|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
24-1443 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1715.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 24 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDP--- 99
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKggh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 100 KMSCIRVTIDAENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 179
Cdd:PTZ00108 81 RMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 180 TASREYKKMFKQTWMDNMGRAGDMELKPFSG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNG 258
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 259 NRLPVKGFRSYVDMYLKDKVDETGNALKVVHEQVNPRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVSKLVD 338
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 339 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKA 418
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 419 QIQLNKKCSAVKHNRIKGIPKLDDANDAGSRNSAECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHK 498
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 499 QIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFITPIV 577
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKYED---PKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 578 KVSK-NKQEIAFYSLPEFEEWKSANPNhKKWKVKYYKGLGTSTSKEAKEYFANMKRHRIQFKYSGPEDDAAISLAFSKKQ 656
Cdd:PTZ00108 558 KATKkGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 657 VDDRKEWLTNFME----DRRQRKllglpedylygqttmyLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC 732
Cdd:PTZ00108 637 VEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFAC 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 733 FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPL 812
Cdd:PTZ00108 701 FKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKI 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 813 ARLLFPSKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYK 892
Cdd:PTZ00108 781 TRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYR 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 893 NYKGTIEELASNQYVINGEVAILNSTTIEITELPIRTWTQTYKEqVLEpmlNGTEKTPPLITDYREYHTDTTVKFVIKMT 972
Cdd:PTZ00108 861 GFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLN 936
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 973 EEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQAR 1052
Cdd:PTZ00108 937 DGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVR 1016
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1053 FILEKIDGKIVIENKPKKELIKVLIQRGYDS-DPVKAWKEAQQKVPEEEENEENEESESESSSPAAESGPTFNYLLDMPL 1131
Cdd:PTZ00108 1017 FIKHVINGELVITNAKKKDLVKELKKLGYVRfKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYDYLLSMPI 1096
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1132 WYLTKEKKDELCKQRDEKEQELNTLKKKTPSDLWKEDLAAFVEELEVVEAKEKQDEQvglpgkgvkakgkkaqisevlps 1211
Cdd:PTZ00108 1097 WSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIA----------------------- 1153
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1212 pVGKRVIPQVTMEMRAEAEKKIRRKIKSENVEGTPAEDGAEPGGLRQRLEKRQKREPGTRAKKQTTlpfkpikkgkkkNP 1291
Cdd:PTZ00108 1154 -KEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKS------------NS 1220
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1292 WSDSESDMSSNESNFDVPPREKEPRIAATKAKFTADLDSDddfsglDEKDEDEDFFPLDDTPPKTKMP--PKNTKKALKP 1369
Cdd:PTZ00108 1221 SGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEF------SSDDLSKEGKPKNAPKRVSAVQysPPPPSKRPDG 1294
|
1370 1380 1390 1400 1410 1420 1430
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2000185986 1370 QKSSTSvDLESDGKDSVPASPGASAADVPAETEPSKPSSKQtvgVKRTITKGQSLTSTAGTKKRAVPKETKSDS 1443
Cdd:PTZ00108 1295 ESNGGS-KPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARK---KKSKTRVKQASASQSSRLLRRPRKKKSDSS 1364
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
28-1177 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1662.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 28 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYdEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVT 107
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 108 IDAENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKK 187
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 188 MFKQTWMDNMGRAGDMELKPF-SGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAG-STKDVKVFLNGNRLPVKG 265
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCkASENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 266 FRSYVDMYLKDKVDEtgNALKVVHEQVNPRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNK 345
Cdd:PLN03128 241 FQDYVGLYLGPNSRE--DPLPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 346 GGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLnKK 425
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 426 CSAVKHNRIKGIPKLDDANDAGSRNSAECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAE 505
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 506 INNIIKIVGLQYKKNYeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HRFLEEFITPIVKVSKNKQ 584
Cdd:PLN03128 478 ITNIKQILGLQFGKTY-DEENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGK 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 585 EIAFYSLPEFEEWK-SANPNHKKWKVKYYKGLGTSTSKEAKEYFANMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEW 663
Cdd:PLN03128 557 SLSFYTMPEYEAWKeSLEGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 664 LTNFMEDrrqrkllglpeDYLyGQTTMYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKV 743
Cdd:PLN03128 637 LNNYEPG-----------TFL-DQTGNGISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 744 AQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPSKDDH 823
Cdd:PLN03128 705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 824 TLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNYKGTIEELA- 902
Cdd:PLN03128 785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEVSt 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 903 --SNQYVINGEVAILNSTTIEITELPIRTWTQTYKEqVLEPMLNGTEKTPPLITDYREYHTDTTVKFVIKMTEEKLAEAE 980
Cdd:PLN03128 865 srSGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARAL 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 981 RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDG 1060
Cdd:PLN03128 944 AEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKG 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1061 KIVIENKPKKELIKVLIQRGYDSDPvkawKEAQQKVpEEEENEENEESESESSSPAAESGPTFNYLLDMPLWYLTKEKKD 1140
Cdd:PLN03128 1024 EIVVNNRKRAELLAELEEKGFDKFP----KTAKISE-TNVVGDRDGEASEEEEASDNELAKSYDYLLGMPISSLTLEKVD 1098
|
1130 1140 1150
....*....|....*....|....*....|....*..
gi 2000185986 1141 ELCKQRDEKEQELNTLKKKTPSDLWKEDLAAFVEELE 1177
Cdd:PLN03128 1099 ELRAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
5-1528 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 1510.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 5 PLQPVNENMLLNKKKNEDGKKrlSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINyREVTFVPGLYKIF 84
Cdd:PLN03237 6 PLQESNSANVAAAPAASSGGK--TIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETDKMVQ-RSVTYVPGLYKIF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 85 DEILVNAADNKQRDPKMSCIRVTIDAENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGY 164
Cdd:PLN03237 83 DEILVNAADNKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 165 GAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGD-MELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAY 243
Cdd:PLN03237 163 GAKLTNIFSTEFVIETADGKRQKKYKQVFSNNMGKKSEpVITKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKRVV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 244 DIAGST-KDVKVFLNGNRLPVKGFRSYVDMYLKDKVDETGNALKVVHEQVNPRWEVCLTMSEKGFQQISFVNSIATSKGG 322
Cdd:PLN03237 243 DIAGCLgKTVKVELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 323 RHVDYVADQIVSKLVDVVKKKNKGGvAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAI 402
Cdd:PLN03237 323 THVDYVTNQIANHVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVM 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 403 GCGIVESILNWVKFKAQIQLnKKCSAVKHNRIKGIPKLDDANDAGSRNSAECTLILTEGDSAKTLAVSGLGVVGRDKYGV 482
Cdd:PLN03237 402 KSGIVENLLSWADFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYGV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 483 FPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEdedSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPS 562
Cdd:PLN03237 481 FPLRGKLLNVREASHKQIMNNAEIENIKQILGLQHGKQYE---SVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPS 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 563 LLR-HRFLEEFITPIVKVSK-NKQEIAFYSLPEFEEWK-SANPNHKKWKVKYYKGLGTSTSKEAKEYFANMKRHRIQFKY 639
Cdd:PLN03237 558 LLKvPSFLVEFITPIVKATRrGKKVLSFYSMPEYEEWKeSLGGNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVW 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 640 SGPEDDAAISLAFSKKQVDDRKEWLTNFMedrrqrkllglPEDYLyGQTTMYLTYNDFINKELILFSNSDNERSIPSMVD 719
Cdd:PLN03237 638 EDEQDGDAIELAFSKKKIEARKNWLRQYE-----------PGTHL-DQTQKDVKYSDFVNKELILFSMADLQRSIPSMVD 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 720 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDS 799
Cdd:PLN03237 706 GLKPGQRKILFCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDH 785
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 800 ASPRYIFTMLSPLARLLFPSKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLL 879
Cdd:PLN03237 786 ASARYIFTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLL 865
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 880 DGEEPLPMLPSYKNYKGTIEELASNQ----YVINGEVAILNSTTIEITELPIRTWTQTYKEqVLEPMLNGTEKTP-PLIT 954
Cdd:PLN03237 866 NGESMEPMHPWYRGFKGTIEKTASKEggctYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKdPFIK 944
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 955 DYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKE 1034
Cdd:PLN03237 945 DVKAYNDDTTVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKE 1024
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1035 WLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAwKEAQQKVPEEEENEENEESESESSS 1114
Cdd:PLN03237 1025 VLLKNLEFELLKLENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPKKA-KSVEAAVAGATDDAAEEEEEIDVSS 1103
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1115 PAAESGPTFNYLLDMPLWYLTKEKKDELCKQRDEKEQELNTLKKKTPSDLWKEDLAAFVEELEVVEAKEKQDEQvglpgk 1194
Cdd:PLN03237 1104 SSGVRGSDYDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLDKEDAKAEE------ 1177
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1195 gvkakgkkaqisevlpspvgkrvipqvtmemraEAEKKIRRKIKSENvegtpaedGAEPgglrqrleKRQKREPGTRAKK 1274
Cdd:PLN03237 1178 ---------------------------------AREKLQRAAARGES--------GAAK--------KVSRQAPKKPAPK 1208
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1275 QTTlpfkPIKKGKKKNPWSDSESDMSSNESNFDVPPREKEPRIAATKAKfTADLDSDDDFSGLDEKDEDedfFPLDDTP- 1353
Cdd:PLN03237 1209 KTT----KKASESETTEETYGSSAMETENVAEVVKPKGRAGAKKKAPAA-AKEKEEEDEILDLKDRLAA---YNLDSAPa 1280
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1354 PKTKMP--------PKNTKKALKPQKSSTSVDLESDGKDSVP-----------ASPGASAADVPAETEPSKPSskqtvgv 1414
Cdd:PLN03237 1281 QSAKMEetvkavpaRRAAARKKPLASVSVISDSDDDDDDFAVevslaerlkkkGGRKPAAANKKAAKPPAAAK------- 1353
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1415 KRTITKGQSltstagtKKRAVPKETKSDSALNAHVSKKPAPAKAKNSRKRKPSSSDSSDSEFEKAISkgATSKKPKGEER 1494
Cdd:PLN03237 1354 KRGPATVQS-------GQKLLTEMLKPAEAIGISPEKKVRKMRASPFNKKSGSVLGRAATNKETESS--ENVSGSSSSEK 1424
|
1530 1540 1550 1560
....*....|....*....|....*....|....*....|
gi 2000185986 1495 DfhvDLDDTVAPRAKSGRaRKPIKYL------EESDDDLF 1528
Cdd:PLN03237 1425 D---EIDVSAKPRPQRAN-RKQTTYVlsdsesESADDSDF 1460
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
79-668 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 782.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 79 GLYKIFDEILVNAADNKQRDPkMSCIRVTIDAENnLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT 158
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKDN-SISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 159 GGRNGYGAKLCNIFSTKFTVETASReyKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSldKDIVALM 238
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 239 VRRAYDIAGSTKDVKVFLNGNR-------LPVKGFRSYVDMYLKDKVDETGNALKVVHEQVNPRWEVCLTMSEKG-FQQI 310
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 311 SFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKGGVA-VKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFG- 388
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKnIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 389 ----STCQLSEKFIKAAIGCGIVESILNWVKFKAQIQ-LNKKCSAVKHNRIKGIPKLDDANDAGsrnSAECTLILTEGDS 463
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAG---PKKCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 464 AKTLAVSGLgvvGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYededSLKTLRYGKIMIMTDQDQ 543
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 544 DGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQ--EIAFYSLPEFEEWKSANPNHK-KWKVKYYKGLGTSTS 620
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNKsKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 2000185986 621 KEAKEYFANMKRHRIQFKYSGPEDDA-AISLAFSKKQVDDRKEWLTNFM 668
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
692-1167 |
0e+00 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 572.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 692 LTYNDFINKELILFSNS-DNERSIPSMVDGLKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSSYH-HGEMSLMMTII 768
Cdd:smart00434 1 IDIEDFINKEYLDYSMSvINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 769 NLAQNFVgsNNLNLLQPIGQFGTRLhGGKDSASPRYIFTMLSPLARLLFPSKDDHTLRFLYD-DNQRVEPEWYIPIIPMV 847
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 848 LINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEP----LPMLPSYKNYKGTIEELASNQYVINGEVAILNSTTIEIT 923
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDAsideLMMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 924 ELPIRTWTQTYKEQVLEPMLNGteKTPPLITDYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFD 1003
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1004 HvGCLKKYDTVlDILRDFFELRLKYYGLRKEWLLGMLGAESsKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDS 1083
Cdd:smart00434 316 N-GRPKKYNLK-EILKEFLDHRLEVYTRRKEYLLGKLEAER-LHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLMER 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1084 DPVKawkEAQqkvpeeeeneeneesesessspaaesgptFNYLLDMPLWYLTKEKKDELCKQRDEKEQELNTLKKKTPSD 1163
Cdd:smart00434 393 FELS---EIQ-----------------------------ADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASE 440
|
....
