NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1917882133|ref|NP_001375216|]
View 

rap1 GTPase-activating protein 1 isoform 36 [Homo sapiens]

Protein Classification

rap1 GTPase-activating protein 1( domain architecture ID 10647782)

rap1 GTPase-activating protein 1 is a GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
275-454 6.75e-88

Rap/ran-GAP;


:

Pssm-ID: 460463  Cd Length: 179  Bit Score: 272.46  E-value: 6.75e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882133 275 FSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGN 354
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882133 355 DIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKG--PEFQEFLltk 432
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157
                         170       180
                  ....*....|....*....|..
gi 1917882133 433 LINAEYACYKAEKFAKLEERTR 454
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
61-81 2.90e-07

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


:

Pssm-ID: 214645  Cd Length: 23  Bit Score: 46.73  E-value: 2.90e-07
                           10        20
                   ....*....|....*....|.
gi 1917882133   61 DLFEMIEKMQGSRMDEQRCSF 81
Cdd:smart00390   3 DLFDLLLRMQSSRMDDQRCEL 23
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
275-454 6.75e-88

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 272.46  E-value: 6.75e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882133 275 FSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGN 354
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882133 355 DIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKG--PEFQEFLltk 432
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157
                         170       180
                  ....*....|....*....|..
gi 1917882133 433 LINAEYACYKAEKFAKLEERTR 454
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
61-81 2.90e-07

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 46.73  E-value: 2.90e-07
                           10        20
                   ....*....|....*....|.
gi 1917882133   61 DLFEMIEKMQGSRMDEQRCSF 81
Cdd:smart00390   3 DLFDLLLRMQSSRMDDQRCEL 23
GoLoco pfam02188
GoLoco motif;
61-81 2.99e-07

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 46.64  E-value: 2.99e-07
                          10        20
                  ....*....|....*....|.
gi 1917882133  61 DLFEMIEKMQGSRMDEQRCSF 81
Cdd:pfam02188   2 DFFDLLARVQSSRLDDQRCSL 22
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
275-454 6.75e-88

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 272.46  E-value: 6.75e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882133 275 FSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGN 354
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917882133 355 DIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKG--PEFQEFLltk 432
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157
                         170       180
                  ....*....|....*....|..
gi 1917882133 433 LINAEYACYKAEKFAKLEERTR 454
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
61-81 2.90e-07

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 46.73  E-value: 2.90e-07
                           10        20
                   ....*....|....*....|.
gi 1917882133   61 DLFEMIEKMQGSRMDEQRCSF 81
Cdd:smart00390   3 DLFDLLLRMQSSRMDDQRCEL 23
GoLoco pfam02188
GoLoco motif;
61-81 2.99e-07

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 46.64  E-value: 2.99e-07
                          10        20
                  ....*....|....*....|.
gi 1917882133  61 DLFEMIEKMQGSRMDEQRCSF 81
Cdd:pfam02188   2 DFFDLLARVQSSRLDDQRCSL 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH