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Conserved domains on  [gi|2033030969|ref|NP_001381723|]
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integrator complex subunit 14 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IntS14_b-barrel pfam19435
Integrator complex subunit 14, beta-barrel domain; This entry represents the central ...
 209-356 8.76e-96

Integrator complex subunit 14, beta-barrel domain; This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14.


:

Pssm-ID: 466081  Cd Length: 147  Bit Score: 286.86  E-value: 8.76e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969 209 YTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTG 288
Cdd:pfam19435   1 YSPFHGTLKCGNLSSPVQLFPPPEPYTKDTDFEPITRTISDDIEICGFIDIADVASPPVISRHLVLPLSTKKEKDESGKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2033030969 289 ITDDnEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPG 356
Cdd:pfam19435  81 GKAG-EDEDESNTDEGKIPSFCVLLHGSLKVENMVALVQVGEDWYGMLYSWADSKKKSNLMLSIFEPG 147
IntS14_C pfam20504
Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal ...
 405-512 9.82e-67

Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13.


:

Pssm-ID: 466653  Cd Length: 103  Bit Score: 210.26  E-value: 9.82e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969 405 VWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQ 484
Cdd:pfam20504   1 VWIKPGGLQSDIQKILRHARKLPEKTQQFYKELNRLRRAALSFGFLELLEGLAAMLERECTLLPGTAHPDAALQLTHAAN 80

                          90       100
                  ....*....|....*....|....*...
gi 2033030969 485 QLKLastgtSEYAAYDQNITPLHTDFSG 512
Cdd:pfam20504  81 QLRK-----SQSRDYKYNITPLQTNFSG 103
VWA_2 pfam13519
von Willebrand factor type A domain;
3-114 7.68e-18

von Willebrand factor type A domain;


:

Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 78.87  E-value: 7.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969   3 TVVVMDVSLSMTRpvsieGSEEYQRKHLAAHGLTMLFEHMATNykleFTALVVFSSLWELMVPFTRDYNTLQEALSNMDD 82
Cdd:pfam13519   1 LVFVLDTSGSMRN-----GDYGPTRLEAAKDAVLALLKSLPGD----RVGLVTFGDGPEVLIPLTKDRAKILRALRRLEP 71

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2033030969  83 Y-DKTCLESALVGVCNIVQQEWGGAiPCQVVLV 114
Cdd:pfam13519  72 KgGGTNLAAALQLARAALKHRRKNQ-PRRIVLI 103
 
Name Accession Description Interval E-value
IntS14_b-barrel pfam19435
Integrator complex subunit 14, beta-barrel domain; This entry represents the central ...
 209-356 8.76e-96

Integrator complex subunit 14, beta-barrel domain; This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14.


Pssm-ID: 466081  Cd Length: 147  Bit Score: 286.86  E-value: 8.76e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969 209 YTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTG 288
Cdd:pfam19435   1 YSPFHGTLKCGNLSSPVQLFPPPEPYTKDTDFEPITRTISDDIEICGFIDIADVASPPVISRHLVLPLSTKKEKDESGKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2033030969 289 ITDDnEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPG 356
Cdd:pfam19435  81 GKAG-EDEDESNTDEGKIPSFCVLLHGSLKVENMVALVQVGEDWYGMLYSWADSKKKSNLMLSIFEPG 147
IntS14_C pfam20504
Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal ...
 405-512 9.82e-67

Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13.


Pssm-ID: 466653  Cd Length: 103  Bit Score: 210.26  E-value: 9.82e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969 405 VWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQ 484
Cdd:pfam20504   1 VWIKPGGLQSDIQKILRHARKLPEKTQQFYKELNRLRRAALSFGFLELLEGLAAMLERECTLLPGTAHPDAALQLTHAAN 80

                          90       100
                  ....*....|....*....|....*...
gi 2033030969 485 QLKLastgtSEYAAYDQNITPLHTDFSG 512
Cdd:pfam20504  81 QLRK-----SQSRDYKYNITPLQTNFSG 103
VWA_2 pfam13519
von Willebrand factor type A domain;
3-114 7.68e-18