gi 2000185986 1164 LWKE 1167
Cdd:smart00434 441 EWLN 444
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
710-1172 |
7.51e-174 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 527.91 E-value: 7.51e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 710 NERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSsYHHGEMSLMMTIINLAQNFvgSNNLNLLQPI 786
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 787 GQFGTRlhGGKDSASPRYIFTMLSPLARLLFPSKDDHTLRFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 865
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 866 FDVREVVNNIRRLLDGEEP-------LPMLPSYKNYkGTIEELAS---------NQYVINGEVAIL---NSTTIEITELP 926
Cdd:cd00187 156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEGRAGireayetgrGRYIIRGKYEIEddeGRNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 927 IRTWTQTYKEQVLEPMlngTEKTPPLITDYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQTSLTCNsMVLFDHVG 1006
Cdd:cd00187 235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1007 CLKKYdTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKID--GKIVIENKPKKELIKVLIQRGYDSD 1084
Cdd:cd00187 311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEviNLIRSSDEAKKALIEELEKLGFSEI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1085 pvkawkeaqqkvpeeeeneeneesesessspaaesgpTFNYLLDMPLWYLTKEKKDELCKQRDEKEQELNTLKKKT---- 1160
Cdd:cd00187 390 -------------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILasee 432
|
490
....*....|...
gi 2000185986 1161 -PSDLWKEDLAAF 1172
Cdd:cd00187 433 rPKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
712-1169 |
2.21e-161 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 494.38 E-value: 2.21e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 712 RSIPSMVDGLKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFVGsnNLNLLQPIGQ 788
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 789 FGTRLHGGKDsASPRYIFTMLSPLARLLFPSKDDHTLRFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFD 867
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 868 VREVVNNIRRLLDGEEP-----LPMLPSYKNYKGTIEELA--------SNQYVINGEVAILNSTTIEITELPIRTWTQTY 934
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGGikeayktgRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 935 KEQvLEPMLNgtEKTPPLITDYREYhTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVgclKKYDTV 1014
Cdd:pfam00521 236 IEK-IEELVK--NGKIKGISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1015 LDILRDFFELRLKYYGLRKEWLLGMLGAESSKLN------NQARFILEKIDGKIViENKPKKELIKVLiqrgydsdpvka 1088
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSID-RKKAKKNLIEEL------------ 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1089 wKEAQqkvpeeeeneeneesesessspaaesgptFNYLLDMPLWYLTKEKKDELCKQRDEKEQELNTLKKKTPS-----D 1163
Cdd:pfam00521 376 -SEIQ-----------------------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekklnD 425
|
....*.
gi 2000185986 1164 LWKEDL 1169
Cdd:pfam00521 426 LWIEEL 431
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
76-221 |
4.95e-95 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 302.33 E-value: 4.95e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 76 FVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDAENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEK 155
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2000185986 156 KVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDMELKPFS-GEDYTCITFQPD 221
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYEkGKDYTKVTFKPD 147
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
264-416 |
1.64e-89 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 286.88 E-value: 1.64e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 264 KGFRSYVDMYLKDKVDETGNALKVVHEQVNPRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKK 343
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2000185986 344 NKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKF 416
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
40-665 |
8.32e-88 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 299.36 E-value: 8.32e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 40 EHILLRPDTYIGSVELVTQQMWVYDedvgiNYREVTFVPGLYKIFDEILVNAADNKQR-DPKMS-CIRVTIDaeNNLISI 117
Cdd:PHA02569 11 EHILKRPGMYIGSVAYEAHERFLFG-----KFTQVEYVPGLVKIIDEIIDNSVDEAIRtNFKFAnKIDVTIK--NNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 118 WNNGKGIP---VVEHKVEKMYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQT-W 193
Cdd:PHA02569 84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCSnG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 194 MDNMgragDMELKPfSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNRLPVKgFRSYVDMY 273
Cdd:PHA02569 163 AENI----SWSTKP-GKGKGTSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVSGK-FKKYAKQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 274 LKDKVdetgnalkvVHEQVNprWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKggVAVKAH 353
Cdd:PHA02569 237 GDDTI---------VQENDN--VSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHK--IEVTKA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 354 QVKN--HMWIFVNALIeNPTFDSQTKENMTLQAKSFGSTCQLSEKFI------KAAIGCGIVESIL--NWVKFKAQIQLN 423
Cdd:PHA02569 304 RVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIakqilkTEAIIMPIIEAALarKLAAEKAAETKA 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 424 KKcSAVKHNRIKGIPklddANDAGSrnSAECTLILTEGDSAKTLAVSglgVVGRDKYGVFPLRGKILNVREASHKQIMEN 503
Cdd:PHA02569 383 AK-KAKKAKVAKHIK----ANLIGK--DAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYADILKN 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 504 AEINNIIKIVGLQYKknyEDEDSLKtlrYGKIMIMTDQDQDG-SHIKGLLINFIhHNWPSLL---RHRFLEefiTPIVKV 579
Cdd:PHA02569 453 KELFDICAITGLVLG---EKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFeqgRIRFVK---TPVIIA 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 580 SKNKQEIAFYSLPEFEEWKSanpNHKKWKVKYYKGLGTSTSKEAKEYFANMKRHRIQFKYSGPEddaAISLAFSKKQvDD 659
Cdd:PHA02569 523 QVGKETKWFYSLDEFEKAKD---SLKKWSIRYIKGLGSLRKSEYRRVINNPVYDVVVLPDDWKE---LFEMLFGDDA-DL 595
|
....*.
