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Conserved domains on  [gi|1912229846|ref|NP_001374219|]
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centromere protein L isoform 2 [Homo sapiens]

Protein Classification

CENP-L domain-containing protein( domain architecture ID 10586779)

CENP-L domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENP-L pfam13092
Kinetochore complex Sim4 subunit Fta1; CENP-L is one of the components that assembles onto the ...
 177-323 1.10e-55

Kinetochore complex Sim4 subunit Fta1; CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta1 is the equivalent component of the fission yeast Sim4 complex. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals.


:

Pssm-ID: 432969  Cd Length: 158  Bit Score: 178.94  E-value: 1.10e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912229846 177 DFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMD------HYVATTEFLWSVPCSPQSL 250
Cdd:pfam13092   1 GFTHLPLLLTRGPASLRQAVISWLSTTFDCRISPLRLPSSFLCWALEMWIGCLGEsdrgpvIKDLQLTLSFSVPPVAPGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1912229846 251 -DISFAIHPEDAKALWDSVHKTP-GEVTQEEVDLFMDCLYSHFHRHFKIHLS--ATRLVRVSTSVASAHTDGKIKIL 323
Cdd:pfam13092  81 kSIDVTIPREDLKRFWRSGHDSSeDEVDDEEVQPFMAALSSYLKRHLALDLShpAVRLSKVACGGFVLGEEGRLKIF 157
 
Name Accession Description Interval E-value
CENP-L pfam13092
Kinetochore complex Sim4 subunit Fta1; CENP-L is one of the components that assembles onto the ...
 177-323 1.10e-55

Kinetochore complex Sim4 subunit Fta1; CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta1 is the equivalent component of the fission yeast Sim4 complex. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals.


Pssm-ID: 432969  Cd Length: 158  Bit Score: 178.94  E-value: 1.10e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912229846 177 DFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMD------HYVATTEFLWSVPCSPQSL 250
Cdd:pfam13092   1 GFTHLPLLLTRGPASLRQAVISWLSTTFDCRISPLRLPSSFLCWALEMWIGCLGEsdrgpvIKDLQLTLSFSVPPVAPGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1912229846 251 -DISFAIHPEDAKALWDSVHKTP-GEVTQEEVDLFMDCLYSHFHRHFKIHLS--ATRLVRVSTSVASAHTDGKIKIL 323
Cdd:pfam13092  81 kSIDVTIPREDLKRFWRSGHDSSeDEVDDEEVQPFMAALSSYLKRHLALDLShpAVRLSKVACGGFVLGEEGRLKIF 157
 
Name Accession Description Interval E-value
CENP-L pfam13092
Kinetochore complex Sim4 subunit Fta1; CENP-L is one of the components that assembles onto the ...
 177-323 1.10e-55

Kinetochore complex Sim4 subunit Fta1; CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta1 is the equivalent component of the fission yeast Sim4 complex. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals.


Pssm-ID: 432969  Cd Length: 158  Bit Score: 178.94  E-value: 1.10e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912229846 177 DFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMD------HYVATTEFLWSVPCSPQSL 250
Cdd:pfam13092   1 GFTHLPLLLTRGPASLRQAVISWLSTTFDCRISPLRLPSSFLCWALEMWIGCLGEsdrgpvIKDLQLTLSFSVPPVAPGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1912229846 251 -DISFAIHPEDAKALWDSVHKTP-GEVTQEEVDLFMDCLYSHFHRHFKIHLS--ATRLVRVSTSVASAHTDGKIKIL 323
Cdd:pfam13092  81 kSIDVTIPREDLKRFWRSGHDSSeDEVDDEEVQPFMAALSSYLKRHLALDLShpAVRLSKVACGGFVLGEEGRLKIF 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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