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Conserved domains on  [gi|1959221289|ref|NP_001378873|]
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zona pellucida sperm-binding protein 1 isoform 3 [Homo sapiens]

Protein Classification

zona pellucida domain-containing protein( domain architecture ID 10443513)

zona pellucida (ZP) domain-containing protein may function as a structural component of egg coats, appendicularian mucous houses, and nematode dauer larvae, or as a mechanotransducer in flies, or as a receptor in mammals and nonmammals

Gene Ontology:  GO:0031012

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
2-149 2.16e-42

Zona pellucida-like domain;


:

Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 144.29  E-value: 2.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959221289   2 TQPGPLRLELRIAKDETFSSYYGEddYPIVRLLREPVHVEVRLLQRTDPNLVLLLHQCWGAPSANPFQQPQWPILSDGCP 81
Cdd:pfam00100 119 SGSGVFLVSMDLYYDSSYTSPYSP--YPVTVLLGDPLYVEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCP 196
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1959221289  82 FKGDSYRTQMVALdgatPFQSHYQRFTVATFALLDSGsqralRGLVYLFCSTSACHTSGlETCSTACS 149
Cdd:pfam00100 197 NDGDSTYPVSSLS----NGPSHYVRFSFKAFRFVGSS-----ISQVYLHCSVSVCSSDS-NSCGKSCS 254
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
2-149 2.16e-42

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 144.29  E-value: 2.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959221289   2 TQPGPLRLELRIAKDETFSSYYGEddYPIVRLLREPVHVEVRLLQRTDPNLVLLLHQCWGAPSANPFQQPQWPILSDGCP 81
Cdd:pfam00100 119 SGSGVFLVSMDLYYDSSYTSPYSP--YPVTVLLGDPLYVEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCP 196
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1959221289  82 FKGDSYRTQMVALdgatPFQSHYQRFTVATFALLDSGsqralRGLVYLFCSTSACHTSGlETCSTACS 149
Cdd:pfam00100 197 NDGDSTYPVSSLS----NGPSHYVRFSFKAFRFVGSS-----ISQVYLHCSVSVCSSDS-NSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
1-150 1.55e-35

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 126.73  E-value: 1.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959221289    1 MTQPGPLRLELRIAKDETFSSYYGEDDYPivrlLREPVHVEVRLLQRTDPNLVLLLHQCWGAPSANPFQQPQWPILSDGC 80
Cdd:smart00241 117 SVSEGPLTCSYRLYKDDSFGSPYQSADYV----LGDPVYHEWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGC 192
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1959221289   81 PFkgDSYRTQMVAldgATPFQSHYQRFTVATFALLDsgsqralRGLVYLFCSTSACHTSGLETCST-ACST 150
Cdd:smart00241 193 PV--DGYLDSTIP---YNSNPLHRARFSVKVFKFAD-------RSLVYFHCQIRLCDKDDGSSCDGpACSS 251
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
2-149 2.16e-42

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 144.29  E-value: 2.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959221289   2 TQPGPLRLELRIAKDETFSSYYGEddYPIVRLLREPVHVEVRLLQRTDPNLVLLLHQCWGAPSANPFQQPQWPILSDGCP 81
Cdd:pfam00100 119 SGSGVFLVSMDLYYDSSYTSPYSP--YPVTVLLGDPLYVEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCP 196
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1959221289  82 FKGDSYRTQMVALdgatPFQSHYQRFTVATFALLDSGsqralRGLVYLFCSTSACHTSGlETCSTACS 149
Cdd:pfam00100 197 NDGDSTYPVSSLS----NGPSHYVRFSFKAFRFVGSS-----ISQVYLHCSVSVCSSDS-NSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
1-150 1.55e-35

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 126.73  E-value: 1.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959221289    1 MTQPGPLRLELRIAKDETFSSYYGEDDYPivrlLREPVHVEVRLLQRTDPNLVLLLHQCWGAPSANPFQQPQWPILSDGC 80
Cdd:smart00241 117 SVSEGPLTCSYRLYKDDSFGSPYQSADYV----LGDPVYHEWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGC 192
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1959221289   81 PFkgDSYRTQMVAldgATPFQSHYQRFTVATFALLDsgsqralRGLVYLFCSTSACHTSGLETCST-ACST 150
Cdd:smart00241 193 PV--DGYLDSTIP---YNSNPLHRARFSVKVFKFAD-------RSLVYFHCQIRLCDKDDGSSCDGpACSS 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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