gi 2000185986 660 RKEWLT 665
Cdd:PHA02569 596 RKDWMS 601
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
690-1172 |
1.16e-81 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 276.17 E-value: 1.16e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 690 MYLTYNDFINKELILFSNSD-NERSIPSMVDGLKPGQRKVLFTC--FKRNDKREV-KVAQLAGSVAEMSsYHHGEMSLMM 765
Cdd:PHA02592 4 KERSLKSIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 766 TIINLAQNFvgSNNLNLLQPIGQFGTRLhgGKDSASPRYIFTMLSPLARLLFpsKDDHtLRFLYDDNQRVEPEWYIPIIP 845
Cdd:PHA02592 83 AGALMANTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIY--KDED-LAPVHEDPEHIPPAFYLPIIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 846 MVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNYKGTIEELASNQYVINGEVAILNSTTIEITEL 925
Cdd:PHA02592 156 MVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 926 PIRTWTQTYKEqVLEPMLngtEKTppLITDYREYHTDtTVKFVIKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLfDHV 1005
Cdd:PHA02592 236 PVKYDRETYVA-VLDPLE---EKG--KIVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVI-NEN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1006 GCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLiqrgydsdp 1085
Cdd:PHA02592 308 GKLKVYENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEEL--------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1086 vKAWKEaqqkvpeeeeneeneesesessspaaeSGPTFNYLLDMPLWYLTKEKKDELCKQRDEKEQELNTLKKKTPSDLW 1165
Cdd:PHA02592 379 -SDNKD---------------------------FGEYADKLVAMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAKKEY 430
|
....*..
gi 2000185986 1166 KEDLAAF 1172
Cdd:PHA02592 431 IKDLEEL 437
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
454-574 |
1.47e-77 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 251.45 E-value: 1.47e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 454 CTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKnyEDEDSLKTLRYG 533
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGK--SDYESTKSLRYG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2000185986 534 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFIT 574
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPgFLVEFIT 120
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
572-710 |
5.23e-76 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 247.43 E-value: 5.23e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 572 FITPIVKVSKNKQEIAFYSLPEFEEWKSANPNHKKWKVKYYKGLGTSTSKEAKEYFANMKRHRIQFKYSGPEDDAAISLA 651
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2000185986 652 FSKKQVDDRKEWLTNFMedrrqrkllglPEDYLYgQTTMYLTYNDFINKELILFSNSDN 710
Cdd:pfam16898 81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
454-574 |
3.44e-63 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 210.44 E-value: 3.44e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 454 CTLILTEGDSAKTLAVSGLGVVgrdKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYG 533
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDDFD---LDKLRYG 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2000185986 534 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFIT 574
Cdd:cd01030 75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
39-666 |
1.05e-57 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 211.88 E-value: 1.05e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 39 LEHILLRPDTYIGSvelvtqqmwvYDEDvginyrevtfvpGLYKIFDEILVNAAD-------NKqrdpkmscIRVTIDAe 111
Cdd:PRK05559 19 LEPVRKRPGMYIGS----------TDTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLHA- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 112 NNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQ 191
Cdd:PRK05559 68 DGSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVK-RD-GKVYRQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 192 TWmDNMGRAGDMEL--KPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRR-AYDIAGstkdVKVFLNGNRLPVKgFRS 268
Cdd:PRK05559 146 RF-EGGDPVGPLEVvgTAGKRKTGTRVRFWPDPKIFDSPKFSPERLKERLRSkAFLLPG----LTITLNDERERQT-FHY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 269 yvDMYLKDKVDETGNALKVVHEQVNPRW---------EVCLTMSEKGFQQI-SFVNSIATSKGGRHVDYVADQIVSKLVD 338
Cdd:PRK05559 220 --ENGLKDYLAELNEGKETLPEEFVGSFegeaegeavEWALQWTDEGGENIeSYVNLIPTPQGGTHENGFREGLLKAVRE 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 339 VVKKKN--KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENM-TLQAKSFgstcqlSEKFIKAAIG------CGIVES 409
Cdd:PRK05559 298 FAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKLgSREARRF------VSGVVKDAFDlwlnqnPELAEK 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 410 ILNWVKFKAQIQLNKKCSAVKHNRIKG---IPKLddaNDAGSRNSAECTLILTEGDSAktlavSGLGVVGRDKY--GVFP 484
Cdd:PRK05559 372 LAEKAIKAAQARLRAAKKVKRKKKTSGpalPGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQARDREfqAILP 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 485 LRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 564
Cdd:PRK05559 444 LRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSFDLED----LRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLV 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 565 R--HRFLEEfiTPIVKVSKNKQEIAFYSLPEFEEW-KSANPNHKKWKVKYYKGLGTSTSKEAKEyfANM---KRHRIQFK 638
Cdd:PRK05559 520 EagHVYIAL--PPLYRVDKGKKKIYALDEEEKEELlKKLGKKGGKPEIQRFKGLGEMNPDQLWE--TTMdpeTRRLVRVT 595
|
650 660 670
....*....|....*....|....*....|.
