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Conserved domains on  [gi|2023614079|ref|NP_001381246|]
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kinetochore protein Spc24 isoform 8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 3-128 1.41e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.61  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023614079   3 AFRDIEEVSQGLLSLLGANRAEAQQRRL---LGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVE 79
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2023614079  80 LQQLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDED 128
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 3-128 1.41e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.61  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023614079   3 AFRDIEEVSQGLLSLLGANRAEAQQRRL---LGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVE 79
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2023614079  80 LQQLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDED 128
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345
Spc24 pfam08286
Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved ...
 82-137 5.31e-03

Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex and is involved in chromosome segregation


Pssm-ID: 429899 [Multi-domain]  Cd Length: 107  Bit Score: 34.50  E-value: 5.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2023614079  82 QLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDEDTTVTIPSAV 137
Cdd:pfam08286   1 ELDNEKFRLAKELNDLESELERLESELAKLKEELEELEEQGVEVDEEDERSEDETV 56
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 3-128 1.41e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.61  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023614079   3 AFRDIEEVSQGLLSLLGANRAEAQQRRL---LGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVE 79
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2023614079  80 LQQLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDED 128
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345
Spc24 pfam08286
Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved ...
 82-137 5.31e-03

Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex and is involved in chromosome segregation


Pssm-ID: 429899 [Multi-domain]  Cd Length: 107  Bit Score: 34.50  E-value: 5.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2023614079  82 QLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDEDTTVTIPSAV 137
Cdd:pfam08286   1 ELDNEKFRLAKELNDLESELERLESELAKLKEELEELEEQGVEVDEEDERSEDETV 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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