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 78.87  E-value: 7.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969   3 TVVVMDVSLSMTRpvsieGSEEYQRKHLAAHGLTMLFEHMATNykleFTALVVFSSLWELMVPFTRDYNTLQEALSNMDD 82
Cdd:pfam13519   1 LVFVLDTSGSMRN-----GDYGPTRLEAAKDAVLALLKSLPGD----RVGLVTFGDGPEVLIPLTKDRAKILRALRRLEP 71

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2033030969  83 Y-DKTCLESALVGVCNIVQQEWGGAiPCQVVLV 114
Cdd:pfam13519  72 KgGGTNLAAALQLARAALKHRRKNQ-PRRIVLI 103
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 4-117 4.39e-07

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 51.48  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969   4 VVVMDVSLSMtrpvsiegsEEYQRKHLAAHGLTMLFEHMATNYKLeftALVVFSSLWELMVPFTRDYNTLQEALSNMDDY 83
Cdd:COG1240    96 VLVVDASGSM---------AAENRLEAAKGALLDFLDDYRPRDRV---GLVAFGGEAEVLLPLTRDREALKRALDELPPG 163

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2033030969  84 DKTCLESALVGVCNIVQQEwGGAIPCQVVLVTDG 117
Cdd:COG1240   164 GGTPLGDALALALELLKRA-DPARRKVIVLLTDG 196
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 4-117 1.72e-04

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 42.17  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969   4 VVVMDVSLSMtrpvsieGSEEYQRKHLAAHGLTMLFEHMATNYKLeftALVVFSSLWELMVPFTRDYN--TLQEALSNMD 81
Cdd:cd00198     4 VFLLDVSGSM-------GGEKLDKAKEALKALVSSLSASPPGDRV---GLVTFGSNARVVLPLTTDTDkaDLLEAIDALK 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2033030969  82 DYDK--TCLESALVGVCNIVQQEWGGAIPCQVVLVTDG 117
Cdd:cd00198    74 KGLGggTNIGAALRLALELLKSAKRPNARRVIILLTDG 111
idnK PRK09825
gluconokinase;
365-489 7.41e-04

gluconokinase;


Pssm-ID: 182097  Cd Length: 176  Bit Score: 40.39  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969 365 KMAQLGPISDAKENPYGEDDNKSPFPLqpknkrsYAQNVTVWIKPSGLQTDVQKILRNARK------LPEKTQTFykeLN 438
Cdd:PRK09825   45 KMSQGIPLTDEDRLPWLERLNDASYSL-------YKKNETGFIVCSSLKKQYRDILRKSSPnvhflwLDGDYETI---LA 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2033030969 439 RLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLA 489
Cdd:PRK09825  115 RMQRRAGHFMPPDLLQSQFDALERPCADEHDIARIDVNHDIENVTEQCRQA 165
 
Name Accession Description Interval E-value
IntS14_b-barrel pfam19435
Integrator complex subunit 14, beta-barrel domain; This entry represents the central ...
 209-356 8.76e-96

Integrator complex subunit 14, beta-barrel domain; This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14.


Pssm-ID: 466081  Cd Length: 147  Bit Score: 286.86  E-value: 8.76e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969 209 YTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTG 288
Cdd:pfam19435   1 YSPFHGTLKCGNLSSPVQLFPPPEPYTKDTDFEPITRTISDDIEICGFIDIADVASPPVISRHLVLPLSTKKEKDESGKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2033030969 289 ITDDnEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPG 356
Cdd:pfam19435  81 GKAG-EDEDESNTDEGKIPSFCVLLHGSLKVENMVALVQVGEDWYGMLYSWADSKKKSNLMLSIFEPG 147
IntS14_C pfam20504
Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal ...
 405-512 9.82e-67

Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13.


Pssm-ID: 466653  Cd Length: 103  Bit Score: 210.26  E-value: 9.82e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969 405 VWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQ 484
Cdd:pfam20504   1 VWIKPGGLQSDIQKILRHARKLPEKTQQFYKELNRLRRAALSFGFLELLEGLAAMLERECTLLPGTAHPDAALQLTHAAN 80

                          90       100
                  ....*....|....*....|....*...
gi 2033030969 485 QLKLastgtSEYAAYDQNITPLHTDFSG 512
Cdd:pfam20504  81 QLRK-----SQSRDYKYNITPLQTNFSG 103
VWA_2 pfam13519
von Willebrand factor type A domain;
3-114 7.68e-18