gi 2000185986 639 YsgpEDDAAISLAFSK---KQVDDRKEWLTN 666
Cdd:PRK05559 596 I---DDAEETEKLVDMlmgKKAEPRREWIEE 623
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
39-616 |
3.60e-42 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 165.59 E-value: 3.60e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 39 LEHILLRPDTYIGSVelvtqqmwvyDEDvginyrevtfvpGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDA 110
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLHA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 111 ENNlISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFK 190
Cdd:COG0187 66 DGS-VTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVK-RD-GKIYR 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 191 QTWMDnmGRA-GDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRR-AYDIAGstkdVKVFLNGNR--LPVK-- 264
Cdd:COG0187 143 QRFER--GKPvGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLAERLRElAFLNKG----LTITLTDEReeEPKEet 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 265 -----GFRSYVDMYLKDKvdetgnalKVVHEQV--------NPRWEVCLTMSEKGFQQI-SFVNSIATSKGGRHV----- 325
Cdd:COG0187 217 fhyegGIKDFVEYLNEDK--------EPLHPEViyfegekdGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHEtgfrt 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 326 -------DYVadqivsKLVDVVKKKNK---------GGVAVkahqvknhmwifVNALIENPTFDSQTKEnmtlqaksfgs 389
Cdd:COG0187 289 altrvinDYA------RKNGLLKEKDKnltgddvreGLTAV------------ISVKLPEPQFEGQTKT----------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 390 tcQLSEKFIKaaigcGIVESILN----------------WVKF------------KAQIQLNKKcSAVKHNRIKGipKLD 441
Cdd:COG0187 340 --KLGNSEAR-----GIVESVVSeklehyleenpaeakkILEKailaarareaarKARELVRRK-SALESSGLPG--KLA 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 442 DANdagSRNSAECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREASHKQIMENAEINNIIKIVGL 515
Cdd:COG0187 410 DCS---SKDPEESELFIVEGDSAggsaKQ---------GRDrEFqAILPLRGKILNVEKARLDKILKNEEIRDLITALGT 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 516 QYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLeeFI--TPIVKVSKNKQEIAFYSLPE 593
Cdd:COG0187 478 GIGDDFDLEK----LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAE 551
|
650 660
....*....|....*....|...
gi 2000185986 594 FEEWKSANPNHKKWKVKYYKGLG 616
Cdd:COG0187 552 LDELLKELKGKKKVEIQRYKGLG 574
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
39-616 |
3.29e-36 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 147.16 E-value: 3.29e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 39 LEHILLRPDTYIGSvelvtqqmwvydedvginyrevTFVPGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDa 110
Cdd:PRK05644 19 LEAVRKRPGMYIGS----------------------TGERGLHHLVYEIVDNSidealagyCDH---------IEVTIN- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 111 ENNLISIWNNGKGIPVVEHKVEKmyVPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETaSREYKKm 188
Cdd:PRK05644 67 EDGSITVTDNGRGIPVDIHPKTG--KPAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEV-KRDGKI- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 189 FKQTWMDnmGR-AGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVAlmvRRAYDIAGSTKDVKVFLNGNRLPVK--- 264
Cdd:PRK05644 143 YYQEYER--GVpVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELAFLNKGLKITLTDEREGEEkee 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 265 ------GFRSYVDmYL-KDKvdetgnalKVVHEQV--------NPRWEVCLTMSEkGFQQ--ISFVNSIATSKGGRHVDY 327
Cdd:PRK05644 218 tfhyegGIKEYVE-YLnRNK--------EPLHEEPiyfegekdGIEVEVAMQYND-GYSEniLSFANNINTHEGGTHEEG 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 328 VADQIVSKLVDVVKKKNK---------------GGVAVKAhqVKnhmwifvnalIENPTFDSQTK------ENMTLQAKS 386
Cdd:PRK05644 288 FKTALTRVINDYARKNKLlkekddnltgedvreGLTAVIS--VK----------HPEPQFEGQTKtklgnsEVRGIVDSV 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 387 FGStcQLSEKF------IKAaigcgIVESILNwvKFKAQIqlnkkcsAVKHNR----------IKGIP-KLDDANdagSR 449
Cdd:PRK05644 356 VSE--ALSEFLeenpnvAKK-----IVEKAIL--AARARE-------AARKAReltrrksaleSSSLPgKLADCS---SK 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 450 NSAECTLILTEGDSAKTLAVSGlgvvgRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKknyeDEDSL 527
Cdd:PRK05644 417 DPEESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIG----DDFDI 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 528 KTLRYGKIMIMTDQDQDGSHIKGLLINFIhhnwpsllrHRFLEEFIT---------PIVKVSKNKQEIAfYSLPEFEEWK 598
Cdd:PRK05644 488 SKLRYHKIIIMTDADVDGAHIRTLLLTFF---------YRYMRPLIEagyvyiaqpPLYKIKKGGKEYA-YSDEELDEIL 557
|
650 660
....*....|....*....|
gi 2000185986 599 SANPNH--KKWKVKYYKGLG 616
Cdd:PRK05644 558 AELKLKgnPKYGIQRYKGLG 577
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
265-425 |
3.19e-33 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 126.96 E-value: 3.19e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 265 GFRSYVDMYLKDKVDETGNALKVVHEQVNPRWEVCLTM---SEKGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVK 341
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 342 KKN---KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGC-GIVESILNWVKFK 417
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEENpEIAKKILEKALQA 160
|
....*...
gi 2000185986 418 AQIQLNKK 425
Cdd:pfam00204 161 AKARLAAR 168
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
711-1072 |
5.93e-27 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 118.27 E-value: 5.93e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 711 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGsvaEMSSYH-HGEMSLMMTIINLAqnfvgsNNLNLLQPIGQF 789
Cdd:PRK09631 22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 790 GTRLHGgkDSAS-PRYIFTMLSPLARLLFPSKDDHTLRFLYdDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDV 868
Cdd:PRK09631 93 GNLFTG--DPASaARYIECRLTPLAKEVLYNKEITEYEPSY-DGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 869 REVVNNIRRLLDGeEPLPMLPSYknYKGTIEELasNQYVI-NGEVAI------LNSTTIEITELPIRTWTQTYKEQVLEP 941
Cdd:PRK09631 170 NEILQAVKSELLG-ESFALYPDF--PTGGIVDV--SEYADgNGKVLVrakietKDEKTIVIREIPFGTTTESLIASIEKA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 942 MLNGTEKTPPlITDYreyhTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHvgcLKKYDTVLDILRdF 1021
Cdd:PRK09631 245 ARKGKIKISS-INDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDR---YPVIYTVTDIIK-F 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2000185986 1022 FELRLKYYgLRKEwllgmLGAESSKLnnqarfiLEKIDGK----IVIENKPKKEL 1072
Cdd:PRK09631 316 HAEHLQKV-LKME-----LELERAKL-------LEKIFAKtleqIFIEERIYKRI 357
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1433-1520 |
9.76e-25 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 99.83 E-value: 9.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1433 RAVPKETK------SDSALNAHVSKKPAPAKAKNSRKRKPSSSDSSD-SEFEKAISKGATSKKPKG--EERDFHVDLDDT 1503
Cdd:pfam08070 1 KAAPKAAKaadkssSDSDSDAGASKKPAPPKGRKARKRKPSSSSDDSdSDFGKKPSKAVAKKKSKKvsDDDDFSVDLDSE 80
|
90
....*....|....*..
