGGLLADA----------------- 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 214 itptdtrwvGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKnenedkqkeevkkekygitkdFLPFMKSLS 293
Cdd:cd17325   147 ---------LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR---------------------LRSGLRLLL 196
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1905437418 294 CNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMK 358
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR 261
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
3-361 8.00e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.15  E-value: 8.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   3 LLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFL 82
Cdd:COG0738    10 LIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  83 kslphflmnqyeyestVSVSGNlssnsflcmengtqilrptqdpsectkevkslmWVYVLVGNIVRGMG----ETPILPL 158
Cdd:COG0738    90 ----------------FALAPS---------------------------------YPLLLLALFLLGLGlgllDVAANPY 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 159 GISyIEDfakfENSPLYIGLVET----GAIIGPLIGLLLASFCANVyvdtgfvntddliitptdtrwvgAWWFGFLICAG 234
Cdd:COG0738   121 VAA-LGP----ETAASRLNLLHAffslGALLGPLLGGLLILLGLSL-----------------------SWHLPYLILAV 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 235 VNVLTAIPFFFLPntLPKEGLETNADIIKNENedkqkeevkkekygitkdflpfMKSLSCNPIYMLFILVSVIQFNAFVN 314
Cdd:COG0738   173 LLLLLALLFLRSK--LPEIEEEEEEAAGSAAS----------------------LKSLLKNPRLLLGGLAIFLYVGAEGA 228
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1905437418 315 MISFMPKYLEQQYGISSSDAIFLMGIYNLpPICIGYIIGGLIMKKFK 361
Cdd:COG0738   229 IGDWLPLYLKDVLGLSEATAALGLSLFWG-GMTIGRFLGGFLLKRFG 274
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
1-388 2.27e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.61  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAItCAFVSKTlSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 80
Cdd:cd17324     1 LLALAL-AAFAIGT-TEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  81 FLKSLphflmnqyeyestvsvsgnlsSNSFLCMengtqilrptqdpsectkevkslmwvyvLVGNIVRGMGETPILPLGI 160
Cdd:cd17324    79 LLAAL---------------------APSFALL----------------------------LLARALAGLAHGGFWAIAA 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 161 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtGFvntddliitptdtRWVgawwfgFLICAGVNVLTA 240
Cdd:cd17324   110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL---GW-------------RAA------FLAIAVLALLAA 167
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 241 IPF-FFLPNTLPKEGletnadiiknenedkqkeevkkekygITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 319
Cdd:cd17324   168 LLLwRLLPSLPPKKP--------------------------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYL 221
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1905437418 320 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKItvKQAAHIGCWLSLLEYLLYFLSFLM 388
Cdd:cd17324   222 APFLTDVPGFSSSAIIGLLLLFGVAGV-VGSPLAGRLADRGGR--RALLIALLLLAAALLLLTLLGPSP 287
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-360 2.51e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.63  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418   1 MFLLAITCAFVSktLSGSYMNSML-TQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 79
Cdd:COG2223     6 VLLLATLAFFLA--FGVWYLWSVLaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418  80 CFLKSLphflmnqyeyestvsvsgnlsSNSFlcmengtqilrptqdpsectkevkslmWVYVLVGNIVrGMGETPILPLG 159
Cdd:COG2223    84 LLLLAL---------------------AVSY---------------------------WLLLLLGLLL-GIGGGGSFAVG 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 160 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLT 239
Cdd:COG2223   115 IALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF----------------------GWRNAFLILGILLLVV 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437418 240 AIPFFFLPNTLPKEGLETNAdiiknenedkqkeevkkekygitKDFLPFMKSLScNPIYMLFILVSVIQFNAFVNMISFM 319
Cdd:COG2223   173 AVLAWLFLRDPPAGAAAAAK-----------------------ASLRDQLEALR-DPRFWLLSLLYFGTFGSFIGFSSWL 228
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1905437418 320 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKF 360
Cdd:COG2223   229 PPYLVDQFGLSAATAGLLAALFALLGA-LGRPLGGWLSDRI 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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