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integrator complex subunit 14 isoform 3 [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
IntS14_b-barrel | pfam19435 | Integrator complex subunit 14, beta-barrel domain; This entry represents the central ... |
245-392 | 1.57e-95 | |||
Integrator complex subunit 14, beta-barrel domain; This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14. : Pssm-ID: 466081 Cd Length: 147 Bit Score: 287.24 E-value: 1.57e-95
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IntS14_C | pfam20504 | Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal ... |
441-548 | 1.67e-66 | |||
Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13. : Pssm-ID: 466653 Cd Length: 103 Bit Score: 210.65 E-value: 1.67e-66
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VWA_2 | pfam13519 | von Willebrand factor type A domain; |
39-150 | 8.83e-18 | |||
von Willebrand factor type A domain; : Pssm-ID: 463909 [Multi-domain] Cd Length: 103 Bit Score: 78.87 E-value: 8.83e-18
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Name | Accession | Description | Interval | E-value | |||
IntS14_b-barrel | pfam19435 | Integrator complex subunit 14, beta-barrel domain; This entry represents the central ... |
245-392 | 1.57e-95 | |||
Integrator complex subunit 14, beta-barrel domain; This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14. Pssm-ID: 466081 Cd Length: 147 Bit Score: 287.24 E-value: 1.57e-95
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IntS14_C | pfam20504 | Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal ... |
441-548 | 1.67e-66 | |||
Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13. Pssm-ID: 466653 Cd Length: 103 Bit Score: 210.65 E-value: 1.67e-66
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VWA_2 | pfam13519 | von Willebrand factor type A domain; |
39-150 | 8.83e-18 | |||
von Willebrand factor type A domain; Pssm-ID: 463909 [Multi-domain] Cd Length: 103 Bit Score: 78.87 E-value: 8.83e-18
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ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
40-153 | 4.82e-07 | |||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 51.48 E-value: 4.82e-07
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vWFA | cd00198 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
40-153 | 1.86e-04 | |||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Pssm-ID: 238119 [Multi-domain] Cd Length: 161 Bit Score: 42.17 E-value: 1.86e-04
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idnK | PRK09825 | gluconokinase; |
401-525 | 8.04e-04 | |||
gluconokinase; Pssm-ID: 182097 Cd Length: 176 Bit Score: 40.39 E-value: 8.04e-04
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Name | Accession | Description | Interval | E-value | |||
IntS14_b-barrel | pfam19435 | Integrator complex subunit 14, beta-barrel domain; This entry represents the central ... |
245-392 | 1.57e-95 | |||
Integrator complex subunit 14, beta-barrel domain; This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14. Pssm-ID: 466081 Cd Length: 147 Bit Score: 287.24 E-value: 1.57e-95
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IntS14_C | pfam20504 | Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal ... |
441-548 | 1.67e-66 | |||
Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13. Pssm-ID: 466653 Cd Length: 103 Bit Score: 210.65 E-value: 1.67e-66
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VWA_2 | pfam13519 | von Willebrand factor type A domain; |
39-150 | 8.83e-18 | |||
von Willebrand factor type A domain; Pssm-ID: 463909 [Multi-domain] Cd Length: 103 Bit Score: 78.87 E-value: 8.83e-18
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ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
40-153 | 4.82e-07 | |||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 51.48 E-value: 4.82e-07
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vWFA | cd00198 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
40-153 | 1.86e-04 | |||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Pssm-ID: 238119 [Multi-domain] Cd Length: 161 Bit Score: 42.17 E-value: 1.86e-04
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ViaA | COG2425 | Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ... |
38-172 | 4.77e-04 | |||
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown]; Pssm-ID: 441973 [Multi-domain] Cd Length: 263 Bit Score: 42.36 E-value: 4.77e-04
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idnK | PRK09825 | gluconokinase; |
401-525 | 8.04e-04 | |||
gluconokinase; Pssm-ID: 182097 Cd Length: 176 Bit Score: 40.39 E-value: 8.04e-04
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YfbK | COG2304 | Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ... |
40-153 | 4.82e-03 | |||
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only]; Pssm-ID: 441879 [Multi-domain] Cd Length: 289 Bit Score: 39.31 E-value: 4.82e-03
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Blast search parameters | ||||
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