gi 2000185986 1504 VAPRAKSGRARKPIKYL 1520
Cdd:pfam08070 81 VAPRARPGRAKKPVKYL 97
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
454-564 |
6.07e-24 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 98.11 E-value: 6.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 454 CTLILTEGDSAktlavSGLGVVGRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEdedsLKTLR 531
Cdd:cd03366 1 SELYIVEGDSA-----GGSAKQGRDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFD----LEKLR 71
|
90 100 110
....*....|....*....|....*....|...
gi 2000185986 532 YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 564
Cdd:cd03366 72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLI 104
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
104-586 |
4.29e-21 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 100.17 E-value: 4.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 104 IRVTIDAENNlISIWNNGKGIPVVEHKVEKmyVPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVeTA 181
Cdd:PRK14939 61 ITVTIHADGS-VSVSDNGRGIPTDIHPEEG--VSAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLEL-TI 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 182 SREyKKMFKQTWmdNMGRA-------GDMELKpfsGedyTCITFQPDLSKFKMQSLDKDIVAlmvRR----AYDIAGstk 250
Cdd:PRK14939 137 RRD-GKIHEQEF--EHGVPvaplkvvGETDKT---G---TEVRFWPSPEIFENTEFDYDILA---KRlrelAFLNSG--- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 251 dVKVFLNGNRLPVK-------GFRSYVDmYLkdkvDETGNAL--KVVH---EQVNPRWEVCL----TMSEKGFqqiSFVN 314
Cdd:PRK14939 202 -VRIRLKDERDGKEeefhyegGIKAFVE-YL----NRNKTPLhpNIFYfsgEKDGIGVEVALqwndSYQENVL---CFTN 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 315 SIATSKGGRHV------------DYVADQIVSKlvdvvKKKNK--------GGVAVKAhqVKnhmwifvnalIENPTFDS 374
Cdd:PRK14939 273 NIPQRDGGTHLagfraaltrtinNYIEKEGLAK-----KAKVSltgddareGLTAVLS--VK----------VPDPKFSS 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 375 QTKENMtlqaksfGStcqlSEkfIKaaigcGIVESILN--WVKF------KAQIQLNKKCSAVKH----------NRIKG 436
Cdd:PRK14939 336 QTKDKL-------VS----SE--VR-----PAVESLVNekLSEFleenpnEAKIIVGKIIDAARAreaarkarelTRRKG 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 437 IpkLDDAN------DAGSRNSAECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREASHKQIMENA 504
Cdd:PRK14939 398 A--LDIAGlpgklaDCQEKDPALSELYLVEGDSAggsaKQ---------GRDrKFqAILPLKGKILNVEKARFDKMLSSQ 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 505 EINNIIKIVGLQYKKnyeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIhhnwpsllrHRFLEEFIT---------P 575
Cdd:PRK14939 467 EIGTLITALGCGIGR---DEFNPDKLRYHKIIIMTDADVDGSHIRTLLLTFF---------YRQMPELIErghlyiaqpP 534
|
570
....*....|.
gi 2000185986 576 IVKVSKNKQEI 586
Cdd:PRK14939 535 LYKVKKGKQEQ 545
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
712-1088 |
3.64e-20 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 97.38 E-value: 3.64e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 712 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 787
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 788 QFGTRlhGGKDSASPRYIFTMLSPLARLLFPSKDDHTLRFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 865
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 866 FDVREVVNNIRRLLDGEE----------PLPMLP-------------SYKNYKGTIeelasnqyVINGEVAILNS----T 918
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiilgrsgirsAYETGRGSI--------VIRARAEIEEDskgrE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 919 TIEITELPIRTWTQTYKEQVLEpMLNgtEKTPPLITDYREYHTDTTVKFVIkmtEEKLAEAERVGLHKVFK---LQTSLT 995
Cdd:TIGR01063 250 AIIVTEIPYQVNKARLIEKIAE-LVR--EKKIEGISDIRDESDREGIRIVI---ELKRDAVAEVVLNNLYKqtqLQVSFG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 996 CNSMVLFDHvgcLKKYDTVLDILRDFFELRLK------YYGLRK-----EWLLGMLGAesskLNNqarfilekIDGKI-V 1063
Cdd:TIGR01063 324 INMLALVKG---LPKVLNLKELLEAFVEHRKDvitrrtIFELRKaeeraHILEGLLIA----LDN--------IDEVIaL 388
|
410 420
....*....|....*....|....*
gi 2000185986 1064 IENKPKKELIKVLIQRGYDSDPVKA 1088
Cdd:TIGR01063 389 IRASQNTEEAKTRLVERFSLSEIQA 413
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
711-933 |
6.25e-20 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 94.96 E-value: 6.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 711 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMSSYHHGEMSLMMTIINLAqnfvgsNNLNLLQPIGQFG 790
Cdd:PRK09630 22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA------NKGYLIDTQGNFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 791 TRLHGGKDSASpRYIFTMLSPLARLLFPSKDDHTLRFLYDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVRE 870
Cdd:PRK09630 94 NPLTGDPHAAA-RYIEARLSPLAKEVLFNTDLMTFHDSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCE 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2000185986 871 VVNNIRRLLDgEEPLPMLPSYknYKGTIEELASNQ-----YVINGEVAILNSTTIEITELPIRTWTQT 933
Cdd:PRK09630 172 LLEAQIAILN-DQPFTLLPDF--PSGGTMDASEYQdglgsITLRASIDIINDKTLLIKEICPSTTTET 236
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
265-583 |
1.88e-19 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 95.33 E-value: 1.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 265 GFRSYVDMYLKDKV----DETGNALKVVHEQVNPRWEVCLTMSEKGFQQISFVNSIATSkGGRHVDYVADQIvSKLVDVV 340
Cdd:PTZ00109 376 GTREFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDGFKYAI-TRCVNGN 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 341 KKKN---KGG-VAVKAHQVKNHMWIFVNALIENPTFDSQTKEnmtlqaksfgstcQLSEKFIKAaigcgIVESILNWvKF 416
