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Conserved domains on  [gi|2029126791|ref|NP_001381444|]
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general transcription factor 3C polypeptide 2 isoform f [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10646020)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 62-255 4.77e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 4.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791  62 DSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKpgRKRGGRTRKGPKRPQQPNPPSAPLVPglldqSNPLSTPMPK 141
Cdd:PTZ00449  541 DEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSK--KPEFPKDPKHPKDPEEPKKPKRPRSA-----QRPTRPKSPK 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791 142 KrgrkskaeLLLLKLSKDLDRPES-QSPKRPPEDFETPSGERP------------------------------------R 184
Cdd:PTZ00449  614 L--------PELLDIPKSPKRPESpKSPKRPPPPQRPSSPERPegpkiikspkppkspkppfdpkfkekfyddyldaaaK 685

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2029126791 185 RRAAQVALLYLQELAEELSTALPAPVSCPegPKVSSPTKPKKIRQPAAC--PGGEEVDGAPRDEDFFLQVEAE 255
Cdd:PTZ00449  686 SKETKTTVVLDESFESILKETLPETPGTP--FTTPRPLPPKLPRDEEFPfePIGDPDAEQPDDIEFFTPPEEE 756
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 553-590 5.53e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.53e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2029126791  553 PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWD 590
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 62-255 4.77e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 4.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791  62 DSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKpgRKRGGRTRKGPKRPQQPNPPSAPLVPglldqSNPLSTPMPK 141
Cdd:PTZ00449  541 DEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSK--KPEFPKDPKHPKDPEEPKKPKRPRSA-----QRPTRPKSPK 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791 142 KrgrkskaeLLLLKLSKDLDRPES-QSPKRPPEDFETPSGERP------------------------------------R 184
Cdd:PTZ00449  614 L--------PELLDIPKSPKRPESpKSPKRPPPPQRPSSPERPegpkiikspkppkspkppfdpkfkekfyddyldaaaK 685

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2029126791 185 RRAAQVALLYLQELAEELSTALPAPVSCPegPKVSSPTKPKKIRQPAAC--PGGEEVDGAPRDEDFFLQVEAE 255
Cdd:PTZ00449  686 SKETKTTVVLDESFESILKETLPETPGTP--FTTPRPLPPKLPRDEEFPfePIGDPDAEQPDDIEFFTPPEEE 756
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 553-590 5.53e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.53e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2029126791  553 PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWD 590
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-592 7.34e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 7.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2029126791 545 SDGSLKLY------PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWDLR 592
Cdd:cd00200   197 SDGTIKLWdlstgkCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 37-238 2.59e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 44.88  E-value: 2.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791   37 KTSSEMTSAEASV---EMSLPTPLPGFEDSPDQRRlPPEQESLSRLEQPDLSSEMSKVS-KPRASKPgrkrggrtrkgPK 112
Cdd:pfam15324  965 REPPVAASVPGDLptkETLLPTPVPTPQPTPPCSP-PSPLKEPSPVKTPDSSPCVSEHDfFPVKEIP-----------PE 1032

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791  113 RPQQPNPPSAPLvpglldqSNPLSTPMPKKRGRKSKAELLLLKLSKDLDRPESQSPKrPPEDFETPSGE---RPRRRAAQ 189
Cdd:pfam15324 1033 KGADTGPAVSLV-------ITPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPK-PWEDSDLPLEEenpNSEQEELH 1104

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2029126791  190 VALLYLQELAEELSTALPAPVSCPEGPKVSSPTKPKKIRQPAACPGGEE 238
Cdd:pfam15324 1105 PRAVVMSVARDEEPESVVLPASPPEPKPLAPPPLGAAPPSPPQSPSSSS 1153
WD40 pfam00400
WD domain, G-beta repeat;
553-590 3.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2029126791 553 PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWD 590
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
526-594 1.77e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2029126791 526 GMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTLQWCkANSHFLVSAGSDRKIKFWDLRRP 594
Cdd:COG2319   184 GTVRLWDLATGKLLRTLT---------------GHTGAVRSVAFS-PDGKLLASGSADGTVRLWDLATG 236
 
Name Accession Description Interval E-value
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 62-255 4.77e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 4.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791  62 DSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKpgRKRGGRTRKGPKRPQQPNPPSAPLVPglldqSNPLSTPMPK 141
Cdd:PTZ00449  541 DEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSK--KPEFPKDPKHPKDPEEPKKPKRPRSA-----QRPTRPKSPK 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791 142 KrgrkskaeLLLLKLSKDLDRPES-QSPKRPPEDFETPSGERP------------------------------------R 184
Cdd:PTZ00449  614 L--------PELLDIPKSPKRPESpKSPKRPPPPQRPSSPERPegpkiikspkppkspkppfdpkfkekfyddyldaaaK 685