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 78.87  E-value: 7.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969   3 TVVVMDVSLSMTRpvsieGSEEYQRKHLAAHGLTMLFEHMATNykleFTALVVFSSLWELMVPFTRDYNTLQEALSNMDD 82
Cdd:pfam13519   1 LVFVLDTSGSMRN-----GDYGPTRLEAAKDAVLALLKSLPGD----RVGLVTFGDGPEVLIPLTKDRAKILRALRRLEP 71

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2033030969  83 Y-DKTCLESALVGVCNIVQQEWGGAiPCQVVLV 114
Cdd:pfam13519  72 KgGGTNLAAALQLARAALKHRRKNQ-PRRIVLI 103
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 4-117 4.39e-07

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 51.48  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969   4 VVVMDVSLSMtrpvsiegsEEYQRKHLAAHGLTMLFEHMATNYKLeftALVVFSSLWELMVPFTRDYNTLQEALSNMDDY 83
Cdd:COG1240    96 VLVVDASGSM---------AAENRLEAAKGALLDFLDDYRPRDRV---GLVAFGGEAEVLLPLTRDREALKRALDELPPG 163

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2033030969  84 DKTCLESALVGVCNIVQQEwGGAIPCQVVLVTDG 117
Cdd:COG1240   164 GGTPLGDALALALELLKRA-DPARRKVIVLLTDG 196
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 4-117 1.72e-04

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 42.17  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969   4 VVVMDVSLSMtrpvsieGSEEYQRKHLAAHGLTMLFEHMATNYKLeftALVVFSSLWELMVPFTRDYN--TLQEALSNMD 81
Cdd:cd00198     4 VFLLDVSGSM-------GGEKLDKAKEALKALVSSLSASPPGDRV---GLVTFGSNARVVLPLTTDTDkaDLLEAIDALK 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2033030969  82 DYDK--TCLESALVGVCNIVQQEWGGAIPCQVVLVTDG 117
Cdd:cd00198    74 KGLGggTNIGAALRLALELLKSAKRPNARRVIILLTDG 111
ViaA COG2425
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ...
 2-136 4.36e-04

Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown];


Pssm-ID: 441973 [Multi-domain]  Cd Length: 263  Bit Score: 42.36  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969   2 PTVVVMDVSLSMtrpvsiEGSEEYQRKHLAAhgltMLFEHMATNyklEFTALVVFSS--LWELMVPFTRDYNTLQEALSN 79
Cdd:COG2425   120 PVVLCVDTSGSM------AGSKEAAAKAAAL----ALLRALRPN---RRFGVILFDTevVEDLPLTADDGLEDAIEFLSG 186

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2033030969  80 MDDYDKTCLESALVGVCNIVQQ-EWGGAipcQVVLVTDGCLGIGRGSLRHSLATQNQR 136
Cdd:COG2425   187 LFAGGGTDIAPALRAALELLEEpDYRNA---DIVLITDGEAGVSPEELLREVRAKESG 241
idnK PRK09825
gluconokinase;
365-489 7.41e-04

gluconokinase;


Pssm-ID: 182097  Cd Length: 176  Bit Score: 40.39  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969 365 KMAQLGPISDAKENPYGEDDNKSPFPLqpknkrsYAQNVTVWIKPSGLQTDVQKILRNARK------LPEKTQTFykeLN 438
Cdd:PRK09825   45 KMSQGIPLTDEDRLPWLERLNDASYSL-------YKKNETGFIVCSSLKKQYRDILRKSSPnvhflwLDGDYETI---LA 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2033030969 439 RLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLA 489
Cdd:PRK09825  115 RMQRRAGHFMPPDLLQSQFDALERPCADEHDIARIDVNHDIENVTEQCRQA 165
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
 4-117 4.42e-03

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 39.31  E-value: 4.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030969   4 VVVMDVSLSMtrpvsiegseEYQRKHLAAHGLTMLFEHMATNYKLeftALVVFSSLWELMVPFTR--DYNTLQEALSNMD 81
Cdd:COG2304    95 VFVIDVSGSM----------SGDKLELAKEAAKLLVDQLRPGDRV---SIVTFAGDARVLLPPTPatDRAKILAAIDRLQ 161

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2033030969  82 DYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDG 117
Cdd:COG2304   162 AGGGTALGAGLELAYELARKHFIPGRVNRVILLTDG 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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