Cdd:PTZ00109 454 IKKNgyfKGNfVNIPGEFIREGMTAIISVKLNGAEFDGQTKT-------------KLGNHLLKT-----ILESIVFE-QL 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 417 KAQIQLNKKCSAVKHNRIKGIPKLDDANDAG-----SRNS-----------AECT--------LILTEGDSAktlAVSGL 472
Cdd:PTZ00109 515 SEILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirQKNNqyystilpgklVDCIsddierneLFIVEGESA---AGNAK 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 473 GVVGRDKYGVFPLRGKILNVRE-ASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLK----------------------- 528
Cdd:PTZ00109 592 QARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLSVNPVTWRQYDLShgtkaskdesvqnnnstltkkkn 671
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 529 -----TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNK 583
Cdd:PTZ00109 672 slfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHGRVYVACPPLYRITNNR 731
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
711-957 |
4.37e-12 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 70.91 E-value: 4.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 711 ERSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 786
Cdd:PRK05561 33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 787 GQFGTRlhGGKDSASPRYIFTMLSPLARLLFPSKDDHTLRFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 864
Cdd:PRK05561 109 GNFGSI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVpnFDGTLK-EPTVLPARFPNLLLNGATGIAVGMATDIP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 865 NFDVREVVNNIRRLLDGEE----------PLPMLPS--------------YKNYKG--------TIEELASNQYVingev 912
Cdd:PRK05561 186 PHNLREVIDAAIHLIDNPDatleelmefvPGPDFPTggeiitgrdgirkaYETGRGsirvrarwEIEDLAGGRWQ----- 260
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2000185986 913 ailnsttIEITELPIrtwtQTYKEQVLEPMLNGT-EKTPPLITDYR 957
Cdd:PRK05561 261 -------IVITELPY----QVSKAKLIEQIAELMnAKKLPGIADVR 295
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
266-378 |
6.72e-12 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 63.43 E-value: 6.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 266 FRSYVDMYLKDKVdetgnALKVVHEQVNP---RWEVCLTMSE----KGFQQISFVNSIATSKGGRHVDYVADQIVSKLvd 338
Cdd:cd00329 1 LKDRLAEILGDKV-----ADKLIYVEGESdgfRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2000185986 339 vvkkknkggvavKAHQVKNHMWIFVNALIEN--PTFD-SQTKE 378
Cdd:cd00329 74 ------------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
80-262 |
9.14e-12 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 65.25 E-value: 9.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 80 LYKIFDEILVNAAD-------NKqrdpkmscIRVTIDaENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDD 152
Cdd:cd16928 1 LHHLVWEIVDNSIDealagyaTE--------IEVTLH-EDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 153 DEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQTWMDNmGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDK 232
Cdd:cd16928 72 GSYKVSGGLHGVGVSVVNALSERLEVEVK-RD-GKIYRQEFSRG-GPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDF 148
|
170 180 190
....*....|....*....|....*....|
gi 2000185986 233 DIVAlmvRRAYDIAGSTKDVKVFLNGNRLP 262
Cdd:cd16928 149 DTLK---RRLRELAFLNKGLKIVLEDERTG 175
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
711-866 |
9.39e-12 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 70.03 E-value: 9.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 711 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEmssYH-HGEMSLMMTIINLAQnfvgsNNLnLLQPIGQF 789
Cdd:PRK12758 41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHTMQ---YHpHGDASIGDALVQLGQ-----KDL-LIDTQGNW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 790 GTRLhGGKDSASPRYIFTMLSPLA-RLLFpsKDDHTLRFLYDDNQRVEPEwYIPI-IPMVLINGAEGIGTGWSCKI-P-N 865
Cdd:PRK12758 112 GNIL-TGDGAAAPRYIEARLSKFAlEVVF--NPKTTEWQLSYDGRKKEPV-TLPVkFPLLLAQGAEGIAVGLSTKIlPhN 187
|
.
gi 2000185986 866 F 866
Cdd:PRK12758 188 F 188
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
711-1003 |
1.52e-10 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 66.28 E-value: 1.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 711 ERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 786
Cdd:PRK13979 36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 787 GQFGTRlhGGKDSASPRYIFTMLSPLARLLFPSKDDHTLRFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 864
Cdd:PRK13979 112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVdnYSDSEK-EPEVLPARYPNLLVNGAFGIAVGLATNIP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 865 NFDVREVVNNIRRLLDGEE-------------PLP----------MLPSYKNYKG--------TIEELAsnqyviNGEVA 913
Cdd:PRK13979 189 PHNLKEVIDGTLAYIDNNEittkelmnyikgpDLPtggiligkksLLSAYETGEGkvtlraktKIEKLE------NGRLG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 914 ILnsttieITELPIRtwtqTYKEQVLEPMLNGT-----EKTPPLITDYREYHTDTTVKFVI---KMTEEKLAEAERVGLH 985
Cdd:PRK13979 263 IV------ITEFPYR----RNKAKLLQTISEMTadkkhSKALENISDIRDESDRNGIRAVIefkKSADEDVAEKVLKYLY 332
|
330
....*....|....*...
gi 2000185986 986 KVFKLQTSLTCNSMVLFD 1003
Cdd:PRK13979 333 KKTDLQCNISFNMVALAD 350
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
712-880 |
7.64e-09 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 60.44 E-value: 7.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 712 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 787
Cdd:COG0188 34 RALPDVRDGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 788 QFGTRlhGGkDS-ASPRYIFTMLSPLARLLFPSKDDHTLRFL--YDDNQRvEPEwYIP-IIPMVLINGAEGIGTGWSCKI 863
Cdd:COG0188 110 NFGSI--DG-DPaAAMRYTEARLAKIAEELLADIDKDTVDFVpnYDGSEQ-EPT-VLPaRFPNLLVNGSSGIAVGMATNI 184
|
170
....*....|....*....
gi 2000185986 864 P--NfdVREVVNNIRRLLD 880
Cdd:COG0188 185 PphN--LGEVIDACIALID 201
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
712-901 |
1.73e-08 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 59.27 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 712 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 787
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 788 QFGTRlhGGkDS-ASPRYIFTMLSPLARLLFPSKDDHTLRFL--YDDNQRvEPEwYIPI-IPMVLINGAEGIGTGWSCKI 863
Cdd:PRK05560 105 NFGSI--DG-DPaAAMRYTEARMSKIAHELLADIDKETVDFVpnYDGSEQ-EPT-VLPArFPNLLVNGSSGIAVGMATNI 179
|
170 180 190
....*....|....*....|....*....|....*...
gi 2000185986 864 PNFDVREVVNNIRRLLDgeeplpmlpsykNYKGTIEEL 901
Cdd:PRK05560 180 PPHNLGEVIDACLALID------------NPDITIEEL 205
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
79-186 |
3.29e-08 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 53.14 E-value: 3.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 79 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDAENNL-ISIWNNGKGIPVVEHKvekmyvpaLIFGQLLTSSnydddekKV 157
Cdd:pfam02518 5 RLRQVLSNLLDNALKHA---AKAGEITVTLSEGGELtLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90 100 110
....*....|....*....|....*....|.
gi 2000185986 158 TGGRNGYGAKLCNIFSTKF--TVETASREYK 186
Cdd:pfam02518 67 GGGGTGLGLSIVRKLVELLggTITVESEPGG 97
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
1301-1463 |
1.61e-06 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 52.77 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1301 SNESNFDVPPREKEPRIAATKAKFTADLDSDDDFSGldekDEDEDFFPLDDTP----PKTKMPPKNTKKALKPQKSSTSV 1376
Cdd:pfam03546 359 SGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESD----SEEAAATPAQVKAsgktPQAKANPAPTKASSAKGAASAPG 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1377 DLESDGKDSVPASPgaSAADVPAETEPSKPSSKQtvGVKRTITKGQSLTSTAGTKKRAV--PKETKSDSALNAHVSKKPA 1454
Cdd:pfam03546 435 KVVAAAAQAKQGSP--AKVKPPARTPQNSAISVR--GQASVPAVGKAVATAAQAQKGPVggPQEEDSESSEEESDSEEEA 510
|
....*....
gi 2000185986 1455 PAKAKNSRK 1463
Cdd:pfam03546 511 PAQAKPSGK 519
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
79-179 |
1.98e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 48.03 E-value: 1.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 79 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDAENN--LISIWNNGKGIPvvEHKVEKMYVPaliFGQLltssnyddDEKK 156
Cdd:smart00387 5 RLRQVLSNLLDNAIKYT---PEGGRITVTLERDGDhvEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRS 68
|
90 100
....*....|....*....|...
gi 2000185986 157 VTGGRNGYGAKLCNIFSTKFTVE 179
Cdd:smart00387 69 RKIGGTGLGLSIVKKLVELHGGE 91
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
455-555 |
1.99e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 47.35 E-value: 1.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 455 TLILTEGDS-AKTLAvsglGVVGRDKYGVFPLRGKILNVREASHKQIMenaeinNIIKIVGLQYKKnyededslktlryg 533
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKAL------KALKELALKAKE-------------- 56
|
90 100
....*....|....*....|..
gi 2000185986 534 kIMIMTDQDQDGSHIKGLLINF 555
Cdd:pfam01751 57 -VILATDPDREGEAIALKLLEL 77
|
|
| PRK13808 |
PRK13808 |
adenylate kinase; Provisional |
1351-1488 |
6.72e-05 |
|
adenylate kinase; Provisional
Pssm-ID: 172341 [Multi-domain] Cd Length: 333 Bit Score: 46.80 E-value: 6.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1351 DTPPKTKMPPKNT---KKALKPQKSSTSVDLESDGKDSVPASPGASAADVPAETEpSKPSSKQTVGVKRTITKgqsltsT 1427
Cdd:PRK13808 198 NAKKAAKTPAAKSgakKASAKAKSAAKKVSKKKAAKTAVSAKKAAKTAAKAAKKA-KKTAKKALKKAAKAVKK------A 270
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2000185986 1428 AGTKKRAVPKETKSdsalNAHVSKKPAPAKAKNSRKRKPSSSDSSDSEFEKAISKGATSKK 1488
Cdd:PRK13808 271 AKKAAKAAAKAAKG----AAKATKGKAKAKKKAGKKAAAGSKAKATAKAPKRGAKGKKAKK 327
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
1308-1491 |
9.90e-05 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 46.99 E-value: 9.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1308 VPPREKEPriAATKAKfTADLDSDDDFSGLDEKDEDEDffplddtPPKTKMPPKNTKKALKPQKSSTSVDL-ESDGKDSV 1386
Cdd:pfam03546 3 ATPGKAGP--AATQAK-AGKPEEDSESSSEEESDSEEE-------TPAAKTPLQAKPSGKTPQVRAASAPAkESPRKGAP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 1387 PASPG-----ASAADVPAETEPSKPSSKQTVGVKRTITKGQSLTSTAGTKKRAVPKETKSDSALNAHVSKK----PAPAK 1457
Cdd:pfam03546 73 PVPPGktgpaAAQAQAGKPEEDSESSSEESDSDGETPAAATLTTSPAQVKPLGKNSQVRPASTVGKGPSGKganpAPPGK 152
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2000185986 1458 AKNS-------RKRKPSSSDSSDSEFEKAISKGATSKKPKG 1491
Cdd:pfam03546 153 AGSAaplvqvgKKEEDSESSSEESDSEGEAPPAATQAKPSG 193
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
454-565 |
7.18e-04 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 40.10 E-value: 7.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185986 454 CTLILTEGDS-AKTLAVSGlgvvgRDKYGVFPLRGKILNvreashkqimenAEINNIIKIVGlqykknyededslktlRY 532
Cdd:cd00188 1 KKLIIVEGPSdALALAQAG-----GYGGAVVALGGHALN------------KTRELLKRLLG----------------EA 47
|
90 100 110
....*....|....*....|....*....|...
gi 2000185986 533 GKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR 565
Cdd:cd00188 48 KEVIIATDADREGEAIALRLLELLKSLGKKVRR 80
|
|
| |
