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Conserved domains on  [gi|1972712206|ref|NP_001378966|]
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mth938 domain-containing protein isoform c [Homo sapiens]

Protein Classification

Mth938-like domain-containing protein( domain architecture ID 10142266)

Mth938-like domain-containing protein similar to Methanobacterium thermoautotrophicum MTH938 and human adipogenesis associated Mth938 domain-containing protein that may play a role in preadipocyte differentiation and adipogenesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mth938 cd05126
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium ...
 5-120 8.90e-52

Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the protein has not been determined.


:

Pssm-ID: 240162  Cd Length: 117  Bit Score: 159.04  E-value: 8.90e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972712206   5 EIASLSWGQMKVKGSNTTyKDCKVWPGGSRTWDWRETG--TEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKVPSSTV 82
Cdd:cd05126     1 EIESTSFGSITVGGETYE-HDIVVYPDGSRARRWKELSkkTGTSHGLQPEELEELLEEGVEVIVIGTGQSGALKVPPETV 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972712206  83 EYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGVFHS 120
Cdd:cd05126    80 EKLEKRGVEVLVLPTEEAVKRYNELAGKGRRVLAVIHV 117
 
Name Accession Description Interval E-value
Mth938 cd05126
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium ...
 5-120 8.90e-52

Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the protein has not been determined.


Pssm-ID: 240162  Cd Length: 117  Bit Score: 159.04  E-value: 8.90e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972712206   5 EIASLSWGQMKVKGSNTTyKDCKVWPGGSRTWDWRETG--TEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKVPSSTV 82
Cdd:cd05126     1 EIESTSFGSITVGGETYE-HDIVVYPDGSRARRWKELSkkTGTSHGLQPEELEELLEEGVEVIVIGTGQSGALKVPPETV 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972712206  83 EYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGVFHS 120
Cdd:cd05126    80 EKLEKRGVEVLVLPTEEAVKRYNELAGKGRRVLAVIHV 117
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 6-119 3.03e-23

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 86.42  E-value: 3.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972712206   6 IASLSWGQMKVKGsnTTY-KDCKVWPGGSRTWDwretgTEHSPGVQPADVKEVVEKgVQTLVIGRGMSeALKVPSSTVEY 84
Cdd:pfam04430   1 IDGYGFGGFRVNG--VRYrGSLLVLPGGVFAWD-----VTKGEDLTPEDLALLLAD-PEVLIIGTGAR-VLFLPPELREA 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1972712206  85 LKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGVFH 119
Cdd:pfam04430  72 LRKRGIGVEVMDTRAACRTYNVLASEGRRVAAALI 106
 
Name Accession Description Interval E-value
Mth938 cd05126
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium ...
 5-120 8.90e-52

Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the protein has not been determined.


Pssm-ID: 240162  Cd Length: 117  Bit Score: 159.04  E-value: 8.90e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972712206   5 EIASLSWGQMKVKGSNTTyKDCKVWPGGSRTWDWRETG--TEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKVPSSTV 82
Cdd:cd05126     1 EIESTSFGSITVGGETYE-HDIVVYPDGSRARRWKELSkkTGTSHGLQPEELEELLEEGVEVIVIGTGQSGALKVPPETV 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972712206  83 EYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGVFHS 120
Cdd:cd05126    80 EKLEKRGVEVLVLPTEEAVKRYNELAGKGRRVLAVIHV 117
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 6-119 3.03e-23

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 86.42  E-value: 3.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972712206   6 IASLSWGQMKVKGsnTTY-KDCKVWPGGSRTWDwretgTEHSPGVQPADVKEVVEKgVQTLVIGRGMSeALKVPSSTVEY 84
Cdd:pfam04430   1 IDGYGFGGFRVNG--VRYrGSLLVLPGGVFAWD-----VTKGEDLTPEDLALLLAD-PEVLIIGTGAR-VLFLPPELREA 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1972712206  85 LKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGVFH 119
Cdd:pfam04430  72 LRKRGIGVEVMDTRAACRTYNVLASEGRRVAAALI 106
Mth938_2P1-like cd05125
Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially ...
 65-115 2.43e-05

Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the Mth938 family, for which structures, but no functional data are available.


Pssm-ID: 240161  Cd Length: 114  Bit Score: 40.26  E-value: 2.43e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1972712206  65 LVIGRGmSEALKVPSSTVEYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVG 115
Cdd:cd05125    58 LVIGTG-RKSRPLSPELRKYFKKLGIAVEVVDTRNACATFNFLAEEGRRVA 107
Mth938-like cd00248
Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and ...
 25-115 6.21e-05

Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. 2P1 is a partially characterized nuclear protein which is homologous to E3-3 from rat and known to be alternately spliced. Xcr35 and Rpa2829 are hypothetical proteins of unknown function from the Xanthomonas campestris and Rhodopseudomonas palustris genomes, respectively, for which the crystal structures have been determined.


Pssm-ID: 238152  Cd Length: 109  Bit Score: 39.15  E-value: 6.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972712206  25 DCKVWPGGSRTWDwretgTEHSPGVQPADVKEVV-EKGVQTLVIGRGMSEALkVPSSTVEYLKKHGIDVRVLQTEQAVKE 103
Cdd:cd00248    20 PLLVLPDGVVPWD-----GTSLSDLDPEALLPLLaEDRPDILLIGTGAEIAF-LPRALRAALRAAGIGVEVMSTGAACRT 93

                          90
                  ....*....|..
gi 1972712206 104 YNALVAQGVRVG 115
Cdd:cd00248    94 YNVLLSEGRRVA 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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