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2029126791 185 RRAAQVALLYLQELAEELSTALPAPVSCPegPKVSSPTKPKKIRQPAAC--PGGEEVDGAPRDEDFFLQVEAE 255
Cdd:PTZ00449  686 SKETKTTVVLDESFESILKETLPETPGTP--FTTPRPLPPKLPRDEEFPfePIGDPDAEQPDDIEFFTPPEEE 756
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 553-590 5.53e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.53e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2029126791  553 PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWD 590
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-592 7.34e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 7.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2029126791 545 SDGSLKLY------PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWDLR 592
Cdd:cd00200   197 SDGTIKLWdlstgkCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 37-238 2.59e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 44.88  E-value: 2.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791   37 KTSSEMTSAEASV---EMSLPTPLPGFEDSPDQRRlPPEQESLSRLEQPDLSSEMSKVS-KPRASKPgrkrggrtrkgPK 112
Cdd:pfam15324  965 REPPVAASVPGDLptkETLLPTPVPTPQPTPPCSP-PSPLKEPSPVKTPDSSPCVSEHDfFPVKEIP-----------PE 1032

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791  113 RPQQPNPPSAPLvpglldqSNPLSTPMPKKRGRKSKAELLLLKLSKDLDRPESQSPKrPPEDFETPSGE---RPRRRAAQ 189
Cdd:pfam15324 1033 KGADTGPAVSLV-------ITPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPK-PWEDSDLPLEEenpNSEQEELH 1104

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2029126791  190 VALLYLQELAEELSTALPAPVSCPEGPKVSSPTKPKKIRQPAACPGGEE 238
Cdd:pfam15324 1105 PRAVVMSVARDEEPESVVLPASPPEPKPLAPPPLGAAPPSPPQSPSSSS 1153
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-592 3.10e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 3.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2029126791 545 SDGSLKLY------PFQCFLAHDQAVRTLQWCkANSHFLVSAGSDRKIKFWDLR 592
Cdd:cd00200    29 GDGTIKVWdletgeLLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWDLE 81
WD40 pfam00400
WD domain, G-beta repeat;
553-590 3.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2029126791 553 PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWD 590
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 47-244 6.24e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791   47 ASVEMSLPTPLPgfedSPDqrrlPPEQESLSRLEQPDLSSEMSKVSKPRASKPGRKRGGRTRKGPKRPQQPNPPSAPLVP 126
Cdd:PHA03247  2562 AAPDRSVPPPRP----APR----PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP 2633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791  127 GLLDQSNPLSTPMPkkrgrKSKAELLLLKLSKDLDRPESQSPKRPPEDFETPsgERPRRRAAQVALLYLQELAEELST-A 205
Cdd:PHA03247  2634 AANEPDPHPPPTVP-----PPERPRDDPAPGRVSRPRRARRLGRAAQASSPP--QRPRRRAARPTVGSLTSLADPPPPpP 2706

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2029126791  206 LPAPVSCPEGPKVSSPTKPKKIRQ----------PAACPGGEEVDGAPR 244
Cdd:PHA03247  2707 TPEPAPHALVSATPLPPGPAAARQaspalpaapaPPAVPAGPATPGGPA 2755
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-592 6.53e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 6.53e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2029126791 545 SDGSLKLYPFQ------CFLAHDQAVRTLQWcKANSHFLVSAGSDRKIKFWDLR 592
Cdd:cd00200    71 SDKTIRLWDLEtgecvrTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVE 123
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 528-592 8.90e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 8.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029126791 528 VVFWNLPTNSPLQRIR---------------------LSDGSLKLY---PFQC---FLAHDQAVRTLQWCKANSHFLvSA 580
Cdd:cd00200   117 IKVWDVETGKCLTTLRghtdwvnsvafspdgtfvassSQDGTIKLWdlrTGKCvatLTGHTGEVNSVAFSPDGEKLL-SS 195

                          90
                  ....*....|..
gi 2029126791 581 GSDRKIKFWDLR 592
Cdd:cd00200   196 SSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
526-594 1.77e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2029126791 526 GMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTLQWCkANSHFLVSAGSDRKIKFWDLRRP 594
Cdd:COG2319   184 GTVRLWDLATGKLLRTLT---------------GHTGAVRSVAFS-PDGKLLASGSADGTVRLWDLATG 236
WD40 COG2319
WD40 repeat [General function prediction only];
526-592 3.68e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 3.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2029126791 526 GMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTLQWCkANSHFLVSAGSDRKIKFWDLR 592
Cdd:COG2319   142 GTVRLWDLATGKLLRTLT---------------GHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLA 192
WD40 COG2319
WD40 repeat [General function prediction only];
526-592 7.30e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 7.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2029126791 526 GMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTLQWcKANSHFLVSAGSDRKIKFWDLR 592
Cdd:COG2319   352 GTVRLWDLATGELLRT---------------LTGHTGAVTSVAF-SPDGRTLASGSADGTVRLWDLA 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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