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Conserved domains on  [gi|1917882205|ref|NP_001375172|]
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rap1 GTPase-activating protein 1 isoform 3 [Homo sapiens]

Protein Classification

GoLoco and Rap_GAP domain-containing protein( domain architecture ID 10490279)

GoLoco and Rap_GAP domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
211-390 1.43e-88

Rap/ran-GAP;


:

Pssm-ID: 460463  Cd Length: 179  Bit Score: 273.62  E-value: 1.43e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882205 211 FSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGN 290
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882205 291 DIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKG--PEFQEFLltk 368
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157
                         170       180
                  ....*....|....*....|..
gi 1917882205 369 LINAEYACYKAEKFAKLEERTR 390
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
GoLoco pfam02188
GoLoco motif;
1-17 8.66e-05

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 39.71  E-value: 8.66e-05
                          10
                  ....*....|....*..
gi 1917882205   1 MIEKMQGSRMDEQRCSF 17
Cdd:pfam02188   6 LLARVQSSRLDDQRCSL 22
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
211-390 1.43e-88

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 273.62  E-value: 1.43e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882205 211 FSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGN 290
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882205 291 DIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKG--PEFQEFLltk 368
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157
                         170       180
                  ....*....|....*....|..
gi 1917882205 369 LINAEYACYKAEKFAKLEERTR 390
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
GoLoco pfam02188
GoLoco motif;
1-17 8.66e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 39.71  E-value: 8.66e-05
                          10
                  ....*....|....*..
gi 1917882205   1 MIEKMQGSRMDEQRCSF 17
Cdd:pfam02188   6 LLARVQSSRLDDQRCSL 22
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
1-17 1.14e-04

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 39.41  E-value: 1.14e-04
                           10
                   ....*....|....*..
gi 1917882205    1 MIEKMQGSRMDEQRCSF 17
Cdd:smart00390   7 LLLRMQSSRMDDQRCEL 23
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
211-390 1.43e-88

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 273.62  E-value: 1.43e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882205 211 FSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGN 290
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882205 291 DIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKG--PEFQEFLltk 368
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157
                         170       180
                  ....*....|....*....|..
gi 1917882205 369 LINAEYACYKAEKFAKLEERTR 390
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
GoLoco pfam02188
GoLoco motif;
1-17 8.66e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 39.71  E-value: 8.66e-05
                          10
                  ....*....|....*..
gi 1917882205   1 MIEKMQGSRMDEQRCSF 17
Cdd:pfam02188   6 LLARVQSSRLDDQRCSL 22
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
1-17 1.14e-04

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 39.41  E-value: 1.14e-04
                           10
                   ....*....|....*..
gi 1917882205    1 MIEKMQGSRMDEQRCSF 17
Cdd:smart00390   7 LLLRMQSSRMDDQRCEL 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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