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Conserved domains on  [gi|1905532669|ref|NP_001373923|]
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transcriptional repressor CTCFL isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 15210836)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens transcriptional repressor CTCFL, a testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|10940247|12665246|11179890
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-403 6.93e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 6.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 259 CDVCMFTSSRMSSFNRHMKT--HTSE--KPHLC--HLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNM------AFVTSG 326
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfspLLNNEP 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 327 ELVRHRRYKHTHEKPFKCSM--CKYASVEASKLKRHVRSHTGERPfQCCQCSY---ASRDTYKLKRHMRTHSGEKPYECH 401
Cdd:COG5048   372 PQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRP-YNCKNPPcskSFNRHYNLIPHKKIHTNHAPLLCS 450


                  ..
gi 1905532669 402 IC 403
Cdd:COG5048   451 IL 452
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 392-432 6.15e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 6.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1905532669 392 HSGEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPH 432
Cdd:cd20908    20 HQKAKHFKCHICHKKLYTAGGLAVHCLQVHKETLTKVPNAL 60
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 459-492 4.20e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 4.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1905532669 459 KCRYCSAVFHERYALIQHQKthknEKRFKCKHCS 492
Cdd:cd20908     3 WCYYCDREFDDEKILIQHQK----AKHFKCHICH 32
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-403 6.93e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 6.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 259 CDVCMFTSSRMSSFNRHMKT--HTSE--KPHLC--HLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNM------AFVTSG 326
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfspLLNNEP 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 327 ELVRHRRYKHTHEKPFKCSM--CKYASVEASKLKRHVRSHTGERPfQCCQCSY---ASRDTYKLKRHMRTHSGEKPYECH 401
Cdd:COG5048   372 PQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRP-YNCKNPPcskSFNRHYNLIPHKKIHTNHAPLLCS 450


                  ..
gi 1905532669 402 IC 403
Cdd:COG5048   451 IL 452
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-409 2.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.16e-04
                          10        20
                  ....*....|....*....|....*
gi 1905532669 385 LKRHMRTHSGEKPYECHICHTRFTQ 409
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 392-432 6.15e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 6.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1905532669 392 HSGEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPH 432
Cdd:cd20908    20 HQKAKHFKCHICHKKLYTAGGLAVHCLQVHKETLTKVPNAL 60
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 459-492 4.20e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 4.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1905532669 459 KCRYCSAVFHERYALIQHQKthknEKRFKCKHCS 492
Cdd:cd20908     3 WCYYCDREFDDEKILIQHQK----AKHFKCHICH 32
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-403 6.93e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 6.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 259 CDVCMFTSSRMSSFNRHMKT--HTSE--KPHLC--HLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNM------AFVTSG 326
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfspLLNNEP 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 327 ELVRHRRYKHTHEKPFKCSM--CKYASVEASKLKRHVRSHTGERPfQCCQCSY---ASRDTYKLKRHMRTHSGEKPYECH 401
Cdd:COG5048   372 PQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRP-YNCKNPPcskSFNRHYNLIPHKKIHTNHAPLLCS 450


                  ..
gi 1905532669 402 IC 403
Cdd:COG5048   451 IL 452
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-570 1.55e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 256 TFHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHL--CLKTFRTVTLLRNHVNTHTGTRPYKCNDCNmafvtSGELVRHRR 333
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSL-----PLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 334 YKHTHE-----KPFKCSMCKYASVEASKLKRHVRSHT--GERPFQCCQCSYASRDTYkLKRHMRTHSGEKPYECHICHTR 406
Cdd:COG5048   108 SSLSSSssnsnDNNLLSSHSLPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQS-NSLHPPLPANSLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 407 FTQSGtmkihilqKHGENVPKYQCPHCATIIARKSDLRVHMRNlhaYSAAELKCRYCSAVFHERYALIQHQKTHKNEKRF 486
Cdd:COG5048   187 LISSN--------VSTSIPSSSENSPLSSSYSIPSSSSDQNLE---NSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 487 KCKHCSYACKQERHMTAHIRTHTGE-------KPFTCLSCNKCFRQKQLLNAHFRKYHD--ANFIPTVYKCSKCGKGFSR 557
Cdd:COG5048   256 SASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHsgESLKPFSCPYSLCGKLFSR 335

                         330
                  ....*....|...
gi 1905532669 558 WINLHRHSEKCGS 570
Cdd:COG5048   336 NDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-409 2.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.16e-04
                          10        20
                  ....*....|....*....|....*
gi 1905532669 385 LKRHMRTHSGEKPYECHICHTRFTQ 409
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-493 3.77e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 265 TSSRMSSFNRHMKTHTSEKPHLChLCLKTFRTVTLLRNHVNTHTG-TRPYKCNDCNMAFVTSGELVRHRRYKHTHEKPFK 343
Cdd:COG5048   242 SQSPSSLSSSDSSSSASESPRSS-LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLK 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532669 344 csmckyasveasklkrhvrshtgerPFQCC--QCSYASRDTYKLKRHMRTHSGEKPYECHI--CHTRFTQSGTMK---IH 416
Cdd:COG5048   321 -------------------------PFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEppqSL 375

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1905532669 417 ILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSA--AELKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSY 493
Cdd:COG5048   376 QQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFrpYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 392-432 6.15e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 6.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1905532669 392 HSGEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPH 432
Cdd:cd20908    20 HQKAKHFKCHICHKKLYTAGGLAVHCLQVHKETLTKVPNAL 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-296 2.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 1905532669 271 SFNRHMKTHTSEKPHLCHLCLKTFRT 296
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
338-400 2.89e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1905532669 338 HEKPFKCSMCKYASVEASKLKRHVRSHTGERPFQC--CQCSYASRDTYKLKRHMRTHSGEKPYEC 400
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 459-492 4.20e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 4.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1905532669 459 KCRYCSAVFHERYALIQHQKthknEKRFKCKHCS 492
Cdd:cd20908     3 WCYYCDREFDDEKILIQHQK----AKHFKCHICH 32
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-378 9.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.00e-03
                          10        20
                  ....*....|....*....|..
gi 1905532669 357 LKRHVRSHTGERPFQCCQCSYA